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Protein

Zinc finger protein 76

Gene

ZNF76

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri165 – 18925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri195 – 21925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24925C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27925C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30925C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33925C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36824C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription from RNA polymerase III promoter Source: ProtInc
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 76
Alternative name(s):
Zinc finger protein 523
Gene namesi
Name:ZNF76
Synonyms:D6S229E, ZNF523
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13149. ZNF76.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37723.

Polymorphism and mutation databases

BioMutaiZNF76.
DMDMi20455531.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Zinc finger protein 76PRO_0000047386Add
BLAST

Proteomic databases

MaxQBiP36508.
PaxDbiP36508.
PRIDEiP36508.

PTM databases

PhosphoSiteiP36508.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiP36508.
CleanExiHS_ZNF76.
ExpressionAtlasiP36508. baseline.
GenevisibleiP36508. HS.

Organism-specific databases

HPAiHPA030090.
HPA030091.

Interactioni

Protein-protein interaction databases

BioGridi113448. 14 interactions.
IntActiP36508. 1 interaction.
MINTiMINT-1189547.
STRINGi9606.ENSP00000363064.

Structurei

3D structure databases

ProteinModelPortaliP36508.
SMRiP36508. Positions 163-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati34 – 45121Add
BLAST
Repeati62 – 73122Add
BLAST
Repeati88 – 99123Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni34 – 99663 X 12 AA approximate repeatsAdd
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri165 – 18925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri195 – 21925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24925C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27925C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30925C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33925C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36824C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000118073.
HOVERGENiHBG053078.
InParanoidiP36508.
OMAiTQDGAQQ.
OrthoDBiEOG7WX080.
PhylomeDBiP36508.
TreeFamiTF333498.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: P36508-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESLGLHTVT LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTVQ
60 70 80 90 100
KEALSFEDGQ PVQLEDGSMA YIHRTPREGY DPSTLEAVQL EDGSTAYIHH
110 120 130 140 150
PVAVPSESTI LAVQTEVGLE DLAAEDDEGF SADAVVALEQ YASKVLHDSQ
160 170 180 190 200
IPRNGKGQQV GDRAFRCGYK GCGRLYTTAH HLKVHERAHT GDRPYRCDFP
210 220 230 240 250
SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG DLQKHVRTHT
260 270 280 290 300
GERPFQCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT
310 320 330 340 350
NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSTC
360 370 380 390 400
GKTYRQTSTL AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK
410 420 430 440 450
RPRIAYLSEV KEERDDIPAQ VAMVTEEDGA PQVALITQDG AQQVSLSPED
460 470 480 490 500
LQALGSAISM VTQHGSTTLT IPSPDADLAT SGTHTVTMVS ADGTQTQPVT
510 520 530 540 550
IITSGAVVAE DSSVASLRHQ QVALLATANG THIAVQLEEQ QTLEEAINVA
560 570
TAAMQQGAVT LETTVSESGC
Length:570
Mass (Da):61,831
Last modified:May 2, 2002 - v2
Checksum:i333C99E0E79D86C2
GO
Isoform 1 (identifier: P36508-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     444-498: Missing.

Note: No experimental confirmation available.
Show »
Length:515
Mass (Da):56,324
Checksum:i473D193AE00E7FB1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti334 – 3352KH → ND in AAA98739 (PubMed:1427894).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481T → M.
Corresponds to variant rs2228265 [ dbSNP | Ensembl ].
VAR_033546
Natural varianti272 – 2721R → C.
Corresponds to variant rs33959228 [ dbSNP | Ensembl ].
VAR_033547
Natural varianti403 – 4031R → Q.
Corresponds to variant rs35582935 [ dbSNP | Ensembl ].
VAR_033548

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei444 – 49855Missing in isoform 1. 1 PublicationVSP_006894Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91592 mRNA. Translation: AAA98739.1.
BT007316 mRNA. Translation: AAP35980.1.
BC000133 mRNA. Translation: AAH00133.1.
BC002549 mRNA. Translation: AAH02549.1.
CCDSiCCDS4801.1. [P36508-1]
CCDS75435.1. [P36508-2]
PIRiA44256.
RefSeqiNP_001278961.1. NM_001292032.1. [P36508-2]
NP_003418.2. NM_003427.4. [P36508-1]
UniGeneiHs.388024.

Genome annotation databases

EnsembliENST00000373953; ENSP00000363064; ENSG00000065029.
GeneIDi7629.
KEGGihsa:7629.
UCSCiuc003oki.1. human. [P36508-1]
uc003okj.1. human. [P36508-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91592 mRNA. Translation: AAA98739.1.
BT007316 mRNA. Translation: AAP35980.1.
BC000133 mRNA. Translation: AAH00133.1.
BC002549 mRNA. Translation: AAH02549.1.
CCDSiCCDS4801.1. [P36508-1]
CCDS75435.1. [P36508-2]
PIRiA44256.
RefSeqiNP_001278961.1. NM_001292032.1. [P36508-2]
NP_003418.2. NM_003427.4. [P36508-1]
UniGeneiHs.388024.

3D structure databases

ProteinModelPortaliP36508.
SMRiP36508. Positions 163-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113448. 14 interactions.
IntActiP36508. 1 interaction.
MINTiMINT-1189547.
STRINGi9606.ENSP00000363064.

PTM databases

PhosphoSiteiP36508.

Polymorphism and mutation databases

BioMutaiZNF76.
DMDMi20455531.

Proteomic databases

MaxQBiP36508.
PaxDbiP36508.
PRIDEiP36508.

Protocols and materials databases

DNASUi7629.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373953; ENSP00000363064; ENSG00000065029.
GeneIDi7629.
KEGGihsa:7629.
UCSCiuc003oki.1. human. [P36508-1]
uc003okj.1. human. [P36508-2]

Organism-specific databases

CTDi7629.
GeneCardsiGC06P037292.
HGNCiHGNC:13149. ZNF76.
HPAiHPA030090.
HPA030091.
MIMi194549. gene.
neXtProtiNX_P36508.
PharmGKBiPA37723.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000118073.
HOVERGENiHBG053078.
InParanoidiP36508.
OMAiTQDGAQQ.
OrthoDBiEOG7WX080.
PhylomeDBiP36508.
TreeFamiTF333498.

Miscellaneous databases

ChiTaRSiZNF76. human.
GeneWikiiZNF76.
GenomeRNAii7629.
NextBioi29732.
PROiP36508.
SOURCEiSearch...

Gene expression databases

BgeeiP36508.
CleanExiHS_ZNF76.
ExpressionAtlasiP36508. baseline.
GenevisibleiP36508. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the T-complex gene tcp-11."
    Ragoussis J., Senger G., Mockridge I., Sanseau P., Ruddy S., Dudley K., Sheer D., Trowsdale J.
    Genomics 14:673-679(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.

Entry informationi

Entry nameiZNF76_HUMAN
AccessioniPrimary (citable) accession number: P36508
Secondary accession number(s): Q9BQB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 2, 2002
Last modified: July 22, 2015
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.