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P36222

- CH3L1_HUMAN

UniProt

P36222 - CH3L1_HUMAN

Protein

Chitinase-3-like protein 1

Gene

CHI3L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.4 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei141 – 1411Chitooligosaccharide
    Binding sitei263 – 2631Chitooligosaccharide
    Binding sitei352 – 3521Chitooligosaccharide

    GO - Molecular functioni

    1. chitin binding Source: UniProtKB
    2. extracellular matrix structural constituent Source: UniProtKB
    3. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

    GO - Biological processi

    1. activation of NF-kappaB-inducing kinase activity Source: UniProtKB
    2. apoptotic process Source: UniProtKB-KW
    3. carbohydrate metabolic process Source: InterPro
    4. cartilage development Source: UniProtKB
    5. cellular response to tumor necrosis factor Source: UniProtKB
    6. chitin catabolic process Source: InterPro
    7. inflammatory response Source: UniProtKB
    8. interleukin-8 secretion Source: UniProtKB
    9. lung development Source: UniProtKB
    10. positive regulation of angiogenesis Source: UniProtKB
    11. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    12. positive regulation of peptidyl-threonine phosphorylation Source: UniProtKB
    13. positive regulation of protein kinase B signaling Source: UniProtKB
    14. response to interleukin-1 Source: UniProtKB
    15. response to interleukin-6 Source: UniProtKB
    16. response to mechanical stimulus Source: UniProtKB
    17. response to tumor necrosis factor Source: UniProtKB

    Keywords - Molecular functioni

    Antimicrobial

    Keywords - Biological processi

    Apoptosis, Inflammatory response

    Keywords - Ligandi

    Lectin

    Protein family/group databases

    CAZyiGH18. Glycoside Hydrolase Family 18.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chitinase-3-like protein 1
    Alternative name(s):
    39 kDa synovial protein
    Cartilage glycoprotein 39
    Short name:
    CGP-39
    Short name:
    GP-39
    Short name:
    hCGP-39
    YKL-40
    Gene namesi
    Name:CHI3L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:1932. CHI3L1.

    Subcellular locationi

    Secretedextracellular space 1 Publication. Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endoplasmic reticulum Source: UniProtKB
    3. extracellular space Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    6. proteinaceous extracellular matrix Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Asthma-related traits 7 (ASRT7) [MIM:611960]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Keywords - Diseasei

    Asthma

    Organism-specific databases

    MIMi611960. phenotype.
    PharmGKBiPA26463.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21212 PublicationsAdd
    BLAST
    Chaini22 – 383362Chitinase-3-like protein 1PRO_0000011965Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 ↔ 51
    Glycosylationi60 – 601N-linked (GlcNAc...)1 Publication
    Disulfide bondi300 ↔ 364

    Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP36222.
    PeptideAtlasiP36222.
    PRIDEiP36222.

    PTM databases

    PhosphoSiteiP36222.

    Expressioni

    Tissue specificityi

    Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.2 Publications

    Inductioni

    Up-regulated in colon under several inflammatory conditions. Down-regulated by hyperoxia in bronchial epithelial cells.2 Publications

    Gene expression databases

    ArrayExpressiP36222.
    BgeeiP36222.
    CleanExiHS_CHI3L1.
    GenevestigatoriP36222.

    Interactioni

    Subunit structurei

    Monomer.2 Publications

    Protein-protein interaction databases

    STRINGi9606.ENSP00000255409.

    Structurei

    Secondary structure

    1
    383
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi23 – 297
    Helixi30 – 345
    Helixi37 – 393
    Helixi43 – 453
    Turni48 – 503
    Beta strandi52 – 6211
    Beta strandi65 – 673
    Helixi73 – 8210
    Helixi83 – 853
    Beta strandi91 – 977
    Turni99 – 1013
    Helixi103 – 1119
    Helixi113 – 13018
    Beta strandi133 – 1386
    Helixi144 – 1463
    Helixi147 – 16519
    Turni166 – 1683
    Beta strandi173 – 1797
    Helixi182 – 1887
    Helixi191 – 1977
    Beta strandi199 – 2046
    Helixi211 – 2133
    Helixi227 – 2293
    Beta strandi233 – 2364
    Helixi237 – 24711
    Helixi251 – 2533
    Beta strandi254 – 27017
    Beta strandi277 – 2815
    Turni286 – 2883
    Beta strandi293 – 2953
    Helixi296 – 3027
    Turni303 – 3053
    Beta strandi307 – 3104
    Turni312 – 3143
    Beta strandi317 – 3215
    Beta strandi324 – 3274
    Helixi331 – 34313
    Beta strandi347 – 3526
    Helixi354 – 3563
    Beta strandi359 – 3613
    Beta strandi363 – 3664
    Helixi371 – 38111

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1HJVX-ray2.75A/B/C/D22-383[»]
    1HJWX-ray2.30A/B22-383[»]
    1HJXX-ray1.85A/B/C/D22-383[»]
    1LA7model-A22-383[»]
    1NWRX-ray2.70A/B/C/D22-383[»]
    1NWSX-ray2.70A/B/C/D22-383[»]
    1NWTX-ray2.50A/B/C/D22-383[»]
    1NWUX-ray2.20A/B/C/D22-383[»]
    ProteinModelPortaliP36222.
    SMRiP36222. Positions 22-382.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP36222.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni70 – 712Chitooligosaccharide binding
    Regioni97 – 1004Chitooligosaccharide binding
    Regioni204 – 2074Chitooligosaccharide binding
    Regioni324 – 33815Important for AKT1 activation and IL8 productionBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 18 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3325.
    HOGENOMiHOG000111109.
    HOVERGENiHBG011684.
    InParanoidiP36222.
    KOiK17523.
    OMAiSNDHIDT.
    OrthoDBiEOG7ZGX3G.
    PhylomeDBiP36222.
    TreeFamiTF315610.

    Family and domain databases

    Gene3Di3.10.50.10. 1 hit.
    3.20.20.80. 2 hits.
    InterProiIPR028538. CHI3L1.
    IPR011583. Chitinase_II.
    IPR029070. Chitinase_insertion.
    IPR001223. Glyco_hydro18cat.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR11177:SF81. PTHR11177:SF81. 1 hit.
    PfamiPF00704. Glyco_hydro_18. 1 hit.
    [Graphical view]
    SMARTiSM00636. Glyco_18. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 2 hits.
    SSF54556. SSF54556. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36222-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVKASQTGF VVLVLLQCCS AYKLVCYYTS WSQYREGDGS CFPDALDRFL    50
    CTHIIYSFAN ISNDHIDTWE WNDVTLYGML NTLKNRNPNL KTLLSVGGWN 100
    FGSQRFSKIA SNTQSRRTFI KSVPPFLRTH GFDGLDLAWL YPGRRDKQHF 150
    TTLIKEMKAE FIKEAQPGKK QLLLSAALSA GKVTIDSSYD IAKISQHLDF 200
    ISIMTYDFHG AWRGTTGHHS PLFRGQEDAS PDRFSNTDYA VGYMLRLGAP 250
    ASKLVMGIPT FGRSFTLASS ETGVGAPISG PGIPGRFTKE AGTLAYYEIC 300
    DFLRGATVHR ILGQQVPYAT KGNQWVGYDD QESVKSKVQY LKDRQLAGAM 350
    VWALDLDDFQ GSFCGQDLRF PLTNAIKDAL AAT 383
    Length:383
    Mass (Da):42,625
    Last modified:December 20, 2005 - v2
    Checksum:i6C9EF133BDC7C2D1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti145 – 1451R → G.2 Publications
    Corresponds to variant rs880633 [ dbSNP | Ensembl ].
    VAR_019838
    Natural varianti311 – 3111I → T.2 Publications
    Corresponds to variant rs1049407 [ dbSNP | Ensembl ].
    VAR_019839

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80927 mRNA. Translation: AAA16074.1.
    Y08374
    , Y08375, Y08376, Y08377, Y08378 Genomic DNA. Translation: CAA69661.1.
    BT007223 mRNA. Translation: AAP35887.1.
    AK312911 mRNA. Translation: BAG35757.1.
    CH471067 Genomic DNA. Translation: EAW91467.1.
    BC008568 mRNA. Translation: AAH08568.1.
    BC038354 mRNA. Translation: AAH38354.1.
    BC039132 mRNA. Translation: AAH39132.1.
    CCDSiCCDS1435.1.
    PIRiA49562.
    RefSeqiNP_001267.2. NM_001276.2.
    UniGeneiHs.382202.
    Hs.733359.

    Genome annotation databases

    EnsembliENST00000255409; ENSP00000255409; ENSG00000133048.
    GeneIDi1116.
    KEGGihsa:1116.
    UCSCiuc001gzi.2. human.

    Polymorphism databases

    DMDMi84028186.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80927 mRNA. Translation: AAA16074.1 .
    Y08374
    , Y08375 , Y08376 , Y08377 , Y08378 Genomic DNA. Translation: CAA69661.1 .
    BT007223 mRNA. Translation: AAP35887.1 .
    AK312911 mRNA. Translation: BAG35757.1 .
    CH471067 Genomic DNA. Translation: EAW91467.1 .
    BC008568 mRNA. Translation: AAH08568.1 .
    BC038354 mRNA. Translation: AAH38354.1 .
    BC039132 mRNA. Translation: AAH39132.1 .
    CCDSi CCDS1435.1.
    PIRi A49562.
    RefSeqi NP_001267.2. NM_001276.2.
    UniGenei Hs.382202.
    Hs.733359.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1HJV X-ray 2.75 A/B/C/D 22-383 [» ]
    1HJW X-ray 2.30 A/B 22-383 [» ]
    1HJX X-ray 1.85 A/B/C/D 22-383 [» ]
    1LA7 model - A 22-383 [» ]
    1NWR X-ray 2.70 A/B/C/D 22-383 [» ]
    1NWS X-ray 2.70 A/B/C/D 22-383 [» ]
    1NWT X-ray 2.50 A/B/C/D 22-383 [» ]
    1NWU X-ray 2.20 A/B/C/D 22-383 [» ]
    ProteinModelPortali P36222.
    SMRi P36222. Positions 22-382.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000255409.

    Protein family/group databases

    CAZyi GH18. Glycoside Hydrolase Family 18.

    PTM databases

    PhosphoSitei P36222.

    Polymorphism databases

    DMDMi 84028186.

    Proteomic databases

    PaxDbi P36222.
    PeptideAtlasi P36222.
    PRIDEi P36222.

    Protocols and materials databases

    DNASUi 1116.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255409 ; ENSP00000255409 ; ENSG00000133048 .
    GeneIDi 1116.
    KEGGi hsa:1116.
    UCSCi uc001gzi.2. human.

    Organism-specific databases

    CTDi 1116.
    GeneCardsi GC01M203148.
    HGNCi HGNC:1932. CHI3L1.
    MIMi 601525. gene.
    611960. phenotype.
    neXtProti NX_P36222.
    PharmGKBi PA26463.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3325.
    HOGENOMi HOG000111109.
    HOVERGENi HBG011684.
    InParanoidi P36222.
    KOi K17523.
    OMAi SNDHIDT.
    OrthoDBi EOG7ZGX3G.
    PhylomeDBi P36222.
    TreeFami TF315610.

    Miscellaneous databases

    ChiTaRSi CHI3L1. human.
    EvolutionaryTracei P36222.
    GeneWikii CHI3L1.
    GenomeRNAii 1116.
    NextBioi 4626.
    PROi P36222.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P36222.
    Bgeei P36222.
    CleanExi HS_CHI3L1.
    Genevestigatori P36222.

    Family and domain databases

    Gene3Di 3.10.50.10. 1 hit.
    3.20.20.80. 2 hits.
    InterProi IPR028538. CHI3L1.
    IPR011583. Chitinase_II.
    IPR029070. Chitinase_insertion.
    IPR001223. Glyco_hydro18cat.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR11177:SF81. PTHR11177:SF81. 1 hit.
    Pfami PF00704. Glyco_hydro_18. 1 hit.
    [Graphical view ]
    SMARTi SM00636. Glyco_18. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 2 hits.
    SSF54556. SSF54556. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family."
      Hakala B.E., White C., Recklies A.D.
      J. Biol. Chem. 268:25803-25810(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANT THR-311.
      Tissue: Cartilage.
    2. "Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation."
      Rehli M., Krause S.W., Andressen R.
      Genomics 43:221-225(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-311.
      Tissue: Blood.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-145.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-145.
      Tissue: Brain.
    7. "Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period."
      Nyirkos P., Golds E.E.
      Biochem. J. 269:265-268(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-45.
    8. "Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages."
      Renkema G.H., Boot R.G., Au F.L., Donker-Koopman W.E., Strijland A., Muijsers A.O., Hrebicek M., Aerts J.M.F.G.
      Eur. J. Biochem. 251:504-509(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF N-TERMINUS, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    9. "Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells."
      Mizoguchi E.
      Gastroenterology 130:398-411(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    10. "Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis."
      Lee C.G., Hartl D., Lee G.R., Koller B., Matsuura H., Da Silva C.A., Sohn M.H., Cohn L., Homer R.J., Kozhich A.A., Humbles A., Kearley J., Coyle A., Chupp G., Reed J., Flavell R.A., Elias J.A.
      J. Exp. Med. 206:1149-1166(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury."
      Sohn M.H., Kang M.J., Matsuura H., Bhandari V., Chen N.Y., Lee C.G., Elias J.A.
      Am. J. Respir. Crit. Care Med. 182:918-928(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    12. "Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes."
      Houston D.R., Recklies A.D., Krupa J.C., van Aalten D.M.F.
      J. Biol. Chem. 278:30206-30212(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 22-383 IN COMPLEX WITH CHITIN OLIGOMERS, DISULFIDE BONDS, GLYCOSYLATION AT ASN-60.
    13. "Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39."
      Fusetti F., Pijning T., Kalk K.H., Bos E., Dijkstra B.W.
      J. Biol. Chem. 278:37753-37760(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 22-383 IN COMPLEX WITH CHITIN OLIGOMERS, DISULFIDE BONDS.
    14. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA-RELATED TRAITS.

    Entry informationi

    Entry nameiCH3L1_HUMAN
    AccessioniPrimary (citable) accession number: P36222
    Secondary accession number(s): B2R7B0
    , P30923, Q8IVA4, Q96HI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Although it belongs to the glycosyl hydrolase 18 family, Leu-140 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3