UniProtKB - P36224 (JNM1_YEAST)
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Protein
Nuclear migration protein JNM1
Gene
JNM1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding (By similarity). The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. JNM1 is associated with the rod and links it to the projecting sidearm. Required for proper nuclear migration during the mitotic cell cycle and for astral microtubule development.By similarity2 Publications
GO - Molecular functioni
- motor activity Source: UniProtKB-KW
- structural constituent of cytoskeleton Source: SGD
GO - Biological processi
- establishment of mitotic spindle orientation Source: SGD
- nuclear migration Source: SGD
Enzyme and pathway databases
BioCyci | YEAST:G3O-32964-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear migration protein JNM1 |
Gene namesi | Name:JNM1 Synonyms:INS1 Ordered Locus Names:YMR294W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YMR294W. |
SGDi | S000004908. JNM1. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084289 | 1 – 373 | Nuclear migration protein JNM1Add BLAST | 373 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 91 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P36224. |
PaxDbi | P36224. |
PRIDEi | P36224. |
PTM databases
iPTMneti | P36224. |
Interactioni
Subunit structurei
Component of the dynactin complex composed of at least ARP1, JNM1, NIP100 and ARP10. Dynactin comprises a short rod of ARP1 polymers attached to ARP10 at its pointed-end and probably associated with the capping protein at its barbed-end. The rod structure is implicated in dynein cargo binding. A sidearm formed by NIP100 projects from the ARP1 filament and is implicated in motor binding (By similarity). Interacts with ARP1.By similarity3 Publications
Binary interactionsi
Protein-protein interaction databases
BioGridi | 35474. 422 interactors. |
DIPi | DIP-2387N. |
IntActi | P36224. 12 interactors. |
STRINGi | 4932.YMR294W. |
Structurei
3D structure databases
ProteinModelPortali | P36224. |
SMRi | P36224. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 114 – 139 | Sequence analysisAdd BLAST | 26 | |
Coiled coili | 200 – 245 | Sequence analysisAdd BLAST | 46 | |
Coiled coili | 331 – 367 | Sequence analysisAdd BLAST | 37 |
Keywords - Domaini
Coiled coilPhylogenomic databases
InParanoidi | P36224. |
KOi | K18599. |
OMAi | FKHIESD. |
OrthoDBi | EOG092C3M4H. |
Family and domain databases
InterProi | View protein in InterPro IPR028133. Dynamitin. |
PANTHERi | PTHR15346. PTHR15346. 2 hits. |
Pfami | View protein in Pfam PF04912. Dynamitin. 1 hit. |
i Sequence
Sequence statusi: Complete.
P36224-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNVIDLSDPA INVDYDSLIG IDNEESQEIF ENEVKEDGQQ EEQEEASSRK
60 70 80 90 100
DGLIVEPGRD VESLRRAIRD QLLFKIHRQN QSDCADARKL SNDEEDESRQ
110 120 130 140 150
QKLERIREEL EELKIENLTS EMQTEIKELC EIQSKLATES SSRLTNLRKK
160 170 180 190 200
LLETYEGQDT VILPNIILDT SNIKRLQKLD QKISLMERFV GIPEALEAEE
210 220 230 240 250
DRKSVHSKVN ELYRSIQLLQ GDDKAEGKLQ KFRDRLVELN EEFENSLLGK
260 270 280 290 300
KIQQDLRLKD DTVSKLVMPE NKVKEINSMY SMFKQYQDSL PLLAERMKSL
310 320 330 340 350
NKMNNRVIEV YETTKGLDSQ ITSIQEQGKV WLKALNELDK KFDEQEVKIR
360 370
ENMEQIRRKI DTLEDEALQR NSK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 92 | N → S in CAA81023 (PubMed:8138567).Curated | 1 | |
Sequence conflicti | 114 | K → R in CAA81023 (PubMed:8138567).Curated | 1 | |
Sequence conflicti | 193 | P → A in CAA81023 (PubMed:8138567).Curated | 1 | |
Sequence conflicti | 201 | D → E in CAA81023 (PubMed:8138567).Curated | 1 | |
Sequence conflicti | 264 | S → N in CAA81023 (PubMed:8138567).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z25750 Genomic DNA. Translation: CAA81023.1. X80836 Genomic DNA. Translation: CAA56803.1. BK006946 Genomic DNA. Translation: DAA10195.1. |
PIRi | S47455. |
RefSeqi | NP_014022.1. NM_001182802.1. |
Genome annotation databases
EnsemblFungii | YMR294W; YMR294W; YMR294W. |
GeneIDi | 855339. |
KEGGi | sce:YMR294W. |
Similar proteinsi
Entry informationi
Entry namei | JNM1_YEAST | |
Accessioni | P36224Primary (citable) accession number: P36224 Secondary accession number(s): D6W0C1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | October 1, 1996 | |
Last modified: | March 28, 2018 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |