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P36226 (KITH_BHV5) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
OrganismBovine herpesvirus 5 (strain N569) (BoHV-5) (Bovine encephalitis herpesvirus)
Taxonomic identifier36350 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostBos taurus (Bovine) [TaxID: 9913]

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

TMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Thymidine kinase
PRO_0000175064

Regions

Nucleotide binding15 – 228ATP By similarity
Compositional bias27 – 359Poly-Ala
Compositional bias315 – 3184Poly-Arg

Sites

Active site441Proton acceptor Potential
Binding site881Substrate By similarity
Binding site1341Substrate By similarity
Binding site1781ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P36226 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: BFBECC84E839919D

FASTA35036,263
        10         20         30         40         50         60 
MAAPALRVVR VYLDGAHGLG KTTTGRALAA AASAAGGPVL FFPEPMAYWR TMFPTDALSG 

        70         80         90        100        110        120 
ILAASARRAA AQGGRADADA AGLVAYYQAR FAAPYLVLHA RVAALLAPPE PAPGGDDVVT 

       130        140        150        160        170        180 
LVFDRHPLAA CLCYPFARYC LREINAEDLL ALAATAPLEA PGANLVVCTL PPAEQQRRLA 

       190        200        210        220        230        240 
ARARPGDRAD AGFWPPLRNA YALLANTCAF LGAGGAWRDG WDALGWADAD ALAALADPRG 

       250        260        270        280        290        300 
GGREPVPAPA LRDTLFAALK CRELYPGGGA DLPAVHAWAL DALADRLAAL EVFMDVSAAP 

       310        320        330        340        350 
DACAAAVLGM RPAMRRRRAD GAAGATLADL ARRFAREMTP GGPEAAPRGL 

« Hide

References

[1]"Nucleotide and amino acid sequence analysis of the thymidine kinase gene of a bovine encephalitis herpesvirus."
Smith G.A., Young P.L., Mattick J.S.
Arch. Virol. 119:199-210(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S56149 Genomic DNA. Translation: AAB19542.1.
PIRA45663.

3D structure databases

ProteinModelPortalP36226.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_BHV5
AccessionPrimary (citable) accession number: P36226
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families