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P36402 (TCF7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor 7

Short name=TCF-7
Alternative name(s):
T-cell-specific transcription factor 1
Short name=T-cell factor 1
Short name=TCF-1
Gene names
Name:TCF7
Synonyms:TCF1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

Subunit structure

Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with AES, TLE1, TLE2, TLE3 and TLE4. Ref.9 Ref.10 Ref.11

Subcellular location

Nucleus.

Tissue specificity

Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium. Ref.7

Induction

By TCF7L2 and CTNNB1. Ref.7

Sequence similarities

Belongs to the TCF/LEF family.

Contains 1 HMG box DNA-binding domain.

Sequence caution

The sequence CAA87441.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
Wnt signaling pathway
   Cellular componentNucleus
   Coding sequence diversityAlternative promoter usage
Alternative splicing
   LigandDNA-binding
   Molecular functionActivator
Repressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell receptor V(D)J recombination

Inferred from electronic annotation. Source: Ensembl

alpha-beta T cell differentiation

Inferred from electronic annotation. Source: Ensembl

brain development

Inferred from Biological aspect of Ancestor. Source: RefGenome

canonical Wnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

canonical Wnt signaling pathway involved in negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-4

Inferred from direct assay PubMed 18579517. Source: UniProtKB

embryonic digestive tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic genitalia morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic hindgut morphogenesis

Inferred from electronic annotation. Source: Ensembl

generation of neurons

Inferred from Biological aspect of Ancestor. Source: RefGenome

immune response

Traceable author statement Ref.2. Source: ProtInc

neural tube development

Inferred from electronic annotation. Source: Ensembl

regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay PubMed 18579517. Source: UniProtKB

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionbeta-catenin binding

Inferred from direct assay Ref.9. Source: BHF-UCL

chromatin binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription regulatory region DNA binding

Inferred from direct assay PubMed 18579517PubMed 20128911. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CTNNB1P352222EBI-2119465,EBI-491549

Alternative products

This entry describes 16 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Note: 2 series of isoforms, L and S, are produced by alternative promoter usage. Additional isoforms seem to exist.
Isoform 4L (identifier: P36402-1)

Also known as: D;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 4S (identifier: P36402-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
Isoform 1L (identifier: P36402-3)

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP
Note: Produced by alternative splicing of isoform 4L.
Isoform 1S (identifier: P36402-4)

Also known as: E;

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP
Note: Produced by alternative splicing of isoform 4S.
Isoform 5L (identifier: P36402-9)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DNSLHYS
Note: Produced by alternative splicing of isoform 4L.
Isoform 5S (identifier: P36402-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DNSLHYS
Note: Produced by alternative splicing of isoform 4S.
Isoform 6L (identifier: P36402-11)

Also known as: E;

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP
Note: Produced by alternative splicing of isoform 4L.
Isoform 6S (identifier: P36402-12)

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP
Note: Produced by alternative splicing of isoform 4S.
Isoform 7L (identifier: P36402-13)

Also known as: F;

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DGIPACTILSP
Note: Produced by alternative splicing of isoform 4L.
Isoform 7S (identifier: P36402-14)

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DGIPACTILSP
Note: Produced by alternative splicing of isoform 4S.
Isoform 8L (identifier: P36402-15)

Also known as: G;

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → QLEDWDGWARKP
Note: Produced by alternative splicing of isoform 4L.
Isoform 8S (identifier: P36402-16)

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → QLEDWDGWARKP
Note: Produced by alternative splicing of isoform 4S.
Isoform 2L (identifier: P36402-5)

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → GGKRNAFGTYPEKAAAPAPFLPMTVL
Note: Produced by alternative splicing of isoform 4L.
Isoform 2S (identifier: P36402-6)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → GGKRNAFGTYPEKAAAPAPFLPMTVL
Note: Produced by alternative splicing of isoform 4S.
Isoform 3L (identifier: P36402-7)

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRARFGLNQQTDWCGPCR
Note: Produced by alternative splicing of isoform 4L.
Isoform 3S (identifier: P36402-8)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRARFGLNQQTDWCGPCR
Note: Produced by alternative splicing of isoform 4S.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Transcription factor 7
PRO_0000048612

Regions

DNA binding269 – 33769HMG box
Region1 – 5959CTNNB1-binding
Motif344 – 3485Nuclear localization signal Potential

Natural variations

Alternative sequence1 – 115115Missing in isoform 1S, isoform 2S, isoform 3S, isoform 4S, isoform 5S, isoform 6S, isoform 7S and isoform 8S.
VSP_006961
Alternative sequence359 – 38426ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCRRKKKCIRYLPGEGRC PSPVPSDDSALGCPGSPAPQ DSPSYHLLPRFPTELLTSPA ERHLHPQVSPLLSASQPQGP HRPPAAPCRAHRYSNRNLRD RWPSRHRTPGRLQEPTP in isoform 1L and isoform 1S.
VSP_006960
Alternative sequence359 – 38426ETNWP…SSSPA → GGKRNAFGTYPEKAAAPAPF LPMTVL in isoform 2L and isoform 2S.
VSP_002191
Alternative sequence359 – 38426ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCR in isoform 3L and isoform 3S.
VSP_002192
Alternative sequence359 – 38426ETNWP…SSSPA → DNSLHYS in isoform 5L and isoform 5S.
VSP_012160
Alternative sequence359 – 38426ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCRKKKCIRYLPGEGRCP SPVPSDDSALGCPGSPAPQD SPSYHLLPRFPTELLTSPAE RHLHPQVSPLLSASQPQGPH RPPAAPCRAHRYSNRNLRDR WPSRHRTPGRLQEPTP in isoform 6L and isoform 6S.
VSP_012161
Alternative sequence359 – 38426ETNWP…SSSPA → DGIPACTILSP in isoform 7L and isoform 7S.
VSP_012162
Alternative sequence359 – 38426ETNWP…SSSPA → QLEDWDGWARKP in isoform 8L and isoform 8S.
VSP_012163

Experimental info

Sequence conflict211D → N in AAF00616. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Isoform 4L (D) [UniParc].

Last modified October 14, 2008. Version 3.
Checksum: 5088C962F2FD0C00

FASTA38441,642
        10         20         30         40         50         60 
MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE LKSSLVNESE 

        70         80         90        100        110        120 
GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP EPLEDGLKAP ECTSGMYKET 

       130        140        150        160        170        180 
VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA NQPPHGVPQL SLYEHFNSPH PTPAPADISQ 

       190        200        210        220        230        240 
KQVHRPLQTP DLSGFYSLTS GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS 

       250        260        270        280        290        300 
GKQELQPFDR NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN 

       310        320        330        340        350        360 
QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR EKHQESTTET 

       370        380 
NWPRELKDGN GQESLSMSSS SSPA 

« Hide

Isoform 4S [UniParc].

Checksum: A90EE1E4E0BEE297
Show »

FASTA26930,264
Isoform 1L [UniParc].

Checksum: 4CDFAA0BD5A4F7B5
Show »

FASTA49554,125
Isoform 1S (E) [UniParc].

Checksum: 886503B2EBAFB4AB
Show »

FASTA38042,748
Isoform 5L (D) [UniParc].

Checksum: A9CFD9CEC784F0D3
Show »

FASTA36539,681
Isoform 5S [UniParc].

Checksum: DDB6697E17A5DDAC
Show »

FASTA25028,304
Isoform 6L (E) [UniParc].

Checksum: 497A6AF1BCC0E439
Show »

FASTA49453,969
Isoform 6S [UniParc].

Checksum: 83D3D3CFB783FAAC
Show »

FASTA37942,592
Isoform 7L (F) [UniParc].

Checksum: B742838D4DCA35EE
Show »

FASTA36939,933
Isoform 7S [UniParc].

Checksum: 18750F35A9B3855E
Show »

FASTA25428,556
Isoform 8L (G) [UniParc].

Checksum: 02C826CE6F741E3B
Show »

FASTA37040,347
Isoform 8S [UniParc].

Checksum: F7671142D790678B
Show »

FASTA25528,970
Isoform 2L [UniParc].

Checksum: 004644F8B23D9484
Show »

FASTA38441,552
Isoform 2S (B) [UniParc].

Checksum: F9C06C7EA07E7A13
Show »

FASTA26930,175
Isoform 3L [UniParc].

Checksum: D6C1D30018F796DA
Show »

FASTA38341,668
Isoform 3S (C) [UniParc].

Checksum: 60E955125B190163
Show »

FASTA26830,291

References

« Hide 'large scale' references
[1]"Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box."
van de Wetering M., Oosterwegel M.A., Dooijes D., Clevers H.
EMBO J. 10:123-132(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4L).
Tissue: T-cell.
[2]"The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization."
van de Wetering M., Oosterwegel M.A., Holstege F., Dooyes D., Suijkerbuijk R., Geurts van Kessel A., Clevers H.
J. Biol. Chem. 267:8530-8536(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
Tissue: T-cell.
[3]"The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA."
Mayer K., Wolff E., Clevers H., Ballhausen W.G.
Biochim. Biophys. Acta 1263:169-172(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5S; 6S; 7S AND 8S).
Tissue: T-cell lymphoma.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2S).
Tissue: Thymus.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2L).
Tissue: Liver and Skin.
[7]"Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1."
Roose J., Huls G., van Beest M., Moerer P., van der Horn K., Goldschmeding R., Logtenberg T., Clevers H.
Science 285:1923-1926(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-68 (ISOFORM 4L), TISSUE SPECIFICITY, INDUCTION BY TCF7L2 AND CTNNB1.
[8]"Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties."
Van de Wetering M., Castrop J., Korinek V., Clevers H.
Mol. Cell. Biol. 16:745-752(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: UTILIZATION OF AN UPSTREAM PROMOTER, IDENTIFICATION (ISOFORMS 1S AND 4L).
[9]"Two members of the Tcf family implicated in Wnt/b-catenin signaling during embryogenesis in the mouse."
Korinek V., Barker N., Willert K., Molenaar M., Roose J., Wagenaar G., Markman M., Lamers W., Destree O., Clevers H.
Mol. Cell. Biol. 18:1248-1256(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CTNNB1.
[10]"The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors."
Roose J., Molenaar M., Peterson J., Hurenkamp J., Brantjes H., Moerer P., van de Wetering M., Destree O., Clevers H.
Nature 395:608-612(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CTNNB1; AES AND TLE4.
[11]"All Tcf HMG box transcription factors interact with Groucho-related co-repressors."
Brantjes H., Roose J., van De Wetering M., Clevers H.
Nucleic Acids Res. 29:1410-1419(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH AES; TLE1; TLE2; TLE3 AND TLE4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59869 mRNA. Translation: CAA42526.1.
X59870 mRNA. Translation: CAA42527.1.
X59871 mRNA. Translation: CAA42528.1.
X63901 Genomic DNA. Translation: CAB56795.1.
Z47361 mRNA. Translation: CAA87439.1.
Z47362 mRNA. Translation: CAA87440.1.
Z47363 mRNA. Translation: CAA87441.1. Sequence problems.
Z47364 mRNA. Translation: CAA87442.1.
AK093530 mRNA. Translation: BAG52735.1.
CH471062 Genomic DNA. Translation: EAW62277.1.
BC048769 mRNA. Translation: AAH48769.1.
BC072023 mRNA. Translation: AAH72023.1.
AF163776 Genomic DNA. Translation: AAF00616.1.
PIRA38095.
B38095.
C38095.
D38095.
S61796.
RefSeqNP_001128323.2. NM_001134851.2.
NP_003193.2. NM_003202.3.
NP_963963.1. NM_201632.3.
NP_963965.1. NM_201634.3.
NP_998813.1. NM_213648.3.
UniGeneHs.573153.

3D structure databases

ProteinModelPortalP36402.
SMRP36402. Positions 17-56, 267-370.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112794. 3 interactions.
IntActP36402. 3 interactions.
MINTMINT-1779551.
STRING9606.ENSP00000340347.

Chemistry

BindingDBP36402.

PTM databases

PhosphoSiteP36402.

Polymorphism databases

DMDM209572716.

Proteomic databases

PaxDbP36402.
PRIDEP36402.

Protocols and materials databases

DNASU6932.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000321584; ENSP00000326540; ENSG00000081059. [P36402-1]
ENST00000321603; ENSP00000326654; ENSG00000081059. [P36402-9]
ENST00000342854; ENSP00000340347; ENSG00000081059. [P36402-5]
ENST00000378560; ENSP00000367822; ENSG00000081059. [P36402-8]
ENST00000378564; ENSP00000367827; ENSG00000081059. [P36402-13]
ENST00000395023; ENSP00000378469; ENSG00000081059. [P36402-6]
ENST00000518915; ENSP00000430179; ENSG00000081059. [P36402-2]
ENST00000520958; ENSP00000429547; ENSG00000081059. [P36402-6]
GeneID6932.
KEGGhsa:6932.
UCSCuc003kyt.3. human. [P36402-5]
uc003kyu.2. human. [P36402-1]
uc003kyv.3. human. [P36402-8]
uc003kyw.3. human. [P36402-6]
uc003kza.3. human. [P36402-10]

Organism-specific databases

CTD6932.
GeneCardsGC05P133478.
HGNCHGNC:11639. TCF7.
HPACAB019403.
MIM189908. gene.
neXtProtNX_P36402.
PharmGKBPA36392.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG252916.
HOGENOMHOG000116032.
HOVERGENHBG000419.
KOK02620.
PhylomeDBP36402.
TreeFamTF318448.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP36402.
BgeeP36402.
CleanExHS_TCF7.
GenevestigatorP36402.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
4.10.900.10. 1 hit.
InterProIPR027397. Catenin_binding_dom.
IPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR024940. TCF/LEF.
IPR028785. Tcf7.
[Graphical view]
PANTHERPTHR10373. PTHR10373. 1 hit.
PTHR10373:SF27. PTHR10373:SF27. 1 hit.
PfamPF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTCF7. human.
GeneWikiTCF7.
GenomeRNAi6932.
NextBio27121.
PROP36402.
SOURCESearch...

Entry information

Entry nameTCF7_HUMAN
AccessionPrimary (citable) accession number: P36402
Secondary accession number(s): B3KSH3, Q86WR9, Q9UKI4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 14, 2008
Last modified: April 16, 2014
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM