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P36369

- K1B26_MOUSE

UniProt

P36369 - K1B26_MOUSE

Protein

Kallikrein 1-related peptidase b26

Gene

Klk1b26

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
    Prorenin-converting enzyme cleaves mouse REN-2 prorenin at a dibasic site to yield mature renin.

    Catalytic activityi

    Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay system
    Active sitei120 – 1201Charge relay system
    Active sitei213 – 2131Charge relay system

    GO - Molecular functioni

    1. peptidase activity Source: MGI
    2. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. brain renin-angiotensin system Source: MGI
    2. zymogen activation Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

    Protein family/group databases

    MEROPSiS01.070.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein 1-related peptidase b26 (EC:3.4.21.35)
    Alternative name(s):
    Glandular kallikrein K26
    Short name:
    mGK-26
    Prorenin-converting enzyme 2
    Short name:
    PRECE-2
    Tissue kallikrein 26
    Gene namesi
    Name:Klk1b26
    Synonyms:Klk-26, Klk26
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:891981. Klk1b26.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818CuratedAdd
    BLAST
    Propeptidei19 – 246Activation peptidePRO_0000027993
    Chaini25 – 261237Kallikrein 1-related peptidase b26PRO_0000027994Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Glycosylationi102 – 1021N-linked (GlcNAc...)Curated
    Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
    Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
    Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiP36369.
    PRIDEiP36369.

    Expressioni

    Gene expression databases

    BgeeiP36369.
    CleanExiMM_KLK1B26.
    GenevestigatoriP36369.

    Structurei

    3D structure databases

    ProteinModelPortaliP36369.
    SMRiP36369. Positions 25-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 258234Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    GeneTreeiENSGT00750000117405.
    HOVERGENiHBG013304.
    InParanoidiP36369.
    KOiK01325.
    OMAiNENCAKV.
    OrthoDBiEOG75B84T.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36369-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWFLILFPAL SLGGIDAAPP LQSRVVGGFN CEKNSQPWQV AVYYQKEHIC    50
    GGVLLDRNWV LTAAHCYVDQ YEVWLGKNKL FQEEPSAQHR LVSKSFPHPG 100
    FNMSLLMLQT TPPGADFSND LMLLRLSKPA DITDVVKPIA LPTKEPKPGS 150
    TCLASGWGSI TPTRWQKSDD LQCVFITLLP NENCAKVYLQ KVTDVMLCAG 200
    EMGGGKDTCA GDSGGPLICD GILQGTTSNG PEPCGKPGVP AIYTNLIKFN 250
    SWIKDTMMKN A 261
    Length:261
    Mass (Da):28,463
    Last modified:June 1, 1994 - v1
    Checksum:i55DCE378F4B007C5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1152GA → EY(PubMed:6174512)Curated
    Sequence conflicti117 – 1171F → Y(PubMed:6174512)Curated
    Sequence conflicti144 – 1441K → E in CAA24211. (PubMed:6174512)Curated
    Sequence conflicti148 – 1481P → L in CAA24211. (PubMed:6174512)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01831 mRNA. Translation: AAA37540.1.
    X63327 mRNA. Translation: CAA44931.1.
    BC024688 mRNA. Translation: AAH24688.1.
    BC138704 mRNA. Translation: AAI38705.1.
    V00828 mRNA. Translation: CAA24211.1.
    CCDSiCCDS39938.1.
    PIRiA00940. EGMSB.
    RefSeqiNP_034774.1. NM_010644.2.
    UniGeneiMm.439663.

    Genome annotation databases

    EnsembliENSMUST00000048945; ENSMUSP00000047488; ENSMUSG00000053719.
    GeneIDi16618.
    KEGGimmu:16618.
    UCSCiuc009gof.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01831 mRNA. Translation: AAA37540.1 .
    X63327 mRNA. Translation: CAA44931.1 .
    BC024688 mRNA. Translation: AAH24688.1 .
    BC138704 mRNA. Translation: AAI38705.1 .
    V00828 mRNA. Translation: CAA24211.1 .
    CCDSi CCDS39938.1.
    PIRi A00940. EGMSB.
    RefSeqi NP_034774.1. NM_010644.2.
    UniGenei Mm.439663.

    3D structure databases

    ProteinModelPortali P36369.
    SMRi P36369. Positions 25-261.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.070.

    Proteomic databases

    MaxQBi P36369.
    PRIDEi P36369.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048945 ; ENSMUSP00000047488 ; ENSMUSG00000053719 .
    GeneIDi 16618.
    KEGGi mmu:16618.
    UCSCi uc009gof.2. mouse.

    Organism-specific databases

    CTDi 16618.
    MGIi MGI:891981. Klk1b26.

    Phylogenomic databases

    GeneTreei ENSGT00750000117405.
    HOVERGENi HBG013304.
    InParanoidi P36369.
    KOi K01325.
    OMAi NENCAKV.
    OrthoDBi EOG75B84T.
    TreeFami TF331065.

    Enzyme and pathway databases

    Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

    Miscellaneous databases

    ChiTaRSi Klk1b26. mouse.
    NextBioi 290219.
    PROi P36369.
    SOURCEi Search...

    Gene expression databases

    Bgeei P36369.
    CleanExi MM_KLK1B26.
    Genevestigatori P36369.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The presence of two types of prorenin converting enzymes in the mouse submandibular gland."
      Kim W.S., Nakayama K., Murakami K.
      FEBS Lett. 293:142-144(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
      Tissue: Submandibular gland.
    2. "Sequence of an epidermal growth factor-binding protein."
      Lundgren S., Ronne H., Rask L., Peterson P.A.
      J. Biol. Chem. 259:7780-7784(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: NMRI.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Brain and Salivary gland.
    4. "Mouse glandular kallikrein genes. Nucleotide sequence of cloned cDNA coding for a member of the kallikrein arginyl esteropeptidase group of serine proteases."
      Richards R.I., Catanzaro D.F., Mason A.J., Morris B.J., Baxter J.D., Shine J.
      J. Biol. Chem. 257:2758-2761(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 113-261.
      Strain: Quakenbush inbred.

    Entry informationi

    Entry nameiK1B26_MOUSE
    AccessioniPrimary (citable) accession number: P36369
    Secondary accession number(s): B9EI06, P00753, P00754
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3