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Protein

DNA-binding protein HU

Gene

hup

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA condensation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-279-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein HU
Gene namesi
Name:hup
Ordered Locus Names:TM_0266
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9090DNA-binding protein HUPRO_0000104989Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0266.

Structurei

Secondary structure

1
90
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1412Combined sources
Helixi18 – 3720Combined sources
Beta strandi42 – 443Combined sources
Turni45 – 473Combined sources
Beta strandi48 – 514Combined sources
Beta strandi78 – 814Combined sources
Helixi83 – 897Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B8ZX-ray1.60A/B1-90[»]
1RIYX-ray1.80A1-90[»]
ProteinModelPortaliP36206.
SMRiP36206. Positions 1-90.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36206.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105K70. Bacteria.
COG0776. LUCA.
InParanoidiP36206.
KOiK03530.
OMAiMNSITYE.
OrthoDBiEOG615VS6.

Family and domain databases

Gene3Di4.10.520.10. 1 hit.
InterProiIPR000119. Hist_DNA-bd.
IPR020816. Histone-like_DNA-bd_CS.
IPR010992. IHF-like_DNA-bd_dom.
[Graphical view]
PfamiPF00216. Bac_DNA_binding. 1 hit.
[Graphical view]
PRINTSiPR01727. DNABINDINGHU.
SMARTiSM00411. BHL. 1 hit.
[Graphical view]
SUPFAMiSSF47729. SSF47729. 1 hit.
PROSITEiPS00045. HISTONE_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKELIDRV AKKAGAKKKD VKLILDTILE TITEALAKGE KVQIVGFGSF
60 70 80 90
EVRKAAARKG VNPQTRKPIT IPERKVPKFK PGKALKEKVK
Length:90
Mass (Da):9,980
Last modified:May 30, 2000 - v2
Checksum:i7C5F31A262DD60D6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21T → N in AAA27416 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23541 Genomic DNA. Translation: AAA27416.1.
AE000512 Genomic DNA. Translation: AAD35355.1.
PIRiH72396.
RefSeqiNP_228079.1. NC_000853.1.
WP_010865085.1. NC_000853.1.

Genome annotation databases

EnsemblBacteriaiAAD35355; AAD35355; TM_0266.
GeneIDi897177.
KEGGitma:TM0266.
PATRICi23935409. VBITheMar51294_0270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23541 Genomic DNA. Translation: AAA27416.1.
AE000512 Genomic DNA. Translation: AAD35355.1.
PIRiH72396.
RefSeqiNP_228079.1. NC_000853.1.
WP_010865085.1. NC_000853.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B8ZX-ray1.60A/B1-90[»]
1RIYX-ray1.80A1-90[»]
ProteinModelPortaliP36206.
SMRiP36206. Positions 1-90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0266.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35355; AAD35355; TM_0266.
GeneIDi897177.
KEGGitma:TM0266.
PATRICi23935409. VBITheMar51294_0270.

Phylogenomic databases

eggNOGiENOG4105K70. Bacteria.
COG0776. LUCA.
InParanoidiP36206.
KOiK03530.
OMAiMNSITYE.
OrthoDBiEOG615VS6.

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-279-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP36206.

Family and domain databases

Gene3Di4.10.520.10. 1 hit.
InterProiIPR000119. Hist_DNA-bd.
IPR020816. Histone-like_DNA-bd_CS.
IPR010992. IHF-like_DNA-bd_dom.
[Graphical view]
PfamiPF00216. Bac_DNA_binding. 1 hit.
[Graphical view]
PRINTSiPR01727. DNABINDINGHU.
SMARTiSM00411. BHL. 1 hit.
[Graphical view]
SUPFAMiSSF47729. SSF47729. 1 hit.
PROSITEiPS00045. HISTONE_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The histone-like protein (HU) of Thermotoga maritima."
    Markiewicz P.G., Ehret S., Miller J.H.
    Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  3. "Cloning, overproduction, purification and crystallization of the DNA binding protein HU from the hyperthermophilic eubacterium Thermotoga maritima."
    Christodoulou E., Vorgias C.E.
    Acta Crystallogr. D 54:1043-1045(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).

Entry informationi

Entry nameiDBH_THEMA
AccessioniPrimary (citable) accession number: P36206
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 30, 2000
Last modified: February 17, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.