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Protein

UDP-glucuronosyltransferase 2A1

Gene

Ugt2a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: RGD

GO - Biological processi

  • cellular response to hormone stimulus Source: GO_Central
  • flavonoid biosynthetic process Source: GO_Central
  • flavonoid glucuronidation Source: GO_Central
  • response to toxic substance Source: RGD
  • sensory perception of smell Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Olfaction, Sensory transduction

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2A1 (EC:2.4.1.17)
Short name:
UDPGT 2A1
Alternative name(s):
UGT-OLF
Gene namesi
Name:Ugt2a1
Synonyms:Ugt2a-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69432. Ugt2a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 490470ExtracellularSequence AnalysisAdd
BLAST
Transmembranei491 – 50717HelicalSequence AnalysisAdd
BLAST
Topological domaini508 – 52720CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 527507UDP-glucuronosyltransferase 2A1PRO_0000036024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
Modified residuei134 – 1341N6-succinyllysineBy similarity
Glycosylationi313 – 3131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP36510.
PRIDEiP36510.

PTM databases

PhosphoSiteiP36510.

Expressioni

Tissue specificityi

Olfactory epithelium. Mainly found in the sustentacular cells and to a lesser extent in Bowman's gland cells. Also expressed in the olfactory sensory neuron nuclei. Neuronal localization within the olfactory bulb is mainly found in the deeper granular cells.1 Publication

Gene expression databases

GenevisibleiP36510. RN.

Structurei

3D structure databases

ProteinModelPortaliP36510.
SMRiP36510. Positions 283-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP36510.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36510-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKNILLWSL QLSLLGMSLG GNVLIWPMEG SHWLNVKIII DELLRKEHNV
60 70 80 90 100
TVLVASGALF ITPSVSPSLT FEIYPVPFGK EKIESVIKDF VLTWLENRPS
110 120 130 140 150
PSTIWTFYKE MAKVIEEFHL VSRGICDGVL KNEKLMTKLQ RGKFEVLLSD
160 170 180 190 200
PVFPCGDIVA LKLGIPFIYS LRFSPASTVE KHCGKVPFPP SYVPAILSEL
210 220 230 240 250
TDQMSFADRV RNFISYRMQD YMFETLWKQW DSYYSKALGR PTTLCETMGK
260 270 280 290 300
AEIWLMRTYW DFEFPRPYLP NFEFVGGLHC KPAKPLPKEM EEFVQTSGEH
310 320 330 340 350
GVVVFSLGSM VKNLTEEKAN LIASALAQIP QKVLWRYKGK IPATLGSNTR
360 370 380 390 400
LFDWIPQNDL LGHPKTRAFI THGGTNGIYE AIYHGIPMVG VPMFADQPDN
410 420 430 440 450
IAHMKAKGAA VEVNMNTMTS ADLLSAVRAV INEPFYKENA MRLSRIHHDQ
460 470 480 490 500
PVKPLDRAVF WIEFVMRHKG AKHLRVAAHD LSWFQYHSLD VIGFLLACMA
510 520
SAILLVIKCC LFVFQKIGKT XKKNKRD
Length:527
Mass (Da):59,916
Last modified:June 1, 1994 - v1
Checksum:i6A32A9B56EE8E8DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57565 Genomic DNA. Translation: CAA40797.1.
PIRiS15089.
RefSeqiNP_071564.1. NM_022228.1.
UniGeneiRn.138121.

Genome annotation databases

GeneIDi63867.
KEGGirno:63867.
UCSCiRGD:69432. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57565 Genomic DNA. Translation: CAA40797.1.
PIRiS15089.
RefSeqiNP_071564.1. NM_022228.1.
UniGeneiRn.138121.

3D structure databases

ProteinModelPortaliP36510.
SMRiP36510. Positions 283-449.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteiP36510.

Proteomic databases

PaxDbiP36510.
PRIDEiP36510.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi63867.
KEGGirno:63867.
UCSCiRGD:69432. rat.

Organism-specific databases

CTDi10941.
RGDi69432. Ugt2a1.

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP36510.
KOiK00699.

Miscellaneous databases

NextBioi612484.
PROiP36510.

Gene expression databases

GenevisibleiP36510. RN.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Odorant signal termination by olfactory UDP glucuronosyl transferase."
    Lazard D., Zupko K., Poria Y., Nef P., Lazarovits J., Horn S., Khen M., Lancet D.
    Nature 349:790-793(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: in situ mRNA localization and quantitative analysis."
    Heydel J.-M., Leclerc S., Bernard P., Pelczar H., Gradinaru D., Magdalou J., Minn A., Artur Y., Goudonnet H.
    Brain Res. Mol. Brain Res. 90:83-92(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiUD2A1_RAT
AccessioniPrimary (citable) accession number: P36510
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 24, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.