P36311 (VNCS_PAVL3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-capsid protein NS-1

Alternative name(s):
Non-structural protein NS1

Gene names

Name:

NS1

Organism

Parvovirus LuIII [Complete proteome]

Taxonomic identifier

35339 [NCBI]

Taxonomic lineage

Viruses › ssDNA viruses › Parvoviridae › Parvovirinae › Parvovirus

Virus host

Rodentia [TaxID: 9989]

Protein attributes

Sequence length	668 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Seems necessary for viral DNA replication.
Sequence similarities	Belongs to the parvoviruses non-capsid protein family. Contains 1 SF3 helicase domain.

Ontologies

Keywords
Biological process	DNA replication Initiation of viral infection Viral penetration into host cytoplasm Viral penetration via permeabilization of host organellar membrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 668	668	Non-capsid protein NS-1		PRO_0000222469
Regions
	Domain	373 – 528	156	SF3 helicase
	Nucleotide binding	399 – 406	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P36311 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: CAE69049F8F86B53	FASTA	668	75,846
	10 20 30 40 50 60 MAGNAYSDEV LGTTNWLKDK SNQEVFSFVF KNEDVQLNGK NIGWNSYRKE LQEEELKSLQ 70 80 90 100 110 120 RGAETTWDQS EDMEWESSVD ELTKKQVFIF DSLVKKCLFE VLSTKNIAPS DVTWFVQHEW 130 140 150 160 170 180 GKDQGWHCHV LIGGKNFSQA QGKWWRRQLN VYWSRWLVTA CSVQLSPAER IKLREIAEDQ 190 200 210 220 230 240 EWVTLLTYKH KQTKKDYTKC VCFGNMVAYY FLTKKKICTS PPRDGGYFLS SDSGWKTNFL 250 260 270 280 290 300 KEGERHLVSK LYTDDMRPET VETTVTTAQE TKRGRIQTKK EVSIKTTLKE LVHKRVTSPE 310 320 330 340 350 360 DWMMMQPDSY IEMMAQPGGE NLLKNTLEIC TLTLARTKTA FDLILEKAET SKLTNFLLAD 370 380 390 400 410 420 TRTCRIFAFH GWNYIKVCHA ICCVLNRQGG KRNTVLFHGP ASTGKSIIAQ AIAQAVGNVG 430 440 450 460 470 480 CYNAANVNFP FNDCTNKNLI WVEEAGNFGQ QVNQFKAICS GQTIRIDQKG KGSKQIEPTP 490 500 510 520 530 540 VIMTTNENIT VVKIGCEERP EHTQPIRDRM LNIHLTHTLP GDFGLVDKNE WPMICAWLVK 550 560 570 580 590 600 NGYQSTMASY CAKWGKVPDW TENWAEPKVT TEINSVGSTN SPSPKSTPLS QNYALTPSDL 610 620 630 640 650 660 EDLALEPWST PSTPVVGTVK TPNTGETGST ACQEAQRSPT WSEIEEDLRA CFSSEHWKSD SEQLPNLD

References

[1]	"The complete nucleotide sequence of parvovirus LuIII and localization of a unique sequence possibly responsible for its encapsidation pattern." Diffoot N., Chen K.C., Bates R.C., Lederma M. Virology 192:339-345(1993) [PubMed: 8517025] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M81888 Genomic DNA. No translation available.
PIR	A44276.
RefSeq	NP_821154.1. NC_004713.1.
3D structure databases
ProteinModelPortal	P36311.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1497265.
Family and domain databases
InterPro	IPR014015. Helicase_SF3_DNA-vir. IPR021972. Parvovirus_NS1_C. IPR001257. Parvovirus_NS1_helicase. IPR021076. Parvovirus_NS1_N. [Graphical view]
Pfam	PF12117. DUF3580. 1 hit. PF01057. Parvo_NS1. 1 hit. PF12433. PV_NSP1. 1 hit. [Graphical view]
PROSITE	PS51206. SF3_HELICASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VNCS_PAVL3

Accession

Primary (citable) accession number: P36311

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	September 21, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program