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Protein

Sex-determining region Y protein

Gene

SRY

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi54 – 12269HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Differentiation, Sexual differentiation, Transcription, Transcription regulation

Keywords - Ligandi

Calmodulin-binding, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sex-determining region Y protein
Alternative name(s):
Testis-determining factor
Gene namesi
Name:SRY
Synonyms:TDF
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

  • Nucleus speckle PROSITE-ProRule annotation
  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Sex-determining region Y proteinPRO_0000048670Add
BLAST

Interactioni

Subunit structurei

Interacts with CALM, EP300, HDAC3, KPNB1, KRAB-O/ZFP748, PARP1, SLC9A3R2 and WT1.By similarity

Structurei

3D structure databases

ProteinModelPortaliP36389.
SMRiP36389. Positions 51-134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SRY family.Curated
Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG008712.
InParanoidiP36389.
KOiK09266.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR017253. SRY.
[Graphical view]
PANTHERiPTHR10270:SF199. PTHR10270:SF199. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFiPIRSF037653. SRY. 1 hit.
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36389-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRVSNSDNY SLAGQQHTVL GSGRTSSLLW TSNPGSHFRS ETRGNGRENG
60 70 80 90 100
QDRVKRPMNA FMVWSRDHRR KVALENPQLQ NSEISKRLGC QWKMLTEAEK
110 120 130 140 150
LPFFEEAQRL RAMHQEKYPD YKYRPRRKAK MPQKSDKPLP QTPLLHCAGR
160 170 180 190 200
RTYTSTSGCP FLIHGRLFLR ATQSQTGGAV KPFAAGATAI SALQQELSQQ
210 220
HRTLRCHSGN VGYADIRRRS LSL
Length:223
Mass (Da):25,353
Last modified:July 15, 1999 - v2
Checksum:i3A5C34F8B272D0ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004572 mRNA. Translation: BAA22428.1.
U66067 Genomic DNA. Translation: AAC10937.1.
Z26908 Genomic DNA. Translation: CAA81534.1.
RefSeqiNP_001075279.1. NM_001081810.1.
UniGeneiEca.12992.

Genome annotation databases

GeneIDi100033824.
KEGGiecb:100033824.

Cross-referencesi

Web resourcesi

Protein Spotlight

The tenuous nature of sex - Issue 80 of March 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004572 mRNA. Translation: BAA22428.1.
U66067 Genomic DNA. Translation: AAC10937.1.
Z26908 Genomic DNA. Translation: CAA81534.1.
RefSeqiNP_001075279.1. NM_001081810.1.
UniGeneiEca.12992.

3D structure databases

ProteinModelPortaliP36389.
SMRiP36389. Positions 51-134.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100033824.
KEGGiecb:100033824.

Organism-specific databases

CTDi6736.

Phylogenomic databases

HOVERGENiHBG008712.
InParanoidiP36389.
KOiK09266.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR017253. SRY.
[Graphical view]
PANTHERiPTHR10270:SF199. PTHR10270:SF199. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFiPIRSF037653. SRY. 1 hit.
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRY_HORSE
AccessioniPrimary (citable) accession number: P36389
Secondary accession number(s): O18729, P79354
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 15, 1999
Last modified: October 14, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.