P36363 (FGF7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 7
Short name=FGF-7

Alternative name(s):
Heparin-binding growth factor 7
Short name=HBGF-7
Keratinocyte growth factor
Short name=KGF

Gene names

Name:	Fgf7
Synonyms:	Fgf-7, Kgf

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation By similarity.
Subunit structure	Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Heparin-binding
Molecular function	Growth factor Mitogen
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin cytoskeleton reorganization Inferred from electronic annotation. Source: Compara branching involved in salivary gland morphogenesis Inferred from direct assay PubMed 18559345. Source: MGI fibroblast growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara hair follicle morphogenesis Inferred from mutant phenotype PubMed 11098134. Source: MGI mesenchymal cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of epithelial cell proliferation Inferred from direct assay PubMed 17187775. Source: MGI positive regulation of epithelial cell proliferation involved in lung morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of keratinocyte migration Inferred from electronic annotation. Source: Compara positive regulation of keratinocyte proliferation Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara protein localization to cell surface Inferred from electronic annotation. Source: Compara regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Inferred from direct assay PubMed 18559345. Source: MGI secretion by lung epithelial cell involved in lung growth Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from direct assay PubMed 12837279. Source: MGI extracellular region Inferred from direct assay PubMed 12837279. Source: MGI
Molecular_function	chemoattractant activity Inferred from electronic annotation. Source: Compara heparin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	By similarity
	Chain	32 – 194	163	Fibroblast growth factor 7		PRO_0000008966
Amino acid modifications
	Glycosylation	45	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P36363 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 805C30D4B1D27C73	FASTA	194	22,347
	10 20 30 40 50 60 MRKWILTRIL PTLLYRSCFH LVCLVGTISL ACNDMSPEQT ATSVNCSSPE RHTRSYDYME 70 80 90 100 110 120 GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNSYNIMEI RTVAVGIVAI KGVESEYYLA 130 140 150 160 170 180 MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHSG GEMFVALNQK GIPVKGKKTK 190 KEQKTAHFLP MAIT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions." Mason I.J., Fuller-Pace F., Smith R., Dickson C. Mech. Dev. 45:15-30(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Jones M.L., Dato M.E., Greenberg J.M. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: FVB/N.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C3H/He. Tissue: Osteoblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z22703 mRNA. Translation: CAA80403.1. U58503 Genomic DNA. Translation: AAB01343.1. BC052847 mRNA. Translation: AAH52847.1.
IPI	IPI00121803.
PIR	I48610.
RefSeq	NP_032034.1. NM_008008.4.
UniGene	Mm.330557.
3D structure databases
ProteinModelPortal	P36363.
SMR	P36363. Positions 63-194.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000106072.
PTM databases
PhosphoSite	P36363.
Proteomic databases
PRIDE	P36363.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000064794; ENSMUSP00000069681; ENSMUSG00000027208. ENSMUST00000110442; ENSMUSP00000106072; ENSMUSG00000027208.
GeneID	14178.
KEGG	mmu:14178.
Organism-specific databases
CTD	2252.
MGI	MGI:95521. Fgf7.
Phylogenomic databases
eggNOG	NOG294282.
HOGENOM	HOG000236341.
HOVERGEN	HBG007580.
InParanoid	P36363.
KO	K04358.
OMA	NCSKHER.
OrthoDB	EOG4J9N0V.
Gene expression databases
ArrayExpress	P36363.
Bgee	P36363.
CleanEx	MM_FGF7.
Genevestigator	P36363.
GermOnline	ENSMUSG00000027208. Mus musculus.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin-bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. PTHR11486. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	285362.
SOURCE	Search...

Entry information

Entry name

FGF7_MOUSE

Accession

Primary (citable) accession number: P36363

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program