P36241 (RL19_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L19

Gene names

Name:	RpL19
Synonyms:	M(2)60E
ORF Names:	CG2746

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the ribosomal protein L19e family.
Sequence caution	The sequence AAL28765.2 differs from that shown. Reason: Erroneous initiation. The sequence ABC86326.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	mitotic spindle elongation Inferred from mutant phenotype. Source: FlyBase translation Inferred from electronic annotation. Source: InterPro
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Aats-tyr	Q9VV60	1	EBI-129593,EBI-162196
CG13074	Q9VUY2	1	EBI-129593,EBI-140695
Chrac-14	Q9V444	1	EBI-129593,EBI-138718
ctp	Q24117	1	EBI-129593,EBI-156442

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	60S ribosomal protein L19		PRO_0000131178
Experimental info
	Sequence conflict	73	1	G → D in CAA52784. Ref.1
	Sequence conflict	100 – 102	3	RVL → PFC in CAA52784. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P36241 [UniParc]. Last modified May 30, 2003. Version 2. Checksum: 0FD89B8545C5C22F	FASTA	203	23,998
	10 20 30 40 50 60 MSSLKLQKRL AASVLRCGKK KVWLDPNEIN EIANTNSRQN IRKLIKDGLI IKKPVVVHSR 70 80 90 100 110 120 YRVRKNTEAR RKGRHCGFGK RKGTANARMP TKLLWMQRQR VLRRLLKKYR DSKKIDRHLY 130 140 150 160 170 180 HDLYMKCKGN VFKNKRVLME YIHKKKAEKQ RSKMLADQAE ARRQKVREAR KRREERIATK 190 200 KQELIALHAK EDEIAAKAAT AGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A Minute encoding a ribosomal protein enhances wing morphogenesis mutants." Hart K., Klein T., Wilcox M. Mech. Dev. 43:101-110(1993) [PubMed: 8297785] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[5]	Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X74776 Genomic DNA. Translation: CAA52784.1. AE013599 Genomic DNA. Translation: AAF47305.1. AE013599 Genomic DNA. Translation: AAS64772.1. AY061217 mRNA. Translation: AAL28765.2. Different initiation. BT024264 mRNA. Translation: ABC86326.1. Different initiation.
PIR	A61627.
RefSeq	NP_476631.1. NM_057283.4. NP_995941.1. NM_206219.1.
UniGene	Dm.3682.
3D structure databases
ProteinModelPortal	P36241.
SMR	P36241. Positions 1-178.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-19985N.
IntAct	P36241. 6 interactions.
MINT	MINT-781765.
STRING	P36241.
Proteomic databases
PRIDE	P36241.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0072405; FBpp0072312; FBgn0002607. FBtr0072406; FBpp0089141; FBgn0002607.
GeneID	37995.
KEGG	dme:Dmel_CG2746.
Organism-specific databases
CTD	6143.
FlyBase	FBgn0002607. RpL19.
Phylogenomic databases
eggNOG	inNOG07529.
GeneTree	EMGT00050000017546.
InParanoid	P36241.
OMA	AGKIDKH.
OrthoDB	EOG43XSKR.
PhylomeDB	P36241.
Gene expression databases
Bgee	P36241.
GermOnline	CG2746. Drosophila melanogaster.
Family and domain databases
InterPro	IPR000196. Ribosomal_L19/L19e. IPR023638. Ribosomal_L19/L19e_CS. IPR015972. Ribosomal_L19/L19e_dom1. IPR015974. Ribosomal_L19/L19e_dom3. [Graphical view]
Gene3D	G3DSA:1.10.1650.10. Ribosomal_L19/L19e_dom1. 1 hit. G3DSA:1.10.1200.60. Ribosomal_L19/L19e_dom3. 1 hit.
KO	K02885.
Pfam	PF01280. Ribosomal_L19e. 1 hit. [Graphical view]
SUPFAM	SSF48140. Ribosomal_L19/L19e. 1 hit.
PROSITE	PS00526. RIBOSOMAL_L19E. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	806442.

Entry information

Entry name

RL19_DROME

Accession

Primary (citable) accession number: P36241
Secondary accession number(s): A4UZV5, Q29QX6, Q9W0X4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	May 30, 2003
Last modified:	January 25, 2012
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project