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P36507

- MP2K2_HUMAN

UniProt

P36507 - MP2K2_HUMAN

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Protein

Dual specificity mitogen-activated protein kinase kinase 2

Gene

MAP2K2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei10 – 112Cleavage; by anthrax lethal factor
Binding sitei101 – 1011ATPPROSITE-ProRule annotation
Active sitei194 – 1941Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi78 – 869ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase activity Source: UniProtKB
  3. PDZ domain binding Source: UniProtKB
  4. protein serine/threonine/tyrosine kinase activity Source: UniProtKB
  5. protein serine/threonine kinase activator activity Source: UniProtKB
  6. protein serine/threonine kinase activity Source: Reactome
  7. protein tyrosine kinase activity Source: UniProtKB-KW
  8. scaffold protein binding Source: UniProtKB

GO - Biological processi

  1. activation of MAPK activity Source: UniProtKB
  2. activation of MAPKK activity Source: Reactome
  3. axon guidance Source: Reactome
  4. epidermal growth factor receptor signaling pathway Source: Reactome
  5. ERK1 and ERK2 cascade Source: Reactome
  6. Fc-epsilon receptor signaling pathway Source: Reactome
  7. fibroblast growth factor receptor signaling pathway Source: Reactome
  8. innate immune response Source: Reactome
  9. insulin receptor signaling pathway Source: Reactome
  10. MAPK cascade Source: Reactome
  11. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  12. MyD88-independent toll-like receptor signaling pathway Source: Reactome
  13. neurotrophin TRK receptor signaling pathway Source: Reactome
  14. peptidyl-serine autophosphorylation Source: UniProtKB
  15. positive regulation of cell motility Source: Ensembl
  16. positive regulation of protein serine/threonine kinase activity Source: UniProtKB
  17. Ras protein signal transduction Source: Reactome
  18. regulation of early endosome to late endosome transport Source: UniProtKB
  19. regulation of Golgi inheritance Source: UniProtKB
  20. regulation of stress-activated MAPK cascade Source: UniProtKB
  21. small GTPase mediated signal transduction Source: Reactome
  22. stress-activated MAPK cascade Source: Reactome
  23. toll-like receptor 10 signaling pathway Source: Reactome
  24. toll-like receptor 2 signaling pathway Source: Reactome
  25. toll-like receptor 3 signaling pathway Source: Reactome
  26. toll-like receptor 4 signaling pathway Source: Reactome
  27. toll-like receptor 5 signaling pathway Source: Reactome
  28. toll-like receptor 9 signaling pathway Source: Reactome
  29. toll-like receptor signaling pathway Source: Reactome
  30. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
  31. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
  32. TRIF-dependent toll-like receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.12.2. 2681.
ReactomeiREACT_1183. ERK2 activation.
REACT_22272. Signal transduction by L1.
REACT_228255. Uptake and function of anthrax toxins.
REACT_614. RAF phosphorylates MEK.
REACT_9470. Signaling by FGFR.
REACT_962. MEK activation.
SignaLinkiP36507.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
Short name:
MAP kinase kinase 2
Short name:
MAPKK 2
Alternative name(s):
ERK activator kinase 2
MAPK/ERK kinase 2
Short name:
MEK 2
Gene namesi
Name:MAP2K2
Synonyms:MEK2, MKK2, PRKMK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6842. MAP2K2.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: UniProtKB
  2. cell cortex Source: Ensembl
  3. cytoplasm Source: HPA
  4. cytoplasmic side of plasma membrane Source: UniProtKB
  5. cytosol Source: UniProtKB
  6. early endosome Source: UniProtKB
  7. endoplasmic reticulum Source: UniProtKB
  8. extracellular region Source: UniProtKB
  9. focal adhesion Source: UniProtKB
  10. Golgi apparatus Source: UniProtKB
  11. late endosome Source: UniProtKB
  12. microtubule Source: UniProtKB
  13. mitochondrion Source: UniProtKB
  14. nucleus Source: UniProtKB
  15. perinuclear region of cytoplasm Source: UniProtKB
  16. peroxisomal membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Cardiofaciocutaneous syndrome 4 (CFC4) [MIM:615280]: A form of cardiofaciocutaneous syndrome, a multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices.3 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571F → C in CFC4. 1 Publication
VAR_035095
Natural varianti57 – 571F → V in CFC4. 1 Publication
VAR_069781
Natural varianti128 – 1281P → Q in CFC4; results in increased kinase activity. 1 Publication
VAR_069782
Natural varianti134 – 1341Y → H in CFC4. 1 Publication
VAR_069783

Keywords - Diseasei

Cardiomyopathy, Disease mutation, Ectodermal dysplasia, Mental retardation

Organism-specific databases

MIMi615280. phenotype.
Orphaneti1340. Cardiofaciocutaneous syndrome.
638. Neurofibromatosis-Noonan syndrome.
PharmGKBiPA30587.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Dual specificity mitogen-activated protein kinase kinase 2PRO_0000086372Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei222 – 2221O-acetylserine; by Yersinia yopJ; alternate1 Publication
Modified residuei222 – 2221Phosphoserine; by RAF; alternate1 Publication
Modified residuei226 – 2261O-acetylserine; by Yersinia yopJ; alternate1 Publication
Modified residuei226 – 2261Phosphoserine; alternate1 Publication
Modified residuei293 – 2931Phosphoserine1 Publication
Modified residuei295 – 2951Phosphoserine2 Publications
Modified residuei394 – 3941Phosphothreonine4 Publications
Modified residuei396 – 3961Phosphothreonine2 Publications

Post-translational modificationi

MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity).By similarity
Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.7 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP36507.
PaxDbiP36507.
PeptideAtlasiP36507.
PRIDEiP36507.

2D gel databases

REPRODUCTION-2DPAGEIPI00003783.

PTM databases

PhosphoSiteiP36507.

Miscellaneous databases

PMAP-CutDBP36507.

Expressioni

Gene expression databases

BgeeiP36507.
CleanExiHS_MAP2K2.
ExpressionAtlasiP36507. baseline and differential.
GenevestigatoriP36507.

Organism-specific databases

HPAiCAB003835.
HPA051993.

Interactioni

Subunit structurei

Interacts with MORG1 (By similarity). Interacts with SGK1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARAFP103984EBI-1056930,EBI-365961
DLG1Q1295910EBI-1056930,EBI-357481

Protein-protein interaction databases

BioGridi111591. 26 interactions.
DIPiDIP-29119N.
IntActiP36507. 14 interactions.
MINTiMINT-99667.
STRINGi9606.ENSP00000262948.

Structurei

Secondary structure

1
400
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi69 – 713Combined sources
Beta strandi72 – 809Combined sources
Beta strandi85 – 917Combined sources
Turni92 – 943Combined sources
Beta strandi97 – 1037Combined sources
Helixi110 – 11910Combined sources
Helixi120 – 1223Combined sources
Beta strandi133 – 14816Combined sources
Helixi155 – 1617Combined sources
Beta strandi162 – 1643Combined sources
Helixi167 – 18620Combined sources
Helixi197 – 1993Combined sources
Beta strandi200 – 2023Combined sources
Beta strandi208 – 2103Combined sources
Helixi217 – 2226Combined sources
Helixi236 – 2394Combined sources
Helixi246 – 26217Combined sources
Helixi272 – 2798Combined sources
Helixi318 – 32710Combined sources
Turni335 – 3373Combined sources
Helixi340 – 34910Combined sources
Turni354 – 3563Combined sources
Helixi360 – 3645Combined sources
Helixi367 – 3748Combined sources
Helixi379 – 3868Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S9IX-ray3.20A/B55-400[»]
4H3QX-ray2.20B4-16[»]
ProteinModelPortaliP36507.
SMRiP36507. Positions 60-393.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36507.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 369298Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi266 – 31550Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119199.
HOGENOMiHOG000234206.
HOVERGENiHBG108518.
InParanoidiP36507.
KOiK04369.
OMAiLSAITEY.
OrthoDBiEOG7HF1KZ.
PhylomeDBiP36507.
TreeFamiTF105137.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36507-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLARRKPVLP ALTINPTIAE GPSPTSEGAS EANLVDLQKK LEELELDEQQ
60 70 80 90 100
KKRLEAFLTQ KAKVGELKDD DFERISELGA GNGGVVTKVQ HRPSGLIMAR
110 120 130 140 150
KLIHLEIKPA IRNQIIRELQ VLHECNSPYI VGFYGAFYSD GEISICMEHM
160 170 180 190 200
DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG LAYLREKHQI MHRDVKPSNI
210 220 230 240 250
LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMAPERLQ GTHYSVQSDI
260 270 280 290 300
WSMGLSLVEL AVGRYPIPPP DAKELEAIFG RPVVDGEEGE PHSISPRPRP
310 320 330 340 350
PGRPVSGHGM DSRPAMAIFE LLDYIVNEPP PKLPNGVFTP DFQEFVNKCL
360 370 380 390 400
IKNPAERADL KMLTNHTFIK RSEVEEVDFA GWLCKTLRLN QPGTPTRTAV
Length:400
Mass (Da):44,424
Last modified:June 1, 1994 - v1
Checksum:i3401D522515C30A5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571F → C in CFC4. 1 Publication
VAR_035095
Natural varianti57 – 571F → V in CFC4. 1 Publication
VAR_069781
Natural varianti128 – 1281P → Q in CFC4; results in increased kinase activity. 1 Publication
VAR_069782
Natural varianti134 – 1341Y → H in CFC4. 1 Publication
VAR_069783

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11285 mRNA. No translation available.
BC000471 mRNA. Translation: AAH00471.1.
BC018645 mRNA. Translation: AAH18645.1.
CCDSiCCDS12120.1.
PIRiA46723.
RefSeqiNP_109587.1. NM_030662.3.
UniGeneiHs.465627.

Genome annotation databases

EnsembliENST00000262948; ENSP00000262948; ENSG00000126934.
GeneIDi5605.
KEGGihsa:5605.
UCSCiuc002lzj.3. human.

Polymorphism databases

DMDMi547915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11285 mRNA. No translation available.
BC000471 mRNA. Translation: AAH00471.1 .
BC018645 mRNA. Translation: AAH18645.1 .
CCDSi CCDS12120.1.
PIRi A46723.
RefSeqi NP_109587.1. NM_030662.3.
UniGenei Hs.465627.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1S9I X-ray 3.20 A/B 55-400 [» ]
4H3Q X-ray 2.20 B 4-16 [» ]
ProteinModelPortali P36507.
SMRi P36507. Positions 60-393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111591. 26 interactions.
DIPi DIP-29119N.
IntActi P36507. 14 interactions.
MINTi MINT-99667.
STRINGi 9606.ENSP00000262948.

Chemistry

BindingDBi P36507.
ChEMBLi CHEMBL2964.
DrugBanki DB06616. Bosutinib.
DB08911. Trametinib.
GuidetoPHARMACOLOGYi 2063.

PTM databases

PhosphoSitei P36507.

Polymorphism databases

DMDMi 547915.

2D gel databases

REPRODUCTION-2DPAGE IPI00003783.

Proteomic databases

MaxQBi P36507.
PaxDbi P36507.
PeptideAtlasi P36507.
PRIDEi P36507.

Protocols and materials databases

DNASUi 5605.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262948 ; ENSP00000262948 ; ENSG00000126934 .
GeneIDi 5605.
KEGGi hsa:5605.
UCSCi uc002lzj.3. human.

Organism-specific databases

CTDi 5605.
GeneCardsi GC19M004090.
GeneReviewsi MAP2K2.
H-InvDB HIX0033655.
HGNCi HGNC:6842. MAP2K2.
HPAi CAB003835.
HPA051993.
MIMi 601263. gene.
615280. phenotype.
neXtProti NX_P36507.
Orphaneti 1340. Cardiofaciocutaneous syndrome.
638. Neurofibromatosis-Noonan syndrome.
PharmGKBi PA30587.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119199.
HOGENOMi HOG000234206.
HOVERGENi HBG108518.
InParanoidi P36507.
KOi K04369.
OMAi LSAITEY.
OrthoDBi EOG7HF1KZ.
PhylomeDBi P36507.
TreeFami TF105137.

Enzyme and pathway databases

BRENDAi 2.7.12.2. 2681.
Reactomei REACT_1183. ERK2 activation.
REACT_22272. Signal transduction by L1.
REACT_228255. Uptake and function of anthrax toxins.
REACT_614. RAF phosphorylates MEK.
REACT_9470. Signaling by FGFR.
REACT_962. MEK activation.
SignaLinki P36507.

Miscellaneous databases

ChiTaRSi MAP2K2. human.
EvolutionaryTracei P36507.
GeneWikii MAP2K2.
GenomeRNAii 5605.
NextBioi 21780.
PMAP-CutDB P36507.
PROi P36507.
SOURCEi Search...

Gene expression databases

Bgeei P36507.
CleanExi HS_MAP2K2.
ExpressionAtlasi P36507. baseline and differential.
Genevestigatori P36507.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2."
    Zheng C.-F., Guan K.-L.
    J. Biol. Chem. 268:11435-11439(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle and Skin.
  3. Bienvenut W.V., Zebisch A., Kolch W.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 40-51; 53-61; 64-100; 102-112; 164-172; 194-205; 265-297; 362-371 AND 389-397, PHOSPHORYLATION AT THR-394, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Colon carcinoma.
  4. "Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling."
    Mittal R., Peak-Chew S.Y., McMahon H.T.
    Proc. Natl. Acad. Sci. U.S.A. 103:18574-18579(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 210-231, INACTIVATION BY YERSINIA YOPJ, PHOSPHORYLATION AT SER-222 AND SER-226, ACETYLATION AT SER-222 AND SER-226, IDENTIFICATION BY MASS SPECTROMETRY.
  5. Cited for: CLEAVAGE BY ANTHRAX LETHAL FACTOR.
  6. "Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor."
    Vitale G., Bernardi L., Napolitani G., Mock M., Montecucco C.
    Biochem. J. 352:739-745(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE BY ANTHRAX LETHAL FACTOR.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293 AND SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394 AND THR-396, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration."
    Won M., Park K.A., Byun H.S., Kim Y.R., Choi B.L., Hong J.H., Park J., Seok J.H., Lee Y.H., Cho C.H., Song I.S., Kim Y.K., Shen H.M., Hur G.M.
    J. Hepatol. 51:67-76(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SGK1.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295 AND THR-394, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394 AND THR-396, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome."
    Rodriguez-Viciana P., Tetsu O., Tidyman W.E., Estep A.L., Conger B.A., Cruz M.S., McCormick F., Rauen K.A.
    Science 311:1287-1290(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CFC4 CYS-57.
  19. Cited for: VARIANTS CFC4 VAL-57 AND HIS-134.
  20. "Molecular and functional analysis of a novel MEK2 mutation in cardio-facio-cutaneous syndrome: transmission through four generations."
    Rauen K.A., Tidyman W.E., Estep A.L., Sampath S., Peltier H.M., Bale S.J., Lacassie Y.
    Am. J. Med. Genet. A 152:807-814(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CFC4 GLN-128, CHARACTERIZATION OF VARIANT CFC4 GLN-128.

Entry informationi

Entry nameiMP2K2_HUMAN
AccessioniPrimary (citable) accession number: P36507
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 26, 2014
This is version 171 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

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