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Protein

Gap junction beta-4 protein

Gene

Gjb4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-4 protein
Alternative name(s):
Connexin-30.3
Short name:
Cx30.3
Gene namesi
Name:Gjb4
Synonyms:Cxn-30.3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621829. Gjb4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence analysisAdd
BLAST
Transmembranei21 – 4020HelicalSequence analysisAdd
BLAST
Topological domaini41 – 7535ExtracellularSequence analysisAdd
BLAST
Transmembranei76 – 9823HelicalSequence analysisAdd
BLAST
Topological domaini99 – 12628CytoplasmicSequence analysisAdd
BLAST
Transmembranei127 – 14923HelicalSequence analysisAdd
BLAST
Topological domaini150 – 18738ExtracellularSequence analysisAdd
BLAST
Transmembranei188 – 21023HelicalSequence analysisAdd
BLAST
Topological domaini211 – 26555CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Gap junction beta-4 proteinPRO_0000057867Add
BLAST

Proteomic databases

PaxDbiP36380.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033893.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE21. Eukaryota.
ENOG410Y9C2. LUCA.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP36380.
KOiK07623.
PhylomeDBiP36380.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002270. Connexin311.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF30. PTHR11984:SF30. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01142. CONNEXINB5.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWGFLQGIL SGVNKYSTAL GRIWLSVVFI FRVLVYVVAA EEVWDDEQKD
60 70 80 90 100
FICNTKQPGC PNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYREE
110 120 130 140 150
RERKHRLKHG PDAPALYSNL SKKRGGLWWT YLLSLIFKAA VDSGFLYIFH
160 170 180 190 200
CIYKDYDMPR VVACSVQPCP HTVDCYISRP TEKKVFTYFM VVTAAICILL
210 220 230 240 250
NLSEVAYLVG KRCMEVFRPR RQKTSRRHQL PDTCPPYVIS KGHPQDESTV
260
LTKAGMATVD AGVYP
Length:265
Mass (Da):30,352
Last modified:June 1, 1994 - v1
Checksum:iF7DA69C513093147
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76168 mRNA. Translation: CAA53762.1.
PIRiI60240. S38891.
RefSeqiNP_446436.1. NM_053984.2.
UniGeneiRn.10344.

Genome annotation databases

GeneIDi117055.
KEGGirno:117055.
UCSCiRGD:621829. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76168 mRNA. Translation: CAA53762.1.
PIRiI60240. S38891.
RefSeqiNP_446436.1. NM_053984.2.
UniGeneiRn.10344.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033893.

Proteomic databases

PaxDbiP36380.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117055.
KEGGirno:117055.
UCSCiRGD:621829. rat.

Organism-specific databases

CTDi127534.
RGDi621829. Gjb4.

Phylogenomic databases

eggNOGiENOG410IE21. Eukaryota.
ENOG410Y9C2. LUCA.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP36380.
KOiK07623.
PhylomeDBiP36380.

Miscellaneous databases

NextBioi619895.
PROiP36380.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002270. Connexin311.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF30. PTHR11984:SF30. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01142. CONNEXINB5.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat connexins 30.3 and 31 are expressed in the kidney."
    Tucker M.A., Barajas L.
    Exp. Cell Res. 213:224-230(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiCXB4_RAT
AccessioniPrimary (citable) accession number: P36380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 11, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.