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Protein

Fibroblast growth factor 7

Gene

Fgf7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity).By similarity

GO - Molecular functioni

  1. chemoattractant activity Source: MGI
  2. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. actin cytoskeleton reorganization Source: MGI
  2. branching involved in salivary gland morphogenesis Source: MGI
  3. fibroblast growth factor receptor signaling pathway Source: MGI
  4. hair follicle morphogenesis Source: MGI
  5. mesenchymal cell proliferation Source: MGI
  6. positive chemotaxis Source: MGI
  7. positive regulation of cell division Source: UniProtKB-KW
  8. positive regulation of cell proliferation Source: MGI
  9. positive regulation of epithelial cell proliferation Source: MGI
  10. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
  11. positive regulation of keratinocyte migration Source: MGI
  12. positive regulation of keratinocyte proliferation Source: MGI
  13. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  14. protein localization to cell surface Source: MGI
  15. regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: MGI
  16. secretion by lung epithelial cell involved in lung growth Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_297015. FGFR2b ligand binding and activation.
REACT_321421. SHC-mediated cascade.
REACT_323826. Phospholipase C-mediated cascade.
REACT_326306. Signaling by FGFR mutants.
REACT_328674. Constitutive PI3K/AKT Signaling in Cancer.
REACT_332023. Negative regulation of FGFR signaling.
REACT_332809. FRS2-mediated cascade.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_334662. PI-3K cascade.
REACT_349060. Activated point mutants of FGFR2.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 7
Short name:
FGF-7
Alternative name(s):
Heparin-binding growth factor 7
Short name:
HBGF-7
Keratinocyte growth factor
Short name:
KGF
Gene namesi
Name:Fgf7
Synonyms:Fgf-7, Kgf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:95521. Fgf7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. Golgi apparatus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131By similarityAdd
BLAST
Chaini32 – 194163Fibroblast growth factor 7PRO_0000008966Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP36363.

PTM databases

PhosphoSiteiP36363.

Expressioni

Gene expression databases

BgeeiP36363.
CleanExiMM_FGF7.
ExpressionAtlasiP36363. baseline and differential.
GenevestigatoriP36363.

Interactioni

Subunit structurei

Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

Protein-protein interaction databases

BioGridi199652. 1 interaction.
IntActiP36363. 1 interaction.
STRINGi10090.ENSMUSP00000106072.

Structurei

3D structure databases

ProteinModelPortaliP36363.
SMRiP36363. Positions 63-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG294282.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP36363.
KOiK04358.
OMAiNCSKHER.
OrthoDBiEOG7992S1.
PhylomeDBiP36363.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028247. FGF7.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF20. PTHR11486:SF20. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKWILTRIL PTLLYRSCFH LVCLVGTISL ACNDMSPEQT ATSVNCSSPE
60 70 80 90 100
RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNSYNIMEI
110 120 130 140 150
RTVAVGIVAI KGVESEYYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT
160 170 180 190
YASAKWTHSG GEMFVALNQK GIPVKGKKTK KEQKTAHFLP MAIT
Length:194
Mass (Da):22,347
Last modified:June 1, 1994 - v1
Checksum:i805C30D4B1D27C73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22703 mRNA. Translation: CAA80403.1.
U58503 Genomic DNA. Translation: AAB01343.1.
BC052847 mRNA. Translation: AAH52847.1.
CCDSiCCDS16681.1.
PIRiI48610.
RefSeqiNP_032034.1. NM_008008.4.
UniGeneiMm.330557.

Genome annotation databases

EnsembliENSMUST00000064794; ENSMUSP00000069681; ENSMUSG00000027208.
ENSMUST00000110442; ENSMUSP00000106072; ENSMUSG00000027208.
GeneIDi14178.
KEGGimmu:14178.
UCSCiuc008mdj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22703 mRNA. Translation: CAA80403.1.
U58503 Genomic DNA. Translation: AAB01343.1.
BC052847 mRNA. Translation: AAH52847.1.
CCDSiCCDS16681.1.
PIRiI48610.
RefSeqiNP_032034.1. NM_008008.4.
UniGeneiMm.330557.

3D structure databases

ProteinModelPortaliP36363.
SMRiP36363. Positions 63-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199652. 1 interaction.
IntActiP36363. 1 interaction.
STRINGi10090.ENSMUSP00000106072.

PTM databases

PhosphoSiteiP36363.

Proteomic databases

PRIDEiP36363.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064794; ENSMUSP00000069681; ENSMUSG00000027208.
ENSMUST00000110442; ENSMUSP00000106072; ENSMUSG00000027208.
GeneIDi14178.
KEGGimmu:14178.
UCSCiuc008mdj.2. mouse.

Organism-specific databases

CTDi2252.
MGIiMGI:95521. Fgf7.

Phylogenomic databases

eggNOGiNOG294282.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP36363.
KOiK04358.
OMAiNCSKHER.
OrthoDBiEOG7992S1.
PhylomeDBiP36363.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiREACT_297015. FGFR2b ligand binding and activation.
REACT_321421. SHC-mediated cascade.
REACT_323826. Phospholipase C-mediated cascade.
REACT_326306. Signaling by FGFR mutants.
REACT_328674. Constitutive PI3K/AKT Signaling in Cancer.
REACT_332023. Negative regulation of FGFR signaling.
REACT_332809. FRS2-mediated cascade.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_334662. PI-3K cascade.
REACT_349060. Activated point mutants of FGFR2.

Miscellaneous databases

NextBioi285362.
PROiP36363.
SOURCEiSearch...

Gene expression databases

BgeeiP36363.
CleanExiMM_FGF7.
ExpressionAtlasiP36363. baseline and differential.
GenevestigatoriP36363.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028247. FGF7.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF20. PTHR11486:SF20. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions."
    Mason I.J., Fuller-Pace F., Smith R., Dickson C.
    Mech. Dev. 45:15-30(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Jones M.L., Dato M.E., Greenberg J.M.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FVB/N.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/He.
    Tissue: Osteoblast.

Entry informationi

Entry nameiFGF7_MOUSE
AccessioniPrimary (citable) accession number: P36363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 1, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.