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Protein

Acetylcholinesterase

Gene

ACHE

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.

Catalytic activityi

Acetylcholine + H2O = choline + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei227 – 2271Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei520 – 5201Charge relay systemBy similarity
Active sitei633 – 6331Charge relay systemBy similarity

GO - Molecular functioni

  1. acetylcholinesterase activity Source: UniProtKB-EC

GO - Biological processi

  1. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Keywords - Biological processi

Neurotransmitter degradation

Protein family/group databases

MEROPSiS09.980.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholinesterase (EC:3.1.1.7)
Short name:
AChE
Gene namesi
Name:ACHE
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-SubCell
  3. plasma membrane Source: UniProtKB-SubCell
  4. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 767748AcetylcholinesterasePRO_0000008591Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi94 ↔ 121By similarity
Disulfide bondi281 ↔ 292By similarity
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi595 ↔ 713By similarity
Glycosylationi650 – 6501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi725 – 7251N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi764 – 764InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Oligomer composed of disulfide-linked homodimers.

Structurei

3D structure databases

ProteinModelPortaliP36196.
SMRiP36196. Positions 32-333, 510-727, 731-761.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG008839.
InParanoidiP36196.
KOiK01049.
PhylomeDBiP36196.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR014788. AChE_tetra.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF08674. AChE_tetra. 1 hit.
PF00135. COesterase. 2 hits.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
ProDomiPD415333. AChE_tetra. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36196-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPLFLLLLL LLSPSPTSAH RFAYSAPNRP EVRTTTGSVR GLLIPAGPSG
60 70 80 90 100
STAAAFLGIP FAVPPLGPLR FRPPLPIPTP WTGIRDADSQ PFACYQMVDT
110 120 130 140 150
TFPGFQGSEM WNPNREMSED CLYLNVWTQK GDPTEPPVLV WIYGGGFTGG
160 170 180 190 200
SVSLDVYDGR YLAAAEEAVV VSMNYRVGSL GFLALAGHRD APGNVGLWDQ
210 220 230 240 250
RLALQWVRDN AEAFGGDPDL ITLFGESAGA ASVGFHLLSP HSKGLFRRAV
260 270 280 290 300
LQSGSPNGPW ATIGAAEGRR RAAALGRAVG CPYGNETEFL GCLRGKEAAD
310 320 330 340 350
VLEGEGVVMP PQSVFRFAFV PVVDGDFVVD SPDVALWGDY GVKGGEGGHG
360 370 380 390 400
VEGGDGGYGV KGGDGVKGGY GGGYGARGVR EGDGDGGYGV KEGLREGYGV
410 420 430 440 450
KEGYGVEGDG ANAYGARVPP RPHRDETPPD AYGAKGSADA YGAKAAPRPH
460 470 480 490 500
RDETSPDAYG AKMPPRPHRD EASPDTYGAK MPPRPHRDET SPDAYGAKMP
510 520 530 540 550
PRPHRAGGEV EVLLGAVRVE GSYFLVYGVP GFGKDNESLI SREEFLGGVR
560 570 580 590 600
MGVPQATELA AEAVVLHYTD WLDADNPVKN REALDDIVGD HNVVCPLMAF
610 620 630 640 650
AQRWAQRGGK VYAYLFDHRS STLLWPSWMG VPHGYEIEFV FGLPLEPRNN
660 670 680 690 700
YTREEVELSR RIMRYWGNFA RTGDPNGGVG GPRWPPYTPS GQRYAHLNAR
710 720 730 740 750
PLSVGHGLRT QICAFWTRFL PKLLNATGPP EDAEREWRLE FHRWSSYMGR
760
WRTQFEHYSR QQPCATL
Length:767
Mass (Da):83,020
Last modified:June 1, 1994 - v1
Checksum:iB1B3DF29C31F6062
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03472 mRNA. Translation: AAA60456.1.
PIRiS47639.
RefSeqiNP_990749.1. NM_205418.1.
UniGeneiGga.52373.
Gga.793.

Genome annotation databases

GeneIDi396388.
KEGGigga:396388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03472 mRNA. Translation: AAA60456.1.
PIRiS47639.
RefSeqiNP_990749.1. NM_205418.1.
UniGeneiGga.52373.
Gga.793.

3D structure databases

ProteinModelPortaliP36196.
SMRiP36196. Positions 32-333, 510-727, 731-761.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS09.980.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396388.
KEGGigga:396388.

Organism-specific databases

CTDi43.

Phylogenomic databases

HOVERGENiHBG008839.
InParanoidiP36196.
KOiK01049.
PhylomeDBiP36196.

Miscellaneous databases

NextBioi20816430.
PROiP36196.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR014788. AChE_tetra.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF08674. AChE_tetra. 1 hit.
PF00135. COesterase. 2 hits.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
ProDomiPD415333. AChE_tetra. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and analysis of chicken acetylcholinesterase transcripts from muscle and brain."
    Randall W.R., Rimer M., Gough N.R.
    Biochim. Biophys. Acta 1218:453-456(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Muscle.

Entry informationi

Entry nameiACES_CHICK
AccessioniPrimary (citable) accession number: P36196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 4, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.