Reviewed,
UniProtKB/Swiss-Prot P36196 (ACES_CHICK)
Last modified
October 13, 2009.
Version 60.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Acetylcholinesterase Short name=AChE EC=3.1.1.7 | ||
| Gene names |
| ||
| Organism | Gallus gallus (Chicken) | ||
| Taxonomic identifier | 9031 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus |
Protein attributes
| Sequence length | 767 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. |
| Catalytic activity | Acetylcholine + H2O = choline + acetate. |
| Subunit structure | Oligomer composed of disulfide-linked homodimers. |
| Subcellular location | Cell junction › synapse. Secreted. Cell membrane; Peripheral membrane protein By similarity. |
| Sequence similarities | Belongs to the type-B carboxylesterase/lipase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Neurotransmitter degradation |
| Cellular component | Cell junction Cell membrane Membrane Secreted Synapse |
| Domain | Signal |
| Molecular function | Hydrolase Serine esterase |
| PTM | Disulfide bond Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | neurotransmitter catabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cell junction Inferred from electronic annotation. Source: UniProtKB-KW extracellular regionInferred from electronic annotation. Source: UniProtKB-SubCell extrinsic to membraneInferred from electronic annotation. Source: UniProtKB-SubCell synapseInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | acetylcholinesterase activity Inferred from electronic annotation. Source: EC cholinesterase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | Potential | ||||||||
| Chain | 20 – 767 | 748 | Acetylcholinesterase | PRO_0000008591 | |||||||
Sites | |||||||||||
| Active site | 227 | 1 | Acyl-ester intermediate By similarity | ||||||||
| Active site | 520 | 1 | Charge relay system By similarity | ||||||||
| Active site | 633 | 1 | Charge relay system By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 285 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 536 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 650 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 725 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 94 ↔ 121 | By similarity | |||||||||
| Disulfide bond | 281 ↔ 292 | By similarity | |||||||||
| Disulfide bond | 595 ↔ 713 | By similarity | |||||||||
| Disulfide bond | 764 | Interchain By similarity | |||||||||
Sequences
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References
| [1] | "Cloning and analysis of chicken acetylcholinesterase transcripts from muscle and brain." Randall W.R., Rimer M., Gough N.R. Biochim. Biophys. Acta 1218:453-456(1994) [PubMed: 8049273] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Muscle. |
Cross-references
Sequence databases | |
|---|---|
| U03472 mRNA. Translation: AAA60456.1. | |
| IPI | IPI00575147. |
| PIR | S47639. |
| RefSeq | NP_990749.1. |
| UniGene | Gga.793 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1N5M based on UniProtKB P21836. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | S09.979. |
Genome annotation databases | |
| GeneID | 396388. |
| KEGG | gga:396388. |
Organism-specific databases | |
| CTD | 396388. |
Phylogenomic databases | |
| HOVERGEN | P36196. |
Enzyme and pathway databases | |
| BRENDA | 3.1.1.7. 4. |
Family and domain databases | |
| InterPro | IPR014788. AChE_tetra. IPR002018. CarbesteraseB. IPR019826. Carboxylesterase_B_AS. IPR019819. Carboxylesterase_B_CS. IPR000997. Cholinesterase. [Graphical view] |
| PANTHER | PTHR11559. CarbesteraseB. 1 hit. |
| Pfam | PF08674. AChE_tetra. 1 hit. PF00135. COesterase. 1 hit. [Graphical view] |
| PRINTS | PR00878. CHOLNESTRASE. |
| PROSITE | PS00122. CARBOXYLESTERASE_B_1. 1 hit. PS00941. CARBOXYLESTERASE_B_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ACES_CHICK | ||||||||
| Accession | Primary (citable) accession number: P36196 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||

Clusters with


