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P36205

- GLNA_THEMA

UniProt

P36205 - GLNA_THEMA

Protein

Glutamine synthetase

Gene

glnA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    Enzyme regulationi

    The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro
    2. nitrogen fixation Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-502.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase (EC:6.3.1.2)
    Short name:
    GS
    Alternative name(s):
    Glutamate--ammonia ligase
    Gene namesi
    Name:glnA
    Ordered Locus Names:TM_0943
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 439439Glutamine synthetasePRO_0000153273Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei369 – 3691O-AMP-tyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

    Protein-protein interaction databases

    STRINGi243274.TM0943.

    Structurei

    3D structure databases

    ProteinModelPortaliP36205.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Phylogenomic databases

    eggNOGiCOG0174.
    KOiK01915.
    OMAiIEWDMFR.
    OrthoDBiEOG6B360N.

    Family and domain databases

    Gene3Di3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    TIGRFAMsiTIGR00653. GlnA. 1 hit.
    PROSITEiPS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36205-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIETIKRII EEENVRFIRL QFTDINGTLK NLEITPDVFL ESWEDGIMFD    50
    GSSIEGFVRI EESDMYLKPV LDTFAVLPWT VDGAKSARVI CDVYTPDGKP 100
    FEGDPRYRLR RMMEKAEQLG YTPYAGPEME FFILPINEKG EPVPEFLDHG 150
    GYFDLLPLSK VEEIRRDIAI ALEKMGITVE ATHHEVAPSQ HEVDFRYDTF 200
    LRTADNAQTV KLVIKTMAIF HGYHATFMPK PFYGVNGSGM HVHMSLFRGD 250
    KNAFYDPDDP LGLSKELRYF VGGILKHAKA LAAVTNPTIN SYKRLVPGYE 300
    APVYISWSVG NRSALIRIPK ARGKATRLEY RSPDPSCNIY LAFAAILAAG 350
    LDGIINKIEP PAPVEENIYH MTSERREELN IESLPGSLKE AVEELKKDDV 400
    IIDALGEHIF EKFVEAAEKD WKEFSTYVTN WELQRYLYL 439
    Length:439
    Mass (Da):50,035
    Last modified:May 30, 2000 - v2
    Checksum:iABE3E674BD2F2359
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti204 – 2041A → G in CAA42729. (PubMed:1348781)Curated
    Sequence conflicti280 – 2801A → R in CAA42729. (PubMed:1348781)Curated
    Sequence conflicti336 – 3361S → T in CAA42729. (PubMed:1348781)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60160 Genomic DNA. Translation: CAA42729.1.
    AE000512 Genomic DNA. Translation: AAD36024.1.
    PIRiB72313.
    RefSeqiNP_228751.1. NC_000853.1.
    YP_007977295.1. NC_021214.1.
    YP_008991957.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD36024; AAD36024; TM_0943.
    GeneIDi898680.
    KEGGitma:TM0943.
    tmi:THEMA_09630.
    tmm:Tmari_0945.
    PATRICi23936817. VBITheMar51294_0957.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60160 Genomic DNA. Translation: CAA42729.1 .
    AE000512 Genomic DNA. Translation: AAD36024.1 .
    PIRi B72313.
    RefSeqi NP_228751.1. NC_000853.1.
    YP_007977295.1. NC_021214.1.
    YP_008991957.1. NC_023151.1.

    3D structure databases

    ProteinModelPortali P36205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM0943.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD36024 ; AAD36024 ; TM_0943 .
    GeneIDi 898680.
    KEGGi tma:TM0943.
    tmi:THEMA_09630.
    tmm:Tmari_0945.
    PATRICi 23936817. VBITheMar51294_0957.

    Phylogenomic databases

    eggNOGi COG0174.
    KOi K01915.
    OMAi IEWDMFR.
    OrthoDBi EOG6B360N.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-502.

    Family and domain databases

    Gene3Di 3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    TIGRFAMsi TIGR00653. GlnA. 1 hit.
    PROSITEi PS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The glnA gene of the extremely thermophilic eubacterium Thermotoga maritima: cloning, primary structure, and expression in Escherichia coli."
      Sanangelantoni A.M., Forlani G., Ambroselli F., Cammarano P., Tiboni O.
      J. Gen. Microbiol. 138:383-393(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

    Entry informationi

    Entry nameiGLNA_THEMA
    AccessioniPrimary (citable) accession number: P36205
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3