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P36514

- UD2C1_RABIT

UniProt

P36514 - UD2C1_RABIT

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Protein
UDP-glucuronosyltransferase 2C1
Gene
UGT2C1, UGT2A2
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2C1 (EC:2.4.1.17)
    Short name:
    UDPGT 2C1
    Gene namesi
    Name:UGT2C1
    Synonyms:UGT2A2
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei466 – 48116Helical; Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 502›502UDP-glucuronosyltransferase 2C1
    PRO_0000074136Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000023419.

    Structurei

    3D structure databases

    ProteinModelPortaliP36514.
    SMRiP36514. Positions 258-419.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOGENOMiHOG000220831.
    HOVERGENiHBG004033.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P36514-1 [UniParc]FASTAAdd to Basket

    « Hide

    AAAMDFSHWI NLKVILEELQ LRGHEITVLV PSPSLLLDHT KIPFNVEVLQ    50
    LQVTKETLME ELNTVLYMSS FELPTLSWWK VLGKMVEMGK QFSKNLRRVC 100
    DSAITNKELL DRLKAAKFDI CLADPLAFCG ELVAELLNIP FVYSFRFSIG 150
    NIIERSCAGL PTPSSYVPGS TSGLTDNMSF VQRLKNWLLY LMNDMMFSHF 200
    MLSEWDEYYS KVLGRRTTIC EIMGKAEMWL IRSYWDFEFP RPFLPNFEYV 250
    GGLHCKPAKP LPEELEEFVQ SSGNDGVVVF TLGSMIQNLT EERSNLIASA 300
    LAQIPQKVLW RYTGKKPATL GPNTRLFEWI PQNDLLGHPK TRAFITHGGT 350
    NGLYEAIYHG VPMVGIPLFG DQPDNIARVK AKGAAVDVDL RIMTTSSLLK 400
    ALKDVINNPS YKENAMKLSR IHHDQPLKPL DRAVFWIEFV MRHKGARHLR 450
    VAAHDLTWFQ YYSLDVVVFL LTCVATIIFL AKKCCLFFYR RFCKTGNKRK 500
    RE 502
    Length:502
    Mass (Da):57,449
    Last modified:June 1, 1994 - v1
    Checksum:iB6E65670BFAE1D35
    GO

    Non-terminal residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01083 mRNA. Translation: AAA18023.1.
    UniGeneiOcu.884.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01083 mRNA. Translation: AAA18023.1 .
    UniGenei Ocu.884.

    3D structure databases

    ProteinModelPortali P36514.
    SMRi P36514. Positions 258-419.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000023419.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG1819.
    HOGENOMi HOG000220831.
    HOVERGENi HBG004033.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13."
      Tukey R.H., Pendurthi U.R., Nguyen N.T., Green M.D., Tephly T.R.
      J. Biol. Chem. 268:15260-15266(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: New Zealand white.
      Tissue: Liver.

    Entry informationi

    Entry nameiUD2C1_RABIT
    AccessioniPrimary (citable) accession number: P36514
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: March 19, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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