Reviewed, UniProtKB/Swiss-Prot P36512 (UDB13_RABIT)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2B13
      Short name=UDPGT 2B13
    EC=2.4.1.17
Alternative name(s):
    EGT10

Gene names

Name:

UGT2B13

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Acts on small phenolic agents such as 2-naphtol and 4-methylumbelliferone as well as bulky phenolic compounds like 2-hydroxy- and 4-hydroxybiphenyl. In contrast to 2B16 it is active toward octylgallate.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Developmental stage	Expressed primarily in adult rabbits.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24
	Chain	25 – 531	507	UDP-glucuronosyltransferase 2B13		PRO_0000036037
Regions
	Transmembrane	495 – 511	17	Potential
Amino acid modifications
	Glycosylation	69	1	N-linked (GlcNAc...) Potential
	Glycosylation	101	1	N-linked (GlcNAc...) Potential
	Glycosylation	317	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P36512-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 961DA58AC4CB9932	FASTA	531	60,552
	10 20 30 40 50 60 MPVKCISVLL LLLQLSCCFS SGSCGKVLVW PMEFSHWMNM KTILDALVQQ GHEVTVLRSS 70 80 90 100 110 120 ASIVIGSNNE SGIKFETFHT SYRKDEIENF FMDWFYKMIY NVSIESYWET FSLTKMVILK 130 140 150 160 170 180 YSDICEDICK EVILNKKLMT KLQESRFDVV LADPVSPGGE LLAELLKIPL VYSLRGFVGY 190 200 210 220 230 240 MLQKHGGGLL LPPSYVPVMM SGLGSQMTFM ERVQNLLCVL YFDFWFPKFN EKRWDQFYSE 250 260 270 280 290 300 VLGRPVTFLE LMGKADMWLI RSYWDLEFPR PLLPNFDFIG GLHCKPAKPL PQEMEDFVQS 310 320 330 340 350 360 SGEEGVVVFS LGSMISNLTE ERANVIASAL AQLPQKVLWR FEGKKPDMLG SNTRLYKWIP 370 380 390 400 410 420 QNDLLGHPKT KAFITHGGAN GVFEAIYHGI PMVGLPLFGD QLDNIVYMKA KGAAVKLNLK 430 440 450 460 470 480 TMSSADLLNA LKTVINDPSY KENAMTLSRI HHDQPMKPLD RAVFWIEYVM RHKGAKHLRV 490 500 510 520 530 AAHDLTWYQY HSLDVIGFLL ACVAITTYLI VKCCLLVYRY VLGAGKKKKR D

References

[1]

"Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13." Tukey R.H., Pendurthi U.R., Nguyen N.T., Green M.D., Tephly T.R. J. Biol. Chem. 268:15260-15266(1993) [PubMed: 8325897] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: New Zealand white. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L01081 mRNA. Translation: AAA18020.1.
PIR	B47113.
3D structure databases
SMR	P36512. Positions 287-448.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Phylogenomic databases
HOVERGEN	P36512.
Enzyme and pathway databases
BRENDA	2.4.1.17. 255.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UDB13_RABIT

Accession

Primary (citable) accession number: P36512

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	June 16, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)