Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P36510 (UD2A1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2A1

Short name=UDPGT 2A1
EC=2.4.1.17
Alternative name(s):
UGT-OLF
Gene names
Name:Ugt2a1
Synonyms:Ugt2a-1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Olfactory epithelium. Mainly found in the sustentacular cells and to a lesser extent in Bowman's gland cells. Also expressed in the olfactory sensory neuron nuclei. Neuronal localization within the olfactory bulb is mainly found in the deeper granular cells. Ref.2

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 527507UDP-glucuronosyltransferase 2A1
PRO_0000036024

Regions

Topological domain21 – 490470Extracellular Potential
Transmembrane491 – 50717Helical; Potential
Topological domain508 – 52720Cytoplasmic Potential

Amino acid modifications

Glycosylation491N-linked (GlcNAc...) Potential
Glycosylation3131N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P36510 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 6A32A9B56EE8E8DE

FASTA52759,916
        10         20         30         40         50         60 
MLKNILLWSL QLSLLGMSLG GNVLIWPMEG SHWLNVKIII DELLRKEHNV TVLVASGALF 

        70         80         90        100        110        120 
ITPSVSPSLT FEIYPVPFGK EKIESVIKDF VLTWLENRPS PSTIWTFYKE MAKVIEEFHL 

       130        140        150        160        170        180 
VSRGICDGVL KNEKLMTKLQ RGKFEVLLSD PVFPCGDIVA LKLGIPFIYS LRFSPASTVE 

       190        200        210        220        230        240 
KHCGKVPFPP SYVPAILSEL TDQMSFADRV RNFISYRMQD YMFETLWKQW DSYYSKALGR 

       250        260        270        280        290        300 
PTTLCETMGK AEIWLMRTYW DFEFPRPYLP NFEFVGGLHC KPAKPLPKEM EEFVQTSGEH 

       310        320        330        340        350        360 
GVVVFSLGSM VKNLTEEKAN LIASALAQIP QKVLWRYKGK IPATLGSNTR LFDWIPQNDL 

       370        380        390        400        410        420 
LGHPKTRAFI THGGTNGIYE AIYHGIPMVG VPMFADQPDN IAHMKAKGAA VEVNMNTMTS 

       430        440        450        460        470        480 
ADLLSAVRAV INEPFYKENA MRLSRIHHDQ PVKPLDRAVF WIEFVMRHKG AKHLRVAAHD 

       490        500        510        520 
LSWFQYHSLD VIGFLLACMA SAILLVIKCC LFVFQKIGKT XKKNKRD 

« Hide

References

[1]"Odorant signal termination by olfactory UDP glucuronosyl transferase."
Lazard D., Zupko K., Poria Y., Nef P., Lazarovits J., Horn S., Khen M., Lancet D.
Nature 349:790-793(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: in situ mRNA localization and quantitative analysis."
Heydel J.-M., Leclerc S., Bernard P., Pelczar H., Gradinaru D., Magdalou J., Minn A., Artur Y., Goudonnet H.
Brain Res. Mol. Brain Res. 90:83-92(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X57565 Genomic DNA. Translation: CAA40797.1.
PIRS15089.
RefSeqNP_071564.1. NM_022228.1.
UniGeneRn.138121.

3D structure databases

ProteinModelPortalP36510.
SMRP36510. Positions 283-449.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000040239.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteP36510.

Proteomic databases

PaxDbP36510.
PRIDEP36510.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID63867.
KEGGrno:63867.
UCSCRGD:69432. rat.

Organism-specific databases

CTD10941.
RGD69432. Ugt2a1.

Phylogenomic databases

eggNOGCOG1819.
HOGENOMHOG000220831.
HOVERGENHBG004033.
InParanoidP36510.
KOK00699.

Gene expression databases

GenevestigatorP36510.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio612484.

Entry information

Entry nameUD2A1_RAT
AccessionPrimary (citable) accession number: P36510
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 19, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families