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Protein

UDP-glucuronosyltransferase 2C1

Gene

UGT2C1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2C1 (EC:2.4.1.17)
Short name:
UDPGT 2C1
Gene namesi
Name:UGT2C1
Synonyms:UGT2A2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei466 – 48116HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 502›502UDP-glucuronosyltransferase 2C1PRO_0000074136Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000023419.

Structurei

3D structure databases

ProteinModelPortaliP36514.
SMRiP36514. Positions 258-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP36514.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P36514-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AAAMDFSHWI NLKVILEELQ LRGHEITVLV PSPSLLLDHT KIPFNVEVLQ
60 70 80 90 100
LQVTKETLME ELNTVLYMSS FELPTLSWWK VLGKMVEMGK QFSKNLRRVC
110 120 130 140 150
DSAITNKELL DRLKAAKFDI CLADPLAFCG ELVAELLNIP FVYSFRFSIG
160 170 180 190 200
NIIERSCAGL PTPSSYVPGS TSGLTDNMSF VQRLKNWLLY LMNDMMFSHF
210 220 230 240 250
MLSEWDEYYS KVLGRRTTIC EIMGKAEMWL IRSYWDFEFP RPFLPNFEYV
260 270 280 290 300
GGLHCKPAKP LPEELEEFVQ SSGNDGVVVF TLGSMIQNLT EERSNLIASA
310 320 330 340 350
LAQIPQKVLW RYTGKKPATL GPNTRLFEWI PQNDLLGHPK TRAFITHGGT
360 370 380 390 400
NGLYEAIYHG VPMVGIPLFG DQPDNIARVK AKGAAVDVDL RIMTTSSLLK
410 420 430 440 450
ALKDVINNPS YKENAMKLSR IHHDQPLKPL DRAVFWIEFV MRHKGARHLR
460 470 480 490 500
VAAHDLTWFQ YYSLDVVVFL LTCVATIIFL AKKCCLFFYR RFCKTGNKRK

RE
Length:502
Mass (Da):57,449
Last modified:June 1, 1994 - v1
Checksum:iB6E65670BFAE1D35
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01083 mRNA. Translation: AAA18023.1.
UniGeneiOcu.884.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01083 mRNA. Translation: AAA18023.1.
UniGeneiOcu.884.

3D structure databases

ProteinModelPortaliP36514.
SMRiP36514. Positions 258-419.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000023419.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP36514.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13."
    Tukey R.H., Pendurthi U.R., Nguyen N.T., Green M.D., Tephly T.R.
    J. Biol. Chem. 268:15260-15266(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Liver.

Entry informationi

Entry nameiUD2C1_RABIT
AccessioniPrimary (citable) accession number: P36514
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: January 7, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.