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Protein

Thromboxane-A synthase

Gene

Tbxas1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi479Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211979. Eicosanoids.
R-MMU-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Names & Taxonomyi

Protein namesi
Recommended name:
Thromboxane-A synthase (EC:5.3.99.5)
Short name:
TS
Short name:
TXA synthase
Short name:
TXS
Alternative name(s):
Cytochrome P450 5A1
Gene namesi
Name:Tbxas1
Synonyms:Cyp5, Cyp5a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:98497. Tbxas1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 75LumenalSequence analysisAdd BLAST44
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 223CytoplasmicSequence analysisAdd BLAST127
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 335LumenalSequence analysisAdd BLAST91
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Topological domaini357 – 533CytoplasmicSequence analysisAdd BLAST177

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000522571 – 533Thromboxane-A synthaseAdd BLAST533

Proteomic databases

MaxQBiP36423.
PaxDbiP36423.
PRIDEiP36423.

PTM databases

PhosphoSitePlusiP36423.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029925.
CleanExiMM_TBXAS1.
ExpressionAtlasiP36423. baseline and differential.
GenevisibleiP36423. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003017.

Chemistry databases

BindingDBiP36423.

Structurei

3D structure databases

ProteinModelPortaliP36423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP36423.
KOiK01832.
OMAiFRFEACA.
OrthoDBiEOG091G0JNC.
PhylomeDBiP36423.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 2 hits.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 2 hits.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVLGLLKFE VSGTIVTVTL LVALLALLKW YSMSAFSRLE KLGIRHPKPS
60 70 80 90 100
PFVGNLMFFR QGFWESQLEL RERYGPLCGY YLGRRMHVVI SEPDMIKQVL
110 120 130 140 150
VENFSNFSNR MASGLEPKMV ADSVLLLRDR RWEEVRGALM SSFSPEKLDE
160 170 180 190 200
MTPLISQACE LLVAHLKRYA ASRDAFNIQR CYCCYTIDVV ASVAFGTQVD
210 220 230 240 250
SQNSPEDPFV QHCRRASTFC IPRPLLVLIL SFPSIMVPLA RILPNKNRDE
260 270 280 290 300
LNGFFNTLIR NVIALRDQQA AEERRRDFLQ MVLDAQHSMN SVGVEGFDMV
310 320 330 340 350
PESLSSSECT KEPPQRCHPT STSKPFTVDE IVGQAFLFLI AGHEVITNTL
360 370 380 390 400
SFITYLLATH PDCQERLLKE VDLFMGKHPA PEYHSLQEGL PYLDMVISET
410 420 430 440 450
LRMYPPAFRF TREAAQDCEV LGQRIPAGTV LEIAVGALHH DPEHWPNPET
460 470 480 490 500
FDPERFTAEA RLQRRPFTYL PFGAGPRSCL GVRLGLLVVK LTILQVLHKF
510 520 530
RFEASPETQV PLQLESKSAL GPKNGVYIKI VSR
Length:533
Mass (Da):60,391
Last modified:November 1, 1997 - v2
Checksum:iA06C3B53738E179A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77 – 87LCGYYLGRRMH → SVWVLSWPSID in AAB87704 (PubMed:9367676).CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L18868 mRNA. Translation: AAB39850.1.
U41397
, U41326, U41327, U41328, U41329, U41330, U41331, U41332, U41333, U41334, U41335, U41336 Genomic DNA. Translation: AAB87704.1.
CCDSiCCDS20018.1.
PIRiJN0683.
RefSeqiNP_035669.3. NM_011539.3.
XP_011239582.1. XM_011241280.2.
XP_017176988.1. XM_017321499.1.
XP_017176989.1. XM_017321500.1.
UniGeneiMm.4054.

Genome annotation databases

EnsembliENSMUST00000003017; ENSMUSP00000003017; ENSMUSG00000029925.
GeneIDi21391.
KEGGimmu:21391.
UCSCiuc009bld.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L18868 mRNA. Translation: AAB39850.1.
U41397
, U41326, U41327, U41328, U41329, U41330, U41331, U41332, U41333, U41334, U41335, U41336 Genomic DNA. Translation: AAB87704.1.
CCDSiCCDS20018.1.
PIRiJN0683.
RefSeqiNP_035669.3. NM_011539.3.
XP_011239582.1. XM_011241280.2.
XP_017176988.1. XM_017321499.1.
XP_017176989.1. XM_017321500.1.
UniGeneiMm.4054.

3D structure databases

ProteinModelPortaliP36423.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003017.

Chemistry databases

BindingDBiP36423.

PTM databases

PhosphoSitePlusiP36423.

Proteomic databases

MaxQBiP36423.
PaxDbiP36423.
PRIDEiP36423.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003017; ENSMUSP00000003017; ENSMUSG00000029925.
GeneIDi21391.
KEGGimmu:21391.
UCSCiuc009bld.1. mouse.

Organism-specific databases

CTDi6916.
MGIiMGI:98497. Tbxas1.

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP36423.
KOiK01832.
OMAiFRFEACA.
OrthoDBiEOG091G0JNC.
PhylomeDBiP36423.
TreeFamiTF105087.

Enzyme and pathway databases

ReactomeiR-MMU-211979. Eicosanoids.
R-MMU-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Miscellaneous databases

PROiP36423.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029925.
CleanExiMM_TBXAS1.
ExpressionAtlasiP36423. baseline and differential.
GenevisibleiP36423. MM.

Family and domain databases

Gene3Di1.10.630.10. 2 hits.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 2 hits.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHAS_MOUSE
AccessioniPrimary (citable) accession number: P36423
Secondary accession number(s): P97505
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.