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Protein

UDP-glucuronosyltransferase 2B13

Gene

UGT2B13

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Acts on small phenolic agents such as 2-beta-naphthol and 4-methylumbelliferone as well as bulky phenolic compounds like 2-hydroxy- and 4-hydroxybiphenyl. In contrast to 2B16 it is active toward octylgallate.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B13 (EC:2.4.1.17)
Short name:
UDPGT 2B13
Alternative name(s):
EGT10
Gene namesi
Name:UGT2B13
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei495 – 511HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000003603725 – 531UDP-glucuronosyltransferase 2B13Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP36512

Expressioni

Developmental stagei

Expressed primarily in adult rabbits.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000021284

Structurei

3D structure databases

ProteinModelPortaliP36512
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
HOGENOMiHOG000220831
HOVERGENiHBG004033
InParanoidiP36512
KOiK00699

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVKCISVLL LLLQLSCCFS SGSCGKVLVW PMEFSHWMNM KTILDALVQQ
60 70 80 90 100
GHEVTVLRSS ASIVIGSNNE SGIKFETFHT SYRKDEIENF FMDWFYKMIY
110 120 130 140 150
NVSIESYWET FSLTKMVILK YSDICEDICK EVILNKKLMT KLQESRFDVV
160 170 180 190 200
LADPVSPGGE LLAELLKIPL VYSLRGFVGY MLQKHGGGLL LPPSYVPVMM
210 220 230 240 250
SGLGSQMTFM ERVQNLLCVL YFDFWFPKFN EKRWDQFYSE VLGRPVTFLE
260 270 280 290 300
LMGKADMWLI RSYWDLEFPR PLLPNFDFIG GLHCKPAKPL PQEMEDFVQS
310 320 330 340 350
SGEEGVVVFS LGSMISNLTE ERANVIASAL AQLPQKVLWR FEGKKPDMLG
360 370 380 390 400
SNTRLYKWIP QNDLLGHPKT KAFITHGGAN GVFEAIYHGI PMVGLPLFGD
410 420 430 440 450
QLDNIVYMKA KGAAVKLNLK TMSSADLLNA LKTVINDPSY KENAMTLSRI
460 470 480 490 500
HHDQPMKPLD RAVFWIEYVM RHKGAKHLRV AAHDLTWYQY HSLDVIGFLL
510 520 530
ACVAITTYLI VKCCLLVYRY VLGAGKKKKR D
Length:531
Mass (Da):60,552
Last modified:June 1, 1994 - v1
Checksum:i961DA58AC4CB9932
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01081 mRNA Translation: AAA18020.1
PIRiB47113
RefSeqiNP_001164485.1, NM_001171014.1
UniGeneiOcu.1815

Genome annotation databases

GeneIDi100328586
KEGGiocu:100328586

Similar proteinsi

Entry informationi

Entry nameiUDB13_RABIT
AccessioniPrimary (citable) accession number: P36512
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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