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Protein

Core protein VP7

Gene

S7

Organism
African horse sickness virus 4 (AHSV-4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Major structural core protein; binds to structural protein VP3. Constitutes the surface of the AHSV core.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Core protein VP7
Alternative name(s):
Capsid protein VP7
VP7 antigen
Gene namesi
Name:S7
OrganismiAfrican horse sickness virus 4 (AHSV-4)
Taxonomic identifieri36421 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeOrbivirus
Virus hostiCamelus dromedarius (Dromedary) (Arabian camel) [TaxID: 9838]
Canis lupus familiaris (Dog) (Canis familiaris) [TaxID: 9615]
Equus asinus (Donkey) (Equus africanus asinus) [TaxID: 9793]
Equus burchelli (Plains zebra) (Equus quagga) [TaxID: 9790]
Equus caballus (Horse) [TaxID: 9796]
Equus hemionus (Onager) (Asian wild ass) [TaxID: 9794]
Loxodonta africana (African elephant) [TaxID: 9785]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Outer capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Core protein VP7PRO_0000222736Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...); by hostSequence analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotrimer.

Structurei

Secondary structure

1
350
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni128 – 1314Combined sources
Beta strandi144 – 15411Combined sources
Beta strandi157 – 1626Combined sources
Beta strandi166 – 1694Combined sources
Helixi171 – 1744Combined sources
Turni178 – 1803Combined sources
Beta strandi184 – 19512Combined sources
Beta strandi209 – 2124Combined sources
Beta strandi215 – 2173Combined sources
Beta strandi223 – 2253Combined sources
Beta strandi227 – 2293Combined sources
Beta strandi231 – 2355Combined sources
Beta strandi237 – 2393Combined sources
Beta strandi241 – 25010Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AHSX-ray2.30A/B/C126-251[»]
ProteinModelPortaliP36325.
SMRiP36325. Positions 126-251.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36325.

Family & Domainsi

Sequence similaritiesi

Belongs to the orbivirus VP7 family.Curated

Family and domain databases

Gene3Di1.10.170.10. 1 hit.
1.10.250.10. 1 hit.
InterProiIPR023176. BTV10_su1_dom1.
IPR008980. Capsid_hemagglutn.
IPR001803. Orbi_VP7_capsid.
IPR023178. Orbi_VP7_capsid_C.
IPR008935. Virus_capsid_a-hlx_vir.
[Graphical view]
PfamiPF00897. Orbi_VP7. 1 hit.
[Graphical view]
PRINTSiPR00903. VP7CAPSID.
SUPFAMiSSF48345. SSF48345. 2 hits.
SSF49818. SSF49818. 1 hit.

Sequencei

Sequence statusi: Complete.

P36325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAIAARALS VVRACVTVTD ARVSLDPGVM ETLGIAINRY NGLTNHSVSM
60 70 80 90 100
RPQTQAERNE MFFMCTDMVL AALNVQIGNI SPDYDQALAT VGALATTEIP
110 120 130 140 150
YNVQAMNDIV RITGQMQTFG PSKVQTGPYA GAVEVQQSGR YYVPQGRTRG
160 170 180 190 200
GYINSNIAEV CMDAGAAGQV NALLAPRRGD AVMIYFVWRP LRIFCDPQGA
210 220 230 240 250
SLESAPGTFV TVDGVNVAAG DVVAWNTIAP VNVGNPGARR SILQFEVLWY
260 270 280 290 300
TSLDRSLDTV PELAPTLTRC YAYVSPTWHA LRAVIFQQMN MQPINPPIFP
310 320 330 340 350
PTERNEIVAY LLLVASLADV YAALRPDFRM NGVVAPVGQI NRALVLAAYH
Length:350
Mass (Da):37,942
Last modified:November 1, 1997 - v2
Checksum:iA58456EFAE5AAB66
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti207 – 2071G → GAPG (PubMed:1646273).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12533 Genomic RNA. Translation: BAA02096.1.
X56676 mRNA. Translation: CAA39999.1.
PIRiJQ1946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12533 Genomic RNA. Translation: BAA02096.1.
X56676 mRNA. Translation: CAA39999.1.
PIRiJQ1946.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AHSX-ray2.30A/B/C126-251[»]
ProteinModelPortaliP36325.
SMRiP36325. Positions 126-251.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP36325.

Family and domain databases

Gene3Di1.10.170.10. 1 hit.
1.10.250.10. 1 hit.
InterProiIPR023176. BTV10_su1_dom1.
IPR008980. Capsid_hemagglutn.
IPR001803. Orbi_VP7_capsid.
IPR023178. Orbi_VP7_capsid_C.
IPR008935. Virus_capsid_a-hlx_vir.
[Graphical view]
PfamiPF00897. Orbi_VP7. 1 hit.
[Graphical view]
PRINTSiPR00903. VP7CAPSID.
SUPFAMiSSF48345. SSF48345. 2 hits.
SSF49818. SSF49818. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete sequence of the group-specific antigen, VP7, of African horsesickness disease virus serotype 4 reveals a close relationship to bluetongue virus."
    Roy P., Hirasawa T., Fernandez M., Blinov V.M., Sanchez-Vixcain Rodrique J.M.
    J. Gen. Virol. 72:1237-1241(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Vaccine.
  2. "Crystal structure of the top domain of African horse sickness virus VP7: comparisons with bluetongue virus VP7."
    Basak A.K., Gouet P., Grimes J., Roy P., Stuart D.
    J. Virol. 70:3797-3806(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS), SEQUENCE REVISION TO 207.
    Strain: Vaccine.

Entry informationi

Entry nameiVP7_AHSV4
AccessioniPrimary (citable) accession number: P36325
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: December 9, 2015
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.