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P36369

- K1B26_MOUSE

UniProt

P36369 - K1B26_MOUSE

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Protein

Kallikrein 1-related peptidase b26

Gene

Klk1b26

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Prorenin-converting enzyme cleaves mouse REN-2 prorenin at a dibasic site to yield mature renin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay system
Active sitei120 – 1201Charge relay system
Active sitei213 – 2131Charge relay system

GO - Molecular functioni

  1. peptidase activity Source: MGI
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. brain renin-angiotensin system Source: MGI
  2. zymogen activation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

Protein family/group databases

MEROPSiS01.070.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein 1-related peptidase b26 (EC:3.4.21.35)
Alternative name(s):
Glandular kallikrein K26
Short name:
mGK-26
Prorenin-converting enzyme 2
Short name:
PRECE-2
Tissue kallikrein 26
Gene namesi
Name:Klk1b26
Synonyms:Klk-26, Klk26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:891981. Klk1b26.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818CuratedAdd
BLAST
Propeptidei19 – 246Activation peptidePRO_0000027993
Chaini25 – 261237Kallikrein 1-related peptidase b26PRO_0000027994Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi102 – 1021N-linked (GlcNAc...)Curated
Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP36369.
PRIDEiP36369.

Expressioni

Gene expression databases

BgeeiP36369.
CleanExiMM_KLK1B26.
GenevestigatoriP36369.

Structurei

3D structure databases

ProteinModelPortaliP36369.
SMRiP36369. Positions 25-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 258234Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00760000118862.
HOVERGENiHBG013304.
InParanoidiP36369.
KOiK01325.
OMAiNENCAKV.
OrthoDBiEOG75B84T.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36369-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWFLILFPAL SLGGIDAAPP LQSRVVGGFN CEKNSQPWQV AVYYQKEHIC
60 70 80 90 100
GGVLLDRNWV LTAAHCYVDQ YEVWLGKNKL FQEEPSAQHR LVSKSFPHPG
110 120 130 140 150
FNMSLLMLQT TPPGADFSND LMLLRLSKPA DITDVVKPIA LPTKEPKPGS
160 170 180 190 200
TCLASGWGSI TPTRWQKSDD LQCVFITLLP NENCAKVYLQ KVTDVMLCAG
210 220 230 240 250
EMGGGKDTCA GDSGGPLICD GILQGTTSNG PEPCGKPGVP AIYTNLIKFN
260
SWIKDTMMKN A
Length:261
Mass (Da):28,463
Last modified:June 1, 1994 - v1
Checksum:i55DCE378F4B007C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1152GA → EY(PubMed:6174512)Curated
Sequence conflicti117 – 1171F → Y(PubMed:6174512)Curated
Sequence conflicti144 – 1441K → E in CAA24211. (PubMed:6174512)Curated
Sequence conflicti148 – 1481P → L in CAA24211. (PubMed:6174512)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01831 mRNA. Translation: AAA37540.1.
X63327 mRNA. Translation: CAA44931.1.
BC024688 mRNA. Translation: AAH24688.1.
BC138704 mRNA. Translation: AAI38705.1.
V00828 mRNA. Translation: CAA24211.1.
CCDSiCCDS39938.1.
PIRiA00940. EGMSB.
RefSeqiNP_034774.1. NM_010644.2.
UniGeneiMm.439663.

Genome annotation databases

EnsembliENSMUST00000048945; ENSMUSP00000047488; ENSMUSG00000053719.
GeneIDi16618.
KEGGimmu:16618.
UCSCiuc009gof.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01831 mRNA. Translation: AAA37540.1 .
X63327 mRNA. Translation: CAA44931.1 .
BC024688 mRNA. Translation: AAH24688.1 .
BC138704 mRNA. Translation: AAI38705.1 .
V00828 mRNA. Translation: CAA24211.1 .
CCDSi CCDS39938.1.
PIRi A00940. EGMSB.
RefSeqi NP_034774.1. NM_010644.2.
UniGenei Mm.439663.

3D structure databases

ProteinModelPortali P36369.
SMRi P36369. Positions 25-261.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.070.

Proteomic databases

MaxQBi P36369.
PRIDEi P36369.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048945 ; ENSMUSP00000047488 ; ENSMUSG00000053719 .
GeneIDi 16618.
KEGGi mmu:16618.
UCSCi uc009gof.2. mouse.

Organism-specific databases

CTDi 16618.
MGIi MGI:891981. Klk1b26.

Phylogenomic databases

GeneTreei ENSGT00760000118862.
HOVERGENi HBG013304.
InParanoidi P36369.
KOi K01325.
OMAi NENCAKV.
OrthoDBi EOG75B84T.
TreeFami TF331065.

Enzyme and pathway databases

Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

Miscellaneous databases

ChiTaRSi Klk1b26. mouse.
NextBioi 290219.
PROi P36369.
SOURCEi Search...

Gene expression databases

Bgeei P36369.
CleanExi MM_KLK1B26.
Genevestigatori P36369.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The presence of two types of prorenin converting enzymes in the mouse submandibular gland."
    Kim W.S., Nakayama K., Murakami K.
    FEBS Lett. 293:142-144(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Submandibular gland.
  2. "Sequence of an epidermal growth factor-binding protein."
    Lundgren S., Ronne H., Rask L., Peterson P.A.
    J. Biol. Chem. 259:7780-7784(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NMRI.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Brain and Salivary gland.
  4. "Mouse glandular kallikrein genes. Nucleotide sequence of cloned cDNA coding for a member of the kallikrein arginyl esteropeptidase group of serine proteases."
    Richards R.I., Catanzaro D.F., Mason A.J., Morris B.J., Baxter J.D., Shine J.
    J. Biol. Chem. 257:2758-2761(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 113-261.
    Strain: Quakenbush inbred.

Entry informationi

Entry nameiK1B26_MOUSE
AccessioniPrimary (citable) accession number: P36369
Secondary accession number(s): B9EI06, P00753, P00754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3