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P36423

- THAS_MOUSE

UniProt

P36423 - THAS_MOUSE

Protein

Thromboxane-A synthase

Gene

Tbxas1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate.

    Cofactori

    Heme group.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi479 – 4791Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
    5. thromboxane-A synthase activity Source: MGI

    GO - Biological processi

    1. cellular chloride ion homeostasis Source: Ensembl
    2. positive regulation of vasoconstriction Source: Ensembl
    3. prostaglandin biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_188623. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thromboxane-A synthase (EC:5.3.99.5)
    Short name:
    TS
    Short name:
    TXA synthase
    Short name:
    TXS
    Alternative name(s):
    Cytochrome P450 5A1
    Gene namesi
    Name:Tbxas1
    Synonyms:Cyp5, Cyp5a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:98497. Tbxas1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 533533Thromboxane-A synthasePRO_0000052257Add
    BLAST

    Proteomic databases

    PaxDbiP36423.
    PRIDEiP36423.

    PTM databases

    PhosphoSiteiP36423.

    Expressioni

    Gene expression databases

    ArrayExpressiP36423.
    BgeeiP36423.
    CleanExiMM_TBXAS1.
    GenevestigatoriP36423.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP36423.
    SMRiP36423. Positions 39-533.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 7544LumenalSequence AnalysisAdd
    BLAST
    Topological domaini97 – 223127CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini245 – 33591LumenalSequence AnalysisAdd
    BLAST
    Topological domaini357 – 533177CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei336 – 35621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00730000110591.
    HOGENOMiHOG000039127.
    HOVERGENiHBG108567.
    InParanoidiP36423.
    KOiK01832.
    OMAiWPRPEAF.
    PhylomeDBiP36423.
    TreeFamiTF105087.

    Family and domain databases

    Gene3Di1.10.630.10. 2 hits.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 2 hits.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36423-1 [UniParc]FASTAAdd to Basket

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    MEVLGLLKFE VSGTIVTVTL LVALLALLKW YSMSAFSRLE KLGIRHPKPS    50
    PFVGNLMFFR QGFWESQLEL RERYGPLCGY YLGRRMHVVI SEPDMIKQVL 100
    VENFSNFSNR MASGLEPKMV ADSVLLLRDR RWEEVRGALM SSFSPEKLDE 150
    MTPLISQACE LLVAHLKRYA ASRDAFNIQR CYCCYTIDVV ASVAFGTQVD 200
    SQNSPEDPFV QHCRRASTFC IPRPLLVLIL SFPSIMVPLA RILPNKNRDE 250
    LNGFFNTLIR NVIALRDQQA AEERRRDFLQ MVLDAQHSMN SVGVEGFDMV 300
    PESLSSSECT KEPPQRCHPT STSKPFTVDE IVGQAFLFLI AGHEVITNTL 350
    SFITYLLATH PDCQERLLKE VDLFMGKHPA PEYHSLQEGL PYLDMVISET 400
    LRMYPPAFRF TREAAQDCEV LGQRIPAGTV LEIAVGALHH DPEHWPNPET 450
    FDPERFTAEA RLQRRPFTYL PFGAGPRSCL GVRLGLLVVK LTILQVLHKF 500
    RFEASPETQV PLQLESKSAL GPKNGVYIKI VSR 533
    Length:533
    Mass (Da):60,391
    Last modified:November 1, 1997 - v2
    Checksum:iA06C3B53738E179A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti77 – 8711LCGYYLGRRMH → SVWVLSWPSID in AAB87704. (PubMed:9367676)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L18868 mRNA. Translation: AAB39850.1.
    U41397
    , U41326, U41327, U41328, U41329, U41330, U41331, U41332, U41333, U41334, U41335, U41336 Genomic DNA. Translation: AAB87704.1.
    CCDSiCCDS20018.1.
    PIRiJN0683.
    RefSeqiNP_035669.3. NM_011539.3.
    XP_006505936.1. XM_006505873.1.
    XP_006505937.1. XM_006505874.1.
    XP_006505938.1. XM_006505875.1.
    UniGeneiMm.4054.

    Genome annotation databases

    EnsembliENSMUST00000003017; ENSMUSP00000003017; ENSMUSG00000029925.
    GeneIDi21391.
    KEGGimmu:21391.
    UCSCiuc009bld.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L18868 mRNA. Translation: AAB39850.1 .
    U41397
    , U41326 , U41327 , U41328 , U41329 , U41330 , U41331 , U41332 , U41333 , U41334 , U41335 , U41336 Genomic DNA. Translation: AAB87704.1 .
    CCDSi CCDS20018.1.
    PIRi JN0683.
    RefSeqi NP_035669.3. NM_011539.3.
    XP_006505936.1. XM_006505873.1.
    XP_006505937.1. XM_006505874.1.
    XP_006505938.1. XM_006505875.1.
    UniGenei Mm.4054.

    3D structure databases

    ProteinModelPortali P36423.
    SMRi P36423. Positions 39-533.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P36423.

    PTM databases

    PhosphoSitei P36423.

    Proteomic databases

    PaxDbi P36423.
    PRIDEi P36423.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003017 ; ENSMUSP00000003017 ; ENSMUSG00000029925 .
    GeneIDi 21391.
    KEGGi mmu:21391.
    UCSCi uc009bld.1. mouse.

    Organism-specific databases

    CTDi 6916.
    MGIi MGI:98497. Tbxas1.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00730000110591.
    HOGENOMi HOG000039127.
    HOVERGENi HBG108567.
    InParanoidi P36423.
    KOi K01832.
    OMAi WPRPEAF.
    PhylomeDBi P36423.
    TreeFami TF105087.

    Enzyme and pathway databases

    Reactomei REACT_188623. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

    Miscellaneous databases

    NextBioi 300648.
    PROi P36423.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P36423.
    Bgeei P36423.
    CleanExi MM_TBXAS1.
    Genevestigatori P36423.

    Family and domain databases

    Gene3Di 1.10.630.10. 2 hits.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 2 hits.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of murine thromboxane synthase."
      Zhang L., Chase M.B., Shen R.F.
      Biochem. Biophys. Res. Commun. 194:741-748(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
      Tissue: Lung.
    2. Zhang L.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Genomic organization, chromosomal localization, and expression of the murine thromboxane synthase gene."
      Zhang L., Xiao H., Schultz R.A., Shen R.-F.
      Genomics 45:519-528(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.

    Entry informationi

    Entry nameiTHAS_MOUSE
    AccessioniPrimary (citable) accession number: P36423
    Secondary accession number(s): P97505
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3