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P36423 (THAS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thromboxane-A synthase

Short name=TS
Short name=TXA synthase
Short name=TXS
EC=5.3.99.5
Alternative name(s):
Cytochrome P450 5A1
Gene names
Name:Tbxas1
Synonyms:Cyp5, Cyp5a1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length533 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate.

Cofactor

Heme group.

Subunit structure

Monomer By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 533533Thromboxane-A synthase
PRO_0000052257

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Potential
Topological domain32 – 7544Lumenal Potential
Transmembrane76 – 9621Helical; Potential
Topological domain97 – 223127Cytoplasmic Potential
Transmembrane224 – 24421Helical; Potential
Topological domain245 – 33591Lumenal Potential
Transmembrane336 – 35621Helical; Potential
Topological domain357 – 533177Cytoplasmic Potential

Sites

Metal binding4791Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict77 – 8711LCGYYLGRRMH → SVWVLSWPSID in AAB87704. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P36423 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: A06C3B53738E179A

FASTA53360,391
        10         20         30         40         50         60 
MEVLGLLKFE VSGTIVTVTL LVALLALLKW YSMSAFSRLE KLGIRHPKPS PFVGNLMFFR 

        70         80         90        100        110        120 
QGFWESQLEL RERYGPLCGY YLGRRMHVVI SEPDMIKQVL VENFSNFSNR MASGLEPKMV 

       130        140        150        160        170        180 
ADSVLLLRDR RWEEVRGALM SSFSPEKLDE MTPLISQACE LLVAHLKRYA ASRDAFNIQR 

       190        200        210        220        230        240 
CYCCYTIDVV ASVAFGTQVD SQNSPEDPFV QHCRRASTFC IPRPLLVLIL SFPSIMVPLA 

       250        260        270        280        290        300 
RILPNKNRDE LNGFFNTLIR NVIALRDQQA AEERRRDFLQ MVLDAQHSMN SVGVEGFDMV 

       310        320        330        340        350        360 
PESLSSSECT KEPPQRCHPT STSKPFTVDE IVGQAFLFLI AGHEVITNTL SFITYLLATH 

       370        380        390        400        410        420 
PDCQERLLKE VDLFMGKHPA PEYHSLQEGL PYLDMVISET LRMYPPAFRF TREAAQDCEV 

       430        440        450        460        470        480 
LGQRIPAGTV LEIAVGALHH DPEHWPNPET FDPERFTAEA RLQRRPFTYL PFGAGPRSCL 

       490        500        510        520        530 
GVRLGLLVVK LTILQVLHKF RFEASPETQV PLQLESKSAL GPKNGVYIKI VSR 

« Hide

References

[1]"Molecular cloning and expression of murine thromboxane synthase."
Zhang L., Chase M.B., Shen R.F.
Biochem. Biophys. Res. Commun. 194:741-748(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
Tissue: Lung.
[2]Zhang L.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Genomic organization, chromosomal localization, and expression of the murine thromboxane synthase gene."
Zhang L., Xiao H., Schultz R.A., Shen R.-F.
Genomics 45:519-528(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L18868 mRNA. Translation: AAB39850.1.
U41397 expand/collapse EMBL AC list , U41326, U41327, U41328, U41329, U41330, U41331, U41332, U41333, U41334, U41335, U41336 Genomic DNA. Translation: AAB87704.1.
CCDSCCDS20018.1.
PIRJN0683.
RefSeqNP_035669.3. NM_011539.3.
XP_006505936.1. XM_006505873.1.
XP_006505937.1. XM_006505874.1.
XP_006505938.1. XM_006505875.1.
UniGeneMm.4054.

3D structure databases

ProteinModelPortalP36423.
SMRP36423. Positions 39-533.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP36423.

PTM databases

PhosphoSiteP36423.

Proteomic databases

PaxDbP36423.
PRIDEP36423.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000003017; ENSMUSP00000003017; ENSMUSG00000029925.
GeneID21391.
KEGGmmu:21391.
UCSCuc009bld.1. mouse.

Organism-specific databases

CTD6916.
MGIMGI:98497. Tbxas1.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00730000110591.
HOGENOMHOG000039127.
HOVERGENHBG108567.
InParanoidP36423.
KOK01832.
OMAWPRPEAF.
PhylomeDBP36423.
TreeFamTF105087.

Gene expression databases

ArrayExpressP36423.
BgeeP36423.
CleanExMM_TBXAS1.
GenevestigatorP36423.

Family and domain databases

Gene3D1.10.630.10. 2 hits.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 2 hits.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio300648.
PROP36423.
SOURCESearch...

Entry information

Entry nameTHAS_MOUSE
AccessionPrimary (citable) accession number: P36423
Secondary accession number(s): P97505
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot