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P36358 (NSP5_ROTPC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-structural protein 5

Short name=NSP5
OrganismRotavirus C (strain Pig/United States/Cowden/1980) (RV-C) [Complete proteome]
Taxonomic identifier10916 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostSus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.

Cofactor

Magnesium for ATPase activity.

Subunit structure

Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.

Subcellular location

Host cytoplasm. Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.

Sequence similarities

Belongs to the rotavirus C NSP5 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Non-structural protein 5
PRO_0000149644

Regions

Compositional bias2 – 8483Ser-rich

Sites

Metal binding861Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
P36358 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 4A3CD910803B0943

FASTA21023,393
        10         20         30         40         50         60 
MSDFGINLDA ICDNVKYKSS NSRTGSQVSN RSSRRMDFVD EEELSTYFNS KASVTQSDSC 

        70         80         90        100        110        120 
SNDLAVKTSI ITEAVICDES EHVSADAIQE KEESIMQVDD NVMKWMMDSH DGISMNGGIN 

       130        140        150        160        170        180 
FSRSKSKTGR SDFTESKSET SVSAHVSAGI SSQLGMFNPI QNTVKKEAIS EMFEDEDGDG 

       190        200        210 
CTCRNCPYRE KYLKLRNKMK SVLVDMINEM 

« Hide

References

[1]"Sequence analysis of three non structural proteins of a porcine group C (Cowden strain) rotavirus."
Bremont M., Chabanne-Vautherot D., Cohen J.
Arch. Virol. 130:85-92(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X65938 mRNA. Translation: CAA46741.1.
PIRB48357.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002512. Rotavirus_A/C_NSP5.
[Graphical view]
PfamPF01525. Rota_NS26. 1 hit.
[Graphical view]
PIRSFPIRSF004006. Rota_NS26. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNSP5_ROTPC
AccessionPrimary (citable) accession number: P36358
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 3, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families