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P36511 (UDB15_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2B15

Short name=UDPGT 2B15
EC=2.4.1.17
Alternative name(s):
UDP-glucuronosyltransferase 2B36
Short name=UDPGT 2B36
Gene names
Name:Ugt2b15
Synonyms:Ugt2b12, Ugt2b36, Ugt2b4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Catalyzes the transfer of glucuronic acid from UDP-glucuronic acid to various aglycone molecules. Catalyzes the glucuronidation of monoterpenoid alcohols, such as (-)-borneol, (+)-menthol, and (-)- nopol. In addition, a number of simple phenolic compounds, such as hydroxybiphenyls, 7-hydroxylated coumarins, p-nitrophenol, and food-derived substances (e.g. naringenin and eugenol), and 4-methylumbelliferone are also substrates.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Tissue specificity

Liver. Lower levels seen in the kidney and testis.

Induction

By phenobarbital.

Post-translational modification

N-glycosylated Probable.

Polymorphism

The sequence shown is that of the liver isozyme. The kidney isoform differsin 12 positions.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.2
Chain24 – 530507UDP-glucuronosyltransferase 2B15
PRO_0000036036

Regions

Transmembrane494 – 51017Helical; Potential

Amino acid modifications

Glycosylation3161N-linked (GlcNAc...) Potential

Natural variations

Natural variant21S → P in kidney.
Natural variant611F → S in kidney.
Natural variant711D → H in kidney.
Natural variant951N → S in kidney.
Natural variant1831Q → K in kidney.
Natural variant3461P → T in kidney.
Natural variant3981A → G in kidney.
Natural variant414 – 4152VE → AT in kidney.
Natural variant4331V → D in kidney.
Natural variant4751K → L in kidney.
Natural variant4881Q → L in kidney.

Sequences

Sequence LengthMass (Da)Tools
P36511 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: D49313CE3E6D5BFD

FASTA53061,060
        10         20         30         40         50         60 
MSGKWISALL LLQISFCFKS GNCGKVLVWP MEYSHWMNIK IILEELVQKG HEVTVLRPSA 

        70         80         90        100        110        120 
FVFLDPKETS DLKFVTFPTS FSSHDLENFF TRFVNVWTYE LPRDTCLSYF LYLQDTIDEY 

       130        140        150        160        170        180 
SDYCLTVCKE AVSNKQFMTK LQESKFDVVF SDAIGPCGEL IAELLQIPFL YSLRFSPGYT 

       190        200        210        220        230        240 
IEQYIGGVLF PPSYVPMIFS GLAGQMTFIE RVHNMICMLY FDFWFQTFRE KKWDPFYSKT 

       250        260        270        280        290        300 
LGRPTTLAEI MGKAEMWLIR SYWDLEFPHP ISPNVDYIGG LHCKPAKPLP KDIEDFVQSS 

       310        320        330        340        350        360 
GEHGVVVFSL GSMVRNMTEE KANIIAWALA QIPQKVLWRF DGKKPPTLGP NTRLYKWLPQ 

       370        380        390        400        410        420 
NDLLGHPKTK AFVTHGGANG IYEAIHHGIP MIGIPLFAEQ HDNIAHMVAK GAAVEVNFRT 

       430        440        450        460        470        480 
MSKSDLLNAL EEVIDNPFYK KNAMWLSTIH HDQPTKPLDR AVFWIEFVMR HKGAKHLRSL 

       490        500        510        520        530 
GHNLPWYQYH SLDVIGFLLS CVAVTVVLAL KCFLFVYRFF VKKEKKTKNE 

« Hide

References

[1]"Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols."
Green M.D., Clarke D.J., Oturu E.M., Styczynski P.B., Jackson M.R., Burchell B., Tephly T.R.
Arch. Biochem. Biophys. 322:460-468(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Kidney and Liver.
[2]"Purification and properties of a rat liver phenobarbital-inducible 4-hydroxybiphenyl UDP-glucuronosyltransferase."
Styczynski P.B., Green M.S., Puig J., Coffman B.L., Tephly T.R.
Mol. Pharmacol. 40:80-84(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-38, CHARACTERIZATION.
Strain: Wistar.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U06273 mRNA. Translation: AAA83404.1.
U06274 mRNA. Translation: AAA83405.1.
PIRS68200.
UniGeneRn.3686.

3D structure databases

ProteinModelPortalP36511.
SMRP36511. Positions 286-447.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4565295.
STRING10116.ENSRNOP00000002712.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbP36511.
PRIDEP36511.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:620895. rat.

Organism-specific databases

RGD620895. Ugt2b36.

Phylogenomic databases

eggNOGCOG1819.
HOVERGENHBG004033.
InParanoidP36511.
PhylomeDBP36511.

Enzyme and pathway databases

BRENDA2.4.1.17. 5301.

Gene expression databases

GenevestigatorP36511.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUDB15_RAT
AccessionPrimary (citable) accession number: P36511
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families