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Protein

Fibroblast growth factor 9

Gene

Fgf9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: RGD
  • growth factor activity Source: RGD
  • heparin binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_280054. FGFR1c ligand binding and activation.
REACT_280631. FGFR3b ligand binding and activation.
REACT_284342. FGFR4 ligand binding and activation.
REACT_291658. PI3K Cascade.
REACT_299102. PIP3 activates AKT signaling.
REACT_311191. FGFR3c ligand binding and activation.
REACT_312503. FGFR2c ligand binding and activation.
REACT_357272. Phospholipase C-mediated cascade: FGFR1.
REACT_357338. Phospholipase C-mediated cascade, FGFR4.
REACT_357361. PI-3K cascade:FGFR4.
REACT_357712. SHC-mediated cascade:FGFR2.
REACT_358624. Negative regulation of FGFR4 signaling.
REACT_358869. Phospholipase C-mediated cascade, FGFR3.
REACT_359240. FRS2-mediated FGFR4 signaling.
REACT_359268. Negative regulation of FGFR2 signaling.
REACT_359276. Negative regulation of FGFR1 signaling.
REACT_359641. PI-3K cascade:FGFR1.
REACT_359767. SHC-mediated cascade:FGFR3.
REACT_360014. FRS-mediated FGFR3 signaling.
REACT_360543. FRS-mediated FGFR2 signaling.
REACT_360800. Negative regulation of FGFR3 signaling.
REACT_360842. PI-3K cascade:FGFR2.
REACT_360887. FRS-mediated FGFR1 signaling.
REACT_360936. Phospholipase C-mediated cascade, FGFR2.
REACT_361671. SHC-mediated cascade:FGFR1.
REACT_362207. SHC-mediated cascade:FGFR4.
REACT_362510. PI-3K cascade:FGFR3.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 9
Short name:
FGF-9
Alternative name(s):
Glia-activating factor
Short name:
GAF
HBGF-9
Gene namesi
Name:Fgf9
Synonyms:Fgf-9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi2610. Fgf9.

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: RGD
  • cytoplasm Source: RGD
  • extracellular exosome Source: Ensembl
  • extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 33By similarityPRO_0000008977
Chaini4 – 208205Fibroblast growth factor 9PRO_0000008978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP36364.

PTM databases

PhosphoSiteiP36364.

Expressioni

Tissue specificityi

Brain and kidney.

Gene expression databases

GenevisibleiP36364. RN.

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015368.

Structurei

3D structure databases

ProteinModelPortaliP36364.
SMRiP36364. Positions 52-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG269410.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP36364.
KOiK04358.
OMAiGELYGSD.
OrthoDBiEOG7992S1.
PhylomeDBiP36364.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028251. FGF9.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF28. PTHR11486:SF28. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLGEVGSY FGVQDAVPFG NVPVLPVDSP VLLSDHLGQS EAGGLPRGPA
60 70 80 90 100
VTDLDHLKGI LRRRQLYCRT GFHLEIFPNG TIQGTRKDHS RFGILEFISI
110 120 130 140 150
AVGLVSIRGV DSGLYLGMNE KGELYGSEKL TQECVFREQF EENWYNTYSS
160 170 180 190 200
NLYKHVDTGR RYYVALNKDG TPREGTRTKR HQKFTHFLPR PVDPDKVPEL

YKDILSQS
Length:208
Mass (Da):23,414
Last modified:October 1, 1994 - v2
Checksum:i4A3CE894DFF643EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14839 mRNA. Translation: BAA03573.1.
RefSeqiNP_037084.1. NM_012952.1.
UniGeneiRn.25174.

Genome annotation databases

EnsembliENSRNOT00000015367; ENSRNOP00000015368; ENSRNOG00000011471.
GeneIDi25444.
KEGGirno:25444.
UCSCiRGD:2610. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14839 mRNA. Translation: BAA03573.1.
RefSeqiNP_037084.1. NM_012952.1.
UniGeneiRn.25174.

3D structure databases

ProteinModelPortaliP36364.
SMRiP36364. Positions 52-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015368.

PTM databases

PhosphoSiteiP36364.

Proteomic databases

PaxDbiP36364.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015367; ENSRNOP00000015368; ENSRNOG00000011471.
GeneIDi25444.
KEGGirno:25444.
UCSCiRGD:2610. rat.

Organism-specific databases

CTDi2254.
RGDi2610. Fgf9.

Phylogenomic databases

eggNOGiNOG269410.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP36364.
KOiK04358.
OMAiGELYGSD.
OrthoDBiEOG7992S1.
PhylomeDBiP36364.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiREACT_280054. FGFR1c ligand binding and activation.
REACT_280631. FGFR3b ligand binding and activation.
REACT_284342. FGFR4 ligand binding and activation.
REACT_291658. PI3K Cascade.
REACT_299102. PIP3 activates AKT signaling.
REACT_311191. FGFR3c ligand binding and activation.
REACT_312503. FGFR2c ligand binding and activation.
REACT_357272. Phospholipase C-mediated cascade: FGFR1.
REACT_357338. Phospholipase C-mediated cascade, FGFR4.
REACT_357361. PI-3K cascade:FGFR4.
REACT_357712. SHC-mediated cascade:FGFR2.
REACT_358624. Negative regulation of FGFR4 signaling.
REACT_358869. Phospholipase C-mediated cascade, FGFR3.
REACT_359240. FRS2-mediated FGFR4 signaling.
REACT_359268. Negative regulation of FGFR2 signaling.
REACT_359276. Negative regulation of FGFR1 signaling.
REACT_359641. PI-3K cascade:FGFR1.
REACT_359767. SHC-mediated cascade:FGFR3.
REACT_360014. FRS-mediated FGFR3 signaling.
REACT_360543. FRS-mediated FGFR2 signaling.
REACT_360800. Negative regulation of FGFR3 signaling.
REACT_360842. PI-3K cascade:FGFR2.
REACT_360887. FRS-mediated FGFR1 signaling.
REACT_360936. Phospholipase C-mediated cascade, FGFR2.
REACT_361671. SHC-mediated cascade:FGFR1.
REACT_362207. SHC-mediated cascade:FGFR4.
REACT_362510. PI-3K cascade:FGFR3.

Miscellaneous databases

NextBioi606671.
PROiP36364.

Gene expression databases

GenevisibleiP36364. RN.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028251. FGF9.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF28. PTHR11486:SF28. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property."
    Miyamoto M., Naruo K., Seko C., Matsumoto S., Kondo T., Kurokawa T.
    Mol. Cell. Biol. 13:4251-4259(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiFGF9_RAT
AccessioniPrimary (citable) accession number: P36364
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 1, 1994
Last modified: June 24, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.