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Protein

Drosocin

Gene

Dro

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Antibacterial peptide with strong anti-Gram-negative bacteria activity.

GO - Biological processi

  • antibacterial humoral response Source: FlyBase
  • defense response Source: FlyBase
  • defense response to bacterium Source: FlyBase
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: FlyBase
  • innate immune response Source: UniProtKB-KW
  • positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria Source: UniProtKB
  • response to bacterium Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Drosocin
Gene namesi
Name:Dro
ORF Names:CG10816
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010388. Dro.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000000495820 – 211 Publication2
PeptideiPRO_000000495922 – 40DrosocinAdd BLAST19
PropeptideiPRO_000000496043 – 64Sequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28O-linked (GalNAc...)1 Publication1
Glycosylationi32O-linked (GalNAc...)1 Publication1

Post-translational modificationi

O-glycosylation is essential for full biological activity.2 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiP36193.

Expressioni

Tissue specificityi

In hemolymph 6 hours after immune challenge, levels of expression increase for first 24 hours and persist for the following two weeks.1 Publication

Developmental stagei

Expressed in larvae and in adults.

Inductioni

By bacterial infection.1 Publication

Gene expression databases

BgeeiFBgn0010388.
ExpressionAtlasiP36193. baseline.
GenevisibleiP36193. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0301076.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EZRX-ray1.90B33-40[»]
SMRiP36193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the drosocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiP36193.
OMAiALAIEDH.
OrthoDBiEOG091G16N4.
PhylomeDBiP36193.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFTIVFLLL ACVFAMGVAT PGKPRPYSPR PTSHPRPIRV RREALAIEDH
60
LTQAAIRPPP ILPA
Length:64
Mass (Da):7,085
Last modified:October 5, 2010 - v2
Checksum:iD715F5BA52FDAD17
GO

Sequence cautioni

The sequence AAM29584 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17G → A in CAA79936 (PubMed:8325867).Curated1
Sequence conflicti17G → A in CAA67062 (PubMed:8944755).Curated1
Sequence conflicti17G → A in AAO72465 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72466 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72467 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72468 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72469 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72470 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72471 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72472 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72473 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72474 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72475 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72476 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72502 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72503 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72504 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72505 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72506 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72507 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72508 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72509 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72510 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72511 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72512 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72513 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72514 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72515 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72516 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72517 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72518 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72519 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72520 (PubMed:12716986).Curated1
Sequence conflicti17G → A in AAO72521 (PubMed:12716986).Curated1

Mass spectrometryi

Molecular mass is 2401.9 Da from positions 22 - 40. Determined by MALDI. With monosaccharide on Thr-32.1 Publication
Molecular mass is 2564.4 Da from positions 22 - 40. Determined by MALDI. With disaccharide on Ser-28 and Thr-32.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti52T → A in strain: 2CPA1, 2CPA12, 2CPA51, 2CPA105, 2CPA118, 2CPA122, 8B, 8D, 8E, 8F, 8G, 9A, 9B, 9C, 9D, 9E, 9F, 9G, 9H, 10B, 10F, 10G, 10H and Oregon-R. 3 Publications1
Natural varianti64A → V in strain: 2CPA51. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21942 Genomic DNA. Translation: CAA79936.1.
X98416 Genomic DNA. Translation: CAA67062.1.
AY224606 Genomic DNA. Translation: AAO72465.1.
AY224607 Genomic DNA. Translation: AAO72466.1.
AY224608 Genomic DNA. Translation: AAO72467.1.
AY224609 Genomic DNA. Translation: AAO72468.1.
AY224610 Genomic DNA. Translation: AAO72469.1.
AY224611 Genomic DNA. Translation: AAO72470.1.
AY224612 Genomic DNA. Translation: AAO72471.1.
AY224613 Genomic DNA. Translation: AAO72472.1.
AY224614 Genomic DNA. Translation: AAO72473.1.
AY224615 Genomic DNA. Translation: AAO72474.1.
AY224616 Genomic DNA. Translation: AAO72475.1.
AY224617 Genomic DNA. Translation: AAO72476.1.
AY224643 Genomic DNA. Translation: AAO72502.1.
AY224644 Genomic DNA. Translation: AAO72503.1.
AY224645 Genomic DNA. Translation: AAO72504.1.
AY224646 Genomic DNA. Translation: AAO72505.1.
AY224647 Genomic DNA. Translation: AAO72506.1.
AY224648 Genomic DNA. Translation: AAO72507.1.
AY224649 Genomic DNA. Translation: AAO72508.1.
AY224650 Genomic DNA. Translation: AAO72509.1.
AY224651 Genomic DNA. Translation: AAO72510.1.
AY224652 Genomic DNA. Translation: AAO72511.1.
AY224653 Genomic DNA. Translation: AAO72512.1.
AY224654 Genomic DNA. Translation: AAO72513.1.
AY224655 Genomic DNA. Translation: AAO72514.1.
AY224656 Genomic DNA. Translation: AAO72515.1.
AY224657 Genomic DNA. Translation: AAO72516.1.
AY224658 Genomic DNA. Translation: AAO72517.1.
AY224659 Genomic DNA. Translation: AAO72518.1.
AY224660 Genomic DNA. Translation: AAO72519.1.
AY224661 Genomic DNA. Translation: AAO72520.1.
AY224662 Genomic DNA. Translation: AAO72521.1.
AE013599 Genomic DNA. Translation: AAF58216.1.
AY113579 mRNA. Translation: AAM29584.2. Different initiation.
PIRiS35984. A47103.
RefSeqiNP_001246324.1. NM_001259395.2.
NP_523744.1. NM_079020.5.

Genome annotation databases

EnsemblMetazoaiFBtr0087436; FBpp0086566; FBgn0010388.
FBtr0309055; FBpp0301076; FBgn0010388.
GeneIDi36635.
KEGGidme:Dmel_CG10816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21942 Genomic DNA. Translation: CAA79936.1.
X98416 Genomic DNA. Translation: CAA67062.1.
AY224606 Genomic DNA. Translation: AAO72465.1.
AY224607 Genomic DNA. Translation: AAO72466.1.
AY224608 Genomic DNA. Translation: AAO72467.1.
AY224609 Genomic DNA. Translation: AAO72468.1.
AY224610 Genomic DNA. Translation: AAO72469.1.
AY224611 Genomic DNA. Translation: AAO72470.1.
AY224612 Genomic DNA. Translation: AAO72471.1.
AY224613 Genomic DNA. Translation: AAO72472.1.
AY224614 Genomic DNA. Translation: AAO72473.1.
AY224615 Genomic DNA. Translation: AAO72474.1.
AY224616 Genomic DNA. Translation: AAO72475.1.
AY224617 Genomic DNA. Translation: AAO72476.1.
AY224643 Genomic DNA. Translation: AAO72502.1.
AY224644 Genomic DNA. Translation: AAO72503.1.
AY224645 Genomic DNA. Translation: AAO72504.1.
AY224646 Genomic DNA. Translation: AAO72505.1.
AY224647 Genomic DNA. Translation: AAO72506.1.
AY224648 Genomic DNA. Translation: AAO72507.1.
AY224649 Genomic DNA. Translation: AAO72508.1.
AY224650 Genomic DNA. Translation: AAO72509.1.
AY224651 Genomic DNA. Translation: AAO72510.1.
AY224652 Genomic DNA. Translation: AAO72511.1.
AY224653 Genomic DNA. Translation: AAO72512.1.
AY224654 Genomic DNA. Translation: AAO72513.1.
AY224655 Genomic DNA. Translation: AAO72514.1.
AY224656 Genomic DNA. Translation: AAO72515.1.
AY224657 Genomic DNA. Translation: AAO72516.1.
AY224658 Genomic DNA. Translation: AAO72517.1.
AY224659 Genomic DNA. Translation: AAO72518.1.
AY224660 Genomic DNA. Translation: AAO72519.1.
AY224661 Genomic DNA. Translation: AAO72520.1.
AY224662 Genomic DNA. Translation: AAO72521.1.
AE013599 Genomic DNA. Translation: AAF58216.1.
AY113579 mRNA. Translation: AAM29584.2. Different initiation.
PIRiS35984. A47103.
RefSeqiNP_001246324.1. NM_001259395.2.
NP_523744.1. NM_079020.5.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EZRX-ray1.90B33-40[»]
SMRiP36193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0301076.

Proteomic databases

PaxDbiP36193.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087436; FBpp0086566; FBgn0010388.
FBtr0309055; FBpp0301076; FBgn0010388.
GeneIDi36635.
KEGGidme:Dmel_CG10816.

Organism-specific databases

CTDi36635.
FlyBaseiFBgn0010388. Dro.

Phylogenomic databases

InParanoidiP36193.
OMAiALAIEDH.
OrthoDBiEOG091G16N4.
PhylomeDBiP36193.

Miscellaneous databases

GenomeRNAii36635.
PROiP36193.

Gene expression databases

BgeeiFBgn0010388.
ExpressionAtlasiP36193. baseline.
GenevisibleiP36193. DM.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiDROS_DROME
AccessioniPrimary (citable) accession number: P36193
Secondary accession number(s): Q53ZZ5
, Q867T5, Q86BV9, Q9V749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.