Reviewed,
UniProtKB/Swiss-Prot P36383 (CXG1_HUMAN)
Last modified
June 16, 2009.
Version 80.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Gap junction gamma-1 protein Alternative name(s): Gap junction alpha-7 protein Connexin-45 Short name=Cx45 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 396 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
| Subunit structure | A connexon is composed of a hexamer of connexins. |
| Subcellular location | Cell membrane; Multi-pass membrane protein. Cell junction › gap junction. |
| Sequence similarities | Belongs to the connexin family. Gamma-type subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell junction Cell membrane Gap junction Membrane |
| Domain | Transmembrane |
| Gene Ontology (GO) | |
| Biological process | cell-cell junction assembly Ref.1 Traceable author statement. Source: ProtInc muscle contraction Ref.1Traceable author statement. Source: ProtInc transport Ref.1Non-traceable author statement. Source: ProtInc |
| Cellular component | connexon complex Inferred from electronic annotation. Source: InterPro integral to membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 396 | 396 | Gap junction gamma-1 protein | PRO_0000057826 | |||||
Regions | |||||||||
| Topological domain | 1 – 22 | 22 | Cytoplasmic Potential | ||||||
| Transmembrane | 23 – 45 | 23 | Potential | ||||||
| Topological domain | 46 – 75 | 30 | Extracellular Potential | ||||||
| Transmembrane | 76 – 95 | 20 | Potential | ||||||
| Topological domain | 96 – 175 | 80 | Cytoplasmic Potential | ||||||
| Transmembrane | 176 – 198 | 23 | Potential | ||||||
| Topological domain | 199 – 228 | 30 | Extracellular Potential | ||||||
| Transmembrane | 229 – 248 | 20 | Potential | ||||||
| Topological domain | 249 – 396 | 148 | Cytoplasmic Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 382 | 1 | T → A in BAG54030. Ref.2 | ||||||
| Sequence conflict | 392 | 1 | T → N in AAA60458. Ref.1 | ||||||
| Sequence conflict | 392 | 1 | T → N in AAH96213. Ref.4 | ||||||
| Sequence conflict | 392 | 1 | T → N in AAH96214. Ref.4 | ||||||
| Sequence conflict | 392 | 1 | T → N in AAH96215. Ref.4 | ||||||
| Sequence conflict | 392 | 1 | T → N in AAH96216. Ref.4 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| U03493 Genomic DNA. Translation: AAA60458.1. AK124339 mRNA. Translation: BAG54030.1. AC005180 Genomic DNA. No translation available. BC096213 mRNA. Translation: AAH96213.1. BC096214 mRNA. Translation: AAH96214.1. BC096215 mRNA. Translation: AAH96215.1. BC096216 mRNA. Translation: AAH96216.1. | |
| IPI | IPI00002946. |
| PIR | I38430. |
| RefSeq | NP_001073852.1. NP_005488.2. |
| UniGene | Hs.532593 Hs.712052 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P36383. |
Proteomic databases | |
| PRIDE | P36383. |
Genome annotation databases | |
| Ensembl | ENSG00000182963. Homo sapiens. [Contig view] |
| GeneID | 10052. |
| KEGG | hsa:10052. |
Organism-specific databases | |
| GeneCards | GC17M040237. |
| HGNC | HGNC:4280. GJC1. |
| MIM | 608655. gene. |
| PharmGKB | PA28691. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P36383. |
| HOVERGEN | P36383. |
| OMA | P36383. SHEEHLP. |
Enzyme and pathway databases | |
| Reactome | REACT_9480. Gap junction trafficking and regulation. REACT_9492. Synthesis of Cx45. |
Gene expression databases | |
| ArrayExpress | P36383. |
| Bgee | P36383. |
| CleanEx | HS_GJC1. |
| GermOnline | ENSG00000182963. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000500. Connexin. IPR002265. Connexin45. IPR019570. Connexin_CCC. IPR017990. Connexin_CS. IPR013092. Connexin_N. IPR017991. connexins_rgn. [Graphical view] |
| PANTHER | PTHR11984. Connexin. 1 hit. |
| Pfam | PF00029. Connexin. 1 hit. PF10582. Connexin_CCC. 1 hit. [Graphical view] |
| PRINTS | PR00206. CONNEXIN. PR01136. CONNEXINA6. |
| SMART | SM00037. CNX. 1 hit. [Graphical view] |
| PROSITE | PS00407. CONNEXINS_1. 1 hit. PS00408. CONNEXINS_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 37975. |
| SOURCE | Search... |
Entry information
| Entry name | CXG1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P36383 Secondary accession number(s): B3KW68, Q4VAY0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


