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P36504

- DURA_STRGV

UniProt

P36504 - DURA_STRGV

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Protein
Lantibiotic duramycin
Gene
N/A
Organism
Streptoverticillium griseoverticillatum
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Is a potent inhibitor of human phospholipase A2.1 Publication

GO - Biological processi

  1. cytolysis Source: UniProtKB-KW
  2. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriocin, Lantibiotic

Names & Taxonomyi

Protein namesi
Recommended name:
Lantibiotic duramycin
Alternative name(s):
Antibiotic PA48009
Leucopeptin
OrganismiStreptoverticillium griseoverticillatum
Taxonomic identifieri68215 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces cinnamoneus group

Subcellular locationi

Secreted Inferred 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 1919Lantibiotic duramycin
PRO_0000043970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki1 ↔ 18Beta-methyllanthionine (Cys-Thr)
Cross-linki4 ↔ 14Lanthionine (Ser-Cys)
Cross-linki5 ↔ 11Beta-methyllanthionine (Cys-Thr)
Cross-linki6 ↔ 19Lysinoalanine (Ser-Lys)
Modified residuei15 – 151(3R)-3-hydroxyaspartate

Post-translational modificationi

Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine or the formation of dialkylamine bonds with lysine. This is followed by membrane translocation and cleavage of the modified precursor.

Keywords - PTMi

Hydroxylation, Thioether bond

Family & Domainsi

Sequence similaritiesi

Sequencei

Sequence statusi: Complete.

P36504-1 [UniParc]FASTAAdd to Basket

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CKQSCSFGPF TFVCDGNTK                                     19
Length:19
Mass (Da):2,069
Last modified:June 1, 1994 - v1
Checksum:i012951AE27362F00
GO

Mass spectrometryi

Molecular mass is 2014 Da from positions 1 - 19. Determined by FAB. 1 Publication

Cross-referencesi

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The structure of PA48009: the revised structure of duramycin."
    Hayashi F., Nagashima K., Terui Y., Kawamura Y., Matsumoto K., Itazaki H.
    J. Antibiot. 43:1421-1430(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, STRUCTURE BY NMR.
    Strain: PA-48009.
  2. "Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin."
    Fredenhagen A., Fendrich G., Marki F., Marki W., Gruner J., Raschdorf F., Peter H.H.
    J. Antibiot. 43:1403-1412(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, CROSS-LINKS, HYDROXYLATION AT ASP-15, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiDURA_STRGV
AccessioniPrimary (citable) accession number: P36504
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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