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P36512 (UDB13_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2B13

Short name=UDPGT 2B13
EC=2.4.1.17
Alternative name(s):
EGT10
Gene names
Name:UGT2B13
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length531 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Acts on small phenolic agents such as 2-beta-naphthol and 4-methylumbelliferone as well as bulky phenolic compounds like 2-hydroxy- and 4-hydroxybiphenyl. In contrast to 2B16 it is active toward octylgallate.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Developmental stage

Expressed primarily in adult rabbits.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Chain25 – 531507UDP-glucuronosyltransferase 2B13
PRO_0000036037

Regions

Transmembrane495 – 51117Helical; Potential

Amino acid modifications

Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation1011N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P36512 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 961DA58AC4CB9932

FASTA53160,552
        10         20         30         40         50         60 
MPVKCISVLL LLLQLSCCFS SGSCGKVLVW PMEFSHWMNM KTILDALVQQ GHEVTVLRSS 

        70         80         90        100        110        120 
ASIVIGSNNE SGIKFETFHT SYRKDEIENF FMDWFYKMIY NVSIESYWET FSLTKMVILK 

       130        140        150        160        170        180 
YSDICEDICK EVILNKKLMT KLQESRFDVV LADPVSPGGE LLAELLKIPL VYSLRGFVGY 

       190        200        210        220        230        240 
MLQKHGGGLL LPPSYVPVMM SGLGSQMTFM ERVQNLLCVL YFDFWFPKFN EKRWDQFYSE 

       250        260        270        280        290        300 
VLGRPVTFLE LMGKADMWLI RSYWDLEFPR PLLPNFDFIG GLHCKPAKPL PQEMEDFVQS 

       310        320        330        340        350        360 
SGEEGVVVFS LGSMISNLTE ERANVIASAL AQLPQKVLWR FEGKKPDMLG SNTRLYKWIP 

       370        380        390        400        410        420 
QNDLLGHPKT KAFITHGGAN GVFEAIYHGI PMVGLPLFGD QLDNIVYMKA KGAAVKLNLK 

       430        440        450        460        470        480 
TMSSADLLNA LKTVINDPSY KENAMTLSRI HHDQPMKPLD RAVFWIEYVM RHKGAKHLRV 

       490        500        510        520        530 
AAHDLTWYQY HSLDVIGFLL ACVAITTYLI VKCCLLVYRY VLGAGKKKKR D 

« Hide

References

[1]"Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13."
Tukey R.H., Pendurthi U.R., Nguyen N.T., Green M.D., Tephly T.R.
J. Biol. Chem. 268:15260-15266(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: New Zealand white.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L01081 mRNA. Translation: AAA18020.1.
PIRB47113.
RefSeqNP_001164485.1. NM_001171014.1.
UniGeneOcu.1815.

3D structure databases

ProteinModelPortalP36512.
SMRP36512. Positions 287-448.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000021284.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100328586.

Organism-specific databases

CTD100328586.

Phylogenomic databases

eggNOGCOG1819.
HOGENOMHOG000220831.
HOVERGENHBG004033.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUDB13_RABIT
AccessionPrimary (citable) accession number: P36512
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families