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P36178

- CTRB2_LITVA

UniProt

P36178 - CTRB2_LITVA

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Protein

Chymotrypsin BII

Gene
N/A
Organism
Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Serine protease with chymotryptic and collagenolytic activities.

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Charge relay system By similarity
Active sitei132 – 1321Charge relay system By similarity
Active sitei223 – 2231Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. collagen catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Collagen degradation

Protein family/group databases

MEROPSiS01.122.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin BII (EC:3.4.21.1)
OrganismiLitopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei)
Taxonomic identifieri6689 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaDendrobranchiataPenaeoideaPenaeidaeLitopenaeus

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed predictionAdd
BLAST
Propeptidei16 – 4530Activation peptidePRO_0000027652Add
BLAST
Chaini46 – 271226Chymotrypsin BIIPRO_0000027653Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 87 By similarity
Disulfide bondi196 ↔ 209 By similarity
Disulfide bondi219 ↔ 245 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP36178.
SMRiP36178. Positions 46-271.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 268223Peptidase S1Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36178-1 [UniParc]FASTAAdd to Basket

« Hide

MIGKLSLLLV CVAVASGNPA AGKPWHWKSP KPLVDPRIHV NATPRIVGGV    50
EATPHSWPHQ AALFIDDMYF CGGSLISSEW VLTAAHCMDG AGFVEVVLGA 100
HNIRQNEASQ VSITSTDFFT HENWNSWLLT NDIALIKLPS PVSLNSNIKT 150
VKLPSSDVAV GTTVTPTGWG RPLDSAGGIS DVLRQVDVPI MTNDDCDAVY 200
GIVGNGVVCI DSEGGKGTCN GDSGGPLNLN GMTYGITSFG SSAGCEVGYP 250
DAFTRVYYYL DWIEQKTGVT P 271
Length:271
Mass (Da):28,723
Last modified:June 1, 1994 - v1
Checksum:i2254D7C7E63FA2E1
GO

Cross-referencesi

3D structure databases

ProteinModelPortali P36178.
SMRi P36178. Positions 46-271.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.122.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a cDNA that encodes a serine protease with chymotryptic and collagenolytic activities in the hepatopancreas of the shrimp Penaeus vanameii (Crustacea, Decapoda)."
    Sellos D., van Wormhoudt A.
    FEBS Lett. 309:219-224(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Hepatopancreas.
  2. "Purification, biochemical characterization and N-terminal sequence of a serine-protease with chymotrypsic and collagenolytic activities in a tropical shrimp, Penaeus vannamei (Crustacea, Decapoda)."
    van Wormhoudt A., le Chevalier P., Sellos D.
    Comp. Biochem. Physiol. 103B:675-680(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 46-65, CHARACTERIZATION.
    Tissue: Hepatopancreas.

Entry informationi

Entry nameiCTRB2_LITVA
AccessioniPrimary (citable) accession number: P36178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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