Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P36374

- KLK6_RAT

UniProt

P36374 - KLK6_RAT

Protein

Prostatic glandular kallikrein-6

Gene

Klk6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

    Catalytic activityi

    Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay system
    Active sitei120 – 1201Charge relay system
    Active sitei213 – 2131Charge relay system

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDAi3.4.21.118. 5301.

    Protein family/group databases

    MEROPSiS01.288.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostatic glandular kallikrein-6 (EC:3.4.21.35)
    Alternative name(s):
    Glandular kallikrein-8
    Short name:
    rGK-8
    P1 kallikrein
    Tissue kallikrein
    Gene namesi
    Name:Klk6
    Synonyms:Klk-8, Klk8
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1305359. Klk6.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818CuratedAdd
    BLAST
    Propeptidei19 – 246Activation peptideCuratedPRO_0000028007
    Chaini25 – 261237Prostatic glandular kallikrein-6PRO_0000028008Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
    Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
    Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Expressioni

    Gene expression databases

    GenevestigatoriP36374.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000025715.

    Structurei

    3D structure databases

    ProteinModelPortaliP36374.
    SMRiP36374. Positions 25-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 258234Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP36374.
    KOiK01325.
    PhylomeDBiP36374.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36374-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWLLILFLIL SLGWNDAAPP GQSRIIGGFN CEKNSQPWQV AVYHFNEPQC    50
    GGVLIHPSWV ITAAHCYSVN YQVWLGRNNL LEDEPFAQHR LVSQSFPHPG 100
    FNLDIIKNHT RKPGNDYSND LMLLHLKTPA DITDGVKVID LPTEEPKVGS 150
    TCLTSGWGSI TPLKWEFPDD LQCVNIHLLS NEKCIKAYND EVTDVMLCAG 200
    EMDGGKDICK GDSGGPLICD GVLQGITSWG SMPCGEPNKP SVYTKLIKFT 250
    SWMKKVMKEN P 261
    Length:261
    Mass (Da):29,013
    Last modified:June 1, 1994 - v1
    Checksum:iCA8F12151B04E337
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27217, M27215, M27216 Genomic DNA. Translation: AAA42036.1.
    PIRiA34079.
    RefSeqiNP_001013085.1. NM_001013067.2.
    UniGeneiRn.79264.

    Genome annotation databases

    GeneIDi292866.
    KEGGirno:292866.
    UCSCiRGD:1305359. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27217 , M27215 , M27216 Genomic DNA. Translation: AAA42036.1 .
    PIRi A34079.
    RefSeqi NP_001013085.1. NM_001013067.2.
    UniGenei Rn.79264.

    3D structure databases

    ProteinModelPortali P36374.
    SMRi P36374. Positions 25-261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000025715.

    Protein family/group databases

    MEROPSi S01.288.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 292866.
    KEGGi rno:292866.
    UCSCi RGD:1305359. rat.

    Organism-specific databases

    CTDi 292866.
    RGDi 1305359. Klk6.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P36374.
    KOi K01325.
    PhylomeDBi P36374.

    Enzyme and pathway databases

    BRENDAi 3.4.21.118. 5301.

    Miscellaneous databases

    NextBioi 634943.

    Gene expression databases

    Genevestigatori P36374.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of two kallikrein gene family members in the rat prostate."
      Brady J.M., Wines D.R., MacDonald R.J.
      Biochemistry 28:5203-5210(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiKLK6_RAT
    AccessioniPrimary (citable) accession number: P36374
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3