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P36383 (CXG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction gamma-1 protein
Alternative name(s):
Connexin-45
Short name=Cx45
Gap junction alpha-7 protein
Gene names
Name:GJC1
Synonyms:GJA7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subunit structure

A connexon is composed of a hexamer of connexins. Interacts with CNST By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctiongap junction.

Sequence similarities

Belongs to the connexin family. Gamma-type subfamily.

Ontologies

Keywords
   Cellular componentCell junction
Cell membrane
Gap junction
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processatrial cardiac muscle cell action potential

Traceable author statement PubMed 23348765. Source: BHF-UCL

cardiac muscle tissue development

Inferred from electronic annotation. Source: Ensembl

cell development

Inferred from electronic annotation. Source: Ensembl

gap junction assembly

Traceable author statement. Source: Reactome

ion transmembrane transport

Inferred from electronic annotation. Source: GOC

muscle contraction

Traceable author statement Ref.1. Source: ProtInc

synaptic transmission

Traceable author statement. Source: Reactome

vasculogenesis

Inferred from electronic annotation. Source: Ensembl

visual perception

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentconnexon complex

Inferred from electronic annotation. Source: Ensembl

endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

gap junction

Traceable author statement Ref.1. Source: ProtInc

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

intercalated disc

Traceable author statement PubMed 23348765. Source: BHF-UCL

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functiongap junction channel activity

Inferred from electronic annotation. Source: Ensembl

ion channel activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396Gap junction gamma-1 protein
PRO_0000057826

Regions

Topological domain1 – 2222Cytoplasmic Potential
Transmembrane23 – 4523Helical; Potential
Topological domain46 – 7530Extracellular Potential
Transmembrane76 – 9520Helical; Potential
Topological domain96 – 17580Cytoplasmic Potential
Transmembrane176 – 19823Helical; Potential
Topological domain199 – 22830Extracellular Potential
Transmembrane229 – 24820Helical; Potential
Topological domain249 – 396148Cytoplasmic Potential

Experimental info

Sequence conflict3821T → A in BAG54030. Ref.2
Sequence conflict3921T → N in AAA60458. Ref.1
Sequence conflict3921T → N in AAH96213. Ref.4
Sequence conflict3921T → N in AAH96214. Ref.4
Sequence conflict3921T → N in AAH96215. Ref.4
Sequence conflict3921T → N in AAH96216. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P36383 [UniParc].

Last modified April 14, 2009. Version 2.
Checksum: C9F67C1D926D40DF

FASTA39645,470
        10         20         30         40         50         60 
MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK FVCNTEQPGC 

        70         80         90        100        110        120 
ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA KMEHGEADKK AARSKPYAMR 

       130        140        150        160        170        180 
WKQHRALEET EEDNEEDPMM YPEMELESDK ENKEQSQPKP KHDGRRRIRE DGLMKIYVLQ 

       190        200        210        220        230        240 
LLARTVFEVG FLIGQYFLYG FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG 

       250        260        270        280        290        300 
LCLLLNIWEM LHLGFGTIRD SLNSKRRELE DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ 

       310        320        330        340        350        360 
YTELSNAKIA YKQNKANTAQ EQQYGSHEEN LPADLEALQR EIRMAQERLD LAVQAYSHQN 

       370        380        390 
NPHGPREKKA KVGSKAGSNK STASSKSGDG KTSVWI 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45."
Kanter H.L., Saffitz J.E., Beyer E.C.
J. Mol. Cell. Cardiol. 26:861-868(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U03493 Genomic DNA. Translation: AAA60458.1.
AK124339 mRNA. Translation: BAG54030.1.
AC005180 Genomic DNA. No translation available.
BC096213 mRNA. Translation: AAH96213.1.
BC096214 mRNA. Translation: AAH96214.1.
BC096215 mRNA. Translation: AAH96215.1.
BC096216 mRNA. Translation: AAH96216.1.
PIRI38430.
RefSeqNP_001073852.1. NM_001080383.1.
NP_005488.2. NM_005497.3.
XP_005256977.1. XM_005256920.1.
XP_005256978.1. XM_005256921.1.
UniGeneHs.712052.
Hs.744748.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3SHWX-ray2.90B387-396[»]
ProteinModelPortalP36383.
SMRP36383. Positions 3-253, 272-383.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115363. 2 interactions.
STRING9606.ENSP00000333193.

Chemistry

GuidetoPHARMACOLOGY729.

PTM databases

PhosphoSiteP36383.

Polymorphism databases

DMDM226693517.

Proteomic databases

PaxDbP36383.
PRIDEP36383.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000330514; ENSP00000333193; ENSG00000182963.
ENST00000426548; ENSP00000411528; ENSG00000182963.
ENST00000590758; ENSP00000466339; ENSG00000182963.
ENST00000592524; ENSP00000467201; ENSG00000182963.
GeneID10052.
KEGGhsa:10052.
UCSCuc002ihj.3. human.

Organism-specific databases

CTD10052.
GeneCardsGC17M042875.
HGNCHGNC:4280. GJC1.
MIM608655. gene.
neXtProtNX_P36383.
PharmGKBPA164741588.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44555.
HOGENOMHOG000231126.
HOVERGENHBG009576.
InParanoidP36383.
KOK07616.
OMARWKQHRG.
PhylomeDBP36383.
TreeFamTF329606.

Enzyme and pathway databases

ReactomeREACT_11123. Membrane Trafficking.
REACT_13685. Neuronal System.

Gene expression databases

ArrayExpressP36383.
BgeeP36383.
CleanExHS_GJC1.
GenevestigatorP36383.

Family and domain databases

InterProIPR000500. Connexin.
IPR002265. Connexin45.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSPR00206. CONNEXIN.
PR01136. CONNEXINA6.
SMARTSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGJC1. human.
GeneWikiGJC1.
GenomeRNAi10052.
NextBio37975.
PROP36383.
SOURCESearch...

Entry information

Entry nameCXG1_HUMAN
AccessionPrimary (citable) accession number: P36383
Secondary accession number(s): B3KW68, Q4VAY0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 14, 2009
Last modified: March 19, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM