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Protein

UDP-glucuronosyltransferase 2B13

Gene

UGT2B13

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Acts on small phenolic agents such as 2-beta-naphthol and 4-methylumbelliferone as well as bulky phenolic compounds like 2-hydroxy- and 4-hydroxybiphenyl. In contrast to 2B16 it is active toward octylgallate.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B13 (EC:2.4.1.17)
Short name:
UDPGT 2B13
Alternative name(s):
EGT10
Gene namesi
Name:UGT2B13
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei495 – 51117HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 531507UDP-glucuronosyltransferase 2B13PRO_0000036037Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
Modified residuei137 – 1371N6-succinyllysineBy similarity
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Developmental stagei

Expressed primarily in adult rabbits.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000021284.

Structurei

3D structure databases

ProteinModelPortaliP36512.
SMRiP36512. Positions 287-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP36512.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVKCISVLL LLLQLSCCFS SGSCGKVLVW PMEFSHWMNM KTILDALVQQ
60 70 80 90 100
GHEVTVLRSS ASIVIGSNNE SGIKFETFHT SYRKDEIENF FMDWFYKMIY
110 120 130 140 150
NVSIESYWET FSLTKMVILK YSDICEDICK EVILNKKLMT KLQESRFDVV
160 170 180 190 200
LADPVSPGGE LLAELLKIPL VYSLRGFVGY MLQKHGGGLL LPPSYVPVMM
210 220 230 240 250
SGLGSQMTFM ERVQNLLCVL YFDFWFPKFN EKRWDQFYSE VLGRPVTFLE
260 270 280 290 300
LMGKADMWLI RSYWDLEFPR PLLPNFDFIG GLHCKPAKPL PQEMEDFVQS
310 320 330 340 350
SGEEGVVVFS LGSMISNLTE ERANVIASAL AQLPQKVLWR FEGKKPDMLG
360 370 380 390 400
SNTRLYKWIP QNDLLGHPKT KAFITHGGAN GVFEAIYHGI PMVGLPLFGD
410 420 430 440 450
QLDNIVYMKA KGAAVKLNLK TMSSADLLNA LKTVINDPSY KENAMTLSRI
460 470 480 490 500
HHDQPMKPLD RAVFWIEYVM RHKGAKHLRV AAHDLTWYQY HSLDVIGFLL
510 520 530
ACVAITTYLI VKCCLLVYRY VLGAGKKKKR D
Length:531
Mass (Da):60,552
Last modified:June 1, 1994 - v1
Checksum:i961DA58AC4CB9932
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01081 mRNA. Translation: AAA18020.1.
PIRiB47113.
RefSeqiNP_001164485.1. NM_001171014.1.
UniGeneiOcu.1815.

Genome annotation databases

GeneIDi100328586.
KEGGiocu:100328586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01081 mRNA. Translation: AAA18020.1.
PIRiB47113.
RefSeqiNP_001164485.1. NM_001171014.1.
UniGeneiOcu.1815.

3D structure databases

ProteinModelPortaliP36512.
SMRiP36512. Positions 287-448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000021284.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100328586.
KEGGiocu:100328586.

Organism-specific databases

CTDi100328586.

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP36512.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13."
    Tukey R.H., Pendurthi U.R., Nguyen N.T., Green M.D., Tephly T.R.
    J. Biol. Chem. 268:15260-15266(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Liver.

Entry informationi

Entry nameiUDB13_RABIT
AccessioniPrimary (citable) accession number: P36512
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: March 4, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.