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P36508

- ZNF76_HUMAN

UniProt

P36508 - ZNF76_HUMAN

Protein

Zinc finger protein 76

Gene

ZNF76

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (02 May 2002)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri165 – 18925C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri195 – 21925C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri225 – 24925C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri255 – 27925C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri285 – 30925C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri315 – 33925C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri345 – 36824C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription from RNA polymerase III promoter Source: ProtInc
    2. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 76
    Alternative name(s):
    Zinc finger protein 523
    Gene namesi
    Name:ZNF76
    Synonyms:D6S229E, ZNF523
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:13149. ZNF76.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37723.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Zinc finger protein 76PRO_0000047386Add
    BLAST

    Proteomic databases

    MaxQBiP36508.
    PaxDbiP36508.
    PRIDEiP36508.

    PTM databases

    PhosphoSiteiP36508.

    Expressioni

    Tissue specificityi

    Testis.

    Gene expression databases

    ArrayExpressiP36508.
    BgeeiP36508.
    CleanExiHS_ZNF76.
    GenevestigatoriP36508.

    Organism-specific databases

    HPAiHPA030090.
    HPA030091.

    Interactioni

    Protein-protein interaction databases

    BioGridi113448. 9 interactions.
    IntActiP36508. 1 interaction.
    MINTiMINT-1189547.
    STRINGi9606.ENSP00000363064.

    Structurei

    3D structure databases

    ProteinModelPortaliP36508.
    SMRiP36508. Positions 163-390.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati34 – 45121Add
    BLAST
    Repeati62 – 73122Add
    BLAST
    Repeati88 – 99123Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni34 – 99663 X 12 AA approximate repeatsAdd
    BLAST

    Sequence similaritiesi

    Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri165 – 18925C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri195 – 21925C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri225 – 24925C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri255 – 27925C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri285 – 30925C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri315 – 33925C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri345 – 36824C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000118073.
    HOVERGENiHBG053078.
    InParanoidiP36508.
    OMAiTQDGAQQ.
    OrthoDBiEOG7WX080.
    PhylomeDBiP36508.
    TreeFamiTF333498.

    Family and domain databases

    Gene3Di3.30.160.60. 7 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 6 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 7 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: P36508-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESLGLHTVT LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTVQ    50
    KEALSFEDGQ PVQLEDGSMA YIHRTPREGY DPSTLEAVQL EDGSTAYIHH 100
    PVAVPSESTI LAVQTEVGLE DLAAEDDEGF SADAVVALEQ YASKVLHDSQ 150
    IPRNGKGQQV GDRAFRCGYK GCGRLYTTAH HLKVHERAHT GDRPYRCDFP 200
    SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG DLQKHVRTHT 250
    GERPFQCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT 300
    NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSTC 350
    GKTYRQTSTL AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK 400
    RPRIAYLSEV KEERDDIPAQ VAMVTEEDGA PQVALITQDG AQQVSLSPED 450
    LQALGSAISM VTQHGSTTLT IPSPDADLAT SGTHTVTMVS ADGTQTQPVT 500
    IITSGAVVAE DSSVASLRHQ QVALLATANG THIAVQLEEQ QTLEEAINVA 550
    TAAMQQGAVT LETTVSESGC 570
    Length:570
    Mass (Da):61,831
    Last modified:May 2, 2002 - v2
    Checksum:i333C99E0E79D86C2
    GO
    Isoform 1 (identifier: P36508-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         444-498: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:515
    Mass (Da):56,324
    Checksum:i473D193AE00E7FB1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti334 – 3352KH → ND in AAA98739. (PubMed:1427894)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti48 – 481T → M.
    Corresponds to variant rs2228265 [ dbSNP | Ensembl ].
    VAR_033546
    Natural varianti272 – 2721R → C.
    Corresponds to variant rs33959228 [ dbSNP | Ensembl ].
    VAR_033547
    Natural varianti403 – 4031R → Q.
    Corresponds to variant rs35582935 [ dbSNP | Ensembl ].
    VAR_033548

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei444 – 49855Missing in isoform 1. 1 PublicationVSP_006894Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91592 mRNA. Translation: AAA98739.1.
    BT007316 mRNA. Translation: AAP35980.1.
    BC000133 mRNA. Translation: AAH00133.1.
    BC002549 mRNA. Translation: AAH02549.1.
    CCDSiCCDS4801.1. [P36508-1]
    PIRiA44256.
    RefSeqiNP_003418.2. NM_003427.4. [P36508-1]
    XP_005249421.1. XM_005249364.1. [P36508-1]
    UniGeneiHs.388024.

    Genome annotation databases

    EnsembliENST00000339411; ENSP00000344097; ENSG00000065029. [P36508-2]
    ENST00000373953; ENSP00000363064; ENSG00000065029. [P36508-1]
    GeneIDi7629.
    KEGGihsa:7629.
    UCSCiuc003oki.1. human. [P36508-1]
    uc003okj.1. human. [P36508-2]

    Polymorphism databases

    DMDMi20455531.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91592 mRNA. Translation: AAA98739.1 .
    BT007316 mRNA. Translation: AAP35980.1 .
    BC000133 mRNA. Translation: AAH00133.1 .
    BC002549 mRNA. Translation: AAH02549.1 .
    CCDSi CCDS4801.1. [P36508-1 ]
    PIRi A44256.
    RefSeqi NP_003418.2. NM_003427.4. [P36508-1 ]
    XP_005249421.1. XM_005249364.1. [P36508-1 ]
    UniGenei Hs.388024.

    3D structure databases

    ProteinModelPortali P36508.
    SMRi P36508. Positions 163-390.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113448. 9 interactions.
    IntActi P36508. 1 interaction.
    MINTi MINT-1189547.
    STRINGi 9606.ENSP00000363064.

    PTM databases

    PhosphoSitei P36508.

    Polymorphism databases

    DMDMi 20455531.

    Proteomic databases

    MaxQBi P36508.
    PaxDbi P36508.
    PRIDEi P36508.

    Protocols and materials databases

    DNASUi 7629.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339411 ; ENSP00000344097 ; ENSG00000065029 . [P36508-2 ]
    ENST00000373953 ; ENSP00000363064 ; ENSG00000065029 . [P36508-1 ]
    GeneIDi 7629.
    KEGGi hsa:7629.
    UCSCi uc003oki.1. human. [P36508-1 ]
    uc003okj.1. human. [P36508-2 ]

    Organism-specific databases

    CTDi 7629.
    GeneCardsi GC06P036306.
    HGNCi HGNC:13149. ZNF76.
    HPAi HPA030090.
    HPA030091.
    MIMi 194549. gene.
    neXtProti NX_P36508.
    PharmGKBi PA37723.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000118073.
    HOVERGENi HBG053078.
    InParanoidi P36508.
    OMAi TQDGAQQ.
    OrthoDBi EOG7WX080.
    PhylomeDBi P36508.
    TreeFami TF333498.

    Miscellaneous databases

    GeneWikii ZNF76.
    GenomeRNAii 7629.
    NextBioi 29732.
    PROi P36508.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P36508.
    Bgeei P36508.
    CleanExi HS_ZNF76.
    Genevestigatori P36508.

    Family and domain databases

    Gene3Di 3.30.160.60. 7 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 6 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 7 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the T-complex gene tcp-11."
      Ragoussis J., Senger G., Mockridge I., Sanseau P., Ruddy S., Dudley K., Sheer D., Trowsdale J.
      Genomics 14:673-679(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.

    Entry informationi

    Entry nameiZNF76_HUMAN
    AccessioniPrimary (citable) accession number: P36508
    Secondary accession number(s): Q9BQB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: May 2, 2002
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3