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P36374

- KLK6_RAT

UniProt

P36374 - KLK6_RAT

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Protein

Prostatic glandular kallikrein-6

Gene

Klk6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay system
Active sitei120 – 1201Charge relay system
Active sitei213 – 2131Charge relay system

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.118. 5301.

Protein family/group databases

MEROPSiS01.288.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostatic glandular kallikrein-6 (EC:3.4.21.35)
Alternative name(s):
Glandular kallikrein-8
Short name:
rGK-8
P1 kallikrein
Tissue kallikrein
Gene namesi
Name:Klk6
Synonyms:Klk-8, Klk8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1305359. Klk6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818CuratedAdd
BLAST
Propeptidei19 – 246Activation peptideCuratedPRO_0000028007
Chaini25 – 261237Prostatic glandular kallikrein-6PRO_0000028008Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Gene expression databases

GenevestigatoriP36374.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025715.

Structurei

3D structure databases

ProteinModelPortaliP36374.
SMRiP36374. Positions 25-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 258234Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP36374.
KOiK01325.
PhylomeDBiP36374.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36374-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWLLILFLIL SLGWNDAAPP GQSRIIGGFN CEKNSQPWQV AVYHFNEPQC
60 70 80 90 100
GGVLIHPSWV ITAAHCYSVN YQVWLGRNNL LEDEPFAQHR LVSQSFPHPG
110 120 130 140 150
FNLDIIKNHT RKPGNDYSND LMLLHLKTPA DITDGVKVID LPTEEPKVGS
160 170 180 190 200
TCLTSGWGSI TPLKWEFPDD LQCVNIHLLS NEKCIKAYND EVTDVMLCAG
210 220 230 240 250
EMDGGKDICK GDSGGPLICD GVLQGITSWG SMPCGEPNKP SVYTKLIKFT
260
SWMKKVMKEN P
Length:261
Mass (Da):29,013
Last modified:June 1, 1994 - v1
Checksum:iCA8F12151B04E337
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27217, M27215, M27216 Genomic DNA. Translation: AAA42036.1.
PIRiA34079.
RefSeqiNP_001013085.1. NM_001013067.2.
UniGeneiRn.79264.

Genome annotation databases

GeneIDi292866.
KEGGirno:292866.
UCSCiRGD:1305359. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27217 , M27215 , M27216 Genomic DNA. Translation: AAA42036.1 .
PIRi A34079.
RefSeqi NP_001013085.1. NM_001013067.2.
UniGenei Rn.79264.

3D structure databases

ProteinModelPortali P36374.
SMRi P36374. Positions 25-261.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000025715.

Protein family/group databases

MEROPSi S01.288.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 292866.
KEGGi rno:292866.
UCSCi RGD:1305359. rat.

Organism-specific databases

CTDi 292866.
RGDi 1305359. Klk6.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P36374.
KOi K01325.
PhylomeDBi P36374.

Enzyme and pathway databases

BRENDAi 3.4.21.118. 5301.

Miscellaneous databases

NextBioi 634943.

Gene expression databases

Genevestigatori P36374.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of two kallikrein gene family members in the rat prostate."
    Brady J.M., Wines D.R., MacDonald R.J.
    Biochemistry 28:5203-5210(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKLK6_RAT
AccessioniPrimary (citable) accession number: P36374
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 1, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3