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P36514 (UD2C1_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2C1

Short name=UDPGT 2C1
EC=2.4.1.17
Gene names
Name:UGT2C1
Synonyms:UGT2A2
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length502 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 502›502UDP-glucuronosyltransferase 2C1
PRO_0000074136

Regions

Transmembrane466 – 48116Helical; Potential

Amino acid modifications

Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation2881N-linked (GlcNAc...) Potential

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P36514 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: B6E65670BFAE1D35

FASTA50257,449
        10         20         30         40         50         60 
AAAMDFSHWI NLKVILEELQ LRGHEITVLV PSPSLLLDHT KIPFNVEVLQ LQVTKETLME 

        70         80         90        100        110        120 
ELNTVLYMSS FELPTLSWWK VLGKMVEMGK QFSKNLRRVC DSAITNKELL DRLKAAKFDI 

       130        140        150        160        170        180 
CLADPLAFCG ELVAELLNIP FVYSFRFSIG NIIERSCAGL PTPSSYVPGS TSGLTDNMSF 

       190        200        210        220        230        240 
VQRLKNWLLY LMNDMMFSHF MLSEWDEYYS KVLGRRTTIC EIMGKAEMWL IRSYWDFEFP 

       250        260        270        280        290        300 
RPFLPNFEYV GGLHCKPAKP LPEELEEFVQ SSGNDGVVVF TLGSMIQNLT EERSNLIASA 

       310        320        330        340        350        360 
LAQIPQKVLW RYTGKKPATL GPNTRLFEWI PQNDLLGHPK TRAFITHGGT NGLYEAIYHG 

       370        380        390        400        410        420 
VPMVGIPLFG DQPDNIARVK AKGAAVDVDL RIMTTSSLLK ALKDVINNPS YKENAMKLSR 

       430        440        450        460        470        480 
IHHDQPLKPL DRAVFWIEFV MRHKGARHLR VAAHDLTWFQ YYSLDVVVFL LTCVATIIFL 

       490        500 
AKKCCLFFYR RFCKTGNKRK RE 

« Hide

References

[1]"Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13."
Tukey R.H., Pendurthi U.R., Nguyen N.T., Green M.D., Tephly T.R.
J. Biol. Chem. 268:15260-15266(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: New Zealand white.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L01083 mRNA. Translation: AAA18023.1.
UniGeneOcu.884.

3D structure databases

ProteinModelPortalP36514.
SMRP36514. Positions 258-419.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000023419.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1819.
HOGENOMHOG000220831.
HOVERGENHBG004033.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUD2C1_RABIT
AccessionPrimary (citable) accession number: P36514
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: March 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families