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P36433

- T2H2_HAEPA

UniProt

P36433 - T2H2_HAEPA

Protein

Type-2 restriction enzyme HpaII

Gene

hpaIIR

Organism
Haemophilus parainfluenzae
Status
Reviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 46 (16 Apr 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Recognizes the double-stranded sequence CCGG and cleaves after C-1.

    Catalytic activityi

    Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

    GO - Molecular functioni

    1. Type II site-specific deoxyribonuclease activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    Restriction system

    Protein family/group databases

    REBASEi1159. HpaII.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type-2 restriction enzyme HpaII (EC:3.1.21.4)
    Short name:
    R.HpaII
    Alternative name(s):
    Endonuclease HpaII
    Type II restriction enzyme HpaII
    Gene namesi
    Name:hpaIIR
    OrganismiHaemophilus parainfluenzae
    Taxonomic identifieri729 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Type-2 restriction enzyme HpaIIPRO_0000077325Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.

    Family & Domainsi

    Family and domain databases

    InterProiIPR019062. Restrct_endonuc_II_HpaII.
    [Graphical view]
    PfamiPF09561. RE_HpaII. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36433-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEFFSGNRG EWSEPYALFK LLADGQLYLG DSQLNKLGIV MPILSILRQE    50
    KNYESSYILH NNSQNIIVTY NNEKFTVPIS GFQEKAVLLL SEIKNASGNR 100
    AFSIPSIDDF LKKLGFTHLS ASSSSKSDIH IVVHDLRTGI TPTLGFSIKS 150
    QLGSPATLLN ASKATNFTFK IYNLKDKQIE YINSLSGIKE KIKEIFSQDG 200
    KLEFVKVESC KFSNNLTLID TKLPEILAEM ILLYYSSKLN KIDDVTEHIS 250
    RLNPLNYNLS CNHNYYEYKV KHFLNDVALG MRPDDVWLGQ YDATGGYLVV 300
    KEDGELLCYH IYSKNSFEDY LYCNTKFDTP SSSRHDFGHI YQVNHDFFIK 350
    LNVQIRFL 358
    Length:358
    Mass (Da):40,926
    Last modified:June 1, 1994 - v1
    Checksum:iECB312180C80303E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L17342 Genomic DNA. Translation: AAA20482.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L17342 Genomic DNA. Translation: AAA20482.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 1159. HpaII.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR019062. Restrct_endonuc_II_HpaII.
    [Graphical view ]
    Pfami PF09561. RE_HpaII. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Organization and sequence of the HpaII restriction-modification system and adjacent genes."
      Kulakauskas S., Barsomian J.M., Lubys A., Roberts R.J., Wilson G.G.
      Gene 142:9-15(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 49669.

    Entry informationi

    Entry nameiT2H2_HAEPA
    AccessioniPrimary (citable) accession number: P36433
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: April 16, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries

    External Data

    Dasty 3