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P36357

- VP7_ROTA1

UniProt

P36357 - VP7_ROTA1

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Protein

Outer capsid glycoprotein VP7

Gene
N/A
Organism
Rotavirus A (strain Turkey/Ireland/Ty-1/1978 G7-P[17]-I4-Rx-Cx-Mx-Ax-N4-Tx-E4-Hx) (RV-A)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. In integrin-dependent strains, VP7 seems to essentially target the integrin heterodimers ITGAX/ITGB2 and ITGA5/ITGB3 at a postbinding stage, once the initial attachment by VP4 has been achieved By similarity.

GO - Biological processi

  1. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Outer capsid glycoprotein VP7
OrganismiRotavirus A (strain Turkey/Ireland/Ty-1/1978 G7-P[17]-I4-Rx-Cx-Mx-Ax-N4-Tx-E4-Hx) (RV-A)
Taxonomic identifieri12584 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiAves [TaxID: 8782]

Subcellular locationi

Virion By similarity. Host endoplasmic reticulum lumen Reviewed prediction
Note: Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles By similarity.

GO - Cellular componenti

  1. host cell endoplasmic reticulum lumen Source: UniProtKB-SubCell
  2. T=13 icosahedral viral capsid Source: UniProtKB-KW
  3. viral outer capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host endoplasmic reticulum, Outer capsid protein, T=13 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5353 Reviewed predictionAdd
BLAST
Chaini54 – 329276Outer capsid glycoprotein VP7 Reviewed predictionPRO_0000149589Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi150 – 1501N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi241 – 2411N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi321 – 3211N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

The N-terminus is blocked possibly by pyroglutamic acid By similarity.
N-glycosylated By similarity.
Intramolecular disulfide bonds By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homotrimer; in the presence of calcium By similarity. Acquisition of the capsid outer layer requires a high calcium concentration inside the endoplasmic reticulum. Following cell entry, the low calcium concentration in the cytoplasm is probably responsible for the solubilization of the outer layer. Interacts with host integrin heterodimers ITGAX/ITGB2 and ITGA5/ITGB3 By similarity.

Family & Domainsi

Sequence similaritiesi

Belongs to the rotavirus VP7 family.

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001963. VP7.
[Graphical view]
PfamiPF00434. VP7. 1 hit.
[Graphical view]
ProDomiPD000191. VP7. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36357-1 [UniParc]FASTAAdd to Basket

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MYSTECTILL IEIIFYFLAA IILYDMLHKM ANSPLLCIAV LTVTLAVTSK    50
CYAQNYGINV PITGSMDVAV PNKTDDQIGL SSTLCIYYPK EAATQMNDAE 100
WKSTVTQLLL AKGWPTTSVY LNEYADLQSF SNDPQLNCDY NIILAKYDQN 150
ETLDMSELAE LLLYEWLCNP MDVTLYYYQQ TSESNKWIAM GSDCTIKVCP 200
LNTQTLGIGC KTTDVSTFEE LTTTEKLAII DVVDGVNHKA NYTISTCTIK 250
NCIRLDPREN VAIIQVGGPE IIDISEDPMV VPHVQRATRI NWKKWWQIFY 300
TVVDYINTII QAMSKRSRSL NTSAYYFRV 329
Length:329
Mass (Da):37,288
Last modified:June 1, 1994 - v1
Checksum:iD396321A9FAE7939
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S58166 mRNA. Translation: AAB26094.1.
PIRiA48351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S58166 mRNA. Translation: AAB26094.1 .
PIRi A48351.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001963. VP7.
[Graphical view ]
Pfami PF00434. VP7. 1 hit.
[Graphical view ]
ProDomi PD000191. VP7. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "The avian rotavirus Ty-1 Vp7 nucleotide and deduced amino acid sequences differ significantly from those of Ch-2 rotavirus."
    Kool D.A., Holmes I.H.
    Arch. Virol. 129:227-234(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiVP7_ROTA1
AccessioniPrimary (citable) accession number: P36357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

In group A rotaviruses, VP7 defines the G serotype.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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