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P36374 (KLK6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prostatic glandular kallikrein-6

EC=3.4.21.35
Alternative name(s):
Glandular kallikrein-8
Short name=rGK-8
P1 kallikrein
Tissue kallikrein
Gene names
Name:Klk6
Synonyms:Klk-8, Klk8
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activity

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Contains 1 peptidase S1 domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Probable
Propeptide19 – 246Activation peptide Probable
PRO_0000028007
Chain25 – 261237Prostatic glandular kallikrein-6
PRO_0000028008

Regions

Domain25 – 258234Peptidase S1

Sites

Active site651Charge relay system
Active site1201Charge relay system
Active site2131Charge relay system

Amino acid modifications

Glycosylation1081N-linked (GlcNAc...) Potential
Disulfide bond31 ↔ 173 By similarity
Disulfide bond50 ↔ 66 By similarity
Disulfide bond152 ↔ 219 By similarity
Disulfide bond184 ↔ 198 By similarity
Disulfide bond209 ↔ 234 By similarity

Sequences

Sequence LengthMass (Da)Tools
P36374 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: CA8F12151B04E337

FASTA26129,013
        10         20         30         40         50         60 
MWLLILFLIL SLGWNDAAPP GQSRIIGGFN CEKNSQPWQV AVYHFNEPQC GGVLIHPSWV 

        70         80         90        100        110        120 
ITAAHCYSVN YQVWLGRNNL LEDEPFAQHR LVSQSFPHPG FNLDIIKNHT RKPGNDYSND 

       130        140        150        160        170        180 
LMLLHLKTPA DITDGVKVID LPTEEPKVGS TCLTSGWGSI TPLKWEFPDD LQCVNIHLLS 

       190        200        210        220        230        240 
NEKCIKAYND EVTDVMLCAG EMDGGKDICK GDSGGPLICD GVLQGITSWG SMPCGEPNKP 

       250        260 
SVYTKLIKFT SWMKKVMKEN P 

« Hide

References

[1]"Expression of two kallikrein gene family members in the rat prostate."
Brady J.M., Wines D.R., MacDonald R.J.
Biochemistry 28:5203-5210(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M27217, M27215, M27216 Genomic DNA. Translation: AAA42036.1.
PIRA34079.
RefSeqNP_001013085.1. NM_001013067.2.
UniGeneRn.79264.

3D structure databases

ProteinModelPortalP36374.
SMRP36374. Positions 25-261.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000025715.

Protein family/group databases

MEROPSS01.288.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID292866.
KEGGrno:292866.
UCSCRGD:1305359. rat.

Organism-specific databases

CTD292866.
RGD1305359. Klk6.

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidP36374.
KOK01325.
PhylomeDBP36374.

Enzyme and pathway databases

BRENDA3.4.21.118. 5301.

Gene expression databases

GenevestigatorP36374.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio634943.

Entry information

Entry nameKLK6_RAT
AccessionPrimary (citable) accession number: P36374
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries