Reviewed, UniProtKB/Swiss-Prot P36510 (UD2A1_RAT)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2A1
      Short name=UDPGT 2A1
    EC=2.4.1.17
Alternative name(s):
    UGT-OLF

Gene names

Name:	Ugt2a1
Synonyms:	Ugt2a-1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Olfactory epithelium. Mainly found in the sustentacular cells and to a lesser extent in Bowman's gland cells. Also expressed in the olfactory sensory neuron nuclei. Neuronal localization within the olfactory bulb is mainly found in the deeper granular cells. Ref.2
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Membrane
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro response to toxin Ref.1 Traceable author statement. Source: RGD sensory perception of smell Ref.1 Inferred from direct assay. Source: RGD
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucuronosyltransferase activity Ref.1 Traceable author statement. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 527	507	UDP-glucuronosyltransferase 2A1		PRO_0000036024
Regions
	Topological domain	21 – 490	470	Extracellular Potential
	Transmembrane	491 – 507	17	Potential
	Topological domain	508 – 527	20	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	49	1	N-linked (GlcNAc...) Potential
	Glycosylation	313	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P36510-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 6A32A9B56EE8E8DE	FASTA	527	59,916
	10 20 30 40 50 60 MLKNILLWSL QLSLLGMSLG GNVLIWPMEG SHWLNVKIII DELLRKEHNV TVLVASGALF 70 80 90 100 110 120 ITPSVSPSLT FEIYPVPFGK EKIESVIKDF VLTWLENRPS PSTIWTFYKE MAKVIEEFHL 130 140 150 160 170 180 VSRGICDGVL KNEKLMTKLQ RGKFEVLLSD PVFPCGDIVA LKLGIPFIYS LRFSPASTVE 190 200 210 220 230 240 KHCGKVPFPP SYVPAILSEL TDQMSFADRV RNFISYRMQD YMFETLWKQW DSYYSKALGR 250 260 270 280 290 300 PTTLCETMGK AEIWLMRTYW DFEFPRPYLP NFEFVGGLHC KPAKPLPKEM EEFVQTSGEH 310 320 330 340 350 360 GVVVFSLGSM VKNLTEEKAN LIASALAQIP QKVLWRYKGK IPATLGSNTR LFDWIPQNDL 370 380 390 400 410 420 LGHPKTRAFI THGGTNGIYE AIYHGIPMVG VPMFADQPDN IAHMKAKGAA VEVNMNTMTS 430 440 450 460 470 480 ADLLSAVRAV INEPFYKENA MRLSRIHHDQ PVKPLDRAVF WIEFVMRHKG AKHLRVAAHD 490 500 510 520 LSWFQYHSLD VIGFLLACMA SAILLVIKCC LFVFQKIGKT XKKNKRD

References

[1]	"Odorant signal termination by olfactory UDP glucuronosyl transferase." Lazard D., Zupko K., Poria Y., Nef P., Lazarovits J., Horn S., Khen M., Lancet D. Nature 349:790-793(1991) [PubMed: 1900353] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: in situ mRNA localization and quantitative analysis." Heydel J.-M., Leclerc S., Bernard P., Pelczar H., Gradinaru D., Magdalou J., Minn A., Artur Y., Goudonnet H. Brain Res. Mol. Brain Res. 90:83-92(2001) [PubMed: 11376859] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X57565 Genomic DNA. Translation: CAA40797.1.
IPI	IPI00203471.
PIR	S15089.
RefSeq	NP_071564.1.
UniGene	Rn.138121
3D structure databases
SMR	P36510. Positions 283-449.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Genome annotation databases
Ensembl	ENSRNOG00000001973. Rattus norvegicus. [Contig view]
GeneID	63867.
KEGG	rno:63867.
Organism-specific databases
RGD	69432. Ugt2a1.
Phylogenomic databases
HOVERGEN	P36510.
Enzyme and pathway databases
BRENDA	2.4.1.17. 248.
Gene expression databases
ArrayExpress	P36510.
GermOnline	ENSRNOG00000001973. Rattus norvegicus.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	612484.

Entry information

Entry name

UD2A1_RAT

Accession

Primary (citable) accession number: P36510

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)