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P36510

- UD2A1_RAT

UniProt

P36510 - UD2A1_RAT

Protein

UDP-glucuronosyltransferase 2A1

Gene

Ugt2a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: RGD

    GO - Biological processi

    1. response to toxic substance Source: RGD
    2. sensory perception of smell Source: RGD

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2A1 (EC:2.4.1.17)
    Short name:
    UDPGT 2A1
    Alternative name(s):
    UGT-OLF
    Gene namesi
    Name:Ugt2a1
    Synonyms:Ugt2a-1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi69432. Ugt2a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 527507UDP-glucuronosyltransferase 2A1PRO_0000036024Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi313 – 3131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP36510.
    PRIDEiP36510.

    PTM databases

    PhosphoSiteiP36510.

    Expressioni

    Tissue specificityi

    Olfactory epithelium. Mainly found in the sustentacular cells and to a lesser extent in Bowman's gland cells. Also expressed in the olfactory sensory neuron nuclei. Neuronal localization within the olfactory bulb is mainly found in the deeper granular cells.1 Publication

    Gene expression databases

    GenevestigatoriP36510.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000040239.

    Structurei

    3D structure databases

    ProteinModelPortaliP36510.
    SMRiP36510. Positions 283-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 490470ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini508 – 52720CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei491 – 50717HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOGENOMiHOG000220831.
    HOVERGENiHBG004033.
    InParanoidiP36510.
    KOiK00699.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36510-1 [UniParc]FASTAAdd to Basket

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    MLKNILLWSL QLSLLGMSLG GNVLIWPMEG SHWLNVKIII DELLRKEHNV    50
    TVLVASGALF ITPSVSPSLT FEIYPVPFGK EKIESVIKDF VLTWLENRPS 100
    PSTIWTFYKE MAKVIEEFHL VSRGICDGVL KNEKLMTKLQ RGKFEVLLSD 150
    PVFPCGDIVA LKLGIPFIYS LRFSPASTVE KHCGKVPFPP SYVPAILSEL 200
    TDQMSFADRV RNFISYRMQD YMFETLWKQW DSYYSKALGR PTTLCETMGK 250
    AEIWLMRTYW DFEFPRPYLP NFEFVGGLHC KPAKPLPKEM EEFVQTSGEH 300
    GVVVFSLGSM VKNLTEEKAN LIASALAQIP QKVLWRYKGK IPATLGSNTR 350
    LFDWIPQNDL LGHPKTRAFI THGGTNGIYE AIYHGIPMVG VPMFADQPDN 400
    IAHMKAKGAA VEVNMNTMTS ADLLSAVRAV INEPFYKENA MRLSRIHHDQ 450
    PVKPLDRAVF WIEFVMRHKG AKHLRVAAHD LSWFQYHSLD VIGFLLACMA 500
    SAILLVIKCC LFVFQKIGKT XKKNKRD 527
    Length:527
    Mass (Da):59,916
    Last modified:June 1, 1994 - v1
    Checksum:i6A32A9B56EE8E8DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57565 Genomic DNA. Translation: CAA40797.1.
    PIRiS15089.
    RefSeqiNP_071564.1. NM_022228.1.
    UniGeneiRn.138121.

    Genome annotation databases

    GeneIDi63867.
    KEGGirno:63867.
    UCSCiRGD:69432. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57565 Genomic DNA. Translation: CAA40797.1 .
    PIRi S15089.
    RefSeqi NP_071564.1. NM_022228.1.
    UniGenei Rn.138121.

    3D structure databases

    ProteinModelPortali P36510.
    SMRi P36510. Positions 283-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000040239.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    PTM databases

    PhosphoSitei P36510.

    Proteomic databases

    PaxDbi P36510.
    PRIDEi P36510.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 63867.
    KEGGi rno:63867.
    UCSCi RGD:69432. rat.

    Organism-specific databases

    CTDi 10941.
    RGDi 69432. Ugt2a1.

    Phylogenomic databases

    eggNOGi COG1819.
    HOGENOMi HOG000220831.
    HOVERGENi HBG004033.
    InParanoidi P36510.
    KOi K00699.

    Miscellaneous databases

    NextBioi 612484.

    Gene expression databases

    Genevestigatori P36510.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Odorant signal termination by olfactory UDP glucuronosyl transferase."
      Lazard D., Zupko K., Poria Y., Nef P., Lazarovits J., Horn S., Khen M., Lancet D.
      Nature 349:790-793(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: in situ mRNA localization and quantitative analysis."
      Heydel J.-M., Leclerc S., Bernard P., Pelczar H., Gradinaru D., Magdalou J., Minn A., Artur Y., Goudonnet H.
      Brain Res. Mol. Brain Res. 90:83-92(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiUD2A1_RAT
    AccessioniPrimary (citable) accession number: P36510
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3