Reviewed, UniProtKB/Swiss-Prot P36304 (POLR_KYMVJ)

Names and origin

Protein names	Recommended name:     RNA replicase polyprotein     EC=2.7.7.48
Organism	Kennedya yellow mosaic virus (strain Jervis bay) (KYMV)
Taxonomic identifier	36392 [NCBI]
Taxonomic lineage	Viruses › ssRNA positive-strand viruses, no DNA stage › Tymoviridae › Tymovirus
Virus host	Desmodium [TaxID: 53866] Indigofera australis [TaxID: 53889] Kennedia rubicunda [TaxID: 76709]

Protein attributes

Sequence length	1874 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Sequence similarities	Belongs to the tymovirus NS35 RNA replicase polyprotein family. Contains 1 RdRp catalytic domain.

Ontologies

Keywords
Biological process	RNA replication
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase RNA-directed RNA polymerase Transferase
Gene Ontology (GO)
Biological process	transcription, RNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from electronic annotation. Source: InterPro RNA helicase activity Inferred from electronic annotation. Source: InterPro RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1874	1874	RNA replicase polyprotein		PRO_0000222935
Regions
	Domain	1601 – 1707	107	RdRp catalytic
	Nucleotide binding	1002 – 1009	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P36304-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 72B6DDE57732A2AD	FASTA	1,874	210,030
	10 20 30 40 50 60 MAFQLALDAL ASTSHKDPSL HPVLESVHDS LTDSLQTYPW MVPQDLQPFL LKSGIPINSF 70 80 90 100 110 120 GSSPHPHPAH KTLETHLLFT HWMHLCTQPS SVLFMKPQKF MKLQRKNKFF QHLHNYRLTP 130 140 150 160 170 180 TDSVRFPSTS PHLPNTPFVF MHDALMYYQP EQILHLFHQV PQLTNLFCSL VTPPESHFTH 190 200 210 220 230 240 LSLMPDLYTF TLKGQTLHYT PEGHSAGSYN QPITALSWLK INSILSPNLN LSITILESWG 250 260 270 280 290 300 PLHSILIQRG LPLPDPKLLV RSLPPFSRSP DPETDLVSFQ VPKSVELPQA TFLSQPLRHR 310 320 330 340 350 360 LVPESVYNAL FTYTRAVRTL RVSDPAGFVR TQSNKPEHKW VTPSAWDNLQ TFALLNCPLR 370 380 390 400 410 420 PNVVYHVLLN PLQKMKLYFS QHWRRLGVIA APGLFCLSLL LRSQKWSLPL PKAKSISVFR 430 440 450 460 470 480 RNLLLPPKPH RPPLLPHPEQ MLQEFKLPWH RPPPKGKRNP FLTLLINLLH IPREICAGIR 490 500 510 520 530 540 RYPSYYQSIQ PKPLNPIQQF RNQLLAQLHT LPLPKKFLSI LPRARKDIPL LPRMSFTTVN 550 560 570 580 590 600 LPLQPPMWLA IGASLVPELA FLLSWLSGDV DLQTQHDIYH HHLHPENFTL SWTRTPYLAL 610 620 630 640 650 660 APSPFLPYAH SPLPPLPVNS SPLFPPPPPL PPSQPPLSQG PATQAPSAQP TPGEPLLAPP 670 680 690 700 710 720 TTELKPESSN PNNPNPSSSA GSNPPPKSSS SDNPPAPNKP TPTSSSTTPP SPNLPLQFGS 730 740 750 760 770 780 IHSPFLSDGQ LNYSALPPPQ DPTNTTLSLL PEPKPPTEVQ SPLMADPTCV GPAVSFSSLY 790 800 810 820 830 840 PRDFFPNTAS FLTRLRLSPP TPLPMPKNNC LLTAVAPSLH INPHRLWTSL QEVLPDSLLS 850 860 870 880 890 900 NSEIDSVGMS TDLLTALSHL FNFQAVVHSE RGDILFGLQS AKTVIHIYHT NGPPAHYSPP 910 920 930 940 950 960 PKIIGSNSPP SSQQHPLEQA ALRFKYQGSH LPFSSFHSFT TSVQHAKNLI SNMKNGFDGV 970 980 990 1000 1010 1020 MSTIEPSIRH QPGHSPREKF IALDAMIDLA RPKTVSMFHL AGFAGCGKTK PLQSLLSTRP 1030 1040 1050 1060 1070 1080 FHSFRVSTPT TELRNEWKKD MNLPASQAFR FCTWESSLLK QTKILVIDEI YKLPRGYLDL 1090 1100 1110 1120 1130 1140 CILADPCLEL VIILGDPLQG EYHSTSPHSS NHQLQSETTR LLPFIDHYCW WTYRVPSHIA 1150 1160 1170 1180 1190 1200 DLFSVPSFNR SEGHYQMAVR TADSYTPGHF NLVNSVATAN AVIQLGFPAT TISASQGVTH 1210 1220 1230 1240 1250 1260 HNRVTILLDK HSRLLSPSNT LVALTRSTVG VEFLGDIGSL SGTNNSSDMF SRAIYRQPIN 1270 1280 1290 1300 1310 1320 LSSSFPRIFH LLPLLNKPIS RRSTRLIGSH SPIFHNPRLT NIHLPPHIPT SYSQDFVVSN 1330 1340 1350 1360 1370 1380 PIFQGQADPR LDTHFLPPTR LPLQSELLPA QLSQTTKPTD SFTNNTPFTP VYPGENFENL 1390 1400 1410 1420 1430 1440 AAFFLPAHDP ELKEVTRRDQ TSAQFPWFDR PFSLSCQPSS LIAAKHSPSQ DPTLLPFSIP 1450 1460 1470 1480 1490 1500 KRLRFRKSDN PHVLSAIDVL LGNQLFFNLC KAYRRNPTHV GPFNPALFAE CIALNDYAQL 1510 1520 1530 1540 1550 1560 SSKTQATLVA NHSRSDPDWR HTAVKIFAKS QHKVNDASIF GNWKACQTLA LMHDFVILSL 1570 1580 1590 1600 1610 1620 GPVKKYQRIF DALDRPPHLY THCGKSPADL SAWCQTHLTG QIKLTNDYTA FDQSQHGESV 1630 1640 1650 1660 1670 1680 ILEALKMKRL SIPSHLIQLH VHLKTNVATQ FGPLTCMRLT GEPGTYDDNS DYNLAVIHSQ 1690 1700 1710 1720 1730 1740 FDMKDIPVMV SGDDSLIDRQ PPLAQSWEAT KRLLHLRFKT EKTTHPLFCG YYTGSAGAIR 1750 1760 1770 1780 1790 1800 NPLALFSKLM IAIDDEAIHD RRLSYLTEFS TGHQLGDALW TLLPESTQIY QSACFDYFCR 1810 1820 1830 1840 1850 1860 HSPPHEKALL SSFELPDSVI SKISSSTKWL SKNAFYALPS KIRKAVIASR HSSSFPENPD 1870 VSQLEFELLQ SFQF

References

[1]	"The nucleotide sequence of the genomic RNA of kennedya yellow mosaic tymovirus-Jervis Bay isolate: relationships with potex- and carlaviruses." Ding S., Keese P., Gibbs A. J. Gen. Virol. 71:925-931(1990) [PubMed: 2324710] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	D00637 Genomic RNA. Translation: BAA00532.1.
PIR	JQ0533.
RefSeq	NP_044328.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	C21.001.
Genome annotation databases
GeneID	1493972.
Family and domain databases
InterPro	IPR008043. Peptidase_C21. IPR001788. RNA-dep_RNA_pol_vir-typ. IPR000606. RNA_helicase1_vir. IPR007094. RNA_pol_PSvir. IPR018308. RNA_replicase_MeTrfase_typovir. [Graphical view]
Pfam	PF10641. Methyltrans_Typ. 1 hit. PF05381. Peptidase_C21. 1 hit. PF00978. RdRP_2. 1 hit. PF01443. Viral_helicase1. 1 hit. [Graphical view]
PROSITE	PS50507. RDRP_SSRNA_POS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

POLR_KYMVJ

Accession

Primary (citable) accession number: P36304

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)