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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 1

Gene

Fmo1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32FADBy similarity1
Sitei208Important for substrate bindingBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 13FADBy similarity5
Nucleotide bindingi40 – 41FADBy similarity2
Nucleotide bindingi60 – 61NADPBy similarity2
Nucleotide bindingi61 – 62FADBy similarity2
Nucleotide bindingi195 – 198NADPBy similarity4

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: InterPro
  • monooxygenase activity Source: RGD
  • N,N-dimethylaniline monooxygenase activity Source: RGD
  • NADP binding Source: InterPro

GO - Biological processi

  • drug metabolic process Source: Ensembl
  • NADPH oxidation Source: Ensembl
  • organic acid metabolic process Source: Ensembl
  • response to lipopolysaccharide Source: RGD
  • response to osmotic stress Source: RGD
  • toxin metabolic process Source: Ensembl

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BRENDAi1.14.13.8 5301
ReactomeiR-RNO-217271 FMO oxidises nucleophiles
SABIO-RKiP36365

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 1
Hepatic flavin-containing monooxygenase 1
Short name:
FMO 1
Gene namesi
Name:Fmo1
Synonyms:Fmo-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi2622 Fmo1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei511 – 531HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476431 – 532Dimethylaniline monooxygenase [N-oxide-forming] 1Add BLAST532

Proteomic databases

PaxDbiP36365
PRIDEiP36365

PTM databases

iPTMnetiP36365
PhosphoSitePlusiP36365

Expressioni

Tissue specificityi

Liver.

Gene expression databases

BgeeiENSRNOG00000034191
GenevisibleiP36365 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044613

Structurei

3D structure databases

ProteinModelPortaliP36365
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1399 Eukaryota
COG2072 LUCA
GeneTreeiENSGT00760000119232
HOGENOMiHOG000076537
HOVERGENiHBG002037
InParanoidiP36365
KOiK00485
OMAiDWEVYVW
PhylomeDBiP36365
TreeFamiTF105285

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR000960 Flavin_mOase
IPR020946 Flavin_mOase-like
IPR002253 Flavin_mOase_1
PfamiView protein in Pfam
PF00743 FMO-like, 1 hit
PIRSFiPIRSF000332 FMO, 1 hit
PRINTSiPR00370 FMOXYGENASE
PR01121 FMOXYGENASE1
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

P36365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSCDLGGL WRFTEHVEEG
60 70 80 90 100
RASLYNSVVS NSSKEMSCYS DFPFPEDYPN FVPNSLFLEY LQLYATQFNL
110 120 130 140 150
LRCIYFNTKV CSITKRPDFA VSGQWEVVTV CQGKQSSDTF DAVMVCTGFL
160 170 180 190 200
TNPHLPLDSF PGIQTFKGQY FHSRQYKHPD VFKDKRVLVV GMGNSGTDIA
210 220 230 240 250
VEASHLAKKV FLSTTGGAWV ISRVFDSGYP WDMIFMTRFQ NMLRNLLPTP
260 270 280 290 300
VVSWLISKKM NSWFNHVNYG VAPEDRTQLR EPVLNDELPG RIITGKVLIK
310 320 330 340 350
PSIKEVKENS VVFNNTPKEE PIDVIVFATG YSFAFPFLDE SIVKVEDGQA
360 370 380 390 400
SLYKYIFPAH LPKPTLAVIG LIKPLGSMIP TGETQARWVV QVLKGATTLP
410 420 430 440 450
PPSVMMKEVN ERKKNKHSGF GLCYCKALQS DYITYIDDLL TSINAKPDLR
460 470 480 490 500
AMLLTDPRLA LSIFFGPCTP YHFRLTGPGK WEGARKAILT QWDRTVNVTK
510 520 530
TRTVQETPST FETLLKLFSF LALLVAVFFI FL
Length:532
Mass (Da):59,825
Last modified:October 25, 2005 - v2
Checksum:i188EABAF96653977
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141D → A in AAA41165 (PubMed:8504165).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84719 mRNA Translation: AAA41165.1
BC061567 mRNA Translation: AAH61567.1
PIRiS33758
RefSeqiNP_036924.1, NM_012792.1
XP_006250207.1, XM_006250145.3
XP_006250208.1, XM_006250146.3
UniGeneiRn.867

Genome annotation databases

EnsembliENSRNOT00000041908; ENSRNOP00000044613; ENSRNOG00000034191
ENSRNOT00000081551; ENSRNOP00000073105; ENSRNOG00000034191
GeneIDi25256
KEGGirno:25256
UCSCiRGD:2622 rat

Similar proteinsi

Entry informationi

Entry nameiFMO1_RAT
AccessioniPrimary (citable) accession number: P36365
Secondary accession number(s): Q6P7Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 25, 2005
Last modified: May 23, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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