JNM1

Functionⁱ

Component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding (By similarity). The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. JNM1 is associated with the rod and links it to the projecting sidearm. Required for proper nuclear migration during the mitotic cell cycle and for astral microtubule development.By similarity2 Publications

GO - Molecular functionⁱ

motor activity Source: UniProtKB-KW
structural constituent of cytoskeleton
Source: SGD
Inferred from physical interactionⁱ
- 9658168

Complete GO annotation...

GO - Biological processⁱ

Complete GO annotation...

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-32964-MONOMER.

BioCycⁱ

YEAST:G3O-32964-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear migration protein JNM1
Gene namesⁱ	Name:JNM1 Synonyms:INS1 Ordered Locus Names:YMR294W
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XIII

Organism-specific databases

EuPathDBⁱ	FungiDB:YMR294W.
Saccharomyces Genome Database More...SGDⁱ	S000004908. JNM1.

Subcellular locationⁱ

Cytoplasm › cytoskeleton Curated

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-KW
dynactin complex
Source: SGD
Inferred from direct assayⁱ
- 9658168
dynein complex Source: UniProtKB-KW
microtubule Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000084289	1 – 373	Nuclear migration protein JNM1Add BLAST		373

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	91	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P36224.
PRIDEⁱ	P36224.

PTM databases

iPTMnetⁱ	P36224.

iPTMnetⁱ

P36224.

Interactionⁱ

Subunit structureⁱ

Component of the dynactin complex composed of at least ARP1, JNM1, NIP100 and ARP10. Dynactin comprises a short rod of ARP1 polymers attached to ARP10 at its pointed-end and probably associated with the capping protein at its barbed-end. The rod structure is implicated in dynein cargo binding. A sidearm formed by NIP100 projects from the ARP1 filament and is implicated in motor binding (By similarity). Interacts with ARP1.By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ARP1	P38696	9	EBI-9415,EBI-2920
ARP10	Q04549	3	EBI-9415,EBI-2977
LDB18	Q07887	4	EBI-9415,EBI-33243
NIP100	P33420	3	EBI-9415,EBI-12049

Show more details

Protein-protein interaction databases

BioGridⁱ	35474. 417 interactors.
Database of interacting proteins More...DIPⁱ	DIP-2387N.
IntActⁱ	P36224. 9 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-493774.
STRINGⁱ	4932.YMR294W.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P36224.
SMRⁱ	P36224.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	114 – 139	Sequence analysisAdd BLAST	26
Coiled coilⁱ	200 – 245	Sequence analysisAdd BLAST	46
Coiled coilⁱ	331 – 367	Sequence analysisAdd BLAST	37

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

InParanoidⁱ	P36224.
KEGG Orthology (KO) More...KOⁱ	K18599.
OMAⁱ	DCERIVE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C3M4H.

Family and domain databases

InterProⁱ	View protein in InterPro IPR028133. Dynamitin.
PANTHERⁱ	PTHR15346:SF1. PTHR15346:SF1. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04912. Dynamitin. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P36224-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNVIDLSDPA INVDYDSLIG IDNEESQEIF ENEVKEDGQQ EEQEEASSRK 
        60         70         80         90        100
DGLIVEPGRD VESLRRAIRD QLLFKIHRQN QSDCADARKL SNDEEDESRQ 
       110        120        130        140        150
QKLERIREEL EELKIENLTS EMQTEIKELC EIQSKLATES SSRLTNLRKK 
       160        170        180        190        200
LLETYEGQDT VILPNIILDT SNIKRLQKLD QKISLMERFV GIPEALEAEE 
       210        220        230        240        250
DRKSVHSKVN ELYRSIQLLQ GDDKAEGKLQ KFRDRLVELN EEFENSLLGK 
       260        270        280        290        300
KIQQDLRLKD DTVSKLVMPE NKVKEINSMY SMFKQYQDSL PLLAERMKSL 
       310        320        330        340        350
NKMNNRVIEV YETTKGLDSQ ITSIQEQGKV WLKALNELDK KFDEQEVKIR 
       360        370 
ENMEQIRRKI DTLEDEALQR NSK

Length:373

Mass (Da):43,607

Last modified:October 1, 1996 - v2

Checksum:ⁱ80646B78B484AE56

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	92	N → S in CAA81023 (PubMed:8138567).Curated	1
Sequence conflictⁱ	114	K → R in CAA81023 (PubMed:8138567).Curated	1
Sequence conflictⁱ	193	P → A in CAA81023 (PubMed:8138567).Curated	1
Sequence conflictⁱ	201	D → E in CAA81023 (PubMed:8138567).Curated	1
Sequence conflictⁱ	264	S → N in CAA81023 (PubMed:8138567).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z25750 Genomic DNA. Translation: CAA81023.1. X80836 Genomic DNA. Translation: CAA56803.1. BK006946 Genomic DNA. Translation: DAA10195.1.
PIRⁱ	S47455.
NCBI Reference Sequences More...RefSeqⁱ	NP_014022.1. NM_001182802.1.

Genome annotation databases

EnsemblFungiⁱ	YMR294W; YMR294W; YMR294W.
GeneIDⁱ	855339.
KEGGⁱ	sce:YMR294W.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z25750 Genomic DNA. Translation: CAA81023.1. X80836 Genomic DNA. Translation: CAA56803.1. BK006946 Genomic DNA. Translation: DAA10195.1.
PIRⁱ	S47455.
NCBI Reference Sequences More...RefSeqⁱ	NP_014022.1. NM_001182802.1.

3D structure databases

ProteinModelPortalⁱ	P36224.
SMRⁱ	P36224.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	35474. 417 interactors.
Database of interacting proteins More...DIPⁱ	DIP-2387N.
IntActⁱ	P36224. 9 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-493774.
STRINGⁱ	4932.YMR294W.

PTM databases

iPTMnetⁱ	P36224.

iPTMnetⁱ

P36224.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P36224.
PRIDEⁱ	P36224.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YMR294W; YMR294W; YMR294W.
GeneIDⁱ	855339.
KEGGⁱ	sce:YMR294W.

Organism-specific databases

EuPathDBⁱ	FungiDB:YMR294W.
Saccharomyces Genome Database More...SGDⁱ	S000004908. JNM1.

Phylogenomic databases

InParanoidⁱ	P36224.
KEGG Orthology (KO) More...KOⁱ	K18599.
OMAⁱ	DCERIVE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C3M4H.

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-32964-MONOMER.

BioCycⁱ

YEAST:G3O-32964-MONOMER.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P36224.

PROⁱ

PR:P36224.

Family and domain databases

InterProⁱ	View protein in InterPro IPR028133. Dynamitin.
PANTHERⁱ	PTHR15346:SF1. PTHR15346:SF1. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04912. Dynamitin. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	JNM1_YEAST
Accessionⁱ	P36224Primary (citable) accession number: P36224 Secondary accession number(s): D6W0C1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	October 1, 1996
	Last modified:	July 5, 2017
	This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P36224 (JNM1_YEAST)

Your basket is currently empty.

Nuclear migration protein JNM1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ