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P36209 (STS1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Delta(24(24(1)))-sterol reductase
EC=1.3.1.71
Alternative name(s):
C-24(28) sterol reductase
Sterol Delta(24(28))-reductase
Gene names
Name:sts1
ORF Names:SPAC20G4.07c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3-beta-ol + NADPH.

Pathway

Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 5/5.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the ERG4/ERG24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Delta(24(24(1)))-sterol reductase
PRO_0000207492

Regions

Transmembrane13 – 3321Helical; Potential
Transmembrane77 – 9721Helical; Potential
Transmembrane118 – 13821Helical; Potential
Transmembrane153 – 17321Helical; Potential
Transmembrane209 – 22921Helical; Potential
Transmembrane278 – 29821Helical; Potential
Transmembrane311 – 33121Helical; Potential
Transmembrane399 – 41921Helical; Potential

Experimental info

Sequence conflict4121C → S in CAA45113. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P36209 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 4740B6EE3BBD27CF

FASTA45352,546
        10         20         30         40         50         60 
MKSTVKKSAP REFGGAKGAL AIMTGFPCLM YYLWACSKFN DSQFIKPESF TIAGFQNFFR 

        70         80         90        100        110        120 
TLGHYIYVGA YPTRYAFLVF WSFCIVQAVM YLTLPGVRTQ GLPLKHRNNE RLPYLCNAIW 

       130        140        150        160        170        180 
SFYTTIVILA VLHVTHVFPI TTFIDMFGPL MSVAIITAFV CTFVLYTGTL LFGDRLFDKP 

       190        200        210        220        230        240 
HRLSGNPIYD AFMGACLNPR LGKLLDFKMF FEVRIPWFIL FFISVGAAVR QYETYGTVSP 

       250        260        270        280        290        300 
QVLFVCLGHY LYANACSKGE QLIVPTWDMA YEKFGFMLIF WNMAGVPFTY SHCTLYLFSH 

       310        320        330        340        350        360 
DPSVYNWSTQ YTTGIYVLLL CCYYIFDTCN GQKNHFRNQI YGTEVHRKTF PQLPWLIIKN 

       370        380        390        400        410        420 
PTFIRCANGG TLLTSGWYRY ARKIHYTADF FQSLSWALIT GFQSPLPYFY PCFFFVVLVH 

       430        440        450 
RVSRDIKKCK AKYGADFDEY CRICPYLFIP YIF

« Hide

References

« Hide 'large scale' references
[1]"Fission yeast sts1+ gene encodes a protein similar to the chicken lamin B receptor and is implicated in pleiotropic drug-sensitivity, divalent cation-sensitivity, and osmoregulation."
Shimanuki M., Goebl M., Yanagida M., Toda T.
Mol. Biol. Cell 3:263-273(1992) [PubMed: 1320960] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway."
Lai M.H., Bard M., Pierson C.A., Alexander J.F., Goebl M., Carter G.T., Kirsch D.R.
Gene 140:41-49(1994) [PubMed: 8125337] [Abstract]
Cited for: CHARACTERIZATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X63549 Genomic DNA. Translation: CAA45113.1.
CU329670 Genomic DNA. Translation: CAB11256.1.
PIRA43765.
RefSeqNP_594742.1. NM_001020170.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP36209.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC20G4.07c.1; SPAC20G4.07c.1:pep; SPAC20G4.07c.
GeneID2541740.
GenomeReviewsGene locus sts1 in contig CU329670_GR.
KEGGspo:SPAC20G4.07c.
NMPDRfig|4896.1.peg.4712.

Organism-specific databases

GeneDB_SpombeSPAC20G4.07c.

Phylogenomic databases

eggNOGfuNOG07477.
GeneTreeEFGT00050000001699.
HOGENOMHBG592488.
OMAFFEVRLP.
OrthoDBEOG4GBBFQ.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-002820-MONOMER.

Gene expression databases

ArrayExpressP36209.

Family and domain databases

InterProIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
KOK00223.
PfamPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSTS1_SCHPO
AccessionPrimary (citable) accession number: P36209
Secondary accession number(s): O13891
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 15, 1998
Last modified: December 14, 2011
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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