Reviewed, UniProtKB/Swiss-Prot P36513 (UDB14_RABIT)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2B14
      Short name=UDPGT 2B14
    EC=2.4.1.17
Alternative name(s):
    EGT12

Gene names

Name:

UGT2B14

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Developmental stage	Expressed primarily in adult rabbits.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	By similarity
	Chain	25 – 530	506	UDP-glucuronosyltransferase 2B14		PRO_0000036038
Regions
	Transmembrane	494 – 510	17	Potential
Amino acid modifications
	Glycosylation	134	1	N-linked (GlcNAc...) Potential
	Glycosylation	316	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P36513-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: CEAA4BF25B53CB35	FASTA	530	60,665
	10 20 30 40 50 60 MSVKHVSVLL LLLQLSCCFR TGSCGKVLVW PMDFSLWMNL NVILDELVRR GHEVIVLRNS 70 80 90 100 110 120 ASIFIDPSKQ ANIKFETFPI AATKDDLEDL FVHYVSTWTN ARQNSQWKYF SLLQKLFSEY 130 140 150 160 170 180 SDSCENACKE VVFNKTLMTK LQESRFDILL SDAIGPCGEL LAELLKIPFV YSLRFTPGYT 190 200 210 220 230 240 MEKYSGGLSV PPSYVPIILS DLSGKMTFME RVNNMLCMLY FDFWFQMFNK KRWDQFYSEV 250 260 270 280 290 300 LGRPVTFSEL VGKADMWLIR SYWDLEFPRP TLPNIQFVGG LHCKPAKPLP KEMEEFVQSS 310 320 330 340 350 360 GEEGVVVFSL GSMVSNMTEE RANLIASAFA QLPQKVIWRF DGQKPETLGP NTRIYDWIPQ 370 380 390 400 410 420 NDLLGHPKTK AFVTHGGANG IYEAIHHGIP MVGLPLFGEQ PDNIAHMTAK GAAIRLNWKT 430 440 450 460 470 480 MSSEDLLNAL KTVINDPSYK ENVMTLSSIH HDQPMKPLDR AVFWIEYVMR HKGAKHLRVA 490 500 510 520 530 AHDLTWFQYH SLDVVGFLVS CAAFLIFLVI KSYLFVYQKL VKIGKKQKRD

References

[1]

"Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13." Tukey R.H., Pendurthi U.R., Nguyen N.T., Green M.D., Tephly T.R. J. Biol. Chem. 268:15260-15266(1993) [PubMed: 8325897] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: New Zealand white. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L01082 mRNA. Translation: AAA18021.1.
PIR	C47113.
RefSeq	NP_001075709.1.
UniGene	Ocu.6432
3D structure databases
SMR	P36513. Positions 286-447.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Genome annotation databases
GeneID	100009057.
Phylogenomic databases
HOVERGEN	P36513.
Enzyme and pathway databases
BRENDA	2.4.1.17. 255.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UDB14_RABIT

Accession

Primary (citable) accession number: P36513

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)