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Protein

Kallikrein 1-related peptidase b26

Gene

Klk1b26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Prorenin-converting enzyme cleaves mouse REN-2 prorenin at a dibasic site to yield mature renin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay system1
Active sitei120Charge relay system1
Active sitei213Charge relay system1

GO - Molecular functioni

GO - Biological processi

  • brain renin-angiotensin system Source: MGI
  • zymogen activation Source: MGI

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.070

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein 1-related peptidase b26 (EC:3.4.21.35)
Alternative name(s):
Glandular kallikrein K26
Short name:
mGK-26
Prorenin-converting enzyme 2
Short name:
PRECE-2
Tissue kallikrein 26
Gene namesi
Name:Klk1b26
Synonyms:Klk-26, Klk26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:891981 Klk1b26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18CuratedAdd BLAST18
PropeptideiPRO_000002799319 – 24Activation peptide6
ChainiPRO_000002799425 – 261Kallikrein 1-related peptidase b26Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi102N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP36369
PaxDbiP36369
PRIDEiP36369

Expressioni

Gene expression databases

BgeeiENSMUSG00000053719
CleanExiMM_KLK1B26
ExpressionAtlasiP36369 baseline and differential
GenevisibleiP36369 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047488

Structurei

3D structure databases

ProteinModelPortaliP36369
SMRiP36369
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 258Peptidase S1PROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00910000144067
HOVERGENiHBG013304
InParanoidiP36369
KOiK01325
OMAiGWECERH
OrthoDBiEOG091G0DF7
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFLILFPAL SLGGIDAAPP LQSRVVGGFN CEKNSQPWQV AVYYQKEHIC
60 70 80 90 100
GGVLLDRNWV LTAAHCYVDQ YEVWLGKNKL FQEEPSAQHR LVSKSFPHPG
110 120 130 140 150
FNMSLLMLQT TPPGADFSND LMLLRLSKPA DITDVVKPIA LPTKEPKPGS
160 170 180 190 200
TCLASGWGSI TPTRWQKSDD LQCVFITLLP NENCAKVYLQ KVTDVMLCAG
210 220 230 240 250
EMGGGKDTCA GDSGGPLICD GILQGTTSNG PEPCGKPGVP AIYTNLIKFN
260
SWIKDTMMKN A
Length:261
Mass (Da):28,463
Last modified:June 1, 1994 - v1
Checksum:i55DCE378F4B007C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114 – 115GA → EY (PubMed:6174512).Curated2
Sequence conflicti117F → Y (PubMed:6174512).Curated1
Sequence conflicti144K → E in CAA24211 (PubMed:6174512).Curated1
Sequence conflicti148P → L in CAA24211 (PubMed:6174512).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01831 mRNA Translation: AAA37540.1
X63327 mRNA Translation: CAA44931.1
BC024688 mRNA Translation: AAH24688.1
BC138704 mRNA Translation: AAI38705.1
V00828 mRNA Translation: CAA24211.1
CCDSiCCDS39938.1
PIRiA00940 EGMSB
RefSeqiNP_034774.1, NM_010644.3
UniGeneiMm.439663

Genome annotation databases

EnsembliENSMUST00000048945; ENSMUSP00000047488; ENSMUSG00000053719
GeneIDi16618
KEGGimmu:16618
UCSCiuc009gof.3 mouse

Similar proteinsi

Entry informationi

Entry nameiK1B26_MOUSE
AccessioniPrimary (citable) accession number: P36369
Secondary accession number(s): B9EI06, P00753, P00754
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 1, 1994
Last modified: April 25, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health