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Lantibiotic duramycin

Streptomyces griseoverticillatus (Streptoverticillium griseoverticillatum)
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli


Is a potent inhibitor of human phospholipase A2.1 Publication

GO - Molecular functioni

GO - Biological processi


Molecular functionAntibiotic, Antimicrobial, Bacteriocin, Lantibiotic

Names & Taxonomyi

Protein namesi
Recommended name:
Lantibiotic duramycin
Alternative name(s):
Antibiotic PA48009
OrganismiStreptomyces griseoverticillatus (Streptoverticillium griseoverticillatum)
Taxonomic identifieri68215 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces cinnamoneus group

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti


PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000439701 – 19Lantibiotic duramycinAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki1 ↔ 18Beta-methyllanthionine (Cys-Thr)
Cross-linki4 ↔ 14Lanthionine (Ser-Cys)
Cross-linki5 ↔ 11Beta-methyllanthionine (Cys-Thr)
Cross-linki6 ↔ 19Lysinoalanine (Ser-Lys)
Modified residuei15(3R)-3-hydroxyaspartate1 Publication1

Post-translational modificationi

Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine or the formation of dialkylamine bonds with lysine. This is followed by membrane translocation and cleavage of the modified precursor.

Keywords - PTMi

Hydroxylation, Thioether bond


GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the type B lantibiotic family.Curated


Sequence statusi: Complete.

P36504-1 [UniParc]FASTAAdd to basket

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Mass (Da):2,069
Last modified:June 1, 1994 - v1

Mass spectrometryi

Molecular mass is 2014 Da from positions 1 - 19. Determined by FAB. 1 Publication

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDURA_STRGV
AccessioniPrimary (citable) accession number: P36504
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 10, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program


Keywords - Technical termi

Direct protein sequencing


  1. SIMILARITY comments
    Index of protein domains and families