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Protein

UDP-glucuronosyltransferase 2B14

Gene

UGT2B14

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B14 (EC:2.4.1.17)
Short name:
UDPGT 2B14
Alternative name(s):
EGT12
Gene namesi
Name:UGT2B14
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei494 – 51017HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 530506UDP-glucuronosyltransferase 2B14PRO_0000036038Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Developmental stagei

Expressed primarily in adult rabbits.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000014798.

Structurei

3D structure databases

ProteinModelPortaliP36513.
SMRiP36513. Positions 286-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOVERGENiHBG004033.
InParanoidiP36513.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36513-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKHVSVLL LLLQLSCCFR TGSCGKVLVW PMDFSLWMNL NVILDELVRR
60 70 80 90 100
GHEVIVLRNS ASIFIDPSKQ ANIKFETFPI AATKDDLEDL FVHYVSTWTN
110 120 130 140 150
ARQNSQWKYF SLLQKLFSEY SDSCENACKE VVFNKTLMTK LQESRFDILL
160 170 180 190 200
SDAIGPCGEL LAELLKIPFV YSLRFTPGYT MEKYSGGLSV PPSYVPIILS
210 220 230 240 250
DLSGKMTFME RVNNMLCMLY FDFWFQMFNK KRWDQFYSEV LGRPVTFSEL
260 270 280 290 300
VGKADMWLIR SYWDLEFPRP TLPNIQFVGG LHCKPAKPLP KEMEEFVQSS
310 320 330 340 350
GEEGVVVFSL GSMVSNMTEE RANLIASAFA QLPQKVIWRF DGQKPETLGP
360 370 380 390 400
NTRIYDWIPQ NDLLGHPKTK AFVTHGGANG IYEAIHHGIP MVGLPLFGEQ
410 420 430 440 450
PDNIAHMTAK GAAIRLNWKT MSSEDLLNAL KTVINDPSYK ENVMTLSSIH
460 470 480 490 500
HDQPMKPLDR AVFWIEYVMR HKGAKHLRVA AHDLTWFQYH SLDVVGFLVS
510 520 530
CAAFLIFLVI KSYLFVYQKL VKIGKKQKRD
Length:530
Mass (Da):60,665
Last modified:June 1, 1994 - v1
Checksum:iCEAA4BF25B53CB35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01082 mRNA. Translation: AAA18021.1.
PIRiC47113.
RefSeqiNP_001075709.1. NM_001082240.1.
UniGeneiOcu.6432.

Genome annotation databases

GeneIDi100009057.
KEGGiocu:100009057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01082 mRNA. Translation: AAA18021.1.
PIRiC47113.
RefSeqiNP_001075709.1. NM_001082240.1.
UniGeneiOcu.6432.

3D structure databases

ProteinModelPortaliP36513.
SMRiP36513. Positions 286-447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000014798.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009057.
KEGGiocu:100009057.

Organism-specific databases

CTDi100009057.

Phylogenomic databases

eggNOGiCOG1819.
HOVERGENiHBG004033.
InParanoidiP36513.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13."
    Tukey R.H., Pendurthi U.R., Nguyen N.T., Green M.D., Tephly T.R.
    J. Biol. Chem. 268:15260-15266(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Liver.

Entry informationi

Entry nameiUDB14_RABIT
AccessioniPrimary (citable) accession number: P36513
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 4, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.