Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L19

Gene

RpL19

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • centrosome duplication Source: FlyBase
  • cytoplasmic translation Source: FlyBase
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L19
Gene namesi
Name:RpL19
Synonyms:M(2)60E
ORF Names:CG2746
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0002607. RpL19.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: GO_Central
  • cytosolic ribosome Source: FlyBase
  • ribosome Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001311781 – 20360S ribosomal protein L19Add BLAST203

Proteomic databases

PaxDbiP36241.
PRIDEiP36241.

Expressioni

Gene expression databases

BgeeiFBgn0002607.
GenevisibleiP36241. DM.

Interactioni

Protein-protein interaction databases

BioGridi63563. 16 interactors.
DIPiDIP-19985N.
IntActiP36241. 7 interactors.
MINTiMINT-781765.
STRINGi7227.FBpp0072312.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CR1-203[»]
ProteinModelPortaliP36241.
SMRiP36241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L19e family.Curated

Phylogenomic databases

eggNOGiKOG1696. Eukaryota.
COG2147. LUCA.
GeneTreeiENSGT00390000012628.
InParanoidiP36241.
KOiK02885.
OMAiARTPQKD.
OrthoDBiEOG091G0MKY.
PhylomeDBiP36241.

Family and domain databases

CDDicd01417. Ribosomal_L19e_E. 1 hit.
Gene3Di1.10.1200.60. 1 hit.
1.10.1650.10. 1 hit.
HAMAPiMF_01475. Ribosomal_L19e. 1 hit.
InterProiIPR000196. Ribosomal_L19/L19e.
IPR023638. Ribosomal_L19/L19e_CS.
IPR015972. Ribosomal_L19/L19e_dom1.
IPR015974. Ribosomal_L19/L19e_dom3.
IPR033935. Ribosomal_L19_euka.
[Graphical view]
PfamiPF01280. Ribosomal_L19e. 1 hit.
[Graphical view]
SMARTiSM01416. Ribosomal_L19e. 1 hit.
[Graphical view]
SUPFAMiSSF48140. SSF48140. 1 hit.
PROSITEiPS00526. RIBOSOMAL_L19E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLKLQKRL AASVLRCGKK KVWLDPNEIN EIANTNSRQN IRKLIKDGLI
60 70 80 90 100
IKKPVVVHSR YRVRKNTEAR RKGRHCGFGK RKGTANARMP TKLLWMQRQR
110 120 130 140 150
VLRRLLKKYR DSKKIDRHLY HDLYMKCKGN VFKNKRVLME YIHKKKAEKQ
160 170 180 190 200
RSKMLADQAE ARRQKVREAR KRREERIATK KQELIALHAK EDEIAAKAAT

AGH
Length:203
Mass (Da):23,998
Last modified:May 30, 2003 - v2
Checksum:i0FD89B8545C5C22F
GO

Sequence cautioni

The sequence AAL28765 differs from that shown. Reason: Erroneous initiation.Curated
The sequence ABC86326 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73G → D in CAA52784 (PubMed:8297785).Curated1
Sequence conflicti100 – 102RVL → PFC in CAA52784 (PubMed:8297785).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74776 Genomic DNA. Translation: CAA52784.1.
AE013599 Genomic DNA. Translation: AAF47305.1.
AE013599 Genomic DNA. Translation: AAS64772.1.
AY061217 mRNA. Translation: AAL28765.2. Different initiation.
BT024264 mRNA. Translation: ABC86326.1. Different initiation.
PIRiA61627.
RefSeqiNP_476631.1. NM_057283.5.
NP_995941.1. NM_206219.2.

Genome annotation databases

EnsemblMetazoaiFBtr0072405; FBpp0072312; FBgn0002607.
FBtr0072406; FBpp0089141; FBgn0002607.
GeneIDi37995.
KEGGidme:Dmel_CG2746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74776 Genomic DNA. Translation: CAA52784.1.
AE013599 Genomic DNA. Translation: AAF47305.1.
AE013599 Genomic DNA. Translation: AAS64772.1.
AY061217 mRNA. Translation: AAL28765.2. Different initiation.
BT024264 mRNA. Translation: ABC86326.1. Different initiation.
PIRiA61627.
RefSeqiNP_476631.1. NM_057283.5.
NP_995941.1. NM_206219.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CR1-203[»]
ProteinModelPortaliP36241.
SMRiP36241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63563. 16 interactors.
DIPiDIP-19985N.
IntActiP36241. 7 interactors.
MINTiMINT-781765.
STRINGi7227.FBpp0072312.

Proteomic databases

PaxDbiP36241.
PRIDEiP36241.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072405; FBpp0072312; FBgn0002607.
FBtr0072406; FBpp0089141; FBgn0002607.
GeneIDi37995.
KEGGidme:Dmel_CG2746.

Organism-specific databases

CTDi6143.
FlyBaseiFBgn0002607. RpL19.

Phylogenomic databases

eggNOGiKOG1696. Eukaryota.
COG2147. LUCA.
GeneTreeiENSGT00390000012628.
InParanoidiP36241.
KOiK02885.
OMAiARTPQKD.
OrthoDBiEOG091G0MKY.
PhylomeDBiP36241.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpL19. fly.
GenomeRNAii37995.
PROiP36241.

Gene expression databases

BgeeiFBgn0002607.
GenevisibleiP36241. DM.

Family and domain databases

CDDicd01417. Ribosomal_L19e_E. 1 hit.
Gene3Di1.10.1200.60. 1 hit.
1.10.1650.10. 1 hit.
HAMAPiMF_01475. Ribosomal_L19e. 1 hit.
InterProiIPR000196. Ribosomal_L19/L19e.
IPR023638. Ribosomal_L19/L19e_CS.
IPR015972. Ribosomal_L19/L19e_dom1.
IPR015974. Ribosomal_L19/L19e_dom3.
IPR033935. Ribosomal_L19_euka.
[Graphical view]
PfamiPF01280. Ribosomal_L19e. 1 hit.
[Graphical view]
SMARTiSM01416. Ribosomal_L19e. 1 hit.
[Graphical view]
SUPFAMiSSF48140. SSF48140. 1 hit.
PROSITEiPS00526. RIBOSOMAL_L19E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL19_DROME
AccessioniPrimary (citable) accession number: P36241
Secondary accession number(s): A4UZV5, Q29QX6, Q9W0X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 30, 2003
Last modified: November 30, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.