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P36292

- MVP_TSWV1

UniProt

P36292 - MVP_TSWV1

Protein

Movement protein

Gene

NSM

Organism
Tomato spotted wilt virus (strain Brazilian Br-01) (TSWV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Viral movemement protein which is responsible for cell-to cell spread of viral genome. Increases the size exclusion limit (SEL) of plasmodesmata by forming tubules structures, thereby allowing viral ribonucleocapsids to spread directly to neighboring cells.4 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. transport of virus in host, cell to cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Viral movement protein

    Keywords - Biological processi

    Host-virus interaction, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Movement protein
    Short name:
    MVP
    Alternative name(s):
    Non-structural movement protein
    Short name:
    NSm
    Gene namesi
    Name:NSM
    OrganismiTomato spotted wilt virus (strain Brazilian Br-01) (TSWV)
    Taxonomic identifieri36413 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeTospovirus
    Virus hostiFrankliniella occidentalis (Western flower thrips) [TaxID: 133901]
    Scirtothrips dorsalis [TaxID: 163899]
    Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
    Thrips tabaci [TaxID: 161014]
    ProteomesiUP000006674: Genome

    Subcellular locationi

    Host cell junctionhost plasmodesma 1 Publication
    Note: Colocalizes with viral nucleocapsid aggregates in host cytoplasm.

    GO - Cellular componenti

    1. host cell plasmodesma Source: UniProtKB

    Keywords - Cellular componenti

    Host cell junction

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301Movement proteinPRO_0000221987Add
    BLAST

    Interactioni

    Subunit structurei

    Oligomerizes to form tubule structures through host plasmodesma. Interacts with host A.thaliana At4g26020 protein, which is involved in intra- and inter-cellular trafficking.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP36292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni19 – 159141Essential for tubule formation and cell-to-cell movementAdd
    BLAST
    Regioni209 – 28375Essential for tubule formation and cell-to-cell movementAdd
    BLAST
    Regioni284 – 2885Essential for long-distance movement

    Sequence similaritiesi

    Belongs to the tospovirus movement protein family.Curated

    Family and domain databases

    InterProiIPR000603. 3A/RNA2_movement_prot.
    IPR006889. Bunya_NSM.
    [Graphical view]
    PfamiPF00803. 3A. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003959. NS-M_TospoV. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P36292-1 [UniParc]FASTAAdd to Basket

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    MLTLFGNKRP SKSAGKDEGP LVSLAKHNGS VEVSKPWSSS DEKLALTKAM    50
    DASKGKILLN IEGTSSFGTY ESDSIIESEG YDLSARMIVD TNHHISNWKN 100
    DLFVGNGKQN ANKVIKICPT WDSRKQYMMI SRIVIWVCPT IPNPTGKLVV 150
    ALIDPNMPSG KQVILKGQGT ITDPICFVFY LNWSIPKMNN TPENCCQLHL 200
    MCSQEYKKGV SFGSVMYSWT KEFGDSPRAD KDKCMVIPLN RAIRARSQAF 250
    IEACKLIIPK CNSEKQIKKQ LKELSSNLER SVEEEEEGIS DSVAQLSFDE 300
    I 301
    Length:301
    Mass (Da):33,564
    Last modified:June 1, 1994 - v1
    Checksum:iB00E16BEE6BA84C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S48091 Genomic RNA. No translation available.
    PIRiJQ1927.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S48091 Genomic RNA. No translation available.
    PIRi JQ1927.

    3D structure databases

    ProteinModelPortali P36292.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR000603. 3A/RNA2_movement_prot.
    IPR006889. Bunya_NSM.
    [Graphical view ]
    Pfami PF00803. 3A. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003959. NS-M_TospoV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of the M RNA segment of tomato spotted wilt virus, a bunyavirus with two ambisense RNA segments."
      Kormelink R., de Haan P., Meurs C., Peters D., Goldbach R.
      J. Gen. Virol. 73:2795-2804(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. Erratum
      Kormelink R., de Haan P., Meurs C., Peters D., Goldbach R.
      J. Gen. Virol. 74:790-790(1993) [PubMed] [Europe PMC] [Abstract]
    3. "Expression and subcellular location of the NSM protein of tomato spotted wilt virus (TSWV), a putative viral movement protein."
      Kormelink R., Storms M., Van Lent J., Peters D., Goldbach R.
      Virology 200:56-65(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
    4. "The nonstructural NSm protein of tomato spotted wilt virus induces tubular structures in plant and insect cells."
      Storms M.M., Kormelink R., Peters D., Van Lent J.W., Goldbach R.W.
      Virology 214:485-493(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "The '30K' superfamily of viral movement proteins."
      Melcher U.
      J. Gen. Virol. 81:257-266(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "The tubule-forming NSm protein from Tomato spotted wilt virus complements cell-to-cell and long-distance movement of Tobacco mosaic virus hybrids."
      Lewandowski D.J., Adkins S.
      Virology 342:26-37(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "At-4/1, an interactor of the Tomato spotted wilt virus movement protein, belongs to a new family of plant proteins capable of directed intra- and intercellular trafficking."
      Paape M., Solovyev A.G., Erokhina T.N., Minina E.A., Schepetilnikov M.V., Lesemann D.-E., Schiemann J., Morozov S.Y., Kellmann J.-W.
      Mol. Plant Microbe Interact. 19:874-883(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HOST ARABIDOPSIS THALIANA AT4G26020 PROTEIN.
    8. "Identification of domains of the Tomato spotted wilt virus NSm protein involved in tubule formation, movement and symptomatology."
      Li W., Lewandowski D.J., Hilf M.E., Adkins S.
      Virology 390:110-121(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiMVP_TSWV1
    AccessioniPrimary (citable) accession number: P36292
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3