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P36433

- T2H2_HAEPA

UniProt

P36433 - T2H2_HAEPA

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Protein
Type-2 restriction enzyme HpaII
Gene
hpaIIR
Organism
Haemophilus parainfluenzae
Status
Reviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

Recognizes the double-stranded sequence CCGG and cleaves after C-1.

Catalytic activityi

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

GO - Molecular functioni

  1. Type II site-specific deoxyribonuclease activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Restriction system

Protein family/group databases

REBASEi1159. HpaII.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 restriction enzyme HpaII (EC:3.1.21.4)
Short name:
R.HpaII
Alternative name(s):
Endonuclease HpaII
Type II restriction enzyme HpaII
Gene namesi
Name:hpaIIR
OrganismiHaemophilus parainfluenzae
Taxonomic identifieri729 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Type-2 restriction enzyme HpaII
PRO_0000077325Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Family & Domainsi

Family and domain databases

InterProiIPR019062. Restrct_endonuc_II_HpaII.
[Graphical view]
PfamiPF09561. RE_HpaII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36433-1 [UniParc]FASTAAdd to Basket

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MTEFFSGNRG EWSEPYALFK LLADGQLYLG DSQLNKLGIV MPILSILRQE    50
KNYESSYILH NNSQNIIVTY NNEKFTVPIS GFQEKAVLLL SEIKNASGNR 100
AFSIPSIDDF LKKLGFTHLS ASSSSKSDIH IVVHDLRTGI TPTLGFSIKS 150
QLGSPATLLN ASKATNFTFK IYNLKDKQIE YINSLSGIKE KIKEIFSQDG 200
KLEFVKVESC KFSNNLTLID TKLPEILAEM ILLYYSSKLN KIDDVTEHIS 250
RLNPLNYNLS CNHNYYEYKV KHFLNDVALG MRPDDVWLGQ YDATGGYLVV 300
KEDGELLCYH IYSKNSFEDY LYCNTKFDTP SSSRHDFGHI YQVNHDFFIK 350
LNVQIRFL 358
Length:358
Mass (Da):40,926
Last modified:June 1, 1994 - v1
Checksum:iECB312180C80303E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L17342 Genomic DNA. Translation: AAA20482.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L17342 Genomic DNA. Translation: AAA20482.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 1159. HpaII.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR019062. Restrct_endonuc_II_HpaII.
[Graphical view ]
Pfami PF09561. RE_HpaII. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Organization and sequence of the HpaII restriction-modification system and adjacent genes."
    Kulakauskas S., Barsomian J.M., Lubys A., Roberts R.J., Wilson G.G.
    Gene 142:9-15(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 49669.

Entry informationi

Entry nameiT2H2_HAEPA
AccessioniPrimary (citable) accession number: P36433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries

External Data

Dasty 3

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