P36402 (TCF7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor 7
Short name=TCF-7

Alternative name(s):
T-cell-specific transcription factor 1
Short name=T-cell factor 1
Short name=TCF-1

Gene names

Name:	TCF7
Synonyms:	TCF1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
Subunit structure	Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with AES, TLE1, TLE2, TLE3 and TLE4. Ref.9 Ref.10 Ref.11
Subcellular location	Nucleus.
Tissue specificity	Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium. Ref.7
Induction	By TCF7L2 and CTNNB1. Ref.7
Sequence similarities	Belongs to the TCF/LEF family. Contains 1 HMG box DNA-binding domain.
Sequence caution	The sequence CAA87441.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Wnt signaling pathway
Cellular component	Nucleus
Coding sequence diversity	Alternative promoter usage Alternative splicing
Ligand	DNA-binding
Molecular function	Activator Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell receptor V(D)J recombination Inferred from electronic annotation. Source: Compara alpha-beta T cell differentiation Inferred from electronic annotation. Source: Compara brain development Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome cellular response to interleukin-4 Inferred from direct assay PubMed 18579517. Source: UniProtKB embryonic digestive tract morphogenesis Inferred from electronic annotation. Source: Compara embryonic genitalia morphogenesis Inferred from electronic annotation. Source: Compara embryonic hindgut morphogenesis Inferred from electronic annotation. Source: Compara generation of neurons Inferred from Biological aspect of Ancestor. Source: RefGenome immune response Traceable author statement Ref.2. Source: ProtInc neural tube development Inferred from electronic annotation. Source: Compara regulation of apoptotic process Inferred from electronic annotation. Source: Compara regulation of cell proliferation Inferred from electronic annotation. Source: Compara regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	transcription factor complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	beta-catenin binding Inferred from direct assay Ref.9. Source: BHF-UCL chromatin binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome transcription regulatory region DNA binding Inferred from direct assay PubMed 18579517PubMed 20128911. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 16 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Note: 2 series of isoforms, L and S, are produced by alternative promoter usage. Additional isoforms seem to exist.

Isoform 4L (identifier: P36402-1)

Also known as: D;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 4S (identifier: P36402-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.

Isoform 1L (identifier: P36402-3)

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4L.

Isoform 1S (identifier: P36402-4)

Also known as: E;

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4S.

Isoform 5L (identifier: P36402-9)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DNSLHYS

Note: Produced by alternative splicing of isoform 4L.

Isoform 5S (identifier: P36402-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DNSLHYS

Note: Produced by alternative splicing of isoform 4S.

Isoform 6L (identifier: P36402-11)

Also known as: E;

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4L.

Isoform 6S (identifier: P36402-12)

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4S.

Isoform 7L (identifier: P36402-13)

Also known as: F;

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DGIPACTILSP

Note: Produced by alternative splicing of isoform 4L.

Isoform 7S (identifier: P36402-14)

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DGIPACTILSP

Note: Produced by alternative splicing of isoform 4S.

Isoform 8L (identifier: P36402-15)

Also known as: G;

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → QLEDWDGWARKP

Note: Produced by alternative splicing of isoform 4L.

Isoform 8S (identifier: P36402-16)

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → QLEDWDGWARKP

Note: Produced by alternative splicing of isoform 4S.

Isoform 2L (identifier: P36402-5)

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → GGKRNAFGTYPEKAAAPAPFLPMTVL

Note: Produced by alternative splicing of isoform 4L.

Isoform 2S (identifier: P36402-6)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → GGKRNAFGTYPEKAAAPAPFLPMTVL

Note: Produced by alternative splicing of isoform 4S.

Isoform 3L (identifier: P36402-7)

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRARFGLNQQTDWCGPCR

Note: Produced by alternative splicing of isoform 4L.

Isoform 3S (identifier: P36402-8)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRARFGLNQQTDWCGPCR

Note: Produced by alternative splicing of isoform 4S.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Transcription factor 7		PRO_0000048612
Regions
	DNA binding	269 – 337	69	HMG box
	Region	1 – 59	59	CTNNB1-binding
	Motif	344 – 348	5	Nuclear localization signal Potential
Natural variations
	Alternative sequence	1 – 115	115	Missing in isoform 1S, isoform 2S, isoform 3S, isoform 4S, isoform 5S, isoform 6S, isoform 7S and isoform 8S.		VSP_006961
	Alternative sequence	359 – 384	26	ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCRRKKKCIRYLPGEGRC PSPVPSDDSALGCPGSPAPQ DSPSYHLLPRFPTELLTSPA ERHLHPQVSPLLSASQPQGP HRPPAAPCRAHRYSNRNLRD RWPSRHRTPGRLQEPTP in isoform 1L and isoform 1S.		VSP_006960
	Alternative sequence	359 – 384	26	ETNWP…SSSPA → GGKRNAFGTYPEKAAAPAPF LPMTVL in isoform 2L and isoform 2S.		VSP_002191
	Alternative sequence	359 – 384	26	ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCR in isoform 3L and isoform 3S.		VSP_002192
	Alternative sequence	359 – 384	26	ETNWP…SSSPA → DNSLHYS in isoform 5L and isoform 5S.		VSP_012160
	Alternative sequence	359 – 384	26	ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCRKKKCIRYLPGEGRCP SPVPSDDSALGCPGSPAPQD SPSYHLLPRFPTELLTSPAE RHLHPQVSPLLSASQPQGPH RPPAAPCRAHRYSNRNLRDR WPSRHRTPGRLQEPTP in isoform 6L and isoform 6S.		VSP_012161
	Alternative sequence	359 – 384	26	ETNWP…SSSPA → DGIPACTILSP in isoform 7L and isoform 7S.		VSP_012162
	Alternative sequence	359 – 384	26	ETNWP…SSSPA → QLEDWDGWARKP in isoform 8L and isoform 8S.		VSP_012163
Experimental info
	Sequence conflict	21	1	D → N in AAF00616. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 4L (D) [UniParc]. Last modified October 14, 2008. Version 3. Checksum: 5088C962F2FD0C00	FASTA	384	41,642
	10 20 30 40 50 60 MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE LKSSLVNESE 70 80 90 100 110 120 GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP EPLEDGLKAP ECTSGMYKET 130 140 150 160 170 180 VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA NQPPHGVPQL SLYEHFNSPH PTPAPADISQ 190 200 210 220 230 240 KQVHRPLQTP DLSGFYSLTS GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS 250 260 270 280 290 300 GKQELQPFDR NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN 310 320 330 340 350 360 QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR EKHQESTTET 370 380 NWPRELKDGN GQESLSMSSS SSPA
	Isoform 4S [UniParc]. Checksum: A90EE1E4E0BEE297	FASTA	269	30,264
	10 20 30 40 50 60 MYKETVYSAF NLLMHYPPPS GAGQHPQPQP PLHKANQPPH GVPQLSLYEH FNSPHPTPAP 70 80 90 100 110 120 ADISQKQVHR PLQTPDLSGF YSLTSGSMGQ LPHTVSWFTH PSLMLGSGVP GHPAAIPHPA 130 140 150 160 170 180 IVPPSGKQEL QPFDRNLKTQ AESKAEKEAK KPTIKKPLNA FMLYMKEMRA KVIAECTLKE 190 200 210 220 230 240 SAAINQILGR RWHALSREEQ AKYYELARKE RQLHMQLYPG WSARDNYGKK KRRSREKHQE 250 260 STTETNWPRE LKDGNGQESL SMSSSSSPA
	Isoform 1L [UniParc]. Checksum: 4CDFAA0BD5A4F7B5	FASTA	495	54,125
	10 20 30 40 50 60 MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE LKSSLVNESE 70 80 90 100 110 120 GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP EPLEDGLKAP ECTSGMYKET 130 140 150 160 170 180 VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA NQPPHGVPQL SLYEHFNSPH PTPAPADISQ 190 200 210 220 230 240 KQVHRPLQTP DLSGFYSLTS GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS 250 260 270 280 290 300 GKQELQPFDR NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN 310 320 330 340 350 360 QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR EKHQESTTDP 370 380 390 400 410 420 GSPKKCRARF GLNQQTDWCG PCRRKKKCIR YLPGEGRCPS PVPSDDSALG CPGSPAPQDS 430 440 450 460 470 480 PSYHLLPRFP TELLTSPAER HLHPQVSPLL SASQPQGPHR PPAAPCRAHR YSNRNLRDRW 490 PSRHRTPGRL QEPTP
	Isoform 1S (E) [UniParc]. Checksum: 886503B2EBAFB4AB	FASTA	380	42,748
	10 20 30 40 50 60 MYKETVYSAF NLLMHYPPPS GAGQHPQPQP PLHKANQPPH GVPQLSLYEH FNSPHPTPAP 70 80 90 100 110 120 ADISQKQVHR PLQTPDLSGF YSLTSGSMGQ LPHTVSWFTH PSLMLGSGVP GHPAAIPHPA 130 140 150 160 170 180 IVPPSGKQEL QPFDRNLKTQ AESKAEKEAK KPTIKKPLNA FMLYMKEMRA KVIAECTLKE 190 200 210 220 230 240 SAAINQILGR RWHALSREEQ AKYYELARKE RQLHMQLYPG WSARDNYGKK KRRSREKHQE 250 260 270 280 290 300 STTDPGSPKK CRARFGLNQQ TDWCGPCRRK KKCIRYLPGE GRCPSPVPSD DSALGCPGSP 310 320 330 340 350 360 APQDSPSYHL LPRFPTELLT SPAERHLHPQ VSPLLSASQP QGPHRPPAAP CRAHRYSNRN 370 380 LRDRWPSRHR TPGRLQEPTP
	Isoform 5L (D) [UniParc]. Checksum: A9CFD9CEC784F0D3	FASTA	365	39,681
	10 20 30 40 50 60 MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE LKSSLVNESE 70 80 90 100 110 120 GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP EPLEDGLKAP ECTSGMYKET 130 140 150 160 170 180 VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA NQPPHGVPQL SLYEHFNSPH PTPAPADISQ 190 200 210 220 230 240 KQVHRPLQTP DLSGFYSLTS GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS 250 260 270 280 290 300 GKQELQPFDR NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN 310 320 330 340 350 360 QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR EKHQESTTDN SLHYS
	Isoform 5S [UniParc]. Checksum: DDB6697E17A5DDAC	FASTA	250	28,304
	10 20 30 40 50 60 MYKETVYSAF NLLMHYPPPS GAGQHPQPQP PLHKANQPPH GVPQLSLYEH FNSPHPTPAP 70 80 90 100 110 120 ADISQKQVHR PLQTPDLSGF YSLTSGSMGQ LPHTVSWFTH PSLMLGSGVP GHPAAIPHPA 130 140 150 160 170 180 IVPPSGKQEL QPFDRNLKTQ AESKAEKEAK KPTIKKPLNA FMLYMKEMRA KVIAECTLKE 190 200 210 220 230 240 SAAINQILGR RWHALSREEQ AKYYELARKE RQLHMQLYPG WSARDNYGKK KRRSREKHQE 250 STTDNSLHYS
	Isoform 6L (E) [UniParc]. Checksum: 497A6AF1BCC0E439	FASTA	494	53,969
	10 20 30 40 50 60 MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE LKSSLVNESE 70 80 90 100 110 120 GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP EPLEDGLKAP ECTSGMYKET 130 140 150 160 170 180 VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA NQPPHGVPQL SLYEHFNSPH PTPAPADISQ 190 200 210 220 230 240 KQVHRPLQTP DLSGFYSLTS GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS 250 260 270 280 290 300 GKQELQPFDR NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN 310 320 330 340 350 360 QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR EKHQESTTDP 370 380 390 400 410 420 GSPKKCRARF GLNQQTDWCG PCRKKKCIRY LPGEGRCPSP VPSDDSALGC PGSPAPQDSP 430 440 450 460 470 480 SYHLLPRFPT ELLTSPAERH LHPQVSPLLS ASQPQGPHRP PAAPCRAHRY SNRNLRDRWP 490 SRHRTPGRLQ EPTP
	Isoform 6S [UniParc]. Checksum: 83D3D3CFB783FAAC	FASTA	379	42,592
	10 20 30 40 50 60 MYKETVYSAF NLLMHYPPPS GAGQHPQPQP PLHKANQPPH GVPQLSLYEH FNSPHPTPAP 70 80 90 100 110 120 ADISQKQVHR PLQTPDLSGF YSLTSGSMGQ LPHTVSWFTH PSLMLGSGVP GHPAAIPHPA 130 140 150 160 170 180 IVPPSGKQEL QPFDRNLKTQ AESKAEKEAK KPTIKKPLNA FMLYMKEMRA KVIAECTLKE 190 200 210 220 230 240 SAAINQILGR RWHALSREEQ AKYYELARKE RQLHMQLYPG WSARDNYGKK KRRSREKHQE 250 260 270 280 290 300 STTDPGSPKK CRARFGLNQQ TDWCGPCRKK KCIRYLPGEG RCPSPVPSDD SALGCPGSPA 310 320 330 340 350 360 PQDSPSYHLL PRFPTELLTS PAERHLHPQV SPLLSASQPQ GPHRPPAAPC RAHRYSNRNL 370 RDRWPSRHRT PGRLQEPTP
	Isoform 7L (F) [UniParc]. Checksum: B742838D4DCA35EE	FASTA	369	39,933
	10 20 30 40 50 60 MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE LKSSLVNESE 70 80 90 100 110 120 GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP EPLEDGLKAP ECTSGMYKET 130 140 150 160 170 180 VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA NQPPHGVPQL SLYEHFNSPH PTPAPADISQ 190 200 210 220 230 240 KQVHRPLQTP DLSGFYSLTS GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS 250 260 270 280 290 300 GKQELQPFDR NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN 310 320 330 340 350 360 QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR EKHQESTTDG IPACTILSP
	Isoform 7S [UniParc]. Checksum: 18750F35A9B3855E	FASTA	254	28,556
	10 20 30 40 50 60 MYKETVYSAF NLLMHYPPPS GAGQHPQPQP PLHKANQPPH GVPQLSLYEH FNSPHPTPAP 70 80 90 100 110 120 ADISQKQVHR PLQTPDLSGF YSLTSGSMGQ LPHTVSWFTH PSLMLGSGVP GHPAAIPHPA 130 140 150 160 170 180 IVPPSGKQEL QPFDRNLKTQ AESKAEKEAK KPTIKKPLNA FMLYMKEMRA KVIAECTLKE 190 200 210 220 230 240 SAAINQILGR RWHALSREEQ AKYYELARKE RQLHMQLYPG WSARDNYGKK KRRSREKHQE 250 STTDGIPACT ILSP
	Isoform 8L (G) [UniParc]. Checksum: 02C826CE6F741E3B	FASTA	370	40,347
	10 20 30 40 50 60 MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE LKSSLVNESE 70 80 90 100 110 120 GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP EPLEDGLKAP ECTSGMYKET 130 140 150 160 170 180 VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA NQPPHGVPQL SLYEHFNSPH PTPAPADISQ 190 200 210 220 230 240 KQVHRPLQTP DLSGFYSLTS GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS 250 260 270 280 290 300 GKQELQPFDR NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN 310 320 330 340 350 360 QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR EKHQESTTQL 370 EDWDGWARKP
	Isoform 8S [UniParc]. Checksum: F7671142D790678B	FASTA	255	28,970
	10 20 30 40 50 60 MYKETVYSAF NLLMHYPPPS GAGQHPQPQP PLHKANQPPH GVPQLSLYEH FNSPHPTPAP 70 80 90 100 110 120 ADISQKQVHR PLQTPDLSGF YSLTSGSMGQ LPHTVSWFTH PSLMLGSGVP GHPAAIPHPA 130 140 150 160 170 180 IVPPSGKQEL QPFDRNLKTQ AESKAEKEAK KPTIKKPLNA FMLYMKEMRA KVIAECTLKE 190 200 210 220 230 240 SAAINQILGR RWHALSREEQ AKYYELARKE RQLHMQLYPG WSARDNYGKK KRRSREKHQE 250 STTQLEDWDG WARKP
	Isoform 2L [UniParc]. Checksum: 004644F8B23D9484	FASTA	384	41,552
	10 20 30 40 50 60 MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE LKSSLVNESE 70 80 90 100 110 120 GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP EPLEDGLKAP ECTSGMYKET 130 140 150 160 170 180 VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA NQPPHGVPQL SLYEHFNSPH PTPAPADISQ 190 200 210 220 230 240 KQVHRPLQTP DLSGFYSLTS GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS 250 260 270 280 290 300 GKQELQPFDR NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN 310 320 330 340 350 360 QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR EKHQESTTGG 370 380 KRNAFGTYPE KAAAPAPFLP MTVL
	Isoform 2S (B) [UniParc]. Checksum: F9C06C7EA07E7A13	FASTA	269	30,175
	10 20 30 40 50 60 MYKETVYSAF NLLMHYPPPS GAGQHPQPQP PLHKANQPPH GVPQLSLYEH FNSPHPTPAP 70 80 90 100 110 120 ADISQKQVHR PLQTPDLSGF YSLTSGSMGQ LPHTVSWFTH PSLMLGSGVP GHPAAIPHPA 130 140 150 160 170 180 IVPPSGKQEL QPFDRNLKTQ AESKAEKEAK KPTIKKPLNA FMLYMKEMRA KVIAECTLKE 190 200 210 220 230 240 SAAINQILGR RWHALSREEQ AKYYELARKE RQLHMQLYPG WSARDNYGKK KRRSREKHQE 250 260 STTGGKRNAF GTYPEKAAAP APFLPMTVL
	Isoform 3L [UniParc]. Checksum: D6C1D30018F796DA	FASTA	383	41,668
	10 20 30 40 50 60 MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE LKSSLVNESE 70 80 90 100 110 120 GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP EPLEDGLKAP ECTSGMYKET 130 140 150 160 170 180 VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA NQPPHGVPQL SLYEHFNSPH PTPAPADISQ 190 200 210 220 230 240 KQVHRPLQTP DLSGFYSLTS GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS 250 260 270 280 290 300 GKQELQPFDR NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN 310 320 330 340 350 360 QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR EKHQESTTDP 370 380 GSPKKCRARF GLNQQTDWCG PCR
	Isoform 3S (C) [UniParc]. Checksum: 60E955125B190163	FASTA	268	30,291
	10 20 30 40 50 60 MYKETVYSAF NLLMHYPPPS GAGQHPQPQP PLHKANQPPH GVPQLSLYEH FNSPHPTPAP 70 80 90 100 110 120 ADISQKQVHR PLQTPDLSGF YSLTSGSMGQ LPHTVSWFTH PSLMLGSGVP GHPAAIPHPA 130 140 150 160 170 180 IVPPSGKQEL QPFDRNLKTQ AESKAEKEAK KPTIKKPLNA FMLYMKEMRA KVIAECTLKE 190 200 210 220 230 240 SAAINQILGR RWHALSREEQ AKYYELARKE RQLHMQLYPG WSARDNYGKK KRRSREKHQE 250 260 STTDPGSPKK CRARFGLNQQ TDWCGPCR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box." van de Wetering M., Oosterwegel M.A., Dooijes D., Clevers H. EMBO J. 10:123-132(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4L). Tissue: T-cell.
[2]	"The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization." van de Wetering M., Oosterwegel M.A., Holstege F., Dooyes D., Suijkerbuijk R., Geurts van Kessel A., Clevers H. J. Biol. Chem. 267:8530-8536(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING. Tissue: T-cell.
[3]	"The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA." Mayer K., Wolff E., Clevers H., Ballhausen W.G. Biochim. Biophys. Acta 1263:169-172(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5S; 6S; 7S AND 8S). Tissue: T-cell lymphoma.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2S). Tissue: Thymus.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2L). Tissue: Liver and Skin.
[7]	"Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1." Roose J., Huls G., van Beest M., Moerer P., van der Horn K., Goldschmeding R., Logtenberg T., Clevers H. Science 285:1923-1926(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-68 (ISOFORM 4L), TISSUE SPECIFICITY, INDUCTION BY TCF7L2 AND CTNNB1.
[8]	"Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties." Van de Wetering M., Castrop J., Korinek V., Clevers H. Mol. Cell. Biol. 16:745-752(1996) [PubMed] [Europe PMC] [Abstract] Cited for: UTILIZATION OF AN UPSTREAM PROMOTER, IDENTIFICATION (ISOFORMS 1S AND 4L).
[9]	"Two members of the Tcf family implicated in Wnt/b-catenin signaling during embryogenesis in the mouse." Korinek V., Barker N., Willert K., Molenaar M., Roose J., Wagenaar G., Markman M., Lamers W., Destree O., Clevers H. Mol. Cell. Biol. 18:1248-1256(1998) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CTNNB1.
[10]	"The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors." Roose J., Molenaar M., Peterson J., Hurenkamp J., Brantjes H., Moerer P., van de Wetering M., Destree O., Clevers H. Nature 395:608-612(1998) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CTNNB1; AES AND TLE4.
[11]	"All Tcf HMG box transcription factors interact with Groucho-related co-repressors." Brantjes H., Roose J., van De Wetering M., Clevers H. Nucleic Acids Res. 29:1410-1419(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH AES; TLE1; TLE2; TLE3 AND TLE4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X59869 mRNA. Translation: CAA42526.1. X59870 mRNA. Translation: CAA42527.1. X59871 mRNA. Translation: CAA42528.1. X63901 Genomic DNA. Translation: CAB56795.1. Z47361 mRNA. Translation: CAA87439.1. Z47362 mRNA. Translation: CAA87440.1. Z47363 mRNA. Translation: CAA87441.1. Sequence problems. Z47364 mRNA. Translation: CAA87442.1. AK093530 mRNA. Translation: BAG52735.1. CH471062 Genomic DNA. Translation: EAW62277.1. BC048769 mRNA. Translation: AAH48769.1. BC072023 mRNA. Translation: AAH72023.1. AF163776 Genomic DNA. Translation: AAF00616.1.
IPI	IPI00003325. IPI00219960. IPI00219961. IPI00219962. IPI00219964. IPI00219965. IPI00334125. IPI00385101. IPI00402002. IPI00477092. IPI00477635. IPI00478219. IPI00478950. IPI00478992. IPI00479370. IPI00479759.
PIR	A38095. B38095. C38095. D38095. S61796.
RefSeq	NP_001128323.2. NM_001134851.2. NP_003193.2. NM_003202.3. NP_963963.1. NM_201632.3. NP_963965.1. NM_201634.3. NP_998813.1. NM_213648.3.
UniGene	Hs.573153.
3D structure databases
ProteinModelPortal	P36402.
ModBase	Search...
Protein-protein interaction databases
IntAct	P36402. 1 interaction.
MINT	MINT-1779551.
STRING	9606.ENSP00000340347.
PTM databases
PhosphoSite	P36402.
Polymorphism databases
DMDM	209572716.
Proteomic databases
PaxDb	P36402.
PRIDE	P36402.
Protocols and materials databases
DNASU	6932.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000321584; ENSP00000326540; ENSG00000081059. ENST00000321603; ENSP00000326654; ENSG00000081059. ENST00000342854; ENSP00000340347; ENSG00000081059. ENST00000378560; ENSP00000367822; ENSG00000081059. ENST00000378564; ENSP00000367827; ENSG00000081059. ENST00000395023; ENSP00000378469; ENSG00000081059. ENST00000518915; ENSP00000430179; ENSG00000081059. ENST00000520958; ENSP00000429547; ENSG00000081059.
GeneID	6932.
KEGG	hsa:6932.
UCSC	uc003kyt.3. human. uc003kyu.2. human. uc003kyv.3. human. uc003kyw.3. human. uc003kza.3. human.
Organism-specific databases
CTD	6932.
GeneCards	GC05P133478.
HGNC	HGNC:11639. TCF7.
HPA	CAB019403.
MIM	189908. gene.
neXtProt	NX_P36402.
PharmGKB	PA36392.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG252916.
HOGENOM	HOG000116032.
HOVERGEN	HBG000419.
KO	K02620.
Gene expression databases
ArrayExpress	P36402.
Bgee	P36402.
CleanEx	HS_TCF7.
Genevestigator	P36402.
GermOnline	ENSG00000081059. Homo sapiens.
Family and domain databases
Gene3D	1.10.30.10. 1 hit.
InterPro	IPR013558. CTNNB1-bd_N. IPR009071. HMG_box_dom. IPR024940. TCF/LEF. [Graphical view]
PANTHER	PTHR10373. PTHR10373. 1 hit.
Pfam	PF08347. CTNNB1_binding. 1 hit. PF00505. HMG_box. 1 hit. [Graphical view]
SMART	SM00398. HMG. 1 hit. [Graphical view]
SUPFAM	SSF47095. HMG-box. 1 hit.
PROSITE	PS50118. HMG_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P36402.
ChEMBL	CHEMBL1075124.
ChiTaRS	TCF7. human.
GenomeRNAi	6932.
NextBio	27121.
SOURCE	Search...

Entry information

Entry name

TCF7_HUMAN

Accession

Primary (citable) accession number: P36402
Secondary accession number(s): B3KSH3, Q86WR9, Q9UKI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	October 14, 2008
Last modified:	May 1, 2013
This is version 137 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.