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Protein

Movement protein

Gene

NSM

Organism
Tomato spotted wilt virus (strain Brazilian Br-01) (TSWV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Viral movemement protein which is responsible for cell-to cell spread of viral genome. Increases the size exclusion limit (SEL) of plasmodesmata by forming tubules structures, thereby allowing viral ribonucleocapsids to spread directly to neighboring cells.4 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Viral movement protein

Keywords - Biological processi

Host-virus interaction, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Movement protein
Short name:
MVP
Alternative name(s):
Non-structural movement protein
Short name:
NSm
Gene namesi
Name:NSM
OrganismiTomato spotted wilt virus (strain Brazilian Br-01) (TSWV)
Taxonomic identifieri36413 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesBunyaviridaeTospovirus
Virus hostiFrankliniella occidentalis (Western flower thrips) [TaxID: 133901]
Scirtothrips dorsalis [TaxID: 163899]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Thrips tabaci [TaxID: 161014]
ProteomesiUP000006674 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • host cell plasmodesma Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Host cell junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Movement proteinPRO_0000221987Add
BLAST

Interactioni

Subunit structurei

Oligomerizes to form tubule structures through host plasmodesma. Interacts with host A.thaliana At4g26020 protein, which is involved in intra- and inter-cellular trafficking.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP36292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 159141Essential for tubule formation and cell-to-cell movementAdd
BLAST
Regioni209 – 28375Essential for tubule formation and cell-to-cell movementAdd
BLAST
Regioni284 – 2885Essential for long-distance movement

Sequence similaritiesi

Belongs to the tospovirus movement protein family.Curated

Family and domain databases

InterProiIPR000603. 3A/RNA2_movement_prot.
IPR006889. Bunya_NSM.
[Graphical view]
PfamiPF00803. 3A. 1 hit.
[Graphical view]
PIRSFiPIRSF003959. NS-M_TospoV. 1 hit.

Sequencei

Sequence statusi: Complete.

P36292-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLFGNKRP SKSAGKDEGP LVSLAKHNGS VEVSKPWSSS DEKLALTKAM
60 70 80 90 100
DASKGKILLN IEGTSSFGTY ESDSIIESEG YDLSARMIVD TNHHISNWKN
110 120 130 140 150
DLFVGNGKQN ANKVIKICPT WDSRKQYMMI SRIVIWVCPT IPNPTGKLVV
160 170 180 190 200
ALIDPNMPSG KQVILKGQGT ITDPICFVFY LNWSIPKMNN TPENCCQLHL
210 220 230 240 250
MCSQEYKKGV SFGSVMYSWT KEFGDSPRAD KDKCMVIPLN RAIRARSQAF
260 270 280 290 300
IEACKLIIPK CNSEKQIKKQ LKELSSNLER SVEEEEEGIS DSVAQLSFDE

I
Length:301
Mass (Da):33,564
Last modified:June 1, 1994 - v1
Checksum:iB00E16BEE6BA84C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S48091 Genomic RNA. No translation available.
PIRiJQ1927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S48091 Genomic RNA. No translation available.
PIRiJQ1927.

3D structure databases

ProteinModelPortaliP36292.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000603. 3A/RNA2_movement_prot.
IPR006889. Bunya_NSM.
[Graphical view]
PfamiPF00803. 3A. 1 hit.
[Graphical view]
PIRSFiPIRSF003959. NS-M_TospoV. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The nucleotide sequence of the M RNA segment of tomato spotted wilt virus, a bunyavirus with two ambisense RNA segments."
    Kormelink R., de Haan P., Meurs C., Peters D., Goldbach R.
    J. Gen. Virol. 73:2795-2804(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Erratum
    Kormelink R., de Haan P., Meurs C., Peters D., Goldbach R.
    J. Gen. Virol. 74:790-790(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Expression and subcellular location of the NSM protein of tomato spotted wilt virus (TSWV), a putative viral movement protein."
    Kormelink R., Storms M., Van Lent J., Peters D., Goldbach R.
    Virology 200:56-65(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
  4. "The nonstructural NSm protein of tomato spotted wilt virus induces tubular structures in plant and insect cells."
    Storms M.M., Kormelink R., Peters D., Van Lent J.W., Goldbach R.W.
    Virology 214:485-493(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "The '30K' superfamily of viral movement proteins."
    Melcher U.
    J. Gen. Virol. 81:257-266(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "The tubule-forming NSm protein from Tomato spotted wilt virus complements cell-to-cell and long-distance movement of Tobacco mosaic virus hybrids."
    Lewandowski D.J., Adkins S.
    Virology 342:26-37(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "At-4/1, an interactor of the Tomato spotted wilt virus movement protein, belongs to a new family of plant proteins capable of directed intra- and intercellular trafficking."
    Paape M., Solovyev A.G., Erokhina T.N., Minina E.A., Schepetilnikov M.V., Lesemann D.-E., Schiemann J., Morozov S.Y., Kellmann J.-W.
    Mol. Plant Microbe Interact. 19:874-883(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOST ARABIDOPSIS THALIANA AT4G26020 PROTEIN.
  8. "Identification of domains of the Tomato spotted wilt virus NSm protein involved in tubule formation, movement and symptomatology."
    Li W., Lewandowski D.J., Hilf M.E., Adkins S.
    Virology 390:110-121(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiMVP_TSWV1
AccessioniPrimary (citable) accession number: P36292
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 24, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.