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P36369 (K1B26_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kallikrein 1-related peptidase b26

EC=3.4.21.35
Alternative name(s):
Glandular kallikrein K26
Short name=mGK-26
Prorenin-converting enzyme 2
Short name=PRECE-2
Tissue kallikrein 26
Gene names
Name:Klk1b26
Synonyms:Klk-26, Klk26
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Prorenin-converting enzyme cleaves mouse REN-2 prorenin at a dibasic site to yield mature renin.

Catalytic activity

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Contains 1 peptidase S1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Probable
Propeptide19 – 246Activation peptide
PRO_0000027993
Chain25 – 261237Kallikrein 1-related peptidase b26
PRO_0000027994

Regions

Domain25 – 258234Peptidase S1

Sites

Active site651Charge relay system
Active site1201Charge relay system
Active site2131Charge relay system

Amino acid modifications

Glycosylation1021N-linked (GlcNAc...) Probable
Disulfide bond31 ↔ 173 By similarity
Disulfide bond50 ↔ 66 By similarity
Disulfide bond152 ↔ 219 By similarity
Disulfide bond184 ↔ 198 By similarity
Disulfide bond209 ↔ 234 By similarity

Experimental info

Sequence conflict114 – 1152GA → EY Ref.4
Sequence conflict1171F → Y Ref.4
Sequence conflict1441K → E in CAA24211. Ref.4
Sequence conflict1481P → L in CAA24211. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P36369 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 55DCE378F4B007C5

FASTA26128,463
        10         20         30         40         50         60 
MWFLILFPAL SLGGIDAAPP LQSRVVGGFN CEKNSQPWQV AVYYQKEHIC GGVLLDRNWV 

        70         80         90        100        110        120 
LTAAHCYVDQ YEVWLGKNKL FQEEPSAQHR LVSKSFPHPG FNMSLLMLQT TPPGADFSND 

       130        140        150        160        170        180 
LMLLRLSKPA DITDVVKPIA LPTKEPKPGS TCLASGWGSI TPTRWQKSDD LQCVFITLLP 

       190        200        210        220        230        240 
NENCAKVYLQ KVTDVMLCAG EMGGGKDTCA GDSGGPLICD GILQGTTSNG PEPCGKPGVP 

       250        260 
AIYTNLIKFN SWIKDTMMKN A 

« Hide

References

« Hide 'large scale' references
[1]"The presence of two types of prorenin converting enzymes in the mouse submandibular gland."
Kim W.S., Nakayama K., Murakami K.
FEBS Lett. 293:142-144(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ICR.
Tissue: Submandibular gland.
[2]"Sequence of an epidermal growth factor-binding protein."
Lundgren S., Ronne H., Rask L., Peterson P.A.
J. Biol. Chem. 259:7780-7784(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: NMRI.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Brain and Salivary gland.
[4]"Mouse glandular kallikrein genes. Nucleotide sequence of cloned cDNA coding for a member of the kallikrein arginyl esteropeptidase group of serine proteases."
Richards R.I., Catanzaro D.F., Mason A.J., Morris B.J., Baxter J.D., Shine J.
J. Biol. Chem. 257:2758-2761(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 113-261.
Strain: Quakenbush inbred.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K01831 mRNA. Translation: AAA37540.1.
X63327 mRNA. Translation: CAA44931.1.
BC024688 mRNA. Translation: AAH24688.1.
BC138704 mRNA. Translation: AAI38705.1.
V00828 mRNA. Translation: CAA24211.1.
PIREGMSB. A00940.
RefSeqNP_034774.1. NM_010644.2.
UniGeneMm.439663.

3D structure databases

ProteinModelPortalP36369.
SMRP36369. Positions 25-261.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.070.

Proteomic databases

PRIDEP36369.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048945; ENSMUSP00000047488; ENSMUSG00000053719.
GeneID16618.
KEGGmmu:16618.
UCSCuc009gof.2. mouse.

Organism-specific databases

CTD16618.
MGIMGI:891981. Klk1b26.

Phylogenomic databases

GeneTreeENSGT00750000117405.
HOVERGENHBG013304.
InParanoidP36369.
KOK01325.
OMAVINEYLC.
OrthoDBEOG75B84T.
TreeFamTF331065.

Gene expression databases

BgeeP36369.
CleanExMM_KLK1B26.
GenevestigatorP36369.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKlk1b26. mouse.
NextBio290219.
PROP36369.
SOURCESearch...

Entry information

Entry nameK1B26_MOUSE
AccessionPrimary (citable) accession number: P36369
Secondary accession number(s): B9EI06, P00753, P00754
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot