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P36512

- UDB13_RABIT

UniProt

P36512 - UDB13_RABIT

Protein

UDP-glucuronosyltransferase 2B13

Gene

UGT2B13

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Acts on small phenolic agents such as 2-beta-naphthol and 4-methylumbelliferone as well as bulky phenolic compounds like 2-hydroxy- and 4-hydroxybiphenyl. In contrast to 2B16 it is active toward octylgallate.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B13 (EC:2.4.1.17)
    Short name:
    UDPGT 2B13
    Alternative name(s):
    EGT10
    Gene namesi
    Name:UGT2B13
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Add
    BLAST
    Chaini25 – 531507UDP-glucuronosyltransferase 2B13PRO_0000036037Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Developmental stagei

    Expressed primarily in adult rabbits.

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000021284.

    Structurei

    3D structure databases

    ProteinModelPortaliP36512.
    SMRiP36512. Positions 287-448.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei495 – 51117HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOGENOMiHOG000220831.
    HOVERGENiHBG004033.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36512-1 [UniParc]FASTAAdd to Basket

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    MPVKCISVLL LLLQLSCCFS SGSCGKVLVW PMEFSHWMNM KTILDALVQQ    50
    GHEVTVLRSS ASIVIGSNNE SGIKFETFHT SYRKDEIENF FMDWFYKMIY 100
    NVSIESYWET FSLTKMVILK YSDICEDICK EVILNKKLMT KLQESRFDVV 150
    LADPVSPGGE LLAELLKIPL VYSLRGFVGY MLQKHGGGLL LPPSYVPVMM 200
    SGLGSQMTFM ERVQNLLCVL YFDFWFPKFN EKRWDQFYSE VLGRPVTFLE 250
    LMGKADMWLI RSYWDLEFPR PLLPNFDFIG GLHCKPAKPL PQEMEDFVQS 300
    SGEEGVVVFS LGSMISNLTE ERANVIASAL AQLPQKVLWR FEGKKPDMLG 350
    SNTRLYKWIP QNDLLGHPKT KAFITHGGAN GVFEAIYHGI PMVGLPLFGD 400
    QLDNIVYMKA KGAAVKLNLK TMSSADLLNA LKTVINDPSY KENAMTLSRI 450
    HHDQPMKPLD RAVFWIEYVM RHKGAKHLRV AAHDLTWYQY HSLDVIGFLL 500
    ACVAITTYLI VKCCLLVYRY VLGAGKKKKR D 531
    Length:531
    Mass (Da):60,552
    Last modified:June 1, 1994 - v1
    Checksum:i961DA58AC4CB9932
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01081 mRNA. Translation: AAA18020.1.
    PIRiB47113.
    RefSeqiNP_001164485.1. NM_001171014.1.
    UniGeneiOcu.1815.

    Genome annotation databases

    GeneIDi100328586.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01081 mRNA. Translation: AAA18020.1 .
    PIRi B47113.
    RefSeqi NP_001164485.1. NM_001171014.1.
    UniGenei Ocu.1815.

    3D structure databases

    ProteinModelPortali P36512.
    SMRi P36512. Positions 287-448.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000021284.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100328586.

    Organism-specific databases

    CTDi 100328586.

    Phylogenomic databases

    eggNOGi COG1819.
    HOGENOMi HOG000220831.
    HOVERGENi HBG004033.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13."
      Tukey R.H., Pendurthi U.R., Nguyen N.T., Green M.D., Tephly T.R.
      J. Biol. Chem. 268:15260-15266(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: New Zealand white.
      Tissue: Liver.

    Entry informationi

    Entry nameiUDB13_RABIT
    AccessioniPrimary (citable) accession number: P36512
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3