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P36364

- FGF9_RAT

UniProt

P36364 - FGF9_RAT

Protein

Fibroblast growth factor 9

Gene

Fgf9

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.

    GO - Molecular functioni

    1. fibroblast growth factor receptor binding Source: RGD
    2. growth factor activity Source: RGD
    3. heparin binding Source: UniProtKB-KW

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. cell-cell signaling Source: Ensembl
    3. chondrocyte differentiation Source: Ensembl
    4. embryonic digestive tract development Source: Ensembl
    5. embryonic limb morphogenesis Source: Ensembl
    6. embryonic skeletal system development Source: Ensembl
    7. fibroblast growth factor receptor signaling pathway Source: RGD
    8. inner ear morphogenesis Source: Ensembl
    9. lung-associated mesenchyme development Source: Ensembl
    10. male gonad development Source: Ensembl
    11. male sex determination Source: Ensembl
    12. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    13. negative regulation of Wnt signaling pathway Source: Ensembl
    14. osteoblast differentiation Source: Ensembl
    15. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    16. positive regulation of cardiac muscle cell proliferation Source: Ensembl
    17. positive regulation of cell division Source: UniProtKB-KW
    18. positive regulation of cell proliferation Source: RGD
    19. positive regulation of epithelial cell proliferation Source: Ensembl
    20. positive regulation of gene expression Source: Ensembl
    21. positive regulation of MAPK cascade Source: MGI
    22. positive regulation of mesenchymal cell proliferation Source: Ensembl
    23. positive regulation of smoothened signaling pathway Source: Ensembl
    24. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
    25. protein import into nucleus Source: Ensembl
    26. regulation of timing of cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Keywords - Biological processi

    Differentiation

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_198665. Signaling by FGFR mutants.
    REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198798. Signaling by activated point mutants of FGFR3.
    REACT_198804. Signaling by FGFR3 mutants.
    REACT_198810. Signaling by activated point mutants of FGFR1.
    REACT_198813. Activated point mutants of FGFR2.
    REACT_198995. Negative regulation of FGFR signaling.
    REACT_202034. Phospholipase C-mediated cascade.
    REACT_79133. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 9
    Short name:
    FGF-9
    Alternative name(s):
    Glia-activating factor
    Short name:
    GAF
    HBGF-9
    Gene namesi
    Name:Fgf9
    Synonyms:Fgf-9
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 15

    Organism-specific databases

    RGDi2610. Fgf9.

    Subcellular locationi

    GO - Cellular componenti

    1. basement membrane Source: RGD
    2. cytoplasm Source: RGD
    3. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 33By similarityPRO_0000008977
    Chaini4 – 208205Fibroblast growth factor 9PRO_0000008978Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP36364.

    PTM databases

    PhosphoSiteiP36364.

    Expressioni

    Tissue specificityi

    Brain and kidney.

    Gene expression databases

    GenevestigatoriP36364.

    Interactioni

    Subunit structurei

    Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000015368.

    Structurei

    3D structure databases

    ProteinModelPortaliP36364.
    SMRiP36364. Positions 52-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG269410.
    GeneTreeiENSGT00730000110261.
    HOGENOMiHOG000236341.
    HOVERGENiHBG007580.
    InParanoidiP36364.
    KOiK04358.
    OMAiGELYGSD.
    OrthoDBiEOG7992S1.
    PhylomeDBiP36364.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028251. FGF9.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF28. PTHR11486:SF28. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36364-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPLGEVGSY FGVQDAVPFG NVPVLPVDSP VLLSDHLGQS EAGGLPRGPA    50
    VTDLDHLKGI LRRRQLYCRT GFHLEIFPNG TIQGTRKDHS RFGILEFISI 100
    AVGLVSIRGV DSGLYLGMNE KGELYGSEKL TQECVFREQF EENWYNTYSS 150
    NLYKHVDTGR RYYVALNKDG TPREGTRTKR HQKFTHFLPR PVDPDKVPEL 200
    YKDILSQS 208
    Length:208
    Mass (Da):23,414
    Last modified:October 1, 1994 - v2
    Checksum:i4A3CE894DFF643EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14839 mRNA. Translation: BAA03573.1.
    RefSeqiNP_037084.1. NM_012952.1.
    UniGeneiRn.25174.

    Genome annotation databases

    EnsembliENSRNOT00000015367; ENSRNOP00000015368; ENSRNOG00000011471.
    GeneIDi25444.
    KEGGirno:25444.
    UCSCiRGD:2610. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14839 mRNA. Translation: BAA03573.1 .
    RefSeqi NP_037084.1. NM_012952.1.
    UniGenei Rn.25174.

    3D structure databases

    ProteinModelPortali P36364.
    SMRi P36364. Positions 52-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000015368.

    PTM databases

    PhosphoSitei P36364.

    Proteomic databases

    PaxDbi P36364.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015367 ; ENSRNOP00000015368 ; ENSRNOG00000011471 .
    GeneIDi 25444.
    KEGGi rno:25444.
    UCSCi RGD:2610. rat.

    Organism-specific databases

    CTDi 2254.
    RGDi 2610. Fgf9.

    Phylogenomic databases

    eggNOGi NOG269410.
    GeneTreei ENSGT00730000110261.
    HOGENOMi HOG000236341.
    HOVERGENi HBG007580.
    InParanoidi P36364.
    KOi K04358.
    OMAi GELYGSD.
    OrthoDBi EOG7992S1.
    PhylomeDBi P36364.
    TreeFami TF317805.

    Enzyme and pathway databases

    Reactomei REACT_198665. Signaling by FGFR mutants.
    REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198798. Signaling by activated point mutants of FGFR3.
    REACT_198804. Signaling by FGFR3 mutants.
    REACT_198810. Signaling by activated point mutants of FGFR1.
    REACT_198813. Activated point mutants of FGFR2.
    REACT_198995. Negative regulation of FGFR signaling.
    REACT_202034. Phospholipase C-mediated cascade.
    REACT_79133. SHC-mediated cascade.

    Miscellaneous databases

    NextBioi 606671.
    PROi P36364.

    Gene expression databases

    Genevestigatori P36364.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028251. FGF9.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF28. PTHR11486:SF28. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property."
      Miyamoto M., Naruo K., Seko C., Matsumoto S., Kondo T., Kurokawa T.
      Mol. Cell. Biol. 13:4251-4259(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiFGF9_RAT
    AccessioniPrimary (citable) accession number: P36364
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3