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P36226

- KITH_BHV5

UniProt

P36226 - KITH_BHV5

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Protein
Thymidine kinase
Gene
TK
Organism
Bovine herpesvirus 5 (strain N569) (BoHV-5) (Bovine encephalitis herpesvirus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton acceptor Reviewed prediction
Binding sitei88 – 881Substrate By similarity
Binding sitei134 – 1341Substrate By similarity
Binding sitei178 – 1781ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
OrganismiBovine herpesvirus 5 (strain N569) (BoHV-5) (Bovine encephalitis herpesvirus)
Taxonomic identifieri36350 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Thymidine kinase
PRO_0000175064Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP36226.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 359Poly-Ala
Compositional biasi315 – 3184Poly-Arg

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P36226-1 [UniParc]FASTAAdd to Basket

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MAAPALRVVR VYLDGAHGLG KTTTGRALAA AASAAGGPVL FFPEPMAYWR    50
TMFPTDALSG ILAASARRAA AQGGRADADA AGLVAYYQAR FAAPYLVLHA 100
RVAALLAPPE PAPGGDDVVT LVFDRHPLAA CLCYPFARYC LREINAEDLL 150
ALAATAPLEA PGANLVVCTL PPAEQQRRLA ARARPGDRAD AGFWPPLRNA 200
YALLANTCAF LGAGGAWRDG WDALGWADAD ALAALADPRG GGREPVPAPA 250
LRDTLFAALK CRELYPGGGA DLPAVHAWAL DALADRLAAL EVFMDVSAAP 300
DACAAAVLGM RPAMRRRRAD GAAGATLADL ARRFAREMTP GGPEAAPRGL 350
Length:350
Mass (Da):36,263
Last modified:June 1, 1994 - v1
Checksum:iBFBECC84E839919D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S56149 Genomic DNA. Translation: AAB19542.1.
PIRiA45663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S56149 Genomic DNA. Translation: AAB19542.1 .
PIRi A45663.

3D structure databases

ProteinModelPortali P36226.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00693. Herpes_TK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide and amino acid sequence analysis of the thymidine kinase gene of a bovine encephalitis herpesvirus."
    Smith G.A., Young P.L., Mattick J.S.
    Arch. Virol. 119:199-210(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKITH_BHV5
AccessioniPrimary (citable) accession number: P36226
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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