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P36402

- TCF7_HUMAN

UniProt

P36402 - TCF7_HUMAN

Protein

Transcription factor 7

Gene

TCF7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 3 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi269 – 33769HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. beta-catenin binding Source: BHF-UCL
    2. chromatin binding Source: RefGenome
    3. protein binding Source: UniProtKB
    4. sequence-specific DNA binding Source: RefGenome
    5. sequence-specific DNA binding transcription factor activity Source: RefGenome
    6. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. alpha-beta T cell differentiation Source: Ensembl
    2. brain development Source: RefGenome
    3. canonical Wnt signaling pathway Source: RefGenome
    4. canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: Ensembl
    5. cellular response to interleukin-4 Source: UniProtKB
    6. embryonic digestive tract morphogenesis Source: Ensembl
    7. embryonic genitalia morphogenesis Source: Ensembl
    8. embryonic hindgut morphogenesis Source: Ensembl
    9. generation of neurons Source: RefGenome
    10. immune response Source: ProtInc
    11. neural tube development Source: Ensembl
    12. regulation of cell proliferation Source: Ensembl
    13. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    14. T cell receptor V(D)J recombination Source: Ensembl
    15. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation, Wnt signaling pathway

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_172761. Ca2+ pathway.
    REACT_200731. deactivation of the beta-catenin transactivating complex.
    REACT_200753. formation of the beta-catenin:TCF transactivating complex.
    REACT_200799. binding of TCF/LEF:CTNNB1 to target gene promoters.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor 7
    Short name:
    TCF-7
    Alternative name(s):
    T-cell-specific transcription factor 1
    Short name:
    T-cell factor 1
    Short name:
    TCF-1
    Gene namesi
    Name:TCF7
    Synonyms:TCF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:11639. TCF7.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. transcription factor complex Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36392.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Transcription factor 7PRO_0000048612Add
    BLAST

    Proteomic databases

    MaxQBiP36402.
    PaxDbiP36402.
    PRIDEiP36402.

    PTM databases

    PhosphoSiteiP36402.

    Expressioni

    Tissue specificityi

    Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.1 Publication

    Inductioni

    By TCF7L2 and CTNNB1.1 Publication

    Gene expression databases

    ArrayExpressiP36402.
    BgeeiP36402.
    CleanExiHS_TCF7.
    GenevestigatoriP36402.

    Organism-specific databases

    HPAiCAB019403.

    Interactioni

    Subunit structurei

    Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with AES, TLE1, TLE2, TLE3 and TLE4.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CTNNB1P352222EBI-2119465,EBI-491549

    Protein-protein interaction databases

    BioGridi112794. 3 interactions.
    IntActiP36402. 3 interactions.
    MINTiMINT-1779551.
    STRINGi9606.ENSP00000340347.

    Structurei

    3D structure databases

    ProteinModelPortaliP36402.
    SMRiP36402. Positions 17-56, 267-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 5959CTNNB1-bindingAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi344 – 3485Nuclear localization signalSequence Analysis

    Sequence similaritiesi

    Belongs to the TCF/LEF family.Curated
    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG252916.
    HOGENOMiHOG000116032.
    HOVERGENiHBG000419.
    KOiK02620.
    PhylomeDBiP36402.
    TreeFamiTF318448.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    4.10.900.10. 1 hit.
    InterProiIPR027397. Catenin_binding_dom.
    IPR013558. CTNNB1-bd_N.
    IPR009071. HMG_box_dom.
    IPR024940. TCF/LEF.
    IPR028785. Tcf7.
    [Graphical view]
    PANTHERiPTHR10373. PTHR10373. 1 hit.
    PTHR10373:SF33. PTHR10373:SF33. 1 hit.
    PfamiPF08347. CTNNB1_binding. 1 hit.
    PF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequences (16)i

    Sequence statusi: Complete.

    This entry describes 16 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Note: 2 series of isoforms, L and S, are produced by alternative promoter usage. Additional isoforms seem to exist.

    Isoform 4L (identifier: P36402-1) [UniParc]FASTAAdd to Basket

    Also known as: D

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE    50
    LKSSLVNESE GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP 100
    EPLEDGLKAP ECTSGMYKET VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA 150
    NQPPHGVPQL SLYEHFNSPH PTPAPADISQ KQVHRPLQTP DLSGFYSLTS 200
    GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS GKQELQPFDR 250
    NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN 300
    QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR 350
    EKHQESTTET NWPRELKDGN GQESLSMSSS SSPA 384
    Length:384
    Mass (Da):41,642
    Last modified:October 14, 2008 - v3
    Checksum:i5088C962F2FD0C00
    GO
    Isoform 4S (identifier: P36402-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-115: Missing.

    Show »
    Length:269
    Mass (Da):30,264
    Checksum:iA90EE1E4E0BEE297
    GO
    Isoform 1L (identifier: P36402-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

    Note: Produced by alternative splicing of isoform 4L.

    Show »
    Length:495
    Mass (Da):54,125
    Checksum:i4CDFAA0BD5A4F7B5
    GO
    Isoform 1S (identifier: P36402-4) [UniParc]FASTAAdd to Basket

    Also known as: E

    The sequence of this isoform differs from the canonical sequence as follows:
         1-115: Missing.
         359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

    Note: Produced by alternative splicing of isoform 4S.

    Show »
    Length:380
    Mass (Da):42,748
    Checksum:i886503B2EBAFB4AB
    GO
    Isoform 5L (identifier: P36402-9) [UniParc]FASTAAdd to Basket

    Also known as: D

    The sequence of this isoform differs from the canonical sequence as follows:
         359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DNSLHYS

    Note: Produced by alternative splicing of isoform 4L.

    Show »
    Length:365
    Mass (Da):39,681
    Checksum:iA9CFD9CEC784F0D3
    GO
    Isoform 5S (identifier: P36402-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-115: Missing.
         359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DNSLHYS

    Note: Produced by alternative splicing of isoform 4S.

    Show »
    Length:250
    Mass (Da):28,304
    Checksum:iDDB6697E17A5DDAC
    GO
    Isoform 6L (identifier: P36402-11) [UniParc]FASTAAdd to Basket

    Also known as: E

    The sequence of this isoform differs from the canonical sequence as follows:
         359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

    Note: Produced by alternative splicing of isoform 4L.

    Show »
    Length:494
    Mass (Da):53,969
    Checksum:i497A6AF1BCC0E439
    GO
    Isoform 6S (identifier: P36402-12) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-115: Missing.
         359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

    Note: Produced by alternative splicing of isoform 4S.

    Show »
    Length:379
    Mass (Da):42,592
    Checksum:i83D3D3CFB783FAAC
    GO
    Isoform 7L (identifier: P36402-13) [UniParc]FASTAAdd to Basket

    Also known as: F

    The sequence of this isoform differs from the canonical sequence as follows:
         359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DGIPACTILSP

    Note: Produced by alternative splicing of isoform 4L.

    Show »
    Length:369
    Mass (Da):39,933
    Checksum:iB742838D4DCA35EE
    GO
    Isoform 7S (identifier: P36402-14) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-115: Missing.
         359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DGIPACTILSP

    Note: Produced by alternative splicing of isoform 4S.

    Show »
    Length:254
    Mass (Da):28,556
    Checksum:i18750F35A9B3855E
    GO
    Isoform 8L (identifier: P36402-15) [UniParc]FASTAAdd to Basket

    Also known as: G

    The sequence of this isoform differs from the canonical sequence as follows:
         359-384: ETNWPRELKDGNGQESLSMSSSSSPA → QLEDWDGWARKP

    Note: Produced by alternative splicing of isoform 4L.

    Show »
    Length:370
    Mass (Da):40,347
    Checksum:i02C826CE6F741E3B
    GO
    Isoform 8S (identifier: P36402-16) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-115: Missing.
         359-384: ETNWPRELKDGNGQESLSMSSSSSPA → QLEDWDGWARKP

    Note: Produced by alternative splicing of isoform 4S.

    Show »
    Length:255
    Mass (Da):28,970
    Checksum:iF7671142D790678B
    GO
    Isoform 2L (identifier: P36402-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         359-384: ETNWPRELKDGNGQESLSMSSSSSPA → GGKRNAFGTYPEKAAAPAPFLPMTVL

    Note: Produced by alternative splicing of isoform 4L.

    Show »
    Length:384
    Mass (Da):41,552
    Checksum:i004644F8B23D9484
    GO
    Isoform 2S (identifier: P36402-6) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         1-115: Missing.
         359-384: ETNWPRELKDGNGQESLSMSSSSSPA → GGKRNAFGTYPEKAAAPAPFLPMTVL

    Note: Produced by alternative splicing of isoform 4S.

    Show »
    Length:269
    Mass (Da):30,175
    Checksum:iF9C06C7EA07E7A13
    GO
    Isoform 3L (identifier: P36402-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRARFGLNQQTDWCGPCR

    Note: Produced by alternative splicing of isoform 4L.

    Show »
    Length:383
    Mass (Da):41,668
    Checksum:iD6C1D30018F796DA
    GO
    Isoform 3S (identifier: P36402-8) [UniParc]FASTAAdd to Basket

    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         1-115: Missing.
         359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRARFGLNQQTDWCGPCR

    Note: Produced by alternative splicing of isoform 4S.

    Show »
    Length:268
    Mass (Da):30,291
    Checksum:i60E955125B190163
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211D → N in AAF00616. (PubMed:10489374)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 115115Missing in isoform 1S, isoform 2S, isoform 3S, isoform 4S, isoform 5S, isoform 6S, isoform 7S and isoform 8S. 2 PublicationsVSP_006961Add
    BLAST
    Alternative sequencei359 – 38426ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCRRKKKCIRYLPGEGRC PSPVPSDDSALGCPGSPAPQ DSPSYHLLPRFPTELLTSPA ERHLHPQVSPLLSASQPQGP HRPPAAPCRAHRYSNRNLRD RWPSRHRTPGRLQEPTP in isoform 1L and isoform 1S. CuratedVSP_006960Add
    BLAST
    Alternative sequencei359 – 38426ETNWP…SSSPA → GGKRNAFGTYPEKAAAPAPF LPMTVL in isoform 2L and isoform 2S. 2 PublicationsVSP_002191Add
    BLAST
    Alternative sequencei359 – 38426ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCR in isoform 3L and isoform 3S. CuratedVSP_002192Add
    BLAST
    Alternative sequencei359 – 38426ETNWP…SSSPA → DNSLHYS in isoform 5L and isoform 5S. 1 PublicationVSP_012160Add
    BLAST
    Alternative sequencei359 – 38426ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCRKKKCIRYLPGEGRCP SPVPSDDSALGCPGSPAPQD SPSYHLLPRFPTELLTSPAE RHLHPQVSPLLSASQPQGPH RPPAAPCRAHRYSNRNLRDR WPSRHRTPGRLQEPTP in isoform 6L and isoform 6S. 1 PublicationVSP_012161Add
    BLAST
    Alternative sequencei359 – 38426ETNWP…SSSPA → DGIPACTILSP in isoform 7L and isoform 7S. 1 PublicationVSP_012162Add
    BLAST
    Alternative sequencei359 – 38426ETNWP…SSSPA → QLEDWDGWARKP in isoform 8L and isoform 8S. 1 PublicationVSP_012163Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59869 mRNA. Translation: CAA42526.1.
    X59870 mRNA. Translation: CAA42527.1.
    X59871 mRNA. Translation: CAA42528.1.
    X63901 Genomic DNA. Translation: CAB56795.1.
    Z47361 mRNA. Translation: CAA87439.1.
    Z47362 mRNA. Translation: CAA87440.1.
    Z47363 mRNA. Translation: CAA87441.1. Sequence problems.
    Z47364 mRNA. Translation: CAA87442.1.
    AK093530 mRNA. Translation: BAG52735.1.
    CH471062 Genomic DNA. Translation: EAW62277.1.
    BC048769 mRNA. Translation: AAH48769.1.
    BC072023 mRNA. Translation: AAH72023.1.
    AF163776 Genomic DNA. Translation: AAF00616.1.
    CCDSiCCDS4169.1. [P36402-5]
    CCDS4170.1. [P36402-6]
    CCDS43362.1. [P36402-8]
    CCDS47263.2. [P36402-2]
    PIRiA38095.
    B38095.
    C38095.
    D38095.
    S61796.
    RefSeqiNP_001128323.2. NM_001134851.2. [P36402-2]
    NP_003193.2. NM_003202.3. [P36402-5]
    NP_963963.1. NM_201632.3. [P36402-6]
    NP_963965.1. NM_201634.3. [P36402-8]
    NP_998813.1. NM_213648.3. [P36402-6]
    XP_006714746.1. XM_006714683.1. [P36402-1]
    XP_006714747.1. XM_006714684.1. [P36402-9]
    UniGeneiHs.573153.

    Genome annotation databases

    EnsembliENST00000342854; ENSP00000340347; ENSG00000081059. [P36402-5]
    ENST00000378560; ENSP00000367822; ENSG00000081059. [P36402-8]
    ENST00000395023; ENSP00000378469; ENSG00000081059. [P36402-6]
    ENST00000518915; ENSP00000430179; ENSG00000081059. [P36402-2]
    ENST00000520958; ENSP00000429547; ENSG00000081059. [P36402-6]
    GeneIDi6932.
    KEGGihsa:6932.
    UCSCiuc003kyt.3. human. [P36402-5]
    uc003kyu.2. human. [P36402-1]
    uc003kyv.3. human. [P36402-8]
    uc003kyw.3. human. [P36402-6]
    uc003kza.3. human. [P36402-10]

    Polymorphism databases

    DMDMi209572716.

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59869 mRNA. Translation: CAA42526.1 .
    X59870 mRNA. Translation: CAA42527.1 .
    X59871 mRNA. Translation: CAA42528.1 .
    X63901 Genomic DNA. Translation: CAB56795.1 .
    Z47361 mRNA. Translation: CAA87439.1 .
    Z47362 mRNA. Translation: CAA87440.1 .
    Z47363 mRNA. Translation: CAA87441.1 . Sequence problems.
    Z47364 mRNA. Translation: CAA87442.1 .
    AK093530 mRNA. Translation: BAG52735.1 .
    CH471062 Genomic DNA. Translation: EAW62277.1 .
    BC048769 mRNA. Translation: AAH48769.1 .
    BC072023 mRNA. Translation: AAH72023.1 .
    AF163776 Genomic DNA. Translation: AAF00616.1 .
    CCDSi CCDS4169.1. [P36402-5 ]
    CCDS4170.1. [P36402-6 ]
    CCDS43362.1. [P36402-8 ]
    CCDS47263.2. [P36402-2 ]
    PIRi A38095.
    B38095.
    C38095.
    D38095.
    S61796.
    RefSeqi NP_001128323.2. NM_001134851.2. [P36402-2 ]
    NP_003193.2. NM_003202.3. [P36402-5 ]
    NP_963963.1. NM_201632.3. [P36402-6 ]
    NP_963965.1. NM_201634.3. [P36402-8 ]
    NP_998813.1. NM_213648.3. [P36402-6 ]
    XP_006714746.1. XM_006714683.1. [P36402-1 ]
    XP_006714747.1. XM_006714684.1. [P36402-9 ]
    UniGenei Hs.573153.

    3D structure databases

    ProteinModelPortali P36402.
    SMRi P36402. Positions 17-56, 267-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112794. 3 interactions.
    IntActi P36402. 3 interactions.
    MINTi MINT-1779551.
    STRINGi 9606.ENSP00000340347.

    Chemistry

    BindingDBi P36402.

    PTM databases

    PhosphoSitei P36402.

    Polymorphism databases

    DMDMi 209572716.

    Proteomic databases

    MaxQBi P36402.
    PaxDbi P36402.
    PRIDEi P36402.

    Protocols and materials databases

    DNASUi 6932.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342854 ; ENSP00000340347 ; ENSG00000081059 . [P36402-5 ]
    ENST00000378560 ; ENSP00000367822 ; ENSG00000081059 . [P36402-8 ]
    ENST00000395023 ; ENSP00000378469 ; ENSG00000081059 . [P36402-6 ]
    ENST00000518915 ; ENSP00000430179 ; ENSG00000081059 . [P36402-2 ]
    ENST00000520958 ; ENSP00000429547 ; ENSG00000081059 . [P36402-6 ]
    GeneIDi 6932.
    KEGGi hsa:6932.
    UCSCi uc003kyt.3. human. [P36402-5 ]
    uc003kyu.2. human. [P36402-1 ]
    uc003kyv.3. human. [P36402-8 ]
    uc003kyw.3. human. [P36402-6 ]
    uc003kza.3. human. [P36402-10 ]

    Organism-specific databases

    CTDi 6932.
    GeneCardsi GC05P133478.
    HGNCi HGNC:11639. TCF7.
    HPAi CAB019403.
    MIMi 189908. gene.
    neXtProti NX_P36402.
    PharmGKBi PA36392.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG252916.
    HOGENOMi HOG000116032.
    HOVERGENi HBG000419.
    KOi K02620.
    PhylomeDBi P36402.
    TreeFami TF318448.

    Enzyme and pathway databases

    Reactomei REACT_172761. Ca2+ pathway.
    REACT_200731. deactivation of the beta-catenin transactivating complex.
    REACT_200753. formation of the beta-catenin:TCF transactivating complex.
    REACT_200799. binding of TCF/LEF:CTNNB1 to target gene promoters.

    Miscellaneous databases

    ChiTaRSi TCF7. human.
    GeneWikii TCF7.
    GenomeRNAii 6932.
    NextBioi 27121.
    PROi P36402.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P36402.
    Bgeei P36402.
    CleanExi HS_TCF7.
    Genevestigatori P36402.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    4.10.900.10. 1 hit.
    InterProi IPR027397. Catenin_binding_dom.
    IPR013558. CTNNB1-bd_N.
    IPR009071. HMG_box_dom.
    IPR024940. TCF/LEF.
    IPR028785. Tcf7.
    [Graphical view ]
    PANTHERi PTHR10373. PTHR10373. 1 hit.
    PTHR10373:SF33. PTHR10373:SF33. 1 hit.
    Pfami PF08347. CTNNB1_binding. 1 hit.
    PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box."
      van de Wetering M., Oosterwegel M.A., Dooijes D., Clevers H.
      EMBO J. 10:123-132(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4L).
      Tissue: T-cell.
    2. "The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization."
      van de Wetering M., Oosterwegel M.A., Holstege F., Dooyes D., Suijkerbuijk R., Geurts van Kessel A., Clevers H.
      J. Biol. Chem. 267:8530-8536(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
      Tissue: T-cell.
    3. "The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA."
      Mayer K., Wolff E., Clevers H., Ballhausen W.G.
      Biochim. Biophys. Acta 1263:169-172(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5S; 6S; 7S AND 8S).
      Tissue: T-cell lymphoma.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2S).
      Tissue: Thymus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2L).
      Tissue: Liver and Skin.
    7. "Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1."
      Roose J., Huls G., van Beest M., Moerer P., van der Horn K., Goldschmeding R., Logtenberg T., Clevers H.
      Science 285:1923-1926(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-68 (ISOFORM 4L), TISSUE SPECIFICITY, INDUCTION BY TCF7L2 AND CTNNB1.
    8. "Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties."
      Van de Wetering M., Castrop J., Korinek V., Clevers H.
      Mol. Cell. Biol. 16:745-752(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: UTILIZATION OF AN UPSTREAM PROMOTER, IDENTIFICATION (ISOFORMS 1S AND 4L).
    9. "Two members of the Tcf family implicated in Wnt/b-catenin signaling during embryogenesis in the mouse."
      Korinek V., Barker N., Willert K., Molenaar M., Roose J., Wagenaar G., Markman M., Lamers W., Destree O., Clevers H.
      Mol. Cell. Biol. 18:1248-1256(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CTNNB1.
    10. "The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors."
      Roose J., Molenaar M., Peterson J., Hurenkamp J., Brantjes H., Moerer P., van de Wetering M., Destree O., Clevers H.
      Nature 395:608-612(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CTNNB1; AES AND TLE4.
    11. "All Tcf HMG box transcription factors interact with Groucho-related co-repressors."
      Brantjes H., Roose J., van De Wetering M., Clevers H.
      Nucleic Acids Res. 29:1410-1419(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AES; TLE1; TLE2; TLE3 AND TLE4.

    Entry informationi

    Entry nameiTCF7_HUMAN
    AccessioniPrimary (citable) accession number: P36402
    Secondary accession number(s): B3KSH3, Q86WR9, Q9UKI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 151 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3