ID   CXG1_HUMAN              Reviewed;         396 AA.
AC   P36383; B3KW68; Q4VAY0;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 2.
DT   03-NOV-2009, entry version 85.
DE   RecName: Full=Gap junction gamma-1 protein;
DE   AltName: Full=Gap junction alpha-7 protein;
DE   AltName: Full=Connexin-45;
DE            Short=Cx45;
GN   Name=GJC1; Synonyms=GJA7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=95055780; PubMed=7966354; DOI=10.1006/jmcc.1994.1103;
RA   Kanter H.L., Saffitz J.E., Beyer E.C.;
RT   "Molecular cloning of two human cardiac gap junction proteins,
RT   connexin40 and connexin45.";
RL   J. Mol. Cell. Cardiol. 26:861-868(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which
CC       materials of low MW diffuse from one cell to a neighboring cell.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC       Cell junction, gap junction.
CC   -!- SIMILARITY: Belongs to the connexin family. Gamma-type subfamily.
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DR   EMBL; U03493; AAA60458.1; -; Genomic_DNA.
DR   EMBL; AK124339; BAG54030.1; -; mRNA.
DR   EMBL; AC005180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC096213; AAH96213.1; -; mRNA.
DR   EMBL; BC096214; AAH96214.1; -; mRNA.
DR   EMBL; BC096215; AAH96215.1; -; mRNA.
DR   EMBL; BC096216; AAH96216.1; -; mRNA.
DR   IPI; IPI00002946; -.
DR   PIR; I38430; I38430.
DR   RefSeq; NP_001073852.1; -.
DR   RefSeq; NP_005488.2; -.
DR   UniGene; Hs.532593; -.
DR   UniGene; Hs.712052; -.
DR   STRING; P36383; -.
DR   PhosphoSite; P36383; -.
DR   PRIDE; P36383; -.
DR   Ensembl; ENST00000330514; ENSP00000333193; ENSG00000182963; Homo sapiens.
DR   Ensembl; ENST00000426548; ENSP00000411528; ENSG00000182963; Homo sapiens.
DR   GeneID; 10052; -.
DR   KEGG; hsa:10052; -.
DR   CTD; 10052; -.
DR   GeneCards; GC17M040237; -.
DR   HGNC; HGNC:4280; GJC1.
DR   MIM; 608655; gene.
DR   PharmGKB; PA28691; -.
DR   HOGENOM; P36383; -.
DR   HOVERGEN; P36383; -.
DR   OMA; SHEEHLP; -.
DR   Reactome; REACT_13685; Synaptic Transmission.
DR   Reactome; REACT_9480; Gap junction trafficking and regulation.
DR   Reactome; REACT_9492; Synthesis of Cx45.
DR   NextBio; 37975; -.
DR   ArrayExpress; P36383; -.
DR   Bgee; P36383; -.
DR   CleanEx; HS_GJC1; -.
DR   Genevestigator; P36383; -.
DR   GermOnline; ENSG00000182963; Homo sapiens.
DR   GO; GO:0005922; C:connexon complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007043; P:cell-cell junction assembly; TAS:ProtInc.
DR   GO; GO:0006936; P:muscle contraction; TAS:ProtInc.
DR   GO; GO:0006810; P:transport; NAS:ProtInc.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR002265; Connexin45.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR017991; connexins_rgn.
DR   PANTHER; PTHR11984; Connexin; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   Pfam; PF10582; Connexin_CCC; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   PRINTS; PR01136; CONNEXINA6.
DR   SMART; SM00037; CNX; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Complete proteome; Gap junction;
KW   Membrane; Transmembrane.
FT   CHAIN         1    396       Gap junction gamma-1 protein.
FT                                /FTId=PRO_0000057826.
FT   TOPO_DOM      1     22       Cytoplasmic (Potential).
FT   TRANSMEM     23     45       Potential.
FT   TOPO_DOM     46     75       Extracellular (Potential).
FT   TRANSMEM     76     95       Potential.
FT   TOPO_DOM     96    175       Cytoplasmic (Potential).
FT   TRANSMEM    176    198       Potential.
FT   TOPO_DOM    199    228       Extracellular (Potential).
FT   TRANSMEM    229    248       Potential.
FT   TOPO_DOM    249    396       Cytoplasmic (Potential).
FT   CONFLICT    382    382       T -> A (in Ref. 2; BAG54030).
FT   CONFLICT    392    392       T -> N (in Ref. 1; AAA60458 and 4;
FT                                AAH96213/AAH96214/AAH96215/AAH96216).
SQ   SEQUENCE   396 AA;  45470 MW;  C9F67C1D926D40DF CRC64;
     MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK FVCNTEQPGC
     ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA KMEHGEADKK AARSKPYAMR
     WKQHRALEET EEDNEEDPMM YPEMELESDK ENKEQSQPKP KHDGRRRIRE DGLMKIYVLQ
     LLARTVFEVG FLIGQYFLYG FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG
     LCLLLNIWEM LHLGFGTIRD SLNSKRRELE DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ
     YTELSNAKIA YKQNKANTAQ EQQYGSHEEN LPADLEALQR EIRMAQERLD LAVQAYSHQN
     NPHGPREKKA KVGSKAGSNK STASSKSGDG KTSVWI
//