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P36383

- CXG1_HUMAN

UniProt

P36383 - CXG1_HUMAN

Protein

Gap junction gamma-1 protein

Gene

GJC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (14 Apr 2009)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

    GO - Molecular functioni

    1. gap junction channel activity Source: Ensembl
    2. ion channel activity Source: Ensembl

    GO - Biological processi

    1. atrial cardiac muscle cell action potential Source: BHF-UCL
    2. cardiac muscle tissue development Source: Ensembl
    3. cell-cell junction assembly Source: ProtInc
    4. cell development Source: Ensembl
    5. gap junction assembly Source: Reactome
    6. membrane organization Source: Reactome
    7. muscle contraction Source: ProtInc
    8. synaptic transmission Source: Reactome
    9. transport Source: ProtInc
    10. vasculogenesis Source: Ensembl
    11. visual perception Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_16970. Electric Transmission Across Gap Junctions.
    REACT_9509. Gap junction assembly.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction gamma-1 protein
    Alternative name(s):
    Connexin-45
    Short name:
    Cx45
    Gap junction alpha-7 protein
    Gene namesi
    Name:GJC1
    Synonyms:GJA7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:4280. GJC1.

    Subcellular locationi

    GO - Cellular componenti

    1. connexon complex Source: Ensembl
    2. endoplasmic reticulum membrane Source: Reactome
    3. gap junction Source: ProtInc
    4. integral component of membrane Source: UniProtKB-KW
    5. intercalated disc Source: BHF-UCL
    6. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164741588.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Gap junction gamma-1 proteinPRO_0000057826Add
    BLAST

    Proteomic databases

    MaxQBiP36383.
    PaxDbiP36383.
    PRIDEiP36383.

    PTM databases

    PhosphoSiteiP36383.

    Expressioni

    Gene expression databases

    ArrayExpressiP36383.
    BgeeiP36383.
    CleanExiHS_GJC1.
    GenevestigatoriP36383.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins. Interacts with CNST By similarity.By similarity

    Protein-protein interaction databases

    BioGridi115363. 2 interactions.
    STRINGi9606.ENSP00000333193.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3SHWX-ray2.90B387-396[»]
    ProteinModelPortaliP36383.
    SMRiP36383. Positions 3-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini46 – 7530ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini96 – 17580CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini199 – 22830ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini249 – 396148CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24820HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the connexin family. Gamma-type subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44555.
    HOGENOMiHOG000231126.
    HOVERGENiHBG009576.
    InParanoidiP36383.
    KOiK07616.
    OMAiRWKQHRG.
    PhylomeDBiP36383.
    TreeFamiTF329606.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR002265. Connexin45.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    PR01136. CONNEXINA6.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36383-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK    50
    FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA 100
    KMEHGEADKK AARSKPYAMR WKQHRALEET EEDNEEDPMM YPEMELESDK 150
    ENKEQSQPKP KHDGRRRIRE DGLMKIYVLQ LLARTVFEVG FLIGQYFLYG 200
    FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG LCLLLNIWEM 250
    LHLGFGTIRD SLNSKRRELE DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ 300
    YTELSNAKIA YKQNKANTAQ EQQYGSHEEN LPADLEALQR EIRMAQERLD 350
    LAVQAYSHQN NPHGPREKKA KVGSKAGSNK STASSKSGDG KTSVWI 396
    Length:396
    Mass (Da):45,470
    Last modified:April 14, 2009 - v2
    Checksum:iC9F67C1D926D40DF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti382 – 3821T → A in BAG54030. (PubMed:14702039)Curated
    Sequence conflicti392 – 3921T → N in AAA60458. (PubMed:7966354)Curated
    Sequence conflicti392 – 3921T → N in AAH96213. (PubMed:15489334)Curated
    Sequence conflicti392 – 3921T → N in AAH96214. (PubMed:15489334)Curated
    Sequence conflicti392 – 3921T → N in AAH96215. (PubMed:15489334)Curated
    Sequence conflicti392 – 3921T → N in AAH96216. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03493 Genomic DNA. Translation: AAA60458.1.
    AK124339 mRNA. Translation: BAG54030.1.
    AC005180 Genomic DNA. No translation available.
    BC096213 mRNA. Translation: AAH96213.1.
    BC096214 mRNA. Translation: AAH96214.1.
    BC096215 mRNA. Translation: AAH96215.1.
    BC096216 mRNA. Translation: AAH96216.1.
    CCDSiCCDS11487.1.
    PIRiI38430.
    RefSeqiNP_001073852.1. NM_001080383.1.
    NP_005488.2. NM_005497.3.
    XP_005256977.1. XM_005256920.1.
    XP_005256978.1. XM_005256921.1.
    UniGeneiHs.712052.
    Hs.744748.

    Genome annotation databases

    GeneIDi10052.
    KEGGihsa:10052.
    UCSCiuc002ihj.3. human.

    Polymorphism databases

    DMDMi226693517.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03493 Genomic DNA. Translation: AAA60458.1 .
    AK124339 mRNA. Translation: BAG54030.1 .
    AC005180 Genomic DNA. No translation available.
    BC096213 mRNA. Translation: AAH96213.1 .
    BC096214 mRNA. Translation: AAH96214.1 .
    BC096215 mRNA. Translation: AAH96215.1 .
    BC096216 mRNA. Translation: AAH96216.1 .
    CCDSi CCDS11487.1.
    PIRi I38430.
    RefSeqi NP_001073852.1. NM_001080383.1.
    NP_005488.2. NM_005497.3.
    XP_005256977.1. XM_005256920.1.
    XP_005256978.1. XM_005256921.1.
    UniGenei Hs.712052.
    Hs.744748.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3SHW X-ray 2.90 B 387-396 [» ]
    ProteinModelPortali P36383.
    SMRi P36383. Positions 3-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115363. 2 interactions.
    STRINGi 9606.ENSP00000333193.

    Chemistry

    GuidetoPHARMACOLOGYi 729.

    PTM databases

    PhosphoSitei P36383.

    Polymorphism databases

    DMDMi 226693517.

    Proteomic databases

    MaxQBi P36383.
    PaxDbi P36383.
    PRIDEi P36383.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 10052.
    KEGGi hsa:10052.
    UCSCi uc002ihj.3. human.

    Organism-specific databases

    CTDi 10052.
    GeneCardsi GC17M042875.
    HGNCi HGNC:4280. GJC1.
    MIMi 608655. gene.
    neXtProti NX_P36383.
    PharmGKBi PA164741588.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44555.
    HOGENOMi HOG000231126.
    HOVERGENi HBG009576.
    InParanoidi P36383.
    KOi K07616.
    OMAi RWKQHRG.
    PhylomeDBi P36383.
    TreeFami TF329606.

    Enzyme and pathway databases

    Reactomei REACT_16970. Electric Transmission Across Gap Junctions.
    REACT_9509. Gap junction assembly.

    Miscellaneous databases

    ChiTaRSi GJC1. human.
    GeneWikii GJC1.
    GenomeRNAii 10052.
    NextBioi 37975.
    PROi P36383.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P36383.
    Bgeei P36383.
    CleanExi HS_GJC1.
    Genevestigatori P36383.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR002265. Connexin45.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    PR01136. CONNEXINA6.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45."
      Kanter H.L., Saffitz J.E., Beyer E.C.
      J. Mol. Cell. Cardiol. 26:861-868(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCXG1_HUMAN
    AccessioniPrimary (citable) accession number: P36383
    Secondary accession number(s): B3KW68, Q4VAY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3