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Protein

DNA-binding protein HU

Gene

hup

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA condensation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein HU
Gene namesi
Name:hup
Ordered Locus Names:TM_0266
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001049891 – 90DNA-binding protein HUAdd BLAST90

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0266

Structurei

Secondary structure

190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 14Combined sources12
Helixi18 – 37Combined sources20
Beta strandi42 – 44Combined sources3
Turni45 – 47Combined sources3
Beta strandi48 – 51Combined sources4
Beta strandi78 – 81Combined sources4
Helixi83 – 89Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8ZX-ray1.60A/B1-90[»]
1RIYX-ray1.80A1-90[»]
ProteinModelPortaliP36206
SMRiP36206
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36206

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105K70 Bacteria
COG0776 LUCA
InParanoidiP36206
KOiK03530
OMAiERKVPKF

Family and domain databases

Gene3Di4.10.520.10, 1 hit
InterProiView protein in InterPro
IPR000119 Hist_DNA-bd
IPR020816 Histone-like_DNA-bd_CS
IPR010992 IHF-like_DNA-bd_dom_sf
PANTHERiPTHR33175 PTHR33175, 1 hit
PfamiView protein in Pfam
PF00216 Bac_DNA_binding, 1 hit
PRINTSiPR01727 DNABINDINGHU
SMARTiView protein in SMART
SM00411 BHL, 1 hit
SUPFAMiSSF47729 SSF47729, 1 hit
PROSITEiView protein in PROSITE
PS00045 HISTONE_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P36206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKELIDRV AKKAGAKKKD VKLILDTILE TITEALAKGE KVQIVGFGSF
60 70 80 90
EVRKAAARKG VNPQTRKPIT IPERKVPKFK PGKALKEKVK
Length:90
Mass (Da):9,980
Last modified:May 30, 2000 - v2
Checksum:i7C5F31A262DD60D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2T → N in AAA27416 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23541 Genomic DNA Translation: AAA27416.1
AE000512 Genomic DNA Translation: AAD35355.1
PIRiH72396
RefSeqiNP_228079.1, NC_000853.1
WP_010865085.1, NC_000853.1

Genome annotation databases

EnsemblBacteriaiAAD35355; AAD35355; TM_0266
GeneIDi897177
KEGGitma:TM0266
PATRICifig|243274.5.peg.270

Similar proteinsi

Entry informationi

Entry nameiDBH_THEMA
AccessioniPrimary (citable) accession number: P36206
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health