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P36402

- TCF7_HUMAN

UniProt

P36402 - TCF7_HUMAN

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Protein

Transcription factor 7

Gene

TCF7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi269 – 33769HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. beta-catenin binding Source: BHF-UCL
  2. chromatin binding Source: RefGenome
  3. sequence-specific DNA binding Source: RefGenome
  4. sequence-specific DNA binding transcription factor activity Source: RefGenome
  5. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. alpha-beta T cell differentiation Source: Ensembl
  2. brain development Source: RefGenome
  3. canonical Wnt signaling pathway Source: RefGenome
  4. canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: Ensembl
  5. cellular response to interleukin-4 Source: UniProtKB
  6. embryonic digestive tract morphogenesis Source: Ensembl
  7. embryonic genitalia morphogenesis Source: Ensembl
  8. embryonic hindgut morphogenesis Source: Ensembl
  9. generation of neurons Source: RefGenome
  10. immune response Source: ProtInc
  11. neural tube development Source: Ensembl
  12. regulation of cell proliferation Source: Ensembl
  13. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  14. T cell receptor V(D)J recombination Source: Ensembl
  15. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_172761. Ca2+ pathway.
REACT_200731. deactivation of the beta-catenin transactivating complex.
REACT_200753. formation of the beta-catenin:TCF transactivating complex.
REACT_200799. binding of TCF/LEF:CTNNB1 to target gene promoters.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 7
Short name:
TCF-7
Alternative name(s):
T-cell-specific transcription factor 1
Short name:
T-cell factor 1
Short name:
TCF-1
Gene namesi
Name:TCF7
Synonyms:TCF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:11639. TCF7.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36392.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Transcription factor 7PRO_0000048612Add
BLAST

Proteomic databases

MaxQBiP36402.
PaxDbiP36402.
PRIDEiP36402.

PTM databases

PhosphoSiteiP36402.

Expressioni

Tissue specificityi

Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.1 Publication

Inductioni

By TCF7L2 and CTNNB1.1 Publication

Gene expression databases

BgeeiP36402.
CleanExiHS_TCF7.
ExpressionAtlasiP36402. baseline and differential.
GenevestigatoriP36402.

Organism-specific databases

HPAiCAB019403.

Interactioni

Subunit structurei

Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with AES, TLE1, TLE2, TLE3 and TLE4.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P352222EBI-2119465,EBI-491549

Protein-protein interaction databases

BioGridi112794. 3 interactions.
IntActiP36402. 3 interactions.
MINTiMINT-1779551.
STRINGi9606.ENSP00000340347.

Structurei

3D structure databases

ProteinModelPortaliP36402.
SMRiP36402. Positions 2-59, 269-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5959CTNNB1-bindingAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi344 – 3485Nuclear localization signalSequence Analysis

Sequence similaritiesi

Belongs to the TCF/LEF family.Curated
Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG252916.
GeneTreeiENSGT00390000009964.
HOGENOMiHOG000116032.
HOVERGENiHBG000419.
InParanoidiP36402.
KOiK02620.
PhylomeDBiP36402.
TreeFamiTF318448.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
4.10.900.10. 1 hit.
InterProiIPR027397. Catenin_binding_dom.
IPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR024940. TCF/LEF.
IPR028785. Tcf7.
[Graphical view]
PANTHERiPTHR10373. PTHR10373. 1 hit.
PTHR10373:SF33. PTHR10373:SF33. 1 hit.
PfamiPF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (16)i

Sequence statusi: Complete.

This entry describes 16 isoformsi produced by alternative promoter usage and alternative splicing. Align

Note: 2 series of isoforms, L and S, are produced by alternative promoter usage. Additional isoforms seem to exist.

Isoform 4L (identifier: P36402-1) [UniParc]FASTAAdd to Basket

Also known as: D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE
60 70 80 90 100
LKSSLVNESE GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP
110 120 130 140 150
EPLEDGLKAP ECTSGMYKET VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA
160 170 180 190 200
NQPPHGVPQL SLYEHFNSPH PTPAPADISQ KQVHRPLQTP DLSGFYSLTS
210 220 230 240 250
GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS GKQELQPFDR
260 270 280 290 300
NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN
310 320 330 340 350
QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR
360 370 380
EKHQESTTET NWPRELKDGN GQESLSMSSS SSPA
Length:384
Mass (Da):41,642
Last modified:October 14, 2008 - v3
Checksum:i5088C962F2FD0C00
GO
Isoform 4S (identifier: P36402-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.

Show »
Length:269
Mass (Da):30,264
Checksum:iA90EE1E4E0BEE297
GO
Isoform 1L (identifier: P36402-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4L.

Show »
Length:495
Mass (Da):54,125
Checksum:i4CDFAA0BD5A4F7B5
GO
Isoform 1S (identifier: P36402-4) [UniParc]FASTAAdd to Basket

Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4S.

Show »
Length:380
Mass (Da):42,748
Checksum:i886503B2EBAFB4AB
GO
Isoform 5L (identifier: P36402-9) [UniParc]FASTAAdd to Basket

Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DNSLHYS

Note: Produced by alternative splicing of isoform 4L.

Show »
Length:365
Mass (Da):39,681
Checksum:iA9CFD9CEC784F0D3
GO
Isoform 5S (identifier: P36402-10) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DNSLHYS

Note: Produced by alternative splicing of isoform 4S.

Show »
Length:250
Mass (Da):28,304
Checksum:iDDB6697E17A5DDAC
GO
Isoform 6L (identifier: P36402-11) [UniParc]FASTAAdd to Basket

Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4L.

Show »
Length:494
Mass (Da):53,969
Checksum:i497A6AF1BCC0E439
GO
Isoform 6S (identifier: P36402-12) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4S.

Show »
Length:379
Mass (Da):42,592
Checksum:i83D3D3CFB783FAAC
GO
Isoform 7L (identifier: P36402-13) [UniParc]FASTAAdd to Basket

Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DGIPACTILSP

Note: Produced by alternative splicing of isoform 4L.

Show »
Length:369
Mass (Da):39,933
Checksum:iB742838D4DCA35EE
GO
Isoform 7S (identifier: P36402-14) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DGIPACTILSP

Note: Produced by alternative splicing of isoform 4S.

Show »
Length:254
Mass (Da):28,556
Checksum:i18750F35A9B3855E
GO
Isoform 8L (identifier: P36402-15) [UniParc]FASTAAdd to Basket

Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → QLEDWDGWARKP

Note: Produced by alternative splicing of isoform 4L.

Show »
Length:370
Mass (Da):40,347
Checksum:i02C826CE6F741E3B
GO
Isoform 8S (identifier: P36402-16) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → QLEDWDGWARKP

Note: Produced by alternative splicing of isoform 4S.

Show »
Length:255
Mass (Da):28,970
Checksum:iF7671142D790678B
GO
Isoform 2L (identifier: P36402-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → GGKRNAFGTYPEKAAAPAPFLPMTVL

Note: Produced by alternative splicing of isoform 4L.

Show »
Length:384
Mass (Da):41,552
Checksum:i004644F8B23D9484
GO
Isoform 2S (identifier: P36402-6) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → GGKRNAFGTYPEKAAAPAPFLPMTVL

Note: Produced by alternative splicing of isoform 4S.

Show »
Length:269
Mass (Da):30,175
Checksum:iF9C06C7EA07E7A13
GO
Isoform 3L (identifier: P36402-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRARFGLNQQTDWCGPCR

Note: Produced by alternative splicing of isoform 4L.

Show »
Length:383
Mass (Da):41,668
Checksum:iD6C1D30018F796DA
GO
Isoform 3S (identifier: P36402-8) [UniParc]FASTAAdd to Basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRARFGLNQQTDWCGPCR

Note: Produced by alternative splicing of isoform 4S.

Show »
Length:268
Mass (Da):30,291
Checksum:i60E955125B190163
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211D → N in AAF00616. (PubMed:10489374)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 115115Missing in isoform 1S, isoform 2S, isoform 3S, isoform 4S, isoform 5S, isoform 6S, isoform 7S and isoform 8S. 2 PublicationsVSP_006961Add
BLAST
Alternative sequencei359 – 38426ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCRRKKKCIRYLPGEGRC PSPVPSDDSALGCPGSPAPQ DSPSYHLLPRFPTELLTSPA ERHLHPQVSPLLSASQPQGP HRPPAAPCRAHRYSNRNLRD RWPSRHRTPGRLQEPTP in isoform 1L and isoform 1S. CuratedVSP_006960Add
BLAST
Alternative sequencei359 – 38426ETNWP…SSSPA → GGKRNAFGTYPEKAAAPAPF LPMTVL in isoform 2L and isoform 2S. 2 PublicationsVSP_002191Add
BLAST
Alternative sequencei359 – 38426ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCR in isoform 3L and isoform 3S. CuratedVSP_002192Add
BLAST
Alternative sequencei359 – 38426ETNWP…SSSPA → DNSLHYS in isoform 5L and isoform 5S. 1 PublicationVSP_012160Add
BLAST
Alternative sequencei359 – 38426ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCRKKKCIRYLPGEGRCP SPVPSDDSALGCPGSPAPQD SPSYHLLPRFPTELLTSPAE RHLHPQVSPLLSASQPQGPH RPPAAPCRAHRYSNRNLRDR WPSRHRTPGRLQEPTP in isoform 6L and isoform 6S. 1 PublicationVSP_012161Add
BLAST
Alternative sequencei359 – 38426ETNWP…SSSPA → DGIPACTILSP in isoform 7L and isoform 7S. 1 PublicationVSP_012162Add
BLAST
Alternative sequencei359 – 38426ETNWP…SSSPA → QLEDWDGWARKP in isoform 8L and isoform 8S. 1 PublicationVSP_012163Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59869 mRNA. Translation: CAA42526.1.
X59870 mRNA. Translation: CAA42527.1.
X59871 mRNA. Translation: CAA42528.1.
X63901 Genomic DNA. Translation: CAB56795.1.
Z47361 mRNA. Translation: CAA87439.1.
Z47362 mRNA. Translation: CAA87440.1.
Z47363 mRNA. Translation: CAA87441.1. Sequence problems.
Z47364 mRNA. Translation: CAA87442.1.
AK093530 mRNA. Translation: BAG52735.1.
CH471062 Genomic DNA. Translation: EAW62277.1.
BC048769 mRNA. Translation: AAH48769.1.
BC072023 mRNA. Translation: AAH72023.1.
AF163776 Genomic DNA. Translation: AAF00616.1.
CCDSiCCDS4169.1. [P36402-5]
CCDS4170.1. [P36402-6]
CCDS43362.1. [P36402-8]
CCDS47263.2. [P36402-2]
PIRiA38095.
B38095.
C38095.
D38095.
S61796.
RefSeqiNP_001128323.2. NM_001134851.2. [P36402-2]
NP_003193.2. NM_003202.3. [P36402-5]
NP_963963.1. NM_201632.3. [P36402-6]
NP_963965.1. NM_201634.3. [P36402-8]
NP_998813.1. NM_213648.3. [P36402-6]
XP_006714746.1. XM_006714683.1. [P36402-1]
XP_006714747.1. XM_006714684.1. [P36402-9]
UniGeneiHs.573153.

Genome annotation databases

EnsembliENST00000342854; ENSP00000340347; ENSG00000081059. [P36402-5]
ENST00000378560; ENSP00000367822; ENSG00000081059. [P36402-8]
ENST00000395023; ENSP00000378469; ENSG00000081059. [P36402-6]
ENST00000518915; ENSP00000430179; ENSG00000081059. [P36402-2]
ENST00000520958; ENSP00000429547; ENSG00000081059. [P36402-6]
GeneIDi6932.
KEGGihsa:6932.
UCSCiuc003kyt.3. human. [P36402-5]
uc003kyu.2. human. [P36402-1]
uc003kyv.3. human. [P36402-8]
uc003kyw.3. human. [P36402-6]
uc003kza.3. human. [P36402-10]

Polymorphism databases

DMDMi209572716.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59869 mRNA. Translation: CAA42526.1 .
X59870 mRNA. Translation: CAA42527.1 .
X59871 mRNA. Translation: CAA42528.1 .
X63901 Genomic DNA. Translation: CAB56795.1 .
Z47361 mRNA. Translation: CAA87439.1 .
Z47362 mRNA. Translation: CAA87440.1 .
Z47363 mRNA. Translation: CAA87441.1 . Sequence problems.
Z47364 mRNA. Translation: CAA87442.1 .
AK093530 mRNA. Translation: BAG52735.1 .
CH471062 Genomic DNA. Translation: EAW62277.1 .
BC048769 mRNA. Translation: AAH48769.1 .
BC072023 mRNA. Translation: AAH72023.1 .
AF163776 Genomic DNA. Translation: AAF00616.1 .
CCDSi CCDS4169.1. [P36402-5 ]
CCDS4170.1. [P36402-6 ]
CCDS43362.1. [P36402-8 ]
CCDS47263.2. [P36402-2 ]
PIRi A38095.
B38095.
C38095.
D38095.
S61796.
RefSeqi NP_001128323.2. NM_001134851.2. [P36402-2 ]
NP_003193.2. NM_003202.3. [P36402-5 ]
NP_963963.1. NM_201632.3. [P36402-6 ]
NP_963965.1. NM_201634.3. [P36402-8 ]
NP_998813.1. NM_213648.3. [P36402-6 ]
XP_006714746.1. XM_006714683.1. [P36402-1 ]
XP_006714747.1. XM_006714684.1. [P36402-9 ]
UniGenei Hs.573153.

3D structure databases

ProteinModelPortali P36402.
SMRi P36402. Positions 2-59, 269-343.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112794. 3 interactions.
IntActi P36402. 3 interactions.
MINTi MINT-1779551.
STRINGi 9606.ENSP00000340347.

Chemistry

BindingDBi P36402.

PTM databases

PhosphoSitei P36402.

Polymorphism databases

DMDMi 209572716.

Proteomic databases

MaxQBi P36402.
PaxDbi P36402.
PRIDEi P36402.

Protocols and materials databases

DNASUi 6932.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342854 ; ENSP00000340347 ; ENSG00000081059 . [P36402-5 ]
ENST00000378560 ; ENSP00000367822 ; ENSG00000081059 . [P36402-8 ]
ENST00000395023 ; ENSP00000378469 ; ENSG00000081059 . [P36402-6 ]
ENST00000518915 ; ENSP00000430179 ; ENSG00000081059 . [P36402-2 ]
ENST00000520958 ; ENSP00000429547 ; ENSG00000081059 . [P36402-6 ]
GeneIDi 6932.
KEGGi hsa:6932.
UCSCi uc003kyt.3. human. [P36402-5 ]
uc003kyu.2. human. [P36402-1 ]
uc003kyv.3. human. [P36402-8 ]
uc003kyw.3. human. [P36402-6 ]
uc003kza.3. human. [P36402-10 ]

Organism-specific databases

CTDi 6932.
GeneCardsi GC05P133478.
HGNCi HGNC:11639. TCF7.
HPAi CAB019403.
MIMi 189908. gene.
neXtProti NX_P36402.
PharmGKBi PA36392.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG252916.
GeneTreei ENSGT00390000009964.
HOGENOMi HOG000116032.
HOVERGENi HBG000419.
InParanoidi P36402.
KOi K02620.
PhylomeDBi P36402.
TreeFami TF318448.

Enzyme and pathway databases

Reactomei REACT_172761. Ca2+ pathway.
REACT_200731. deactivation of the beta-catenin transactivating complex.
REACT_200753. formation of the beta-catenin:TCF transactivating complex.
REACT_200799. binding of TCF/LEF:CTNNB1 to target gene promoters.

Miscellaneous databases

ChiTaRSi TCF7. human.
GeneWikii TCF7.
GenomeRNAii 6932.
NextBioi 27121.
PROi P36402.
SOURCEi Search...

Gene expression databases

Bgeei P36402.
CleanExi HS_TCF7.
ExpressionAtlasi P36402. baseline and differential.
Genevestigatori P36402.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
4.10.900.10. 1 hit.
InterProi IPR027397. Catenin_binding_dom.
IPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR024940. TCF/LEF.
IPR028785. Tcf7.
[Graphical view ]
PANTHERi PTHR10373. PTHR10373. 1 hit.
PTHR10373:SF33. PTHR10373:SF33. 1 hit.
Pfami PF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box."
    van de Wetering M., Oosterwegel M.A., Dooijes D., Clevers H.
    EMBO J. 10:123-132(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4L).
    Tissue: T-cell.
  2. "The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization."
    van de Wetering M., Oosterwegel M.A., Holstege F., Dooyes D., Suijkerbuijk R., Geurts van Kessel A., Clevers H.
    J. Biol. Chem. 267:8530-8536(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
    Tissue: T-cell.
  3. "The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA."
    Mayer K., Wolff E., Clevers H., Ballhausen W.G.
    Biochim. Biophys. Acta 1263:169-172(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5S; 6S; 7S AND 8S).
    Tissue: T-cell lymphoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2S).
    Tissue: Thymus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2L).
    Tissue: Liver and Skin.
  7. "Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1."
    Roose J., Huls G., van Beest M., Moerer P., van der Horn K., Goldschmeding R., Logtenberg T., Clevers H.
    Science 285:1923-1926(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-68 (ISOFORM 4L), TISSUE SPECIFICITY, INDUCTION BY TCF7L2 AND CTNNB1.
  8. "Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties."
    Van de Wetering M., Castrop J., Korinek V., Clevers H.
    Mol. Cell. Biol. 16:745-752(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: UTILIZATION OF AN UPSTREAM PROMOTER, IDENTIFICATION (ISOFORMS 1S AND 4L).
  9. "Two members of the Tcf family implicated in Wnt/b-catenin signaling during embryogenesis in the mouse."
    Korinek V., Barker N., Willert K., Molenaar M., Roose J., Wagenaar G., Markman M., Lamers W., Destree O., Clevers H.
    Mol. Cell. Biol. 18:1248-1256(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTNNB1.
  10. "The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors."
    Roose J., Molenaar M., Peterson J., Hurenkamp J., Brantjes H., Moerer P., van de Wetering M., Destree O., Clevers H.
    Nature 395:608-612(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTNNB1; AES AND TLE4.
  11. "All Tcf HMG box transcription factors interact with Groucho-related co-repressors."
    Brantjes H., Roose J., van De Wetering M., Clevers H.
    Nucleic Acids Res. 29:1410-1419(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AES; TLE1; TLE2; TLE3 AND TLE4.

Entry informationi

Entry nameiTCF7_HUMAN
AccessioniPrimary (citable) accession number: P36402
Secondary accession number(s): B3KSH3, Q86WR9, Q9UKI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 14, 2008
Last modified: October 29, 2014
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3