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P36511

- UDB15_RAT

UniProt

P36511 - UDB15_RAT

Protein

UDP-glucuronosyltransferase 2B15

Gene

Ugt2b15

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Catalyzes the transfer of glucuronic acid from UDP-glucuronic acid to various aglycone molecules. Catalyzes the glucuronidation of monoterpenoid alcohols, such as (-)-borneol, (+)-menthol, and (-)- nopol. In addition, a number of simple phenolic compounds, such as hydroxybiphenyls, 7-hydroxylated coumarins, p-nitrophenol, and food-derived substances (e.g. naringenin and eugenol), and 4-methylumbelliferone are also substrates.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: RGD

    GO - Biological processi

    1. aromatic compound catabolic process Source: RGD
    2. response to drug Source: RGD

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.17. 5301.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B15 (EC:2.4.1.17)
    Short name:
    UDPGT 2B15
    Alternative name(s):
    UDP-glucuronosyltransferase 2B36
    Short name:
    UDPGT 2B36
    Gene namesi
    Name:Ugt2b15
    Synonyms:Ugt2b12, Ugt2b36, Ugt2b4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620895. Ugt2b36.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. intracellular membrane-bounded organelle Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 530507UDP-glucuronosyltransferase 2B15PRO_0000036036Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.Curated

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP36511.
    PRIDEiP36511.

    Expressioni

    Tissue specificityi

    Liver. Lower levels seen in the kidney and testis.

    Inductioni

    By phenobarbital.

    Gene expression databases

    GenevestigatoriP36511.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4565295.
    STRINGi10116.ENSRNOP00000002712.

    Structurei

    3D structure databases

    ProteinModelPortaliP36511.
    SMRiP36511. Positions 286-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei494 – 51017HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOVERGENiHBG004033.
    InParanoidiP36511.
    PhylomeDBiP36511.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36511-1 [UniParc]FASTAAdd to Basket

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    MSGKWISALL LLQISFCFKS GNCGKVLVWP MEYSHWMNIK IILEELVQKG    50
    HEVTVLRPSA FVFLDPKETS DLKFVTFPTS FSSHDLENFF TRFVNVWTYE 100
    LPRDTCLSYF LYLQDTIDEY SDYCLTVCKE AVSNKQFMTK LQESKFDVVF 150
    SDAIGPCGEL IAELLQIPFL YSLRFSPGYT IEQYIGGVLF PPSYVPMIFS 200
    GLAGQMTFIE RVHNMICMLY FDFWFQTFRE KKWDPFYSKT LGRPTTLAEI 250
    MGKAEMWLIR SYWDLEFPHP ISPNVDYIGG LHCKPAKPLP KDIEDFVQSS 300
    GEHGVVVFSL GSMVRNMTEE KANIIAWALA QIPQKVLWRF DGKKPPTLGP 350
    NTRLYKWLPQ NDLLGHPKTK AFVTHGGANG IYEAIHHGIP MIGIPLFAEQ 400
    HDNIAHMVAK GAAVEVNFRT MSKSDLLNAL EEVIDNPFYK KNAMWLSTIH 450
    HDQPTKPLDR AVFWIEFVMR HKGAKHLRSL GHNLPWYQYH SLDVIGFLLS 500
    CVAVTVVLAL KCFLFVYRFF VKKEKKTKNE 530
    Length:530
    Mass (Da):61,060
    Last modified:June 1, 1994 - v1
    Checksum:iD49313CE3E6D5BFD
    GO

    Polymorphismi

    The sequence shown is that of the liver isozyme. The kidney isoform differs in 12 positions.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21S → P in kidney.
    Natural varianti61 – 611F → S in kidney.
    Natural varianti71 – 711D → H in kidney.
    Natural varianti95 – 951N → S in kidney.
    Natural varianti183 – 1831Q → K in kidney.
    Natural varianti346 – 3461P → T in kidney.
    Natural varianti398 – 3981A → G in kidney.
    Natural varianti414 – 4152VE → AT in kidney.
    Natural varianti433 – 4331V → D in kidney.
    Natural varianti475 – 4751K → L in kidney.
    Natural varianti488 – 4881Q → L in kidney.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06273 mRNA. Translation: AAA83404.1.
    U06274 mRNA. Translation: AAA83405.1.
    PIRiS68200.
    UniGeneiRn.3686.

    Genome annotation databases

    UCSCiRGD:620895. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06273 mRNA. Translation: AAA83404.1 .
    U06274 mRNA. Translation: AAA83405.1 .
    PIRi S68200.
    UniGenei Rn.3686.

    3D structure databases

    ProteinModelPortali P36511.
    SMRi P36511. Positions 286-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4565295.
    STRINGi 10116.ENSRNOP00000002712.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PaxDbi P36511.
    PRIDEi P36511.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:620895. rat.

    Organism-specific databases

    RGDi 620895. Ugt2b36.

    Phylogenomic databases

    eggNOGi COG1819.
    HOVERGENi HBG004033.
    InParanoidi P36511.
    PhylomeDBi P36511.

    Enzyme and pathway databases

    BRENDAi 2.4.1.17. 5301.

    Gene expression databases

    Genevestigatori P36511.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols."
      Green M.D., Clarke D.J., Oturu E.M., Styczynski P.B., Jackson M.R., Burchell B., Tephly T.R.
      Arch. Biochem. Biophys. 322:460-468(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Kidney and Liver.
    2. "Purification and properties of a rat liver phenobarbital-inducible 4-hydroxybiphenyl UDP-glucuronosyltransferase."
      Styczynski P.B., Green M.S., Puig J., Coffman B.L., Tephly T.R.
      Mol. Pharmacol. 40:80-84(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-38, CHARACTERIZATION.
      Strain: Wistar.
      Tissue: Liver.

    Entry informationi

    Entry nameiUDB15_RAT
    AccessioniPrimary (citable) accession number: P36511
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3