Reviewed, UniProtKB/Swiss-Prot P36189 (FAS_ANSAN)

Names and origin

Protein names

Recommended name:
    Fatty acid synthase
    EC=2.3.1.85

Gene names

Name:	FASN
Synonyms:	FAS

Organism

Anser anser anser (Western graylag goose)

Taxonomic identifier

8844 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Anseriformes › Anatidae › Anser

Protein attributes

Sequence length	352 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has seven catalytic activities and an acyl carrier protein.
Catalytic activity	Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+.
Subunit structure	Homodimer which monomers are arranged in a head to tail fashion.
Induction	By triiodothyronine.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Ligand	NAD NADP Phosphopantetheine
Molecular function	Hydrolase Ligase Oxidoreductase Transferase
Technical term	Direct protein sequencing Multifunctional enzyme
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	fatty-acid synthase activity Inferred from electronic annotation. Source: EC hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW ligase activity Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›352	›352	Fatty acid synthase		PRO_0000180272
Regions
	Region	1 – ›352	›352	Beta-ketoacyl synthase
Sites
	Active site	161	1	For beta-ketoacyl synthase activity By similarity
Experimental info
	Non-terminal residue	352	1

Sequences

	Sequence		Length	Mass (Da)
	P36189-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 908530BF76762335	FASTA	352	37,912
	10 20 30 40 50 60 MEDVVIAGIA GKLPESENLQ EFWEKLLNGV DMVTEDDRRW KPGMYGLPKR NGKLKDISKF 70 80 90 100 110 120 DASFFGVHPK QAHTMDPQLR LLLEVSYEAI LDGGINPATL RGTDTGVWVG ASGSEAGEAF 130 140 150 160 170 180 SQDPEQLLGY SMIGCQRAMF ANRISYFYDF KGPSLSIDTA CSSSLMALEN AYKAIRNGRC 190 200 210 220 230 240 SAAVVGGVNL LLKPNTSVQF MKLGMLSPDG ACKVFDASGD GYCRSEAVVV VLLTKKSMAK 250 260 270 280 290 300 RIYATIVNAG SNTDGFKEQG VTFPSGDMQR QLVSSLHREC GIKPGDIEYV ETHGTGTKVG 310 320 330 340 350 DPQEVNGLAD LFCQCEREPL LIGSTKSNMG HPEPASGLAA LAKVVLSLEH GL

References

[1]	"Isolation and partial characterization of the gene for goose fatty acid synthase." Kameda K., Goodridge A.G. J. Biol. Chem. 266:419-426(1991) [PubMed: 1702426] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Specific modification of the condensation domain of fatty acid synthase and the determination of the primary structure of the modified active site peptides." Pouloe A.J., Bonsall R.F., Kolattukudy P.E. Arch. Biochem. Biophys. 230:117-128(1984) [PubMed: 6712225] [Abstract] Cited for: PROTEIN SEQUENCE OF 152-173.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M60622 mRNA. Translation: AAA49316.1.
PIR	A39042.
3D structure databases
SMR	P36189. Positions 2-352.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P36189.
Family and domain databases
InterPro	IPR000794. Beta-ketoacyl_synthase. IPR018201. Ketoacyl_synth_AS. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
PANTHER	PTHR11712. Ketoacyl_synth. 1 hit.
Pfam	PF00109. ketoacyl-synt. 1 hit. PF02801. Ketoacyl-synt_C. 1 hit. [Graphical view]
PROSITE	PS00606. B_KETOACYL_SYNTHASE. 1 hit. PS00012. PHOSPHOPANTETHEINE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FAS_ANSAN

Accession

Primary (citable) accession number: P36189

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	January 19, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)