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Protein

Type-2 restriction enzyme HpaII

Gene

hpaIIR

Organism
Haemophilus parainfluenzae
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Recognizes the double-stranded sequence CCGG and cleaves after C-1.

Catalytic activityi

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processRestriction system

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 restriction enzyme HpaII (EC:3.1.21.4)
Short name:
R.HpaII
Alternative name(s):
Endonuclease HpaII
Type II restriction enzyme HpaII
Gene namesi
Name:hpaIIR
OrganismiHaemophilus parainfluenzae
Taxonomic identifieri729 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000773251 – 358Type-2 restriction enzyme HpaIIAdd BLAST358

Proteomic databases

PRIDEiP36433

Interactioni

Subunit structurei

Homodimer.

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR019062 Restrct_endonuc_II_HpaII
PfamiView protein in Pfam
PF09561 RE_HpaII, 1 hit

Sequencei

Sequence statusi: Complete.

P36433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEFFSGNRG EWSEPYALFK LLADGQLYLG DSQLNKLGIV MPILSILRQE
60 70 80 90 100
KNYESSYILH NNSQNIIVTY NNEKFTVPIS GFQEKAVLLL SEIKNASGNR
110 120 130 140 150
AFSIPSIDDF LKKLGFTHLS ASSSSKSDIH IVVHDLRTGI TPTLGFSIKS
160 170 180 190 200
QLGSPATLLN ASKATNFTFK IYNLKDKQIE YINSLSGIKE KIKEIFSQDG
210 220 230 240 250
KLEFVKVESC KFSNNLTLID TKLPEILAEM ILLYYSSKLN KIDDVTEHIS
260 270 280 290 300
RLNPLNYNLS CNHNYYEYKV KHFLNDVALG MRPDDVWLGQ YDATGGYLVV
310 320 330 340 350
KEDGELLCYH IYSKNSFEDY LYCNTKFDTP SSSRHDFGHI YQVNHDFFIK

LNVQIRFL
Length:358
Mass (Da):40,926
Last modified:June 1, 1994 - v1
Checksum:iECB312180C80303E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L17342 Genomic DNA Translation: AAA20482.1

Similar proteinsi

Entry informationi

Entry nameiT2H2_HAEPA
AccessioniPrimary (citable) accession number: P36433
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries

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