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Protein

Zinc finger E-box-binding homeobox 1

Gene

ZEB1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional repressor. Positively regulates neuronal differentiation. Represses transcription by binding to the E box-containing promoter (By similarity). Binds to delta 1-crystallin enhancer core and represses lens-specific transcription. It binds as well many other non-lens specific DNA sequences.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri170 – 19324C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29225C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST
DNA bindingi581 – 64060Homeobox; atypicalAdd
BLAST
Zinc fingeri904 – 92623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri932 – 95423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri960 – 98122C2H2-type 7; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger E-box-binding homeobox 1
Alternative name(s):
Delta EF1
Delta-crystallin enhancer-binding factor
Transcription factor 8
Short name:
TCF-8
Gene namesi
Name:ZEB1
Synonyms:TCF8
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11141114Zinc finger E-box-binding homeobox 1PRO_0000047235Add
BLAST

Proteomic databases

PaxDbiP36197.
PRIDEiP36197.

Expressioni

Tissue specificityi

Expression is developmentally regulated with high expression in mesoderm, nervous system and lens.

Developmental stagei

Expression starts after gastrulation, when organogenesis has just begun.

Interactioni

Subunit structurei

May interact with CTBP1.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011738.

Structurei

3D structure databases

ProteinModelPortaliP36197.
SMRiP36197. Positions 583-642.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi767 – 7715CTBP-binding motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi989 – 108193Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri170 – 19324C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29225C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri904 – 92623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri932 – 95423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri960 – 98122C2H2-type 7; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IMF6. Eukaryota.
ENOG41105SH. LUCA.
HOGENOMiHOG000264256.
HOVERGENiHBG004697.
InParanoidiP36197.
KOiK09299.
PhylomeDBiP36197.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.30.160.60. 5 hits.
InterProiIPR008598. Di19_Zn_binding_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF05605. zf-Di19. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGPRCKRR KQANPRRNNV TNYNNVIEAN SDSDDEDKLH IVEEESITDA
60 70 80 90 100
ADCDASVPED DLPTDHTVLP ENSEREGSTN SCWEDEGKET KEILGPEAQS
110 120 130 140 150
DEVGCTVKED ECDSDAENEQ NHDPNVEEFL QQEDTAVIYP EAPEEDQRQG
160 170 180 190 200
TPEASGQDEN GTPDAFSQLL TCPYCDRGYK RFTSLKEHIK YRHEKNEDNF
210 220 230 240 250
SCSLCSYTFA YRTQLDRHMT SHKSGRDQRH VTQSSGNRKF KCTECGKAFK
260 270 280 290 300
YKHHLKEHLR IHSGEKPYEC PNCKKRFSHS GSYSSHISSK KCIGLMPVKG
310 320 330 340 350
RARSGLKTSQ CSSPSLSASP GSPARPQIRQ KIENKPLQEQ LPVNQIKTEP
360 370 380 390 400
VDYEFKPIVV ASGINCSTPL QNGVFSGGSP LQATSSPQGV VQAVVLPTVG
410 420 430 440 450
LVSPISINLS DIQNVLKVAV DGNVIRQVLE NNHANLASKE QETISNASIQ
460 470 480 490 500
QAGHSLISAI SLPLVDQDGT TKIIINYSLE QPSQLQVVPQ NLKKEHSVPT
510 520 530 540 550
NSCKNEKLPE DLTVKSEKDK NFEGETNDST CLLCDDCPGD LNALQELKHY
560 570 580 590 600
ETKNPPQLPQ SSGTEAEKPS SPAPSETGEN NLSPGQPPLK NLLSLLKAYY
610 620 630 640 650
ALNAQPSAEE LSKIADSVNL PLDVVKKWFE KMQAGQISVQ SSGPSSPEQV
660 670 680 690 700
KISSPTDNDD QAATTNESEP QNSTNNSQNP ANTSKSQTSS GGSTQNGSRS
710 720 730 740 750
STPSPSPLNL SSSRNSQGYT YTAEGVQEEP QMEPLDLSLP KQHGELLERS
760 770 780 790 800
TITSVYQNSV YSVQEEPLNL TCAKKEPQKD NSITDSDPIV NVIPPSANPI
810 820 830 840 850
NIAIPTVTAQ LPTIVAIADQ NSVPCLRALA ANKQTILIPQ VAYTYSTTVS
860 870 880 890 900
PAVQETPPKQ TQANGSQDER QDTSSEGVSN VEDQNDSDST PPKKKMRKTE
910 920 930 940 950
NGMYACDLCD KIFQKSSSLL RHKYEHTGKR PHECGICKKA FKHKHHLIEH
960 970 980 990 1000
MRLHSGEKPY QCDKCGKRFS HSGSYSQHMN HRYSYCKREA EERDSTEQEE
1010 1020 1030 1040 1050
VGQEVLSSEH AGARASPSQI DSDERESLTR EEEEDSEKEE EEEEEKDVEG
1060 1070 1080 1090 1100
LQEEKECRKL QDVEEEEEVE EEEEEEEGKT EGNKNDDVVN RASNAEPEVI
1110
QSNGQVSEEK TNKA
Length:1,114
Mass (Da):123,151
Last modified:June 1, 1994 - v1
Checksum:iD914284143E7D279
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti299 – 2991K → N in BAA11178 (PubMed:8964504).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14313 mRNA. Translation: BAA03259.1.
D76434 Genomic DNA. Translation: BAA11178.1.
PIRiI50222.
RefSeqiNP_990462.1. NM_205131.1.
UniGeneiGga.3548.

Genome annotation databases

GeneIDi396029.
KEGGigga:396029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14313 mRNA. Translation: BAA03259.1.
D76434 Genomic DNA. Translation: BAA11178.1.
PIRiI50222.
RefSeqiNP_990462.1. NM_205131.1.
UniGeneiGga.3548.

3D structure databases

ProteinModelPortaliP36197.
SMRiP36197. Positions 583-642.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011738.

Proteomic databases

PaxDbiP36197.
PRIDEiP36197.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396029.
KEGGigga:396029.

Organism-specific databases

CTDi6935.

Phylogenomic databases

eggNOGiENOG410IMF6. Eukaryota.
ENOG41105SH. LUCA.
HOGENOMiHOG000264256.
HOVERGENiHBG004697.
InParanoidiP36197.
KOiK09299.
PhylomeDBiP36197.

Miscellaneous databases

PROiP36197.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.30.160.60. 5 hits.
InterProiIPR008598. Di19_Zn_binding_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF05605. zf-Di19. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZEB1_CHICK
AccessioniPrimary (citable) accession number: P36197
Secondary accession number(s): O42408
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.