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Protein

Cysteine-rich protein 2

Gene

Crip2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 2
Short name:
CRP-2
Alternative name(s):
Protein ESP1
Gene namesi
Name:Crip2
Synonyms:Crp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1302959. Crip2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757131 – 208Cysteine-rich protein 2Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineBy similarity1
Modified residuei104PhosphoserineBy similarity1
Modified residuei138N6-acetyllysineBy similarity1
Modified residuei144N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP36201.
PRIDEiP36201.

PTM databases

iPTMnetiP36201.
PhosphoSitePlusiP36201.

Expressioni

Tissue specificityi

Expressed more abundantly in liver and kidney of females than that of males. Equally expressed in brain, lung and heart.

Gene expression databases

BgeeiENSRNOG00000005041.
GenevisibleiP36201. RN.

Interactioni

Subunit structurei

Interacts with TGFB1I1.By similarity

Protein-protein interaction databases

MINTiMINT-4565784.
STRINGi10116.ENSRNOP00000006804.

Structurei

3D structure databases

ProteinModelPortaliP36201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 57LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini126 – 178LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 73Gly-richAdd BLAST11
Compositional biasi180 – 194Gly-richAdd BLAST15

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410ITI5. Eukaryota.
ENOG410XUEW. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111234.
HOVERGENiHBG051143.
InParanoidiP36201.
OMAiYCKAHFE.
OrthoDBiEOG091G11RX.
PhylomeDBiP36201.
TreeFamiTF313758.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKCPKCDK TVYFAEKVSS LGKDWHKFCL KCERCNKTLT PGGHAEHDGK
60 70 80 90 100
PFCHKPCYAT LFGPKGVNIG GAGSYIYEKP PTEAPQVTGP IEVPVVRTEE
110 120 130 140 150
RKTSGPPKGP SKASSVTTFT GEPNMCPRCN KRVYFAEKVT SLGKDWHRPC
160 170 180 190 200
LRCERCSKTL TPGGHAEHDG QPYCHKPCYG ILFGPKGVNT GAVGSYIYDK

DPEGTVQP
Length:208
Mass (Da):22,696
Last modified:June 1, 1994 - v1
Checksum:i6F3B5F8A8FBBAD19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17512 mRNA. Translation: BAA04464.1.
BC061774 mRNA. Translation: AAH61774.1.
PIRiS38745.
RefSeqiNP_071946.1. NM_022501.1.
UniGeneiRn.4267.

Genome annotation databases

EnsembliENSRNOT00000006804; ENSRNOP00000006804; ENSRNOG00000005041.
GeneIDi338401.
KEGGirno:338401.
UCSCiRGD:1302959. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17512 mRNA. Translation: BAA04464.1.
BC061774 mRNA. Translation: AAH61774.1.
PIRiS38745.
RefSeqiNP_071946.1. NM_022501.1.
UniGeneiRn.4267.

3D structure databases

ProteinModelPortaliP36201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4565784.
STRINGi10116.ENSRNOP00000006804.

PTM databases

iPTMnetiP36201.
PhosphoSitePlusiP36201.

Proteomic databases

PaxDbiP36201.
PRIDEiP36201.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006804; ENSRNOP00000006804; ENSRNOG00000005041.
GeneIDi338401.
KEGGirno:338401.
UCSCiRGD:1302959. rat.

Organism-specific databases

CTDi1397.
RGDi1302959. Crip2.

Phylogenomic databases

eggNOGiENOG410ITI5. Eukaryota.
ENOG410XUEW. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111234.
HOVERGENiHBG051143.
InParanoidiP36201.
OMAiYCKAHFE.
OrthoDBiEOG091G11RX.
PhylomeDBiP36201.
TreeFamiTF313758.

Miscellaneous databases

PROiP36201.

Gene expression databases

BgeeiENSRNOG00000005041.
GenevisibleiP36201. RN.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRIP2_RAT
AccessioniPrimary (citable) accession number: P36201
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.