Reviewed, UniProtKB/Swiss-Prot P36514 (UD2C1_RABIT)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2C1
      Short name=UDPGT 2C1
    EC=2.4.1.17

Gene names

Name:	UGT2C1
Synonyms:	UGT2A2

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	502 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 502	›502	UDP-glucuronosyltransferase 2C1		PRO_0000074136
Regions
	Transmembrane	466 – 481	16	Potential
Amino acid modifications
	Glycosylation	177	1	N-linked (GlcNAc...) Potential
	Glycosylation	288	1	N-linked (GlcNAc...) Potential
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P36514-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: B6E65670BFAE1D35	FASTA	502	57,449
	10 20 30 40 50 60 AAAMDFSHWI NLKVILEELQ LRGHEITVLV PSPSLLLDHT KIPFNVEVLQ LQVTKETLME 70 80 90 100 110 120 ELNTVLYMSS FELPTLSWWK VLGKMVEMGK QFSKNLRRVC DSAITNKELL DRLKAAKFDI 130 140 150 160 170 180 CLADPLAFCG ELVAELLNIP FVYSFRFSIG NIIERSCAGL PTPSSYVPGS TSGLTDNMSF 190 200 210 220 230 240 VQRLKNWLLY LMNDMMFSHF MLSEWDEYYS KVLGRRTTIC EIMGKAEMWL IRSYWDFEFP 250 260 270 280 290 300 RPFLPNFEYV GGLHCKPAKP LPEELEEFVQ SSGNDGVVVF TLGSMIQNLT EERSNLIASA 310 320 330 340 350 360 LAQIPQKVLW RYTGKKPATL GPNTRLFEWI PQNDLLGHPK TRAFITHGGT NGLYEAIYHG 370 380 390 400 410 420 VPMVGIPLFG DQPDNIARVK AKGAAVDVDL RIMTTSSLLK ALKDVINNPS YKENAMKLSR 430 440 450 460 470 480 IHHDQPLKPL DRAVFWIEFV MRHKGARHLR VAAHDLTWFQ YYSLDVVVFL LTCVATIIFL 490 500 AKKCCLFFYR RFCKTGNKRK RE

References

[1]

"Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13." Tukey R.H., Pendurthi U.R., Nguyen N.T., Green M.D., Tephly T.R. J. Biol. Chem. 268:15260-15266(1993) [PubMed: 8325897] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: New Zealand white. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L01083 mRNA. Translation: AAA18023.1.
UniGene	Ocu.6431
3D structure databases
SMR	P36514. Positions 258-419.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Phylogenomic databases
HOVERGEN	P36514.
Enzyme and pathway databases
BRENDA	2.4.1.17. 255.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UD2C1_RABIT

Accession

Primary (citable) accession number: P36514

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)