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Protein

Defensin

Gene

Def

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Responsible for the anti Gram-positive activity of immune hemolymph. Expressed in the absence of immune challenge during metamorphosis.1 Publication

GO - Biological processi

  • antibacterial humoral response Source: FlyBase
  • defense response to bacterium Source: FlyBase
  • defense response to Gram-positive bacterium Source: FlyBase
  • humoral immune response Source: FlyBase
  • innate immune response Source: UniProtKB-KW
  • response to bacterium Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Keywords - Biological processi

Immunity, Innate immunity

Protein family/group databases

TCDBi1.C.47.1.1. the insect/fungal defensin (insect/fungal defensin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin
Gene namesi
Name:Def
ORF Names:CG1385
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010385. Def.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000000674221 – 52Add BLAST32
ChainiPRO_000000674353 – 92DefensinAdd BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 82PROSITE-ProRule annotation
Disulfide bondi68 ↔ 88PROSITE-ProRule annotation
Disulfide bondi72 ↔ 90PROSITE-ProRule annotation

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP36192.
PRIDEiP36192.

Expressioni

Gene expression databases

BgeeiFBgn0010385.
GenevisibleiP36192. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0087518.

Structurei

3D structure databases

ProteinModelPortaliP36192.
SMRiP36192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the invertebrate defensin family. Type 1 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J8FB. Eukaryota.
ENOG410Z251. LUCA.
InParanoidiP36192.
KOiK20668.
OMAiACMVQAQ.
OrthoDBiEOG091G1AEF.
PhylomeDBiP36192.

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR001542. Defensin_invertebrate/fungal.
IPR003614. Scorpion_toxin-like.
[Graphical view]
PfamiPF01097. Defensin_2. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS51378. INVERT_DEFENSINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFVLVAIA FALLACVAQA QPVSDVDPIP EDHVLVHEDA HQEVLQHSRQ
60 70 80 90
KRATCDLLSK WNWNHTACAG HCIAKGFKGG YCNDKAVCVC RN
Length:92
Mass (Da):10,190
Last modified:June 1, 1994 - v1
Checksum:i3E092BBAC640EDF6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti6L → P in strain: 2CPA7 and 2CPA14. 1
Natural varianti15A → T in strain: 2CPA12, 2CPA43, 2CPA46, 2CPA51, 2CPA103 and 2CPA105. 1
Natural varianti17V → M in strain: 2CPA1, 2CPA12, 2CPA43, 2CPA46, 2CPA51, 2CPA103 and 2CPA105. 1
Natural varianti38E → D in strain: 2CPA7 and 2CPA14. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27247 mRNA. Translation: CAA81760.1.
AY224631 Genomic DNA. Translation: AAO72490.1.
AY224632 Genomic DNA. Translation: AAO72491.1.
AY224633 Genomic DNA. Translation: AAO72492.1.
AY224634 Genomic DNA. Translation: AAO72493.1.
AY224635 Genomic DNA. Translation: AAO72494.1.
AY224636 Genomic DNA. Translation: AAO72495.1.
AY224637 Genomic DNA. Translation: AAO72496.1.
AY224638 Genomic DNA. Translation: AAO72497.1.
AY224639 Genomic DNA. Translation: AAO72498.1.
AY224640 Genomic DNA. Translation: AAO72499.1.
AY224641 Genomic DNA. Translation: AAO72500.1.
AY224642 Genomic DNA. Translation: AAO72501.1.
AE013599 Genomic DNA. Translation: AAF58855.1.
BT023384 mRNA. Translation: AAY55800.1.
PIRiS43228.
RefSeqiNP_523672.1. NM_078948.3.
UniGeneiDm.19893.
Dm.29454.

Genome annotation databases

EnsemblMetazoaiFBtr0088432; FBpp0087518; FBgn0010385.
GeneIDi36047.
KEGGidme:Dmel_CG1385.
UCSCiCG1385-RA. d. melanogaster.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27247 mRNA. Translation: CAA81760.1.
AY224631 Genomic DNA. Translation: AAO72490.1.
AY224632 Genomic DNA. Translation: AAO72491.1.
AY224633 Genomic DNA. Translation: AAO72492.1.
AY224634 Genomic DNA. Translation: AAO72493.1.
AY224635 Genomic DNA. Translation: AAO72494.1.
AY224636 Genomic DNA. Translation: AAO72495.1.
AY224637 Genomic DNA. Translation: AAO72496.1.
AY224638 Genomic DNA. Translation: AAO72497.1.
AY224639 Genomic DNA. Translation: AAO72498.1.
AY224640 Genomic DNA. Translation: AAO72499.1.
AY224641 Genomic DNA. Translation: AAO72500.1.
AY224642 Genomic DNA. Translation: AAO72501.1.
AE013599 Genomic DNA. Translation: AAF58855.1.
BT023384 mRNA. Translation: AAY55800.1.
PIRiS43228.
RefSeqiNP_523672.1. NM_078948.3.
UniGeneiDm.19893.
Dm.29454.

3D structure databases

ProteinModelPortaliP36192.
SMRiP36192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0087518.

Protein family/group databases

TCDBi1.C.47.1.1. the insect/fungal defensin (insect/fungal defensin) family.

Proteomic databases

PaxDbiP36192.
PRIDEiP36192.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088432; FBpp0087518; FBgn0010385.
GeneIDi36047.
KEGGidme:Dmel_CG1385.
UCSCiCG1385-RA. d. melanogaster.

Organism-specific databases

CTDi36047.
FlyBaseiFBgn0010385. Def.

Phylogenomic databases

eggNOGiENOG410J8FB. Eukaryota.
ENOG410Z251. LUCA.
InParanoidiP36192.
KOiK20668.
OMAiACMVQAQ.
OrthoDBiEOG091G1AEF.
PhylomeDBiP36192.

Miscellaneous databases

GenomeRNAii36047.
PROiP36192.

Gene expression databases

BgeeiFBgn0010385.
GenevisibleiP36192. DM.

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR001542. Defensin_invertebrate/fungal.
IPR003614. Scorpion_toxin-like.
[Graphical view]
PfamiPF01097. Defensin_2. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS51378. INVERT_DEFENSINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEFI_DROME
AccessioniPrimary (citable) accession number: P36192
Secondary accession number(s): Q4V3H2
, Q867E6, Q867G6, Q86BV6, Q86BV7, Q9V5F5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.