Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P36217

- XYN2_HYPJE

UniProt

P36217 - XYN2_HYPJE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Endo-1,4-beta-xylanase 2

Gene

xyn2

Organism
Hypocrea jecorina (Trichoderma reesei)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei118 – 1181Nucleophile
Active sitei209 – 2091Proton donor

GO - Molecular functioni

  1. endo-1,4-beta-xylanase activity Source: UniProtKB-EC

GO - Biological processi

  1. xylan catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

UniPathwayiUPA00114.

Protein family/group databases

CAZyiGH11. Glycoside Hydrolase Family 11.
mycoCLAPiXYN11B_TRIRE.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-1,4-beta-xylanase 2 (EC:3.2.1.8)
Short name:
Xylanase 2
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase 2
Gene namesi
Name:xyn2
OrganismiHypocrea jecorina (Trichoderma reesei)
Taxonomic identifieri51453 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Add
BLAST
Chaini33 – 222190Endo-1,4-beta-xylanase 2PRO_0000008014Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331Pyrrolidone carboxylic acid1 Publication
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi37 – 426
Beta strandi45 – 517
Beta strandi57 – 615
Beta strandi66 – 738
Beta strandi76 – 8510
Beta strandi91 – 11323
Turni114 – 1163
Beta strandi117 – 12711
Turni130 – 1334
Beta strandi135 – 1428
Beta strandi145 – 15713
Beta strandi162 – 17514
Beta strandi178 – 1836
Helixi184 – 19310
Beta strandi200 – 21213
Beta strandi214 – 2229

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ENXX-ray1.50A/B34-222[»]
1REDX-ray1.60A/B34-222[»]
1REEX-ray1.60A/B34-222[»]
1REFX-ray1.80A/B34-222[»]
1XYOX-ray1.50A/B34-222[»]
1XYPX-ray1.50A/B34-222[»]
2D97X-ray2.01A34-222[»]
2D98X-ray2.00A34-222[»]
2DFBX-ray1.11A33-222[»]
2DFCX-ray1.19A33-222[»]
3LGRX-ray1.64A34-222[»]
4HK8X-ray1.15A34-222[»]
4HK9X-ray1.55A35-222[»]
4HKLX-ray1.10A34-222[»]
4HKOX-ray1.50A34-222[»]
4HKWX-ray1.65A34-222[»]
ProteinModelPortaliP36217.
SMRiP36217. Positions 34-222.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36217.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG05353.

Family and domain databases

Gene3Di2.60.120.180. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001137. Glyco_hydro_11.
IPR013319. Glyco_hydro_11/12.
IPR018208. Glyco_hydro_11_AS.
[Graphical view]
PfamiPF00457. Glyco_hydro_11. 1 hit.
[Graphical view]
PRINTSiPR00911. GLHYDRLASE11.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00776. GLYCOSYL_HYDROL_F11_1. 1 hit.
PS00777. GLYCOSYL_HYDROL_F11_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36217-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSFTSLLAA SPPSRASCRP AAEVESVAVE KRQTIQPGTG YNNGYFYSYW
60 70 80 90 100
NDGHGGVTYT NGPGGQFSVN WSNSGNFVGG KGWQPGTKNK VINFSGSYNP
110 120 130 140 150
NGNSYLSVYG WSRNPLIEYY IVENFGTYNP STGATKLGEV TSDGSVYDIY
160 170 180 190 200
RTQRVNQPSI IGTATFYQYW SVRRNHRSSG SVNTANHFNA WAQQGLTLGT
210 220
MDYQIVAVEG YFSSGSASIT VS
Length:222
Mass (Da):24,172
Last modified:June 1, 1994 - v1
Checksum:i15F7032FACF963FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69573 Genomic DNA. Translation: CAA49293.1.
PIRiS39154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69573 Genomic DNA. Translation: CAA49293.1 .
PIRi S39154.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ENX X-ray 1.50 A/B 34-222 [» ]
1RED X-ray 1.60 A/B 34-222 [» ]
1REE X-ray 1.60 A/B 34-222 [» ]
1REF X-ray 1.80 A/B 34-222 [» ]
1XYO X-ray 1.50 A/B 34-222 [» ]
1XYP X-ray 1.50 A/B 34-222 [» ]
2D97 X-ray 2.01 A 34-222 [» ]
2D98 X-ray 2.00 A 34-222 [» ]
2DFB X-ray 1.11 A 33-222 [» ]
2DFC X-ray 1.19 A 33-222 [» ]
3LGR X-ray 1.64 A 34-222 [» ]
4HK8 X-ray 1.15 A 34-222 [» ]
4HK9 X-ray 1.55 A 35-222 [» ]
4HKL X-ray 1.10 A 34-222 [» ]
4HKO X-ray 1.50 A 34-222 [» ]
4HKW X-ray 1.65 A 34-222 [» ]
ProteinModelPortali P36217.
SMRi P36217. Positions 34-222.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH11. Glycoside Hydrolase Family 11.
mycoCLAPi XYN11B_TRIRE.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG05353.

Enzyme and pathway databases

UniPathwayi UPA00114 .

Miscellaneous databases

EvolutionaryTracei P36217.

Family and domain databases

Gene3Di 2.60.120.180. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR001137. Glyco_hydro_11.
IPR013319. Glyco_hydro_11/12.
IPR018208. Glyco_hydro_11_AS.
[Graphical view ]
Pfami PF00457. Glyco_hydro_11. 1 hit.
[Graphical view ]
PRINTSi PR00911. GLHYDRLASE11.
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS00776. GLYCOSYL_HYDROL_F11_1. 1 hit.
PS00777. GLYCOSYL_HYDROL_F11_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The two major xylanases from Trichoderma reesei: characterization of both enzymes and genes."
    Toerroenen A., Mach R.L., Messner R., Gonzalez R., Kalkkinen N., Harkki A., Kubicek C.P.
    Biotechnology (N.Y.) 10:1461-1465(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-33.
    Strain: C30.
  2. "Three-dimensional structure of endo-1,4-beta-xylanase II from Trichoderma reesei: two conformational states in the active site."
    Toerroenen A., Harkki A., Rouvinen J.
    EMBO J. 13:2493-2501(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
    Strain: C30.
  3. "Structural comparison of two major endo-1,4-xylanases from Trichoderma reesei."
    Toerroenen A., Rouvinen J.
    Biochemistry 34:847-856(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS).
    Strain: C30.
  4. "Covalent binding of three epoxyalkyl xylosides to the active site of endo-1,4-xylanase II from Trichoderma reesei."
    Havukainen R., Toerroenen A., Laitinen T., Rouvinen J.
    Biochemistry 35:9617-9624(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).
    Strain: C30.

Entry informationi

Entry nameiXYN2_HYPJE
AccessioniPrimary (citable) accession number: P36217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3