P36508 (ZNF76_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 76

Alternative name(s):
Zinc finger protein 523

Gene names

Name:	ZNF76
Synonyms:	D6S229E, ZNF523

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	570 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Tissue specificity	Testis.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 7 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription from RNA polymerase II promoter Traceable author statement PubMed 9705341. Source: ProtInc regulation of transcription from RNA polymerase III promoter Traceable author statement PubMed 9705341. Source: ProtInc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 (identifier: P36508-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: P36508-2)

The sequence of this isoform differs from the canonical sequence as follows:
     444-498: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 570	570	Zinc finger protein 76		PRO_0000047386
Regions
	Repeat	34 – 45	12	1
	Repeat	62 – 73	12	2
	Repeat	88 – 99	12	3
	Zinc finger	165 – 189	25	C2H2-type 1
	Zinc finger	195 – 219	25	C2H2-type 2
	Zinc finger	225 – 249	25	C2H2-type 3
	Zinc finger	255 – 279	25	C2H2-type 4
	Zinc finger	285 – 309	25	C2H2-type 5
	Zinc finger	315 – 339	25	C2H2-type 6
	Zinc finger	345 – 368	24	C2H2-type 7
	Region	34 – 99	66	3 X 12 AA approximate repeats
Natural variations
	Alternative sequence	444 – 498	55	Missing in isoform 1.		VSP_006894
	Natural variant	48	1	T → M. Corresponds to variant rs2228265 [ dbSNP | Ensembl ].		VAR_033546
	Natural variant	272	1	R → C. Corresponds to variant rs33959228 [ dbSNP | Ensembl ].		VAR_033547
	Natural variant	403	1	R → Q. Corresponds to variant rs35582935 [ dbSNP | Ensembl ].		VAR_033548
Experimental info
	Sequence conflict	334 – 335	2	KH → ND in AAA98739. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 [UniParc]. Last modified May 2, 2002. Version 2. Checksum: 333C99E0E79D86C2	FASTA	570	61,831
	10 20 30 40 50 60 MESLGLHTVT LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTVQ KEALSFEDGQ 70 80 90 100 110 120 PVQLEDGSMA YIHRTPREGY DPSTLEAVQL EDGSTAYIHH PVAVPSESTI LAVQTEVGLE 130 140 150 160 170 180 DLAAEDDEGF SADAVVALEQ YASKVLHDSQ IPRNGKGQQV GDRAFRCGYK GCGRLYTTAH 190 200 210 220 230 240 HLKVHERAHT GDRPYRCDFP SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG 250 260 270 280 290 300 DLQKHVRTHT GERPFQCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT 310 320 330 340 350 360 NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSTC GKTYRQTSTL 370 380 390 400 410 420 AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK RPRIAYLSEV KEERDDIPAQ 430 440 450 460 470 480 VAMVTEEDGA PQVALITQDG AQQVSLSPED LQALGSAISM VTQHGSTTLT IPSPDADLAT 490 500 510 520 530 540 SGTHTVTMVS ADGTQTQPVT IITSGAVVAE DSSVASLRHQ QVALLATANG THIAVQLEEQ 550 560 570 QTLEEAINVA TAAMQQGAVT LETTVSESGC
	Isoform 1 [UniParc]. Checksum: 473D193AE00E7FB1	FASTA	515	56,324
	10 20 30 40 50 60 MESLGLHTVT LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTVQ KEALSFEDGQ 70 80 90 100 110 120 PVQLEDGSMA YIHRTPREGY DPSTLEAVQL EDGSTAYIHH PVAVPSESTI LAVQTEVGLE 130 140 150 160 170 180 DLAAEDDEGF SADAVVALEQ YASKVLHDSQ IPRNGKGQQV GDRAFRCGYK GCGRLYTTAH 190 200 210 220 230 240 HLKVHERAHT GDRPYRCDFP SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG 250 260 270 280 290 300 DLQKHVRTHT GERPFQCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT 310 320 330 340 350 360 NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSTC GKTYRQTSTL 370 380 390 400 410 420 AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK RPRIAYLSEV KEERDDIPAQ 430 440 450 460 470 480 VAMVTEEDGA PQVALITQDG AQQVTIITSG AVVAEDSSVA SLRHQQVALL ATANGTHIAV 490 500 510 QLEEQQTLEE AINVATAAMQ QGAVTLETTV SESGC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the T-complex gene tcp-11." Ragoussis J., Senger G., Mockridge I., Sanseau P., Ruddy S., Dudley K., Sheer D., Trowsdale J. Genomics 14:673-679(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M91592 mRNA. Translation: AAA98739.1. BT007316 mRNA. Translation: AAP35980.1. BC000133 mRNA. Translation: AAH00133.1. BC002549 mRNA. Translation: AAH02549.1.
IPI	IPI00003784. IPI00218817.
PIR	A44256.
RefSeq	NP_003418.2. NM_003427.3.
UniGene	Hs.388024.
3D structure databases
ProteinModelPortal	P36508.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1189547.
STRING	9606.ENSP00000363064.
PTM databases
PhosphoSite	P36508.
Polymorphism databases
DMDM	20455531.
Proteomic databases
PaxDb	P36508.
PRIDE	P36508.
Protocols and materials databases
DNASU	7629.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339411; ENSP00000344097; ENSG00000065029. ENST00000373953; ENSP00000363064; ENSG00000065029.
GeneID	7629.
KEGG	hsa:7629.
UCSC	uc003oki.1. human. uc003okj.1. human.
Organism-specific databases
CTD	7629.
GeneCards	GC06P035323.
HGNC	HGNC:13149. ZNF76.
HPA	HPA030090. HPA030091.
MIM	194549. gene.
neXtProt	NX_P36508.
PharmGKB	PA37723.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000118073.
HOVERGEN	HBG053078.
InParanoid	P36508.
OMA	TQDGAQQ.
OrthoDB	EOG4QFWCV.
Gene expression databases
ArrayExpress	P36508.
Bgee	P36508.
CleanEx	HS_ZNF76.
Genevestigator	P36508.
GermOnline	ENSG00000065029. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 7 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00096. zf-C2H2. 3 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 7 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 7 hits. PS50157. ZINC_FINGER_C2H2_2. 7 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7629.
NextBio	29732.
SOURCE	Search...

Entry information

Entry name

ZNF76_HUMAN

Accession

Primary (citable) accession number: P36508
Secondary accession number(s): Q9BQB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	May 2, 2002
Last modified:	May 1, 2013
This is version 125 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.