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Protein

Sex-determining region Y protein

Gene

SRY

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi54 – 122HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Calmodulin-binding, DNA-binding, Repressor
Biological processDifferentiation, Sexual differentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Sex-determining region Y protein
Alternative name(s):
Testis-determining factor
Gene namesi
Name:SRY
Synonyms:TDF
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000486701 – 223Sex-determining region Y proteinAdd BLAST223

Post-translational modificationi

Acetylation of Lys-130 contributes to its nuclear localization and enhances its interaction with KPNB1. Deacetylated by HDAC3.By similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Interacts with CALM, EP300, HDAC3, KPNB1, KRAB-O/ZFP748, PARP1, SLC9A3R2 and WT1.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP36389.
SMRiP36389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SRY family.Curated

Phylogenomic databases

HOVERGENiHBG008712.
InParanoidiP36389.
KOiK09266.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR017253. SRY.
PANTHERiPTHR10270:SF251. PTHR10270:SF251. 1 hit.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PIRSFiPIRSF037653. SRY. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P36389-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRVSNSDNY SLAGQQHTVL GSGRTSSLLW TSNPGSHFRS ETRGNGRENG
60 70 80 90 100
QDRVKRPMNA FMVWSRDHRR KVALENPQLQ NSEISKRLGC QWKMLTEAEK
110 120 130 140 150
LPFFEEAQRL RAMHQEKYPD YKYRPRRKAK MPQKSDKPLP QTPLLHCAGR
160 170 180 190 200
RTYTSTSGCP FLIHGRLFLR ATQSQTGGAV KPFAAGATAI SALQQELSQQ
210 220
HRTLRCHSGN VGYADIRRRS LSL
Length:223
Mass (Da):25,353
Last modified:July 15, 1999 - v2
Checksum:i3A5C34F8B272D0ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004572 mRNA. Translation: BAA22428.1.
U66067 Genomic DNA. Translation: AAC10937.1.
Z26908 Genomic DNA. Translation: CAA81534.1.
RefSeqiNP_001075279.1. NM_001081810.1.
UniGeneiEca.12992.

Genome annotation databases

GeneIDi100033824.
KEGGiecb:100033824.

Similar proteinsi

Entry informationi

Entry nameiSRY_HORSE
AccessioniPrimary (citable) accession number: P36389
Secondary accession number(s): O18729, P79354
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 15, 1999
Last modified: August 30, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families