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P36383

- CXG1_HUMAN

UniProt

P36383 - CXG1_HUMAN

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Protein

Gap junction gamma-1 protein

Gene

GJC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  1. gap junction channel activity Source: Ensembl
  2. ion channel activity Source: Ensembl

GO - Biological processi

  1. atrial cardiac muscle cell action potential Source: BHF-UCL
  2. cardiac muscle tissue development Source: Ensembl
  3. cell-cell junction assembly Source: ProtInc
  4. cell development Source: Ensembl
  5. gap junction assembly Source: Reactome
  6. membrane organization Source: Reactome
  7. muscle contraction Source: ProtInc
  8. synaptic transmission Source: Reactome
  9. transport Source: ProtInc
  10. vasculogenesis Source: Ensembl
  11. visual perception Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_16970. Electric Transmission Across Gap Junctions.
REACT_9509. Gap junction assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-1 protein
Alternative name(s):
Connexin-45
Short name:
Cx45
Gap junction alpha-7 protein
Gene namesi
Name:GJC1
Synonyms:GJA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:4280. GJC1.

Subcellular locationi

GO - Cellular componenti

  1. connexon complex Source: Ensembl
  2. endoplasmic reticulum membrane Source: Reactome
  3. gap junction Source: ProtInc
  4. integral component of membrane Source: UniProtKB-KW
  5. intercalated disc Source: BHF-UCL
  6. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164741588.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Gap junction gamma-1 proteinPRO_0000057826Add
BLAST

Proteomic databases

MaxQBiP36383.
PaxDbiP36383.
PRIDEiP36383.

PTM databases

PhosphoSiteiP36383.

Expressioni

Gene expression databases

BgeeiP36383.
CleanExiHS_GJC1.
ExpressionAtlasiP36383. baseline and differential.
GenevestigatoriP36383.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST By similarity.By similarity

Protein-protein interaction databases

BioGridi115363. 6 interactions.
STRINGi9606.ENSP00000333193.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3SHWX-ray2.90B387-396[»]
ProteinModelPortaliP36383.
SMRiP36383. Positions 3-253.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini46 – 7530ExtracellularSequence AnalysisAdd
BLAST
Topological domaini96 – 17580CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini199 – 22830ExtracellularSequence AnalysisAdd
BLAST
Topological domaini249 – 396148CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4523HelicalSequence AnalysisAdd
BLAST
Transmembranei76 – 9520HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19823HelicalSequence AnalysisAdd
BLAST
Transmembranei229 – 24820HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44555.
GeneTreeiENSGT00760000118780.
HOGENOMiHOG000231126.
HOVERGENiHBG009576.
InParanoidiP36383.
KOiK07616.
OMAiRWKQHRG.
PhylomeDBiP36383.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002265. Connexin45.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01136. CONNEXINA6.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36383-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK
60 70 80 90 100
FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA
110 120 130 140 150
KMEHGEADKK AARSKPYAMR WKQHRALEET EEDNEEDPMM YPEMELESDK
160 170 180 190 200
ENKEQSQPKP KHDGRRRIRE DGLMKIYVLQ LLARTVFEVG FLIGQYFLYG
210 220 230 240 250
FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG LCLLLNIWEM
260 270 280 290 300
LHLGFGTIRD SLNSKRRELE DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ
310 320 330 340 350
YTELSNAKIA YKQNKANTAQ EQQYGSHEEN LPADLEALQR EIRMAQERLD
360 370 380 390
LAVQAYSHQN NPHGPREKKA KVGSKAGSNK STASSKSGDG KTSVWI
Length:396
Mass (Da):45,470
Last modified:April 14, 2009 - v2
Checksum:iC9F67C1D926D40DF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti382 – 3821T → A in BAG54030. (PubMed:14702039)Curated
Sequence conflicti392 – 3921T → N in AAA60458. (PubMed:7966354)Curated
Sequence conflicti392 – 3921T → N in AAH96213. (PubMed:15489334)Curated
Sequence conflicti392 – 3921T → N in AAH96214. (PubMed:15489334)Curated
Sequence conflicti392 – 3921T → N in AAH96215. (PubMed:15489334)Curated
Sequence conflicti392 – 3921T → N in AAH96216. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03493 Genomic DNA. Translation: AAA60458.1.
AK124339 mRNA. Translation: BAG54030.1.
AC005180 Genomic DNA. No translation available.
BC096213 mRNA. Translation: AAH96213.1.
BC096214 mRNA. Translation: AAH96214.1.
BC096215 mRNA. Translation: AAH96215.1.
BC096216 mRNA. Translation: AAH96216.1.
CCDSiCCDS11487.1.
PIRiI38430.
RefSeqiNP_001073852.1. NM_001080383.1.
NP_005488.2. NM_005497.3.
XP_005256977.1. XM_005256920.1.
XP_005256978.1. XM_005256921.1.
UniGeneiHs.712052.
Hs.744748.

Genome annotation databases

GeneIDi10052.
KEGGihsa:10052.
UCSCiuc002ihj.3. human.

Polymorphism databases

DMDMi226693517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03493 Genomic DNA. Translation: AAA60458.1 .
AK124339 mRNA. Translation: BAG54030.1 .
AC005180 Genomic DNA. No translation available.
BC096213 mRNA. Translation: AAH96213.1 .
BC096214 mRNA. Translation: AAH96214.1 .
BC096215 mRNA. Translation: AAH96215.1 .
BC096216 mRNA. Translation: AAH96216.1 .
CCDSi CCDS11487.1.
PIRi I38430.
RefSeqi NP_001073852.1. NM_001080383.1.
NP_005488.2. NM_005497.3.
XP_005256977.1. XM_005256920.1.
XP_005256978.1. XM_005256921.1.
UniGenei Hs.712052.
Hs.744748.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3SHW X-ray 2.90 B 387-396 [» ]
ProteinModelPortali P36383.
SMRi P36383. Positions 3-253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115363. 6 interactions.
STRINGi 9606.ENSP00000333193.

Chemistry

GuidetoPHARMACOLOGYi 729.

PTM databases

PhosphoSitei P36383.

Polymorphism databases

DMDMi 226693517.

Proteomic databases

MaxQBi P36383.
PaxDbi P36383.
PRIDEi P36383.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 10052.
KEGGi hsa:10052.
UCSCi uc002ihj.3. human.

Organism-specific databases

CTDi 10052.
GeneCardsi GC17M042875.
HGNCi HGNC:4280. GJC1.
MIMi 608655. gene.
neXtProti NX_P36383.
PharmGKBi PA164741588.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44555.
GeneTreei ENSGT00760000118780.
HOGENOMi HOG000231126.
HOVERGENi HBG009576.
InParanoidi P36383.
KOi K07616.
OMAi RWKQHRG.
PhylomeDBi P36383.
TreeFami TF329606.

Enzyme and pathway databases

Reactomei REACT_16970. Electric Transmission Across Gap Junctions.
REACT_9509. Gap junction assembly.

Miscellaneous databases

ChiTaRSi GJC1. human.
GeneWikii GJC1.
GenomeRNAii 10052.
NextBioi 37975.
PROi P36383.
SOURCEi Search...

Gene expression databases

Bgeei P36383.
CleanExi HS_GJC1.
ExpressionAtlasi P36383. baseline and differential.
Genevestigatori P36383.

Family and domain databases

InterProi IPR000500. Connexin.
IPR002265. Connexin45.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
PR01136. CONNEXINA6.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45."
    Kanter H.L., Saffitz J.E., Beyer E.C.
    J. Mol. Cell. Cardiol. 26:861-868(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCXG1_HUMAN
AccessioniPrimary (citable) accession number: P36383
Secondary accession number(s): B3KW68, Q4VAY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 14, 2009
Last modified: October 29, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3