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P36363

- FGF7_MOUSE

UniProt

P36363 - FGF7_MOUSE

Protein

Fibroblast growth factor 7

Gene

Fgf7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation By similarity.By similarity

    GO - Molecular functioni

    1. chemoattractant activity Source: Ensembl
    2. heparin binding Source: UniProtKB-KW
    3. protein binding Source: MGI

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: Ensembl
    2. branching involved in salivary gland morphogenesis Source: MGI
    3. fibroblast growth factor receptor signaling pathway Source: InterPro
    4. hair follicle morphogenesis Source: MGI
    5. mesenchymal cell proliferation Source: Ensembl
    6. positive regulation of cell division Source: UniProtKB-KW
    7. positive regulation of cell proliferation Source: MGI
    8. positive regulation of epithelial cell proliferation Source: MGI
    9. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
    10. positive regulation of keratinocyte migration Source: Ensembl
    11. positive regulation of keratinocyte proliferation Source: Ensembl
    12. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    13. protein localization to cell surface Source: Ensembl
    14. regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: MGI
    15. secretion by lung epithelial cell involved in lung growth Source: Ensembl

    Keywords - Molecular functioni

    Growth factor, Mitogen

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_196455. Signaling by FGFR mutants.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_223937. FGFR2b ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 7
    Short name:
    FGF-7
    Alternative name(s):
    Heparin-binding growth factor 7
    Short name:
    HBGF-7
    Keratinocyte growth factor
    Short name:
    KGF
    Gene namesi
    Name:Fgf7
    Synonyms:Fgf-7, Kgf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:95521. Fgf7.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: MGI
    2. Golgi apparatus Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131By similarityAdd
    BLAST
    Chaini32 – 194163Fibroblast growth factor 7PRO_0000008966Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP36363.

    PTM databases

    PhosphoSiteiP36363.

    Expressioni

    Gene expression databases

    ArrayExpressiP36363.
    BgeeiP36363.
    CleanExiMM_FGF7.
    GenevestigatoriP36363.

    Interactioni

    Subunit structurei

    Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors By similarity.By similarity

    Protein-protein interaction databases

    BioGridi199652. 1 interaction.
    STRINGi10090.ENSMUSP00000106072.

    Structurei

    3D structure databases

    ProteinModelPortaliP36363.
    SMRiP36363. Positions 63-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG294282.
    HOGENOMiHOG000236341.
    HOVERGENiHBG007580.
    InParanoidiP36363.
    KOiK04358.
    OMAiNCSKHER.
    OrthoDBiEOG7992S1.
    PhylomeDBiP36363.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028247. FGF7.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF20. PTHR11486:SF20. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36363-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKWILTRIL PTLLYRSCFH LVCLVGTISL ACNDMSPEQT ATSVNCSSPE    50
    RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNSYNIMEI 100
    RTVAVGIVAI KGVESEYYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT 150
    YASAKWTHSG GEMFVALNQK GIPVKGKKTK KEQKTAHFLP MAIT 194
    Length:194
    Mass (Da):22,347
    Last modified:June 1, 1994 - v1
    Checksum:i805C30D4B1D27C73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22703 mRNA. Translation: CAA80403.1.
    U58503 Genomic DNA. Translation: AAB01343.1.
    BC052847 mRNA. Translation: AAH52847.1.
    CCDSiCCDS16681.1.
    PIRiI48610.
    RefSeqiNP_032034.1. NM_008008.4.
    UniGeneiMm.330557.

    Genome annotation databases

    EnsembliENSMUST00000064794; ENSMUSP00000069681; ENSMUSG00000027208.
    ENSMUST00000110442; ENSMUSP00000106072; ENSMUSG00000027208.
    GeneIDi14178.
    KEGGimmu:14178.
    UCSCiuc008mdj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22703 mRNA. Translation: CAA80403.1 .
    U58503 Genomic DNA. Translation: AAB01343.1 .
    BC052847 mRNA. Translation: AAH52847.1 .
    CCDSi CCDS16681.1.
    PIRi I48610.
    RefSeqi NP_032034.1. NM_008008.4.
    UniGenei Mm.330557.

    3D structure databases

    ProteinModelPortali P36363.
    SMRi P36363. Positions 63-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199652. 1 interaction.
    STRINGi 10090.ENSMUSP00000106072.

    PTM databases

    PhosphoSitei P36363.

    Proteomic databases

    PRIDEi P36363.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000064794 ; ENSMUSP00000069681 ; ENSMUSG00000027208 .
    ENSMUST00000110442 ; ENSMUSP00000106072 ; ENSMUSG00000027208 .
    GeneIDi 14178.
    KEGGi mmu:14178.
    UCSCi uc008mdj.2. mouse.

    Organism-specific databases

    CTDi 2252.
    MGIi MGI:95521. Fgf7.

    Phylogenomic databases

    eggNOGi NOG294282.
    HOGENOMi HOG000236341.
    HOVERGENi HBG007580.
    InParanoidi P36363.
    KOi K04358.
    OMAi NCSKHER.
    OrthoDBi EOG7992S1.
    PhylomeDBi P36363.
    TreeFami TF317805.

    Enzyme and pathway databases

    Reactomei REACT_196455. Signaling by FGFR mutants.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_223937. FGFR2b ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Miscellaneous databases

    NextBioi 285362.
    PROi P36363.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P36363.
    Bgeei P36363.
    CleanExi MM_FGF7.
    Genevestigatori P36363.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028247. FGF7.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF20. PTHR11486:SF20. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions."
      Mason I.J., Fuller-Pace F., Smith R., Dickson C.
      Mech. Dev. 45:15-30(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Jones M.L., Dato M.E., Greenberg J.M.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FVB/N.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C3H/He.
      Tissue: Osteoblast.

    Entry informationi

    Entry nameiFGF7_MOUSE
    AccessioniPrimary (citable) accession number: P36363
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3