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P36292 (MVP_TSWV1) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Movement protein

Short name=MVP
Alternative name(s):
Non-structural movement protein
Short name=NSm
Gene names
Name:NSM
OrganismTomato spotted wilt virus (strain Brazilian Br-01) (TSWV) [Reference proteome]
Taxonomic identifier36413 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeTospovirus
Virus hostFrankliniella occidentalis (Western flower thrips) [TaxID: 133901]
Scirtothrips dorsalis [TaxID: 163899]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Thrips tabaci [TaxID: 161014]

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Viral movemement protein which is responsible for cell-to cell spread of viral genome. Increases the size exclusion limit (SEL) of plasmodesmata by forming tubules structures, thereby allowing viral ribonucleocapsids to spread directly to neighboring cells. Ref.4 Ref.5 Ref.6 Ref.8

Subunit structure

Oligomerizes to form tubule structures through host plasmodesma. Interacts with host A.thaliana At4g26020 protein, which is involved in intra- and inter-cellular trafficking. Ref.7

Subcellular location

Host cell junctionhost plasmodesma. Note: Colocalizes with viral nucleocapsid aggregates in host cytoplasm. Ref.3

Sequence similarities

Belongs to the tospovirus movement protein family.

Ontologies

Keywords
   Biological processHost-virus interaction
Transport
   Cellular componentHost cell junction
   Molecular functionViral movement protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransport of virus in host, cell to cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell plasmodesma

Inferred from direct assay Ref.7. Source: UniProtKB

   Molecular_functionprotein binding

Inferred from physical interaction Ref.7. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Movement protein
PRO_0000221987

Regions

Region19 – 159141Essential for tubule formation and cell-to-cell movement
Region209 – 28375Essential for tubule formation and cell-to-cell movement
Region284 – 2885Essential for long-distance movement

Sequences

Sequence LengthMass (Da)Tools
P36292 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: B00E16BEE6BA84C6

FASTA30133,564
        10         20         30         40         50         60 
MLTLFGNKRP SKSAGKDEGP LVSLAKHNGS VEVSKPWSSS DEKLALTKAM DASKGKILLN 

        70         80         90        100        110        120 
IEGTSSFGTY ESDSIIESEG YDLSARMIVD TNHHISNWKN DLFVGNGKQN ANKVIKICPT 

       130        140        150        160        170        180 
WDSRKQYMMI SRIVIWVCPT IPNPTGKLVV ALIDPNMPSG KQVILKGQGT ITDPICFVFY 

       190        200        210        220        230        240 
LNWSIPKMNN TPENCCQLHL MCSQEYKKGV SFGSVMYSWT KEFGDSPRAD KDKCMVIPLN 

       250        260        270        280        290        300 
RAIRARSQAF IEACKLIIPK CNSEKQIKKQ LKELSSNLER SVEEEEEGIS DSVAQLSFDE 


I 

« Hide

References

[1]"The nucleotide sequence of the M RNA segment of tomato spotted wilt virus, a bunyavirus with two ambisense RNA segments."
Kormelink R., de Haan P., Meurs C., Peters D., Goldbach R.
J. Gen. Virol. 73:2795-2804(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]Erratum
Kormelink R., de Haan P., Meurs C., Peters D., Goldbach R.
J. Gen. Virol. 74:790-790(1993) [PubMed] [Europe PMC] [Abstract]
[3]"Expression and subcellular location of the NSM protein of tomato spotted wilt virus (TSWV), a putative viral movement protein."
Kormelink R., Storms M., Van Lent J., Peters D., Goldbach R.
Virology 200:56-65(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
[4]"The nonstructural NSm protein of tomato spotted wilt virus induces tubular structures in plant and insect cells."
Storms M.M., Kormelink R., Peters D., Van Lent J.W., Goldbach R.W.
Virology 214:485-493(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"The '30K' superfamily of viral movement proteins."
Melcher U.
J. Gen. Virol. 81:257-266(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"The tubule-forming NSm protein from Tomato spotted wilt virus complements cell-to-cell and long-distance movement of Tobacco mosaic virus hybrids."
Lewandowski D.J., Adkins S.
Virology 342:26-37(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"At-4/1, an interactor of the Tomato spotted wilt virus movement protein, belongs to a new family of plant proteins capable of directed intra- and intercellular trafficking."
Paape M., Solovyev A.G., Erokhina T.N., Minina E.A., Schepetilnikov M.V., Lesemann D.-E., Schiemann J., Morozov S.Y., Kellmann J.-W.
Mol. Plant Microbe Interact. 19:874-883(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HOST ARABIDOPSIS THALIANA AT4G26020 PROTEIN.
[8]"Identification of domains of the Tomato spotted wilt virus NSm protein involved in tubule formation, movement and symptomatology."
Li W., Lewandowski D.J., Hilf M.E., Adkins S.
Virology 390:110-121(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S48091 Genomic RNA. No translation available.
PIRJQ1927.

3D structure databases

ProteinModelPortalP36292.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000603. 3A/RNA2_movement_prot.
IPR006889. Bunya_NSM.
[Graphical view]
PfamPF00803. 3A. 1 hit.
[Graphical view]
PIRSFPIRSF003959. NS-M_TospoV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMVP_TSWV1
AccessionPrimary (citable) accession number: P36292
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families