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Protein

Fibroblast growth factor 9

Gene

Fgf9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.

GO - Molecular functioni

  1. fibroblast growth factor receptor binding Source: RGD
  2. growth factor activity Source: RGD
  3. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. cell-cell signaling Source: Ensembl
  3. chondrocyte differentiation Source: Ensembl
  4. embryonic digestive tract development Source: Ensembl
  5. embryonic limb morphogenesis Source: Ensembl
  6. embryonic skeletal system development Source: Ensembl
  7. fibroblast growth factor receptor signaling pathway Source: RGD
  8. inner ear morphogenesis Source: Ensembl
  9. lung-associated mesenchyme development Source: Ensembl
  10. male gonad development Source: Ensembl
  11. male sex determination Source: Ensembl
  12. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  13. negative regulation of Wnt signaling pathway Source: Ensembl
  14. osteoblast differentiation Source: Ensembl
  15. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  16. positive regulation of cardiac muscle cell proliferation Source: Ensembl
  17. positive regulation of cell division Source: UniProtKB-KW
  18. positive regulation of cell proliferation Source: RGD
  19. positive regulation of epithelial cell proliferation Source: Ensembl
  20. positive regulation of gene expression Source: Ensembl
  21. positive regulation of MAPK cascade Source: MGI
  22. positive regulation of mesenchymal cell proliferation Source: Ensembl
  23. positive regulation of smoothened signaling pathway Source: Ensembl
  24. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
  25. protein import into nucleus Source: Ensembl
  26. regulation of timing of cell differentiation Source: Ensembl
  27. substantia nigra development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_198665. Signaling by FGFR mutants.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198798. Signaling by activated point mutants of FGFR3.
REACT_198804. Signaling by FGFR3 mutants.
REACT_198810. Signaling by activated point mutants of FGFR1.
REACT_198813. Activated point mutants of FGFR2.
REACT_198995. Negative regulation of FGFR signaling.
REACT_202034. Phospholipase C-mediated cascade.
REACT_235451. FGFR4 ligand binding and activation.
REACT_240421. FRS2-mediated cascade.
REACT_244272. FGFR3c ligand binding and activation.
REACT_255209. FGFR1c ligand binding and activation.
REACT_256279. PI3K Cascade.
REACT_256376. PI-3K cascade.
REACT_257653. PIP3 activates AKT signaling.
REACT_259886. FGFR3b ligand binding and activation.
REACT_262505. FGFR2c ligand binding and activation.
REACT_79133. SHC-mediated cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 9
Short name:
FGF-9
Alternative name(s):
Glia-activating factor
Short name:
GAF
HBGF-9
Gene namesi
Name:Fgf9
Synonyms:Fgf-9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 15

Organism-specific databases

RGDi2610. Fgf9.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: RGD
  2. cytoplasm Source: RGD
  3. extracellular space Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 33By similarityPRO_0000008977
Chaini4 – 208205Fibroblast growth factor 9PRO_0000008978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP36364.

PTM databases

PhosphoSiteiP36364.

Expressioni

Tissue specificityi

Brain and kidney.

Gene expression databases

GenevestigatoriP36364.

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015368.

Structurei

3D structure databases

ProteinModelPortaliP36364.
SMRiP36364. Positions 52-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG269410.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP36364.
KOiK04358.
OMAiGELYGSD.
OrthoDBiEOG7992S1.
PhylomeDBiP36364.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028251. FGF9.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF28. PTHR11486:SF28. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36364-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPLGEVGSY FGVQDAVPFG NVPVLPVDSP VLLSDHLGQS EAGGLPRGPA
60 70 80 90 100
VTDLDHLKGI LRRRQLYCRT GFHLEIFPNG TIQGTRKDHS RFGILEFISI
110 120 130 140 150
AVGLVSIRGV DSGLYLGMNE KGELYGSEKL TQECVFREQF EENWYNTYSS
160 170 180 190 200
NLYKHVDTGR RYYVALNKDG TPREGTRTKR HQKFTHFLPR PVDPDKVPEL

YKDILSQS
Length:208
Mass (Da):23,414
Last modified:October 1, 1994 - v2
Checksum:i4A3CE894DFF643EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14839 mRNA. Translation: BAA03573.1.
RefSeqiNP_037084.1. NM_012952.1.
UniGeneiRn.25174.

Genome annotation databases

EnsembliENSRNOT00000015367; ENSRNOP00000015368; ENSRNOG00000011471.
GeneIDi25444.
KEGGirno:25444.
UCSCiRGD:2610. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14839 mRNA. Translation: BAA03573.1.
RefSeqiNP_037084.1. NM_012952.1.
UniGeneiRn.25174.

3D structure databases

ProteinModelPortaliP36364.
SMRiP36364. Positions 52-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015368.

PTM databases

PhosphoSiteiP36364.

Proteomic databases

PaxDbiP36364.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015367; ENSRNOP00000015368; ENSRNOG00000011471.
GeneIDi25444.
KEGGirno:25444.
UCSCiRGD:2610. rat.

Organism-specific databases

CTDi2254.
RGDi2610. Fgf9.

Phylogenomic databases

eggNOGiNOG269410.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP36364.
KOiK04358.
OMAiGELYGSD.
OrthoDBiEOG7992S1.
PhylomeDBiP36364.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiREACT_198665. Signaling by FGFR mutants.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198798. Signaling by activated point mutants of FGFR3.
REACT_198804. Signaling by FGFR3 mutants.
REACT_198810. Signaling by activated point mutants of FGFR1.
REACT_198813. Activated point mutants of FGFR2.
REACT_198995. Negative regulation of FGFR signaling.
REACT_202034. Phospholipase C-mediated cascade.
REACT_235451. FGFR4 ligand binding and activation.
REACT_240421. FRS2-mediated cascade.
REACT_244272. FGFR3c ligand binding and activation.
REACT_255209. FGFR1c ligand binding and activation.
REACT_256279. PI3K Cascade.
REACT_256376. PI-3K cascade.
REACT_257653. PIP3 activates AKT signaling.
REACT_259886. FGFR3b ligand binding and activation.
REACT_262505. FGFR2c ligand binding and activation.
REACT_79133. SHC-mediated cascade.

Miscellaneous databases

NextBioi606671.
PROiP36364.

Gene expression databases

GenevestigatoriP36364.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028251. FGF9.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF28. PTHR11486:SF28. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property."
    Miyamoto M., Naruo K., Seko C., Matsumoto S., Kondo T., Kurokawa T.
    Mol. Cell. Biol. 13:4251-4259(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiFGF9_RAT
AccessioniPrimary (citable) accession number: P36364
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 1, 1994
Last modified: January 7, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.