P36364 (FGF9_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 9
Short name=FGF-9

Alternative name(s):
Glia-activating factor
Short name=GAF
HBGF-9

Gene names

Name:	Fgf9
Synonyms:	Fgf-9

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
Subunit structure	Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors By similarity.
Subcellular location	Secreted.
Tissue specificity	Brain and kidney.
Post-translational modification	N-glycosylated.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Biological process	Differentiation
Cellular component	Secreted
Ligand	Heparin-binding
Molecular function	Developmental protein Growth factor Mitogen
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from electronic annotation. Source: Compara cell-cell signaling Inferred from electronic annotation. Source: Compara chondrocyte differentiation Inferred from electronic annotation. Source: Compara embryonic digestive tract development Inferred from electronic annotation. Source: Compara embryonic limb morphogenesis Inferred from electronic annotation. Source: Compara embryonic skeletal system development Inferred from electronic annotation. Source: Compara fibroblast growth factor receptor signaling pathway Inferred from direct assay PubMed 15231666. Source: RGD inner ear morphogenesis Inferred from electronic annotation. Source: Compara lung-associated mesenchyme development Inferred from electronic annotation. Source: Compara male gonad development Inferred from electronic annotation. Source: Compara male sex determination Inferred from electronic annotation. Source: Compara negative regulation of Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara osteoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of MAPK cascade Inferred from genetic interaction PubMed 17192470. Source: MGI positive regulation of canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of cardiac muscle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cell proliferation Inferred from direct assay PubMed 15231666. Source: RGD positive regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of gene expression Inferred from electronic annotation. Source: Compara positive regulation of mesenchymal cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of smoothened signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of vascular endothelial growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara protein import into nucleus Inferred from electronic annotation. Source: Compara regulation of timing of cell differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	basement membrane Inferred from direct assay PubMed 17494997. Source: RGD cytoplasm Inferred from direct assay PubMed 17494997. Source: RGD extracellular space Inferred from electronic annotation. Source: Compara
Molecular_function	growth factor activity Inferred from direct assay PubMed 15231666. Source: RGD heparin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 3	3	By similarity		PRO_0000008977
	Chain	4 – 208	205	Fibroblast growth factor 9		PRO_0000008978
Amino acid modifications
	Glycosylation	79	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P36364 [UniParc]. Last modified October 1, 1994. Version 2. Checksum: 4A3CE894DFF643EB	FASTA	208	23,414
	10 20 30 40 50 60 MAPLGEVGSY FGVQDAVPFG NVPVLPVDSP VLLSDHLGQS EAGGLPRGPA VTDLDHLKGI 70 80 90 100 110 120 LRRRQLYCRT GFHLEIFPNG TIQGTRKDHS RFGILEFISI AVGLVSIRGV DSGLYLGMNE 130 140 150 160 170 180 KGELYGSEKL TQECVFREQF EENWYNTYSS NLYKHVDTGR RYYVALNKDG TPREGTRTKR 190 200 HQKFTHFLPR PVDPDKVPEL YKDILSQS

References

[1]	"Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property." Miyamoto M., Naruo K., Seko C., Matsumoto S., Kondo T., Kurokawa T. Mol. Cell. Biol. 13:4251-4259(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D14839 mRNA. Translation: BAA03573.1.
IPI	IPI00201563.
RefSeq	NP_037084.1. NM_012952.1.
UniGene	Rn.25174.
3D structure databases
ProteinModelPortal	P36364.
SMR	P36364. Positions 52-208.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000015368.
PTM databases
PhosphoSite	P36364.
Proteomic databases
PaxDb	P36364.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000015367; ENSRNOP00000015368; ENSRNOG00000011471.
GeneID	25444.
KEGG	rno:25444.
UCSC	RGD:2610. rat.
Organism-specific databases
CTD	2254.
RGD	2610. Fgf9.
Phylogenomic databases
eggNOG	NOG269410.
GeneTree	ENSGT00700000104323.
HOGENOM	HOG000236341.
HOVERGEN	HBG007580.
InParanoid	P36364.
KO	K04358.
OMA	GTKSRRH.
OrthoDB	EOG46WZ9V.
Gene expression databases
Genevestigator	P36364.
GermOnline	ENSRNOG00000011471. Rattus norvegicus.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin-bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. PTHR11486. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	606671.

Entry information

Entry name

FGF9_RAT

Accession

Primary (citable) accession number: P36364

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	October 1, 1994
Last modified:	April 3, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program