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Protein

ADP-ribosylation factor-like protein 3

Gene

ARL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi31 – 311MagnesiumBy similarity
Metal bindingi48 – 481MagnesiumBy similarity
Binding sitei48 – 481GTPBy similarity
Binding sitei70 – 701GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318GTPBy similarity
Nucleotide bindingi67 – 715GTPBy similarity
Nucleotide bindingi126 – 1294GTPBy similarity
Nucleotide bindingi159 – 1613GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTPase activity Source: Ensembl
  3. GTP binding Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW
  5. microtubule binding Source: UniProtKB

GO - Biological processi

  1. cilium morphogenesis Source: UniProtKB
  2. cytokinesis Source: UniProtKB
  3. intraciliary transport Source: Ensembl
  4. kidney development Source: UniProtKB
  5. organelle organization Source: Reactome
  6. photoreceptor cell development Source: UniProtKB
  7. post-Golgi vesicle-mediated transport Source: MGI
  8. protein transport Source: UniProtKB-KW
  9. small GTPase mediated signal transduction Source: UniProtKB
  10. smoothened signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_268425. Trafficking of myristoylated proteins to the cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 3
Gene namesi
Name:ARL3
Synonyms:ARFL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:694. ARL3.

Subcellular locationi

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmcytoskeletonspindle. Nucleus. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Cytoplasm. Cell projectioncilium
Note: Detected predominantly in the photoreceptor connecting cilium. Present on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules.

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasmic microtubule Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProtKB
  4. Golgi apparatus Source: UniProtKB
  5. Golgi membrane Source: UniProtKB-SubCell
  6. midbody Source: UniProtKB
  7. nucleus Source: UniProtKB
  8. photoreceptor connecting cilium Source: UniProtKB
  9. primary cilium Source: UniProtKB
  10. spindle microtubule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi31 – 311T → N: Enhances the interaction with RP2. 2 Publications
Mutagenesisi71 – 711Q → L: Enhances the interaction with RP2. Does not induce a mitotic arrest resulting from the loss of the microtubule-based mitotic spindle. Induces release of myristoylated proteins from UNC119. Interacts with ARL2BP, GOLGA4, PDE6D and UNC119. 4 Publications

Organism-specific databases

PharmGKBiPA24987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedSequence Analysis
Chaini2 – 182181ADP-ribosylation factor-like protein 3PRO_0000207456Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence Analysis
Modified residuei5 – 51Phosphoserine1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiP36405.
PaxDbiP36405.
PeptideAtlasiP36405.
PRIDEiP36405.

2D gel databases

REPRODUCTION-2DPAGEIPI00003327.
UCD-2DPAGEP36405.

PTM databases

PhosphoSiteiP36405.

Expressioni

Tissue specificityi

Expressed in the retina. Strongly expressed in connecting cilium, the myoid region of the inner segments (IS) and in cone photoreceptors (at protein level).1 Publication

Gene expression databases

BgeeiP36405.
CleanExiHS_ARL3.
GenevestigatoriP36405.

Organism-specific databases

HPAiHPA036292.
HPA063596.

Interactioni

Subunit structurei

Interacts with RP2. The GTP-bound form interacts with PDE6D. Found in a complex with ARL3, RP2 and UNC119 (or UNC119B); RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119 (or UNC119B). Interacts with SYS1. The GTP-bound form interacts with ARL2BP and PDE6D. Interacts with RP2; interaction is direct and stimulated with the activated GTP-bound form of ARL3. Microtubule-associated protein. Does not interact with TBCC. May interact with GOLGA4.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PDE6DO439242EBI-712710,EBI-712685
UNC119Q134325EBI-712710,EBI-711260

Protein-protein interaction databases

BioGridi106896. 10 interactions.
IntActiP36405. 10 interactions.
MINTiMINT-1368863.
STRINGi9606.ENSP00000260746.

Structurei

3D structure databases

ProteinModelPortaliP36405.
SMRiP36405. Positions 2-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00780000121965.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP36405.
KOiK07944.
OMAiIQEGMNW.
OrthoDBiEOG7M98HG.
PhylomeDBiP36405.
TreeFamiTF105463.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SMARTiSM00177. ARF. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLSILRKL KSAPDQEVRI LLLGLDNAGK TTLLKQLASE DISHITPTQG
60 70 80 90 100
FNIKSVQSQG FKLNVWDIGG QRKIRPYWKN YFENTDILIY VIDSADRKRF
110 120 130 140 150
EETGQELAEL LEEEKLSCVP VLIFANKQDL LTAAPASEIA EGLNLHTIRD
160 170 180
RVWQIQSCSA LTGEGVQDGM NWVCKNVNAK KK
Length:182
Mass (Da):20,456
Last modified:January 31, 1995 - v2
Checksum:iE5C1ACAD0BD55537
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341L → M.1 Publication
Corresponds to variant rs1141895 [ dbSNP | Ensembl ].
VAR_014869

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07151 mRNA. Translation: AAA21654.1.
AF493889 mRNA. Translation: AAM12603.1.
AK312525 mRNA. Translation: BAG35424.1.
CR407637 mRNA. Translation: CAG28565.1.
AL391121 Genomic DNA. Translation: CAI40862.1.
BC009841 mRNA. Translation: AAH09841.1.
CCDSiCCDS7538.1.
PIRiA54869.
RefSeqiNP_004302.1. NM_004311.3.
UniGeneiHs.182215.

Genome annotation databases

EnsembliENST00000260746; ENSP00000260746; ENSG00000138175.
GeneIDi403.
KEGGihsa:403.
UCSCiuc001kwa.3. human.

Polymorphism databases

DMDMi543851.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07151 mRNA. Translation: AAA21654.1.
AF493889 mRNA. Translation: AAM12603.1.
AK312525 mRNA. Translation: BAG35424.1.
CR407637 mRNA. Translation: CAG28565.1.
AL391121 Genomic DNA. Translation: CAI40862.1.
BC009841 mRNA. Translation: AAH09841.1.
CCDSiCCDS7538.1.
PIRiA54869.
RefSeqiNP_004302.1. NM_004311.3.
UniGeneiHs.182215.

3D structure databases

ProteinModelPortaliP36405.
SMRiP36405. Positions 2-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106896. 10 interactions.
IntActiP36405. 10 interactions.
MINTiMINT-1368863.
STRINGi9606.ENSP00000260746.

PTM databases

PhosphoSiteiP36405.

Polymorphism databases

DMDMi543851.

2D gel databases

REPRODUCTION-2DPAGEIPI00003327.
UCD-2DPAGEP36405.

Proteomic databases

MaxQBiP36405.
PaxDbiP36405.
PeptideAtlasiP36405.
PRIDEiP36405.

Protocols and materials databases

DNASUi403.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260746; ENSP00000260746; ENSG00000138175.
GeneIDi403.
KEGGihsa:403.
UCSCiuc001kwa.3. human.

Organism-specific databases

CTDi403.
GeneCardsiGC10M104423.
HGNCiHGNC:694. ARL3.
HPAiHPA036292.
HPA063596.
MIMi604695. gene.
neXtProtiNX_P36405.
PharmGKBiPA24987.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00780000121965.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP36405.
KOiK07944.
OMAiIQEGMNW.
OrthoDBiEOG7M98HG.
PhylomeDBiP36405.
TreeFamiTF105463.

Enzyme and pathway databases

ReactomeiREACT_268425. Trafficking of myristoylated proteins to the cilium.

Miscellaneous databases

GeneWikiiARL3.
GenomeRNAii403.
NextBioi1689.
PROiP36405.
SOURCEiSearch...

Gene expression databases

BgeeiP36405.
CleanExiHS_ARL3.
GenevestigatoriP36405.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SMARTiSM00177. ARF. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues."
    Cavenagh M.A., Breiner M., Schurmann A., Rosenwald A.G., Terui T., Zhang C.-J., Randoazzo P.A., Adams M., Joost H.-G., Kahn R.A.
    J. Biol. Chem. 269:18937-18942(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-34.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  7. Lubec G., Vishwanath V.
    Submitted (FEB-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 80-97 AND 128-149, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain and Cajal-Retzius cell.
  8. "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin."
    Bhamidipati A., Lewis S.A., Cowan N.J.
    J. Cell Biol. 149:1087-1096(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF INTERACTION WITH TBCC.
  9. "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins."
    Van Valkenburgh H., Shern J.F., Sharer J.D., Zhu X., Kahn R.A.
    J. Biol. Chem. 276:22826-22837(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARL2BP; GOLGA4; PDE6D AND UNC119, MUTAGENESIS OF GLN-71.
  10. "Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3."
    Grayson C., Bartolini F., Chapple J.P., Willison K.R., Bhamidipati A., Lewis S.A., Luthert P.J., Hardcastle A.J., Cowan N.J., Cheetham M.E.
    Hum. Mol. Genet. 11:3065-3074(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION WITH MICROTUBULES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  11. "Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C."
    Bartolini F., Bhamidipati A., Thomas S., Schwahn U., Lewis S.A., Cowan N.J.
    J. Biol. Chem. 277:14629-14634(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RP2 AND ARL2BP, MUTAGENESIS OF THR-31 AND GLN-71.
  12. "Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p."
    Behnia R., Panic B., Whyte J.R.C., Munro S.
    Nat. Cell Biol. 6:405-413(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SYS1, SUBCELLULAR LOCATION.
  13. "Arl2 and Arl3 regulate different microtubule-dependent processes."
    Zhou C., Cunningham L., Marcus A.I., Li Y., Kahn R.A.
    Mol. Biol. Cell 17:2476-2487(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF GLN-71, SUBCELLULAR LOCATION.
  14. "Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3."
    Kuehnel K., Veltel S., Schlichting I., Wittinghofer A.
    Structure 14:367-378(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RP2.
  15. "Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex."
    Veltel S., Kravchenko A., Ismail S., Wittinghofer A.
    FEBS Lett. 582:2501-2507(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GTP/GDP BINDING, IDENTIFICATION IN A COMPLEX WITH UNC119 AND RP2, SUBCELLULAR LOCATION.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. Cited for: FUNCTION, MUTAGENESIS OF THR-31 AND GLN-71.
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiARL3_HUMAN
AccessioniPrimary (citable) accession number: P36405
Secondary accession number(s): B2R6C7, Q53X83, Q5JSM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 1994
Last sequence update: January 31, 1995
Last modified: March 31, 2015
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.