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Protein

Modification methylase CviJI

Gene

CVIJIM

Organism
Paramecium bursaria Chlorella virus IL3A (PBCV-IL3A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence RGCY, causes specific methylation on C-3 on both strands, and protects the DNA from cleavage by the CviJI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3353 M.CviJI

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase CviJI (EC:2.1.1.37)
Short name:
M.CviJI
Alternative name(s):
Cytosine-specific methyltransferase CviJI
Gene namesi
Name:CVIJIM
OrganismiParamecium bursaria Chlorella virus IL3A (PBCV-IL3A)
Taxonomic identifieri46019 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePhycodnaviridaeChlorovirus
Virus hostiChlorella [TaxID: 3071]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878711 – 367Modification methylase CviJIAdd BLAST367

Proteomic databases

PRIDEiP36216

Structurei

3D structure databases

ProteinModelPortaliP36216
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 367SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST365

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 2 hits
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P36216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRTLELFA GIAGISHGLR GISTPVAFVE INEDAQKFLK TKFSDASVFN
60 70 80 90 100
DVTKFTKSDF PEDIDMITAG FPCTGFSIAG SRTGFEHKES GLFADVVRIT
110 120 130 140 150
EEYKPKIVFL ENSHMLSHTY NLDVVVKKMD EIGYFCKWVT CRASIIGAHH
160 170 180 190 200
QRHRWFCLAI RKDYEPEEII VSVNATKFDW ENNEPPCQVD NKSYENSTLV
210 220 230 240 250
RLAGYSVVPD QIRYAFTGLF TGDFESSWKT TLTPGTIIGT EHKKMKGTYD
260 270 280 290 300
KVINGYYEND VYYSFSRKEV HRAPLNISVK PRDIPEKHNG KTLVDREMIK
310 320 330 340 350
KYWCTPCASY GTATAGCNVL TDRQSHALPT QVRFSYRGVC GRHLSGIWCA
360
WLMGYDQEYL GYLVQYD
Length:367
Mass (Da):41,861
Last modified:June 1, 1994 - v1
Checksum:i15BD56B0354E2ECC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27265 Genomic DNA Translation: AAA88826.1
U09001 Genomic DNA Translation: AAC55063.1
PIRiA46355

Entry informationi

Entry nameiMTC1_PBCVI
AccessioniPrimary (citable) accession number: P36216
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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