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P36226

- KITH_BHV5

UniProt

P36226 - KITH_BHV5

Protein

Thymidine kinase

Gene

TK

Organism
Bovine herpesvirus 5 (strain N569) (BoHV-5) (Bovine encephalitis herpesvirus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei44 – 441Proton acceptorSequence Analysis
    Binding sitei88 – 881SubstrateBy similarity
    Binding sitei134 – 1341SubstrateBy similarity
    Binding sitei178 – 1781ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. TMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    OrganismiBovine herpesvirus 5 (strain N569) (BoHV-5) (Bovine encephalitis herpesvirus)
    Taxonomic identifieri36350 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
    Virus hostiBos taurus (Bovine) [TaxID: 9913]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350Thymidine kinasePRO_0000175064Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP36226.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi27 – 359Poly-Ala
    Compositional biasi315 – 3184Poly-Arg

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00693. Herpes_TK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P36226-1 [UniParc]FASTAAdd to Basket

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    MAAPALRVVR VYLDGAHGLG KTTTGRALAA AASAAGGPVL FFPEPMAYWR    50
    TMFPTDALSG ILAASARRAA AQGGRADADA AGLVAYYQAR FAAPYLVLHA 100
    RVAALLAPPE PAPGGDDVVT LVFDRHPLAA CLCYPFARYC LREINAEDLL 150
    ALAATAPLEA PGANLVVCTL PPAEQQRRLA ARARPGDRAD AGFWPPLRNA 200
    YALLANTCAF LGAGGAWRDG WDALGWADAD ALAALADPRG GGREPVPAPA 250
    LRDTLFAALK CRELYPGGGA DLPAVHAWAL DALADRLAAL EVFMDVSAAP 300
    DACAAAVLGM RPAMRRRRAD GAAGATLADL ARRFAREMTP GGPEAAPRGL 350
    Length:350
    Mass (Da):36,263
    Last modified:June 1, 1994 - v1
    Checksum:iBFBECC84E839919D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S56149 Genomic DNA. Translation: AAB19542.1.
    PIRiA45663.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S56149 Genomic DNA. Translation: AAB19542.1 .
    PIRi A45663.

    3D structure databases

    ProteinModelPortali P36226.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00693. Herpes_TK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide and amino acid sequence analysis of the thymidine kinase gene of a bovine encephalitis herpesvirus."
      Smith G.A., Young P.L., Mattick J.S.
      Arch. Virol. 119:199-210(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiKITH_BHV5
    AccessioniPrimary (citable) accession number: P36226
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3