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Protein

Defensin

Gene

Def

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Responsible for the anti Gram-positive activity of immune hemolymph. Expressed in the absence of immune challenge during metamorphosis.1 Publication

GO - Biological processi

  • antibacterial humoral response Source: FlyBase
  • defense response to bacterium Source: FlyBase
  • defense response to Gram-positive bacterium Source: FlyBase
  • humoral immune response Source: FlyBase
  • innate immune response Source: UniProtKB-KW
  • positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria Source: FlyBase
  • response to bacterium Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Keywords - Biological processi

Immunity, Innate immunity

Protein family/group databases

TCDBi1.C.47.1.1. the insect/fungal defensin (insect/fungal defensin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin
Gene namesi
Name:Def
ORF Names:CG1385
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010385. Def.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Propeptidei21 – 5232PRO_0000006742Add
BLAST
Chaini53 – 9240DefensinPRO_0000006743Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 82PROSITE-ProRule annotation
Disulfide bondi68 ↔ 88PROSITE-ProRule annotation
Disulfide bondi72 ↔ 90PROSITE-ProRule annotation

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP36192.
PRIDEiP36192.

Expressioni

Gene expression databases

BgeeiFBgn0010385.
GenevisibleiP36192. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0087518.

Structurei

3D structure databases

ProteinModelPortaliP36192.
SMRiP36192. Positions 53-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the invertebrate defensin family. Type 1 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J8FB. Eukaryota.
ENOG410Z251. LUCA.
InParanoidiP36192.
OMAiACMVQAQ.
OrthoDBiEOG091G1AEF.
PhylomeDBiP36192.

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR001542. Defensin_invertebrate/fungal.
IPR003614. Scorpion_toxin-like.
[Graphical view]
PfamiPF01097. Defensin_2. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS51378. INVERT_DEFENSINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFVLVAIA FALLACVAQA QPVSDVDPIP EDHVLVHEDA HQEVLQHSRQ
60 70 80 90
KRATCDLLSK WNWNHTACAG HCIAKGFKGG YCNDKAVCVC RN
Length:92
Mass (Da):10,190
Last modified:June 1, 1994 - v1
Checksum:i3E092BBAC640EDF6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61L → P in strain: 2CPA7 and 2CPA14.
Natural varianti15 – 151A → T in strain: 2CPA12, 2CPA43, 2CPA46, 2CPA51, 2CPA103 and 2CPA105.
Natural varianti17 – 171V → M in strain: 2CPA1, 2CPA12, 2CPA43, 2CPA46, 2CPA51, 2CPA103 and 2CPA105.
Natural varianti38 – 381E → D in strain: 2CPA7 and 2CPA14.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27247 mRNA. Translation: CAA81760.1.
AY224631 Genomic DNA. Translation: AAO72490.1.
AY224632 Genomic DNA. Translation: AAO72491.1.
AY224633 Genomic DNA. Translation: AAO72492.1.
AY224634 Genomic DNA. Translation: AAO72493.1.
AY224635 Genomic DNA. Translation: AAO72494.1.
AY224636 Genomic DNA. Translation: AAO72495.1.
AY224637 Genomic DNA. Translation: AAO72496.1.
AY224638 Genomic DNA. Translation: AAO72497.1.
AY224639 Genomic DNA. Translation: AAO72498.1.
AY224640 Genomic DNA. Translation: AAO72499.1.
AY224641 Genomic DNA. Translation: AAO72500.1.
AY224642 Genomic DNA. Translation: AAO72501.1.
AE013599 Genomic DNA. Translation: AAF58855.1.
BT023384 mRNA. Translation: AAY55800.1.
PIRiS43228.
RefSeqiNP_523672.1. NM_078948.3.
UniGeneiDm.19893.
Dm.29454.

Genome annotation databases

EnsemblMetazoaiFBtr0088432; FBpp0087518; FBgn0010385.
GeneIDi36047.
KEGGidme:Dmel_CG1385.
UCSCiCG1385-RA. d. melanogaster.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27247 mRNA. Translation: CAA81760.1.
AY224631 Genomic DNA. Translation: AAO72490.1.
AY224632 Genomic DNA. Translation: AAO72491.1.
AY224633 Genomic DNA. Translation: AAO72492.1.
AY224634 Genomic DNA. Translation: AAO72493.1.
AY224635 Genomic DNA. Translation: AAO72494.1.
AY224636 Genomic DNA. Translation: AAO72495.1.
AY224637 Genomic DNA. Translation: AAO72496.1.
AY224638 Genomic DNA. Translation: AAO72497.1.
AY224639 Genomic DNA. Translation: AAO72498.1.
AY224640 Genomic DNA. Translation: AAO72499.1.
AY224641 Genomic DNA. Translation: AAO72500.1.
AY224642 Genomic DNA. Translation: AAO72501.1.
AE013599 Genomic DNA. Translation: AAF58855.1.
BT023384 mRNA. Translation: AAY55800.1.
PIRiS43228.
RefSeqiNP_523672.1. NM_078948.3.
UniGeneiDm.19893.
Dm.29454.

3D structure databases

ProteinModelPortaliP36192.
SMRiP36192. Positions 53-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0087518.

Protein family/group databases

TCDBi1.C.47.1.1. the insect/fungal defensin (insect/fungal defensin) family.

Proteomic databases

PaxDbiP36192.
PRIDEiP36192.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088432; FBpp0087518; FBgn0010385.
GeneIDi36047.
KEGGidme:Dmel_CG1385.
UCSCiCG1385-RA. d. melanogaster.

Organism-specific databases

CTDi36047.
FlyBaseiFBgn0010385. Def.

Phylogenomic databases

eggNOGiENOG410J8FB. Eukaryota.
ENOG410Z251. LUCA.
InParanoidiP36192.
OMAiACMVQAQ.
OrthoDBiEOG091G1AEF.
PhylomeDBiP36192.

Miscellaneous databases

GenomeRNAii36047.
PROiP36192.

Gene expression databases

BgeeiFBgn0010385.
GenevisibleiP36192. DM.

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR001542. Defensin_invertebrate/fungal.
IPR003614. Scorpion_toxin-like.
[Graphical view]
PfamiPF01097. Defensin_2. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS51378. INVERT_DEFENSINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEFI_DROME
AccessioniPrimary (citable) accession number: P36192
Secondary accession number(s): Q4V3H2
, Q867E6, Q867G6, Q86BV6, Q86BV7, Q9V5F5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.