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P36267 (GGT_PSEUA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyltranspeptidase
EC=2.3.2.2

Cleaved into the following 2 chains:

  1. Gamma-glutamyltranspeptidase large chain
  2. Gamma-glutamyltranspeptidase small chain
Gene names
Name:ggt
OrganismPseudomonas sp. (strain A14)
Taxonomic identifier69010 [NCBI]
Taxonomic lineageBacteria › Proteobacteria

Protein attributes

Sequence length575 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.

Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathway

Sulfur metabolism; glutathione metabolism.

Subunit structure

This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

Subcellular location

Periplasm By similarity.

Sequence similarities

Belongs to the gamma-glutamyltransferase family.

Ontologies

Keywords
   Biological processGlutathione biosynthesis
   Cellular componentPeriplasm
   DomainSignal
   Molecular functionAcyltransferase
Transferase
   PTMZymogen
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processglutathione biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentperiplasmic space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiongamma-glutamyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Chain25 – 376352Gamma-glutamyltranspeptidase large chain
PRO_0000011054
Chain377 – 575199Gamma-glutamyltranspeptidase small chain
PRO_0000011055

Sequences

Sequence LengthMass (Da)Tools
P36267 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: CF2EB69F02CD0201

FASTA57561,301
        10         20         30         40         50         60 
MKNQTFSKAL LATALSCALF NVHAASQAPV GAENGMVVTA QHIASKVGVE VLKSGGNAID 

        70         80         90        100        110        120 
AAVAVGYALA VVYPAAGNIG GGGFMTIQLA DGRKTFLDFR EKAPLAATAN MYLDKDGNVI 

       130        140        150        160        170        180 
KGASTTGYLA VGVPGTVSGM EYAREKYGTK TRQQLISPAI TLADKGFVLE QGDVDMLWTS 

       190        200        210        220        230        240 
TKDFEKDRAN SGAIFMNKGQ PFQPGERLVQ KDLARTLRLI SAKGTDGFYK GEVADKLVAS 

       250        260        270        280        290        300 
MKAGGGIITQ ADLDQYKTRE LAPVECDYRG YHVVSAPPPS SGGVVICEIM NILEGYPMKE 

       310        320        330        340        350        360 
LGYHSAQGVH YTIEAMRHAY VDRNSYLGDP DFVKNPLAHL LDKDYAAKIR AAINPQKAGI 

       370        380        390        400        410        420 
SQEIKPGVPP HEGSNTTHYS IVDKDGNAVS VTYTLNDWFG AKVMANGTGV LLNDEMDDFT 

       430        440        450        460        470        480 
SKVGVPNMYG LIQGEANAIG PGRRPLSSMS PTIVTKDGKT VMVVGTPGGS RIITATLLTM 

       490        500        510        520        530        540 
LNMIDYGMNL QEAVDAPRFH QQWMPESTNI EAFALSPDTQ KILESWGQKF AGPQPANHIA 

       550        560        570 
AILVGAPSLG GKPIGKNRFY GANDPRRNTG LALGY

« Hide

References

[1]"Molecular cloning of the gamma-glutamyltranspeptidase gene from a Pseudomonas strain."
Ishiye M., Yamashita M., Niwa M.
Biotechnol. Prog. 9:323-331(1993) [PubMed: 7765305] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		S63255 Genomic DNA. Translation: AAC60442.1.

3D structure databases

ProteinModelPortalP36267.
ModBaseSearch...

Protein family/group databases

MEROPST03.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000101. GGT_peptidase.
[Graphical view]
PANTHERPTHR11686. GGT_peptidase. 1 hit.
PfamPF01019. G_glu_transpept. 1 hit.
[Graphical view]
PRINTSPR01210. GGTRANSPTASE.
TIGRFAMsTIGR00066. G_glut_trans. 1 hit.
PROSITEPS00462. G_GLU_TRANSPEPTIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGGT_PSEUA
AccessionPrimary (citable) accession number: P36267
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 19, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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