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Protein

Protein RecA

Gene

recA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 75ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RecAUniRule annotation
Alternative name(s):
Recombinase AUniRule annotation
Gene namesi
Name:recAUniRule annotation
Ordered Locus Names:TM_1859
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001228781 – 356Protein RecAAdd BLAST356

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1859.

Structurei

Secondary structure

1356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 22Combined sources18
Helixi47 – 52Combined sources6
Beta strandi54 – 59Combined sources6
Beta strandi62 – 69Combined sources8
Helixi74 – 87Combined sources14
Beta strandi92 – 98Combined sources7
Helixi103 – 109Combined sources7
Helixi113 – 115Combined sources3
Beta strandi117 – 119Combined sources3
Helixi124 – 136Combined sources13
Beta strandi141 – 146Combined sources6
Turni148 – 150Combined sources3
Helixi154 – 157Combined sources4
Helixi168 – 185Combined sources18
Beta strandi190 – 199Combined sources10
Beta strandi201 – 205Combined sources5
Helixi213 – 220Combined sources8
Beta strandi222 – 235Combined sources14
Beta strandi238 – 254Combined sources17
Beta strandi259 – 265Combined sources7
Turni266 – 268Combined sources3
Helixi272 – 282Combined sources11
Beta strandi285 – 289Combined sources5
Beta strandi292 – 296Combined sources5
Beta strandi302 – 307Combined sources6
Helixi308 – 318Combined sources11
Helixi320 – 333Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HR8X-ray1.95A1-356[»]
ProteinModelPortaliP36203.
SMRiP36203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C68. Bacteria.
COG0468. LUCA.
InParanoidiP36203.
KOiK03553.
OMAiTRKGAWY.

Family and domain databases

CDDicd00983. recA. 1 hit.
Gene3Di3.30.250.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00268. RecA. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013765. DNA_recomb/repair_RecA.
IPR020584. DNA_recomb/repair_RecA_CS.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR023400. RecA_C.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PANTHERiPTHR22942:SF1. PTHR22942:SF1. 1 hit.
PfamiPF00154. RecA. 1 hit.
[Graphical view]
PRINTSiPR00142. RECA.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54752. SSF54752. 1 hit.
TIGRFAMsiTIGR02012. tigrfam_recA. 1 hit.
PROSITEiPS00321. RECA_1. 1 hit.
PS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEEKQKKSV LEKALKRIEE NFGKGSIMIL GDETQVQPVE VIPTGSLAID
60 70 80 90 100
IATGVGGYPR GRIVEIFGQE SSGKTTLALH AIAEAQKMGG VAAFIDAEHA
110 120 130 140 150
LDPVYAKNLG VDLKSLLISQ PDHGEQALEI VDELVRSGVV DLIVVDSVAA
160 170 180 190 200
LVPRAEIEGA MGDMQVGLQA RLMSQALRKI AGSVNKSKAV VIFTNQIRMK
210 220 230 240 250
IGVMFGSPET TTGGLALKFY ATMRMEVRRG EPIKEGKDVI GNVISVKIVK
260 270 280 290 300
NKVAPPFKTA QTYIIYGKGI DREYELFNIA VNEGIVDRKG SWYYYTTLKG
310 320 330 340 350
EEVSLGQGSS NAVQFLKDNP EIAGEIERRI REKYGLLSVE KEEQRKEKKS

SGEEAS
Length:356
Mass (Da):38,798
Last modified:June 1, 1994 - v1
Checksum:iA2B70853C26C95FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23425 Genomic DNA. Translation: AAA27417.1.
AE000512 Genomic DNA. Translation: AAD36921.1.
PIRiD55020.
RefSeqiNP_229655.1. NC_000853.1.
WP_004082410.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36921; AAD36921; TM_1859.
GeneIDi897122.
KEGGitma:TM1859.
PATRICi23938707. VBITheMar51294_1880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23425 Genomic DNA. Translation: AAA27417.1.
AE000512 Genomic DNA. Translation: AAD36921.1.
PIRiD55020.
RefSeqiNP_229655.1. NC_000853.1.
WP_004082410.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HR8X-ray1.95A1-356[»]
ProteinModelPortaliP36203.
SMRiP36203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1859.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36921; AAD36921; TM_1859.
GeneIDi897122.
KEGGitma:TM1859.
PATRICi23938707. VBITheMar51294_1880.

Phylogenomic databases

eggNOGiENOG4105C68. Bacteria.
COG0468. LUCA.
InParanoidiP36203.
KOiK03553.
OMAiTRKGAWY.

Family and domain databases

CDDicd00983. recA. 1 hit.
Gene3Di3.30.250.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00268. RecA. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013765. DNA_recomb/repair_RecA.
IPR020584. DNA_recomb/repair_RecA_CS.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR023400. RecA_C.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PANTHERiPTHR22942:SF1. PTHR22942:SF1. 1 hit.
PfamiPF00154. RecA. 1 hit.
[Graphical view]
PRINTSiPR00142. RECA.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54752. SSF54752. 1 hit.
TIGRFAMsiTIGR02012. tigrfam_recA. 1 hit.
PROSITEiPS00321. RECA_1. 1 hit.
PS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRECA_THEMA
AccessioniPrimary (citable) accession number: P36203
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.