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P36513

- UDB14_RABIT

UniProt

P36513 - UDB14_RABIT

Protein

UDP-glucuronosyltransferase 2B14

Gene

UGT2B14

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B14 (EC:2.4.1.17)
    Short name:
    UDPGT 2B14
    Alternative name(s):
    EGT12
    Gene namesi
    Name:UGT2B14
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Chaini25 – 530506UDP-glucuronosyltransferase 2B14PRO_0000036038Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Developmental stagei

    Expressed primarily in adult rabbits.

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000014798.

    Structurei

    3D structure databases

    ProteinModelPortaliP36513.
    SMRiP36513. Positions 286-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei494 – 51017HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOVERGENiHBG004033.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36513-1 [UniParc]FASTAAdd to Basket

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    MSVKHVSVLL LLLQLSCCFR TGSCGKVLVW PMDFSLWMNL NVILDELVRR    50
    GHEVIVLRNS ASIFIDPSKQ ANIKFETFPI AATKDDLEDL FVHYVSTWTN 100
    ARQNSQWKYF SLLQKLFSEY SDSCENACKE VVFNKTLMTK LQESRFDILL 150
    SDAIGPCGEL LAELLKIPFV YSLRFTPGYT MEKYSGGLSV PPSYVPIILS 200
    DLSGKMTFME RVNNMLCMLY FDFWFQMFNK KRWDQFYSEV LGRPVTFSEL 250
    VGKADMWLIR SYWDLEFPRP TLPNIQFVGG LHCKPAKPLP KEMEEFVQSS 300
    GEEGVVVFSL GSMVSNMTEE RANLIASAFA QLPQKVIWRF DGQKPETLGP 350
    NTRIYDWIPQ NDLLGHPKTK AFVTHGGANG IYEAIHHGIP MVGLPLFGEQ 400
    PDNIAHMTAK GAAIRLNWKT MSSEDLLNAL KTVINDPSYK ENVMTLSSIH 450
    HDQPMKPLDR AVFWIEYVMR HKGAKHLRVA AHDLTWFQYH SLDVVGFLVS 500
    CAAFLIFLVI KSYLFVYQKL VKIGKKQKRD 530
    Length:530
    Mass (Da):60,665
    Last modified:June 1, 1994 - v1
    Checksum:iCEAA4BF25B53CB35
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01082 mRNA. Translation: AAA18021.1.
    PIRiC47113.
    RefSeqiNP_001075709.1. NM_001082240.1.
    UniGeneiOcu.6432.

    Genome annotation databases

    GeneIDi100009057.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01082 mRNA. Translation: AAA18021.1 .
    PIRi C47113.
    RefSeqi NP_001075709.1. NM_001082240.1.
    UniGenei Ocu.6432.

    3D structure databases

    ProteinModelPortali P36513.
    SMRi P36513. Positions 286-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000014798.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100009057.

    Organism-specific databases

    CTDi 100009057.

    Phylogenomic databases

    eggNOGi COG1819.
    HOVERGENi HBG004033.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13."
      Tukey R.H., Pendurthi U.R., Nguyen N.T., Green M.D., Tephly T.R.
      J. Biol. Chem. 268:15260-15266(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: New Zealand white.
      Tissue: Liver.

    Entry informationi

    Entry nameiUDB14_RABIT
    AccessioniPrimary (citable) accession number: P36513
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3