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P36358

- NSP5_ROTPC

UniProt

P36358 - NSP5_ROTPC

Protein

Non-structural protein 5

Gene
N/A
Organism
Rotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.By similarity

    Cofactori

    Magnesium for ATPase activity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi86 – 861MagnesiumSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. magnesium ion binding Source: InterPro
    3. nucleotide binding Source: UniProtKB-KW
    4. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. viral genome replication Source: InterPro

    Keywords - Ligandi

    Magnesium, Metal-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein 5
    Short name:
    NSP5
    OrganismiRotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
    Taxonomic identifieri10916 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiSus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000008175: Genome

    Subcellular locationi

    Host cytoplasm
    Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.By similarity

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 210210Non-structural protein 5PRO_0000149644Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.By similarity

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 8483Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the rotavirus C NSP5 family.Curated

    Family and domain databases

    InterProiIPR002512. Rotavirus_A/C_NSP5.
    [Graphical view]
    PfamiPF01525. Rota_NS26. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004006. Rota_NS26. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P36358-1 [UniParc]FASTAAdd to Basket

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    MSDFGINLDA ICDNVKYKSS NSRTGSQVSN RSSRRMDFVD EEELSTYFNS    50
    KASVTQSDSC SNDLAVKTSI ITEAVICDES EHVSADAIQE KEESIMQVDD 100
    NVMKWMMDSH DGISMNGGIN FSRSKSKTGR SDFTESKSET SVSAHVSAGI 150
    SSQLGMFNPI QNTVKKEAIS EMFEDEDGDG CTCRNCPYRE KYLKLRNKMK 200
    SVLVDMINEM 210
    Length:210
    Mass (Da):23,393
    Last modified:June 1, 1994 - v1
    Checksum:i4A3CD910803B0943
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65938 mRNA. Translation: CAA46741.1.
    PIRiB48357.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65938 mRNA. Translation: CAA46741.1 .
    PIRi B48357.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR002512. Rotavirus_A/C_NSP5.
    [Graphical view ]
    Pfami PF01525. Rota_NS26. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004006. Rota_NS26. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of three non structural proteins of a porcine group C (Cowden strain) rotavirus."
      Bremont M., Chabanne-Vautherot D., Cohen J.
      Arch. Virol. 130:85-92(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiNSP5_ROTPC
    AccessioniPrimary (citable) accession number: P36358
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3