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P36423

- THAS_MOUSE

UniProt

P36423 - THAS_MOUSE

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Protein

Thromboxane-A synthase

Gene

Tbxas1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate.

Cofactori

Heme group.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi479 – 4791Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
  5. thromboxane-A synthase activity Source: MGI

GO - Biological processi

  1. cellular chloride ion homeostasis Source: Ensembl
  2. positive regulation of vasoconstriction Source: Ensembl
  3. prostaglandin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_188623. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Names & Taxonomyi

Protein namesi
Recommended name:
Thromboxane-A synthase (EC:5.3.99.5)
Short name:
TS
Short name:
TXA synthase
Short name:
TXS
Alternative name(s):
Cytochrome P450 5A1
Gene namesi
Name:Tbxas1
Synonyms:Cyp5, Cyp5a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:98497. Tbxas1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Thromboxane-A synthasePRO_0000052257Add
BLAST

Proteomic databases

PaxDbiP36423.
PRIDEiP36423.

PTM databases

PhosphoSiteiP36423.

Expressioni

Gene expression databases

BgeeiP36423.
CleanExiMM_TBXAS1.
ExpressionAtlasiP36423. baseline and differential.
GenevestigatoriP36423.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP36423.
SMRiP36423. Positions 39-533.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Topological domaini32 – 7544LumenalSequence AnalysisAdd
BLAST
Topological domaini97 – 223127CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini245 – 33591LumenalSequence AnalysisAdd
BLAST
Topological domaini357 – 533177CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence AnalysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP36423.
KOiK01832.
OMAiWPRPEAF.
PhylomeDBiP36423.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 2 hits.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 2 hits.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36423-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVLGLLKFE VSGTIVTVTL LVALLALLKW YSMSAFSRLE KLGIRHPKPS
60 70 80 90 100
PFVGNLMFFR QGFWESQLEL RERYGPLCGY YLGRRMHVVI SEPDMIKQVL
110 120 130 140 150
VENFSNFSNR MASGLEPKMV ADSVLLLRDR RWEEVRGALM SSFSPEKLDE
160 170 180 190 200
MTPLISQACE LLVAHLKRYA ASRDAFNIQR CYCCYTIDVV ASVAFGTQVD
210 220 230 240 250
SQNSPEDPFV QHCRRASTFC IPRPLLVLIL SFPSIMVPLA RILPNKNRDE
260 270 280 290 300
LNGFFNTLIR NVIALRDQQA AEERRRDFLQ MVLDAQHSMN SVGVEGFDMV
310 320 330 340 350
PESLSSSECT KEPPQRCHPT STSKPFTVDE IVGQAFLFLI AGHEVITNTL
360 370 380 390 400
SFITYLLATH PDCQERLLKE VDLFMGKHPA PEYHSLQEGL PYLDMVISET
410 420 430 440 450
LRMYPPAFRF TREAAQDCEV LGQRIPAGTV LEIAVGALHH DPEHWPNPET
460 470 480 490 500
FDPERFTAEA RLQRRPFTYL PFGAGPRSCL GVRLGLLVVK LTILQVLHKF
510 520 530
RFEASPETQV PLQLESKSAL GPKNGVYIKI VSR
Length:533
Mass (Da):60,391
Last modified:November 1, 1997 - v2
Checksum:iA06C3B53738E179A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 8711LCGYYLGRRMH → SVWVLSWPSID in AAB87704. (PubMed:9367676)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L18868 mRNA. Translation: AAB39850.1.
U41397
, U41326, U41327, U41328, U41329, U41330, U41331, U41332, U41333, U41334, U41335, U41336 Genomic DNA. Translation: AAB87704.1.
CCDSiCCDS20018.1.
PIRiJN0683.
RefSeqiNP_035669.3. NM_011539.3.
XP_006505936.1. XM_006505873.1.
XP_006505937.1. XM_006505874.1.
XP_006505938.1. XM_006505875.1.
UniGeneiMm.4054.

Genome annotation databases

EnsembliENSMUST00000003017; ENSMUSP00000003017; ENSMUSG00000029925.
GeneIDi21391.
KEGGimmu:21391.
UCSCiuc009bld.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L18868 mRNA. Translation: AAB39850.1 .
U41397
, U41326 , U41327 , U41328 , U41329 , U41330 , U41331 , U41332 , U41333 , U41334 , U41335 , U41336 Genomic DNA. Translation: AAB87704.1 .
CCDSi CCDS20018.1.
PIRi JN0683.
RefSeqi NP_035669.3. NM_011539.3.
XP_006505936.1. XM_006505873.1.
XP_006505937.1. XM_006505874.1.
XP_006505938.1. XM_006505875.1.
UniGenei Mm.4054.

3D structure databases

ProteinModelPortali P36423.
SMRi P36423. Positions 39-533.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P36423.

PTM databases

PhosphoSitei P36423.

Proteomic databases

PaxDbi P36423.
PRIDEi P36423.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003017 ; ENSMUSP00000003017 ; ENSMUSG00000029925 .
GeneIDi 21391.
KEGGi mmu:21391.
UCSCi uc009bld.1. mouse.

Organism-specific databases

CTDi 6916.
MGIi MGI:98497. Tbxas1.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118816.
HOGENOMi HOG000039127.
HOVERGENi HBG108567.
InParanoidi P36423.
KOi K01832.
OMAi WPRPEAF.
PhylomeDBi P36423.
TreeFami TF105087.

Enzyme and pathway databases

Reactomei REACT_188623. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Miscellaneous databases

NextBioi 300648.
PROi P36423.
SOURCEi Search...

Gene expression databases

Bgeei P36423.
CleanExi MM_TBXAS1.
ExpressionAtlasi P36423. baseline and differential.
Genevestigatori P36423.

Family and domain databases

Gene3Di 1.10.630.10. 2 hits.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 2 hits.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of murine thromboxane synthase."
    Zhang L., Chase M.B., Shen R.F.
    Biochem. Biophys. Res. Commun. 194:741-748(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Lung.
  2. Zhang L.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Genomic organization, chromosomal localization, and expression of the murine thromboxane synthase gene."
    Zhang L., Xiao H., Schultz R.A., Shen R.-F.
    Genomics 45:519-528(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.

Entry informationi

Entry nameiTHAS_MOUSE
AccessioniPrimary (citable) accession number: P36423
Secondary accession number(s): P97505
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3