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P36196

- ACES_CHICK

UniProt

P36196 - ACES_CHICK

Protein

Acetylcholinesterase

Gene

ACHE

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.

    Catalytic activityi

    Acetylcholine + H2O = choline + acetate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei227 – 2271Acyl-ester intermediatePROSITE-ProRule annotation
    Active sitei520 – 5201Charge relay systemBy similarity
    Active sitei633 – 6331Charge relay systemBy similarity

    GO - Molecular functioni

    1. acetylcholinesterase activity Source: RefGenome
    2. cholinesterase activity Source: RefGenome

    GO - Biological processi

    1. choline metabolic process Source: RefGenome
    2. neurotransmitter catabolic process Source: UniProtKB-KW
    3. regulation of axonogenesis Source: RefGenome
    4. regulation of dendrite morphogenesis Source: RefGenome
    5. synapse assembly Source: RefGenome
    6. synaptic transmission, cholinergic Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Keywords - Biological processi

    Neurotransmitter degradation

    Protein family/group databases

    MEROPSiS09.979.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylcholinesterase (EC:3.1.1.7)
    Short name:
    AChE
    Gene namesi
    Name:ACHE
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: RefGenome
    2. cell junction Source: UniProtKB-KW
    3. cell surface Source: RefGenome
    4. dendrite Source: RefGenome
    5. endoplasmic reticulum lumen Source: RefGenome
    6. extracellular space Source: RefGenome
    7. neuromuscular junction Source: RefGenome
    8. postsynaptic membrane Source: RefGenome
    9. presynaptic membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Secreted, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 767748AcetylcholinesterasePRO_0000008591Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi94 ↔ 121By similarity
    Disulfide bondi281 ↔ 292By similarity
    Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi595 ↔ 713By similarity
    Glycosylationi650 – 6501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi725 – 7251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi764 – 764InterchainBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Oligomer composed of disulfide-linked homodimers.

    Structurei

    3D structure databases

    ProteinModelPortaliP36196.
    SMRiP36196. Positions 32-333, 510-727, 731-761.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG008839.
    KOiK01049.
    PhylomeDBiP36196.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR014788. AChE_tetra.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    IPR000997. Cholinesterase.
    [Graphical view]
    PfamiPF08674. AChE_tetra. 1 hit.
    PF00135. COesterase. 2 hits.
    [Graphical view]
    PRINTSiPR00878. CHOLNESTRASE.
    ProDomiPD415333. AChE_tetra. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF53474. SSF53474. 2 hits.
    PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36196-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPLFLLLLL LLSPSPTSAH RFAYSAPNRP EVRTTTGSVR GLLIPAGPSG    50
    STAAAFLGIP FAVPPLGPLR FRPPLPIPTP WTGIRDADSQ PFACYQMVDT 100
    TFPGFQGSEM WNPNREMSED CLYLNVWTQK GDPTEPPVLV WIYGGGFTGG 150
    SVSLDVYDGR YLAAAEEAVV VSMNYRVGSL GFLALAGHRD APGNVGLWDQ 200
    RLALQWVRDN AEAFGGDPDL ITLFGESAGA ASVGFHLLSP HSKGLFRRAV 250
    LQSGSPNGPW ATIGAAEGRR RAAALGRAVG CPYGNETEFL GCLRGKEAAD 300
    VLEGEGVVMP PQSVFRFAFV PVVDGDFVVD SPDVALWGDY GVKGGEGGHG 350
    VEGGDGGYGV KGGDGVKGGY GGGYGARGVR EGDGDGGYGV KEGLREGYGV 400
    KEGYGVEGDG ANAYGARVPP RPHRDETPPD AYGAKGSADA YGAKAAPRPH 450
    RDETSPDAYG AKMPPRPHRD EASPDTYGAK MPPRPHRDET SPDAYGAKMP 500
    PRPHRAGGEV EVLLGAVRVE GSYFLVYGVP GFGKDNESLI SREEFLGGVR 550
    MGVPQATELA AEAVVLHYTD WLDADNPVKN REALDDIVGD HNVVCPLMAF 600
    AQRWAQRGGK VYAYLFDHRS STLLWPSWMG VPHGYEIEFV FGLPLEPRNN 650
    YTREEVELSR RIMRYWGNFA RTGDPNGGVG GPRWPPYTPS GQRYAHLNAR 700
    PLSVGHGLRT QICAFWTRFL PKLLNATGPP EDAEREWRLE FHRWSSYMGR 750
    WRTQFEHYSR QQPCATL 767
    Length:767
    Mass (Da):83,020
    Last modified:June 1, 1994 - v1
    Checksum:iB1B3DF29C31F6062
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03472 mRNA. Translation: AAA60456.1.
    PIRiS47639.
    RefSeqiNP_990749.1. NM_205418.1.
    UniGeneiGga.52373.
    Gga.793.

    Genome annotation databases

    GeneIDi396388.
    KEGGigga:396388.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03472 mRNA. Translation: AAA60456.1 .
    PIRi S47639.
    RefSeqi NP_990749.1. NM_205418.1.
    UniGenei Gga.52373.
    Gga.793.

    3D structure databases

    ProteinModelPortali P36196.
    SMRi P36196. Positions 32-333, 510-727, 731-761.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.979.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396388.
    KEGGi gga:396388.

    Organism-specific databases

    CTDi 43.

    Phylogenomic databases

    HOVERGENi HBG008839.
    KOi K01049.
    PhylomeDBi P36196.

    Miscellaneous databases

    NextBioi 20816430.
    PROi P36196.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR014788. AChE_tetra.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    IPR000997. Cholinesterase.
    [Graphical view ]
    Pfami PF08674. AChE_tetra. 1 hit.
    PF00135. COesterase. 2 hits.
    [Graphical view ]
    PRINTSi PR00878. CHOLNESTRASE.
    ProDomi PD415333. AChE_tetra. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF53474. SSF53474. 2 hits.
    PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and analysis of chicken acetylcholinesterase transcripts from muscle and brain."
      Randall W.R., Rimer M., Gough N.R.
      Biochim. Biophys. Acta 1218:453-456(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Muscle.

    Entry informationi

    Entry nameiACES_CHICK
    AccessioniPrimary (citable) accession number: P36196
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3