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P36292

- MVP_TSWV1

UniProt

P36292 - MVP_TSWV1

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Protein
Movement protein
Gene
NSM
Organism
Tomato spotted wilt virus (strain Brazilian Br-01) (TSWV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Viral movemement protein which is responsible for cell-to cell spread of viral genome. Increases the size exclusion limit (SEL) of plasmodesmata by forming tubules structures, thereby allowing viral ribonucleocapsids to spread directly to neighboring cells.4 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. transport of virus in host, cell to cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Viral movement protein

Keywords - Biological processi

Host-virus interaction, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Movement protein
Short name:
MVP
Alternative name(s):
Non-structural movement protein
Short name:
NSm
Gene namesi
Name:NSM
OrganismiTomato spotted wilt virus (strain Brazilian Br-01) (TSWV)
Taxonomic identifieri36413 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeTospovirus
Virus hostiFrankliniella occidentalis (Western flower thrips) [TaxID: 133901]
Scirtothrips dorsalis [TaxID: 163899]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Thrips tabaci [TaxID: 161014]
ProteomesiUP000006674: Genome

Subcellular locationi

Host cell junctionhost plasmodesma
Note: Colocalizes with viral nucleocapsid aggregates in host cytoplasm.1 Publication

GO - Cellular componenti

  1. host cell plasmodesma Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Host cell junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Movement protein
PRO_0000221987Add
BLAST

Interactioni

Subunit structurei

Oligomerizes to form tubule structures through host plasmodesma. Interacts with host A.thaliana At4g26020 protein, which is involved in intra- and inter-cellular trafficking.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP36292.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 159141Essential for tubule formation and cell-to-cell movement
Add
BLAST
Regioni209 – 28375Essential for tubule formation and cell-to-cell movement
Add
BLAST
Regioni284 – 2885Essential for long-distance movement

Sequence similaritiesi

Family and domain databases

InterProiIPR000603. 3A/RNA2_movement_prot.
IPR006889. Bunya_NSM.
[Graphical view]
PfamiPF00803. 3A. 1 hit.
[Graphical view]
PIRSFiPIRSF003959. NS-M_TospoV. 1 hit.

Sequencei

Sequence statusi: Complete.

P36292-1 [UniParc]FASTAAdd to Basket

« Hide

MLTLFGNKRP SKSAGKDEGP LVSLAKHNGS VEVSKPWSSS DEKLALTKAM    50
DASKGKILLN IEGTSSFGTY ESDSIIESEG YDLSARMIVD TNHHISNWKN 100
DLFVGNGKQN ANKVIKICPT WDSRKQYMMI SRIVIWVCPT IPNPTGKLVV 150
ALIDPNMPSG KQVILKGQGT ITDPICFVFY LNWSIPKMNN TPENCCQLHL 200
MCSQEYKKGV SFGSVMYSWT KEFGDSPRAD KDKCMVIPLN RAIRARSQAF 250
IEACKLIIPK CNSEKQIKKQ LKELSSNLER SVEEEEEGIS DSVAQLSFDE 300
I 301
Length:301
Mass (Da):33,564
Last modified:June 1, 1994 - v1
Checksum:iB00E16BEE6BA84C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S48091 Genomic RNA. No translation available.
PIRiJQ1927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S48091 Genomic RNA. No translation available.
PIRi JQ1927.

3D structure databases

ProteinModelPortali P36292.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR000603. 3A/RNA2_movement_prot.
IPR006889. Bunya_NSM.
[Graphical view ]
Pfami PF00803. 3A. 1 hit.
[Graphical view ]
PIRSFi PIRSF003959. NS-M_TospoV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The nucleotide sequence of the M RNA segment of tomato spotted wilt virus, a bunyavirus with two ambisense RNA segments."
    Kormelink R., de Haan P., Meurs C., Peters D., Goldbach R.
    J. Gen. Virol. 73:2795-2804(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Erratum
    Kormelink R., de Haan P., Meurs C., Peters D., Goldbach R.
    J. Gen. Virol. 74:790-790(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Expression and subcellular location of the NSM protein of tomato spotted wilt virus (TSWV), a putative viral movement protein."
    Kormelink R., Storms M., Van Lent J., Peters D., Goldbach R.
    Virology 200:56-65(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
  4. "The nonstructural NSm protein of tomato spotted wilt virus induces tubular structures in plant and insect cells."
    Storms M.M., Kormelink R., Peters D., Van Lent J.W., Goldbach R.W.
    Virology 214:485-493(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "The '30K' superfamily of viral movement proteins."
    Melcher U.
    J. Gen. Virol. 81:257-266(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "The tubule-forming NSm protein from Tomato spotted wilt virus complements cell-to-cell and long-distance movement of Tobacco mosaic virus hybrids."
    Lewandowski D.J., Adkins S.
    Virology 342:26-37(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "At-4/1, an interactor of the Tomato spotted wilt virus movement protein, belongs to a new family of plant proteins capable of directed intra- and intercellular trafficking."
    Paape M., Solovyev A.G., Erokhina T.N., Minina E.A., Schepetilnikov M.V., Lesemann D.-E., Schiemann J., Morozov S.Y., Kellmann J.-W.
    Mol. Plant Microbe Interact. 19:874-883(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOST ARABIDOPSIS THALIANA AT4G26020 PROTEIN.
  8. "Identification of domains of the Tomato spotted wilt virus NSm protein involved in tubule formation, movement and symptomatology."
    Li W., Lewandowski D.J., Hilf M.E., Adkins S.
    Virology 390:110-121(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiMVP_TSWV1
AccessioniPrimary (citable) accession number: P36292
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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