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P36508 (ZNF76_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 76
Alternative name(s):
Zinc finger protein 523
Gene names
Name:ZNF76
Synonyms:D6S229E, ZNF523
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Tissue specificity

Testis.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 7 C2H2-type zinc fingers.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 2 (identifier: P36508-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: P36508-2)

The sequence of this isoform differs from the canonical sequence as follows:
     444-498: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Zinc finger protein 76
PRO_0000047386

Regions

Repeat34 – 45121
Repeat62 – 73122
Repeat88 – 99123
Zinc finger165 – 18925C2H2-type 1
Zinc finger195 – 21925C2H2-type 2
Zinc finger225 – 24925C2H2-type 3
Zinc finger255 – 27925C2H2-type 4
Zinc finger285 – 30925C2H2-type 5
Zinc finger315 – 33925C2H2-type 6
Zinc finger345 – 36824C2H2-type 7
Region34 – 99663 X 12 AA approximate repeats

Natural variations

Alternative sequence444 – 49855Missing in isoform 1.
VSP_006894
Natural variant481T → M.
Corresponds to variant rs2228265 [ dbSNP | Ensembl ].
VAR_033546
Natural variant2721R → C.
Corresponds to variant rs33959228 [ dbSNP | Ensembl ].
VAR_033547
Natural variant4031R → Q.
Corresponds to variant rs35582935 [ dbSNP | Ensembl ].
VAR_033548

Experimental info

Sequence conflict334 – 3352KH → ND in AAA98739. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 2 [UniParc].

Last modified May 2, 2002. Version 2.
Checksum: 333C99E0E79D86C2

FASTA57061,831
        10         20         30         40         50         60 
MESLGLHTVT LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTVQ KEALSFEDGQ 

        70         80         90        100        110        120 
PVQLEDGSMA YIHRTPREGY DPSTLEAVQL EDGSTAYIHH PVAVPSESTI LAVQTEVGLE 

       130        140        150        160        170        180 
DLAAEDDEGF SADAVVALEQ YASKVLHDSQ IPRNGKGQQV GDRAFRCGYK GCGRLYTTAH 

       190        200        210        220        230        240 
HLKVHERAHT GDRPYRCDFP SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG 

       250        260        270        280        290        300 
DLQKHVRTHT GERPFQCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT 

       310        320        330        340        350        360 
NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSTC GKTYRQTSTL 

       370        380        390        400        410        420 
AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK RPRIAYLSEV KEERDDIPAQ 

       430        440        450        460        470        480 
VAMVTEEDGA PQVALITQDG AQQVSLSPED LQALGSAISM VTQHGSTTLT IPSPDADLAT 

       490        500        510        520        530        540 
SGTHTVTMVS ADGTQTQPVT IITSGAVVAE DSSVASLRHQ QVALLATANG THIAVQLEEQ 

       550        560        570 
QTLEEAINVA TAAMQQGAVT LETTVSESGC 

« Hide

Isoform 1 [UniParc].

Checksum: 473D193AE00E7FB1
Show »

FASTA51556,324

References

« Hide 'large scale' references
[1]"A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the T-complex gene tcp-11."
Ragoussis J., Senger G., Mockridge I., Sanseau P., Ruddy S., Dudley K., Sheer D., Trowsdale J.
Genomics 14:673-679(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M91592 mRNA. Translation: AAA98739.1.
BT007316 mRNA. Translation: AAP35980.1.
BC000133 mRNA. Translation: AAH00133.1.
BC002549 mRNA. Translation: AAH02549.1.
PIRA44256.
RefSeqNP_003418.2. NM_003427.3.
XP_005249421.1. XM_005249364.1.
XP_005249426.1. XM_005249369.1.
XP_005249427.1. XM_005249370.1.
UniGeneHs.388024.

3D structure databases

ProteinModelPortalP36508.
SMRP36508. Positions 160-391.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113448. 9 interactions.
IntActP36508. 1 interaction.
MINTMINT-1189547.
STRING9606.ENSP00000363064.

PTM databases

PhosphoSiteP36508.

Polymorphism databases

DMDM20455531.

Proteomic databases

PaxDbP36508.
PRIDEP36508.

Protocols and materials databases

DNASU7629.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339411; ENSP00000344097; ENSG00000065029. [P36508-2]
ENST00000373953; ENSP00000363064; ENSG00000065029. [P36508-1]
GeneID7629.
KEGGhsa:7629.
UCSCuc003oki.1. human. [P36508-1]
uc003okj.1. human. [P36508-2]

Organism-specific databases

CTD7629.
GeneCardsGC06P036306.
HGNCHGNC:13149. ZNF76.
HPAHPA030090.
HPA030091.
MIM194549. gene.
neXtProtNX_P36508.
PharmGKBPA37723.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000118073.
HOVERGENHBG053078.
InParanoidP36508.
OMATQDGAQQ.
OrthoDBEOG7WX080.
PhylomeDBP36508.
TreeFamTF333498.

Gene expression databases

ArrayExpressP36508.
BgeeP36508.
CleanExHS_ZNF76.
GenevestigatorP36508.

Family and domain databases

Gene3D3.30.160.60. 7 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF76.
GenomeRNAi7629.
NextBio29732.
PROP36508.
SOURCESearch...

Entry information

Entry nameZNF76_HUMAN
AccessionPrimary (citable) accession number: P36508
Secondary accession number(s): Q9BQB2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 2, 2002
Last modified: April 16, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM