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P36363 (FGF7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 7

Short name=FGF-7
Alternative name(s):
Heparin-binding growth factor 7
Short name=HBGF-7
Keratinocyte growth factor
Short name=KGF
Gene names
Name:Fgf7
Synonyms:Fgf-7, Kgf
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation By similarity.

Subunit structure

Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   LigandHeparin-binding
   Molecular functionGrowth factor
Mitogen
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin cytoskeleton reorganization

Inferred from electronic annotation. Source: Ensembl

branching involved in salivary gland morphogenesis

Inferred from direct assay PubMed 18559345. Source: MGI

fibroblast growth factor receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

hair follicle morphogenesis

Inferred from mutant phenotype PubMed 11098134. Source: MGI

mesenchymal cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of cell proliferation

Inferred from direct assay PubMed 14697353PubMed 15806171. Source: MGI

positive regulation of epithelial cell proliferation

Inferred from direct assay PubMed 17187775. Source: MGI

positive regulation of epithelial cell proliferation involved in lung morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of keratinocyte migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of keratinocyte proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

protein localization to cell surface

Inferred from electronic annotation. Source: Ensembl

regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

Inferred from direct assay PubMed 18559345. Source: MGI

secretion by lung epithelial cell involved in lung growth

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from direct assay PubMed 12837279. Source: MGI

extracellular region

Inferred from direct assay PubMed 12837279. Source: MGI

   Molecular_functionchemoattractant activity

Inferred from electronic annotation. Source: Ensembl

heparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 By similarity
Chain32 – 194163Fibroblast growth factor 7
PRO_0000008966

Amino acid modifications

Glycosylation451N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P36363 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 805C30D4B1D27C73

FASTA19422,347
        10         20         30         40         50         60 
MRKWILTRIL PTLLYRSCFH LVCLVGTISL ACNDMSPEQT ATSVNCSSPE RHTRSYDYME 

        70         80         90        100        110        120 
GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNSYNIMEI RTVAVGIVAI KGVESEYYLA 

       130        140        150        160        170        180 
MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHSG GEMFVALNQK GIPVKGKKTK 

       190 
KEQKTAHFLP MAIT 

« Hide

References

« Hide 'large scale' references
[1]"FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions."
Mason I.J., Fuller-Pace F., Smith R., Dickson C.
Mech. Dev. 45:15-30(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Jones M.L., Dato M.E., Greenberg J.M.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: FVB/N.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C3H/He.
Tissue: Osteoblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z22703 mRNA. Translation: CAA80403.1.
U58503 Genomic DNA. Translation: AAB01343.1.
BC052847 mRNA. Translation: AAH52847.1.
PIRI48610.
RefSeqNP_032034.1. NM_008008.4.
UniGeneMm.330557.

3D structure databases

ProteinModelPortalP36363.
SMRP36363. Positions 63-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199652. 1 interaction.
STRING10090.ENSMUSP00000106072.

PTM databases

PhosphoSiteP36363.

Proteomic databases

PRIDEP36363.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000064794; ENSMUSP00000069681; ENSMUSG00000027208.
ENSMUST00000110442; ENSMUSP00000106072; ENSMUSG00000027208.
GeneID14178.
KEGGmmu:14178.
UCSCuc008mdj.2. mouse.

Organism-specific databases

CTD2252.
MGIMGI:95521. Fgf7.

Phylogenomic databases

eggNOGNOG294282.
HOGENOMHOG000236341.
HOVERGENHBG007580.
InParanoidP36363.
KOK04358.
OMANCSKHER.
OrthoDBEOG7992S1.
PhylomeDBP36363.
TreeFamTF317805.

Gene expression databases

ArrayExpressP36363.
BgeeP36363.
CleanExMM_FGF7.
GenevestigatorP36363.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028247. FGF7.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF20. PTHR11486:SF20. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285362.
PROP36363.
SOURCESearch...

Entry information

Entry nameFGF7_MOUSE
AccessionPrimary (citable) accession number: P36363
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot