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Protein

Kallikrein 1-related peptidase b26

Gene

Klk1b26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Prorenin-converting enzyme cleaves mouse REN-2 prorenin at a dibasic site to yield mature renin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay system1
Active sitei120Charge relay system1
Active sitei213Charge relay system1

GO - Molecular functioni

GO - Biological processi

  • brain renin-angiotensin system Source: MGI
  • zymogen activation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-MMU-1592389. Activation of Matrix Metalloproteinases.
R-MMU-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiS01.173.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein 1-related peptidase b26 (EC:3.4.21.35)
Alternative name(s):
Glandular kallikrein K26
Short name:
mGK-26
Prorenin-converting enzyme 2
Short name:
PRECE-2
Tissue kallikrein 26
Gene namesi
Name:Klk1b26
Synonyms:Klk-26, Klk26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:891981. Klk1b26.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
  • nucleus Source: MGI
  • protein complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18CuratedAdd BLAST18
PropeptideiPRO_000002799319 – 24Activation peptide6
ChainiPRO_000002799425 – 261Kallikrein 1-related peptidase b26Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi102N-linked (GlcNAc...)Curated1
Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP36369.
PaxDbiP36369.
PRIDEiP36369.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053719.
CleanExiMM_KLK1B26.
GenevisibleiP36369. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047488.

Structurei

3D structure databases

ProteinModelPortaliP36369.
SMRiP36369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 258Peptidase S1PROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOVERGENiHBG013304.
InParanoidiP36369.
KOiK01325.
OrthoDBiEOG091G0DF7.
TreeFamiTF331065.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFLILFPAL SLGGIDAAPP LQSRVVGGFN CEKNSQPWQV AVYYQKEHIC
60 70 80 90 100
GGVLLDRNWV LTAAHCYVDQ YEVWLGKNKL FQEEPSAQHR LVSKSFPHPG
110 120 130 140 150
FNMSLLMLQT TPPGADFSND LMLLRLSKPA DITDVVKPIA LPTKEPKPGS
160 170 180 190 200
TCLASGWGSI TPTRWQKSDD LQCVFITLLP NENCAKVYLQ KVTDVMLCAG
210 220 230 240 250
EMGGGKDTCA GDSGGPLICD GILQGTTSNG PEPCGKPGVP AIYTNLIKFN
260
SWIKDTMMKN A
Length:261
Mass (Da):28,463
Last modified:June 1, 1994 - v1
Checksum:i55DCE378F4B007C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114 – 115GA → EY (PubMed:6174512).Curated2
Sequence conflicti117F → Y (PubMed:6174512).Curated1
Sequence conflicti144K → E in CAA24211 (PubMed:6174512).Curated1
Sequence conflicti148P → L in CAA24211 (PubMed:6174512).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01831 mRNA. Translation: AAA37540.1.
X63327 mRNA. Translation: CAA44931.1.
BC024688 mRNA. Translation: AAH24688.1.
BC138704 mRNA. Translation: AAI38705.1.
V00828 mRNA. Translation: CAA24211.1.
CCDSiCCDS39938.1.
PIRiA00940. EGMSB.
RefSeqiNP_034774.1. NM_010644.3.
UniGeneiMm.439663.

Genome annotation databases

EnsembliENSMUST00000048945; ENSMUSP00000047488; ENSMUSG00000053719.
GeneIDi16618.
KEGGimmu:16618.
UCSCiuc009gof.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01831 mRNA. Translation: AAA37540.1.
X63327 mRNA. Translation: CAA44931.1.
BC024688 mRNA. Translation: AAH24688.1.
BC138704 mRNA. Translation: AAI38705.1.
V00828 mRNA. Translation: CAA24211.1.
CCDSiCCDS39938.1.
PIRiA00940. EGMSB.
RefSeqiNP_034774.1. NM_010644.3.
UniGeneiMm.439663.

3D structure databases

ProteinModelPortaliP36369.
SMRiP36369.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047488.

Protein family/group databases

MEROPSiS01.173.

Proteomic databases

MaxQBiP36369.
PaxDbiP36369.
PRIDEiP36369.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048945; ENSMUSP00000047488; ENSMUSG00000053719.
GeneIDi16618.
KEGGimmu:16618.
UCSCiuc009gof.3. mouse.

Organism-specific databases

CTDi16618.
MGIiMGI:891981. Klk1b26.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOVERGENiHBG013304.
InParanoidiP36369.
KOiK01325.
OrthoDBiEOG091G0DF7.
TreeFamiTF331065.

Enzyme and pathway databases

ReactomeiR-MMU-1592389. Activation of Matrix Metalloproteinases.
R-MMU-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

ChiTaRSiKlk1b26. mouse.
PROiP36369.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053719.
CleanExiMM_KLK1B26.
GenevisibleiP36369. MM.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1B26_MOUSE
AccessioniPrimary (citable) accession number: P36369
Secondary accession number(s): B9EI06, P00753, P00754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.