SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P36510

- UD2A1_RAT

UniProt

P36510 - UD2A1_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

UDP-glucuronosyltransferase 2A1

Gene
Ugt2a1, Ugt2a-1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: RGD

GO - Biological processi

  1. response to toxic substance Source: RGD
  2. sensory perception of smell Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Olfaction, Sensory transduction

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2A1 (EC:2.4.1.17)
Short name:
UDPGT 2A1
Alternative name(s):
UGT-OLF
Gene namesi
Name:Ugt2a1
Synonyms:Ugt2a-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi69432. Ugt2a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 490470Extracellular Reviewed predictionAdd
BLAST
Transmembranei491 – 50717Helical; Reviewed predictionAdd
BLAST
Topological domaini508 – 52720Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 527507UDP-glucuronosyltransferase 2A1PRO_0000036024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi313 – 3131N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP36510.
PRIDEiP36510.

PTM databases

PhosphoSiteiP36510.

Expressioni

Tissue specificityi

Olfactory epithelium. Mainly found in the sustentacular cells and to a lesser extent in Bowman's gland cells. Also expressed in the olfactory sensory neuron nuclei. Neuronal localization within the olfactory bulb is mainly found in the deeper granular cells.1 Publication

Gene expression databases

GenevestigatoriP36510.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040239.

Structurei

3D structure databases

ProteinModelPortaliP36510.
SMRiP36510. Positions 283-449.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP36510.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36510-1 [UniParc]FASTAAdd to Basket

« Hide

MLKNILLWSL QLSLLGMSLG GNVLIWPMEG SHWLNVKIII DELLRKEHNV    50
TVLVASGALF ITPSVSPSLT FEIYPVPFGK EKIESVIKDF VLTWLENRPS 100
PSTIWTFYKE MAKVIEEFHL VSRGICDGVL KNEKLMTKLQ RGKFEVLLSD 150
PVFPCGDIVA LKLGIPFIYS LRFSPASTVE KHCGKVPFPP SYVPAILSEL 200
TDQMSFADRV RNFISYRMQD YMFETLWKQW DSYYSKALGR PTTLCETMGK 250
AEIWLMRTYW DFEFPRPYLP NFEFVGGLHC KPAKPLPKEM EEFVQTSGEH 300
GVVVFSLGSM VKNLTEEKAN LIASALAQIP QKVLWRYKGK IPATLGSNTR 350
LFDWIPQNDL LGHPKTRAFI THGGTNGIYE AIYHGIPMVG VPMFADQPDN 400
IAHMKAKGAA VEVNMNTMTS ADLLSAVRAV INEPFYKENA MRLSRIHHDQ 450
PVKPLDRAVF WIEFVMRHKG AKHLRVAAHD LSWFQYHSLD VIGFLLACMA 500
SAILLVIKCC LFVFQKIGKT XKKNKRD 527
Length:527
Mass (Da):59,916
Last modified:June 1, 1994 - v1
Checksum:i6A32A9B56EE8E8DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57565 Genomic DNA. Translation: CAA40797.1.
PIRiS15089.
RefSeqiNP_071564.1. NM_022228.1.
UniGeneiRn.138121.

Genome annotation databases

GeneIDi63867.
KEGGirno:63867.
UCSCiRGD:69432. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57565 Genomic DNA. Translation: CAA40797.1 .
PIRi S15089.
RefSeqi NP_071564.1. NM_022228.1.
UniGenei Rn.138121.

3D structure databases

ProteinModelPortali P36510.
SMRi P36510. Positions 283-449.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000040239.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitei P36510.

Proteomic databases

PaxDbi P36510.
PRIDEi P36510.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 63867.
KEGGi rno:63867.
UCSCi RGD:69432. rat.

Organism-specific databases

CTDi 10941.
RGDi 69432. Ugt2a1.

Phylogenomic databases

eggNOGi COG1819.
HOGENOMi HOG000220831.
HOVERGENi HBG004033.
InParanoidi P36510.
KOi K00699.

Miscellaneous databases

NextBioi 612484.

Gene expression databases

Genevestigatori P36510.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Odorant signal termination by olfactory UDP glucuronosyl transferase."
    Lazard D., Zupko K., Poria Y., Nef P., Lazarovits J., Horn S., Khen M., Lancet D.
    Nature 349:790-793(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: in situ mRNA localization and quantitative analysis."
    Heydel J.-M., Leclerc S., Bernard P., Pelczar H., Gradinaru D., Magdalou J., Minn A., Artur Y., Goudonnet H.
    Brain Res. Mol. Brain Res. 90:83-92(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiUD2A1_RAT
AccessioniPrimary (citable) accession number: P36510
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 19, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi