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Protein

Glutathione exchanger 2

Gene

GEX2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proton/glutathione antiporter that imports glutathione from the vacuole and exports it through the plasma membrane. Involved in resistance to oxidative stress and modulation of the PKA pathway.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32068-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione exchanger 2
Gene namesi
Name:GEX2
Ordered Locus Names:YKR106W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR106W.
SGDiS000001814. GEX2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 58CytoplasmicSequence analysisAdd BLAST58
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 120ExtracellularSequence analysisAdd BLAST41
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 152CytoplasmicSequence analysisAdd BLAST11
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 216ExtracellularSequence analysisAdd BLAST43
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 275CytoplasmicSequence analysisAdd BLAST38
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Topological domaini297 – 307ExtracellularSequence analysisAdd BLAST11
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 343CytoplasmicSequence analysisAdd BLAST15
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 383ExtracellularSequence analysisAdd BLAST19
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 407CytoplasmicSequence analysis3
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21
Topological domaini429 – 440ExtracellularSequence analysisAdd BLAST12
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 471CytoplasmicSequence analysis10
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493 – 548ExtracellularSequence analysisAdd BLAST56
Transmembranei549 – 569HelicalSequence analysisAdd BLAST21
Topological domaini570 – 615CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

  • endosome Source: GO_Central
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
  • vacuolar membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032311 – 615Glutathione exchanger 2Add BLAST615

Expressioni

Inductioni

By iron depletion. Expressed at a very low level.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi34237. 9 interactors.
DIPiDIP-4917N.
MINTiMINT-497647.

Structurei

3D structure databases

ProteinModelPortaliP36173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002930.
InParanoidiP36173.
OMAiMEAVFAT.
OrthoDBiEOG092C2P9I.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequencei

Sequence statusi: Complete.

P36173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSVVGASS NKKSGIRQSC EIIERERHSN DDTYSMTSTF FKLKENEIMS
60 70 80 90 100
AQFDSLKYKI LLISTAFVCG FGISLDYTLR STYTGYATNS YSEHSLLSTV
110 120 130 140 150
QVINAVVSVG SQVVYSRLSD HFGRLRLFLV ATIFYIMGTI IQSQATRLTM
160 170 180 190 200
YAAGSVFYNC GYVGTNLLLT LILSDFSSLK WRMFYQYASY WPYIIIPWIS
210 220 230 240 250
GNIITAANPQ KNWSWNIAMW AFIYPLSTLP IIFLILYMKY KSSKTAEWRS
260 270 280 290 300
LKEQARKERT GGLFENLVFL FWKLDIVGIL LITVSLGCIL VPLTLANETS
310 320 330 340 350
QKWHNSKIIA TLVSGGCLFF IFLYWEAKFA KSPLLPFKLL SDRGIWAPLG
360 370 380 390 400
VTFFNFFTFF ISCDYLYPVL LVSMKESSTS AARIVNLPDF VAATASPFYS
410 420 430 440 450
LLVAKTRKLK LSVIGGCAAW MVCMGLFYKY RGGSGSHEGV IAASVIMGLS
460 470 480 490 500
GLLCSNSVIV ILQAMTTHSR MAVITGIQYT FSKLGAAIGA SVSGAIWTQT
510 520 530 540 550
MPNQLYKNLG NDTLAEIAYA SPYTFISDYP WGSPERDAVV ESYRYVQRII
560 570 580 590 600
MTVGLACTVP FFTFTMFMRN PELIDKATHE EFTEDGLVVL PDEENIFSQI
610
KALFRHNRSN KKSGC
Length:615
Mass (Da):68,954
Last modified:June 1, 1994 - v1
Checksum:iB548FBC6E49326AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28202 Genomic DNA. Translation: CAA82047.1.
BK006944 Genomic DNA. Translation: DAA09257.1.
PIRiS40624.
RefSeqiNP_013032.1. NM_001179896.1.

Genome annotation databases

EnsemblFungiiYKR106W; YKR106W; YKR106W.
GeneIDi853981.
KEGGisce:YKR106W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28202 Genomic DNA. Translation: CAA82047.1.
BK006944 Genomic DNA. Translation: DAA09257.1.
PIRiS40624.
RefSeqiNP_013032.1. NM_001179896.1.

3D structure databases

ProteinModelPortaliP36173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34237. 9 interactors.
DIPiDIP-4917N.
MINTiMINT-497647.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR106W; YKR106W; YKR106W.
GeneIDi853981.
KEGGisce:YKR106W.

Organism-specific databases

EuPathDBiFungiDB:YKR106W.
SGDiS000001814. GEX2.

Phylogenomic databases

GeneTreeiENSGT00390000002930.
InParanoidiP36173.
OMAiMEAVFAT.
OrthoDBiEOG092C2P9I.

Enzyme and pathway databases

BioCyciYEAST:G3O-32068-MONOMER.

Miscellaneous databases

PROiP36173.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGEX2_YEAST
AccessioniPrimary (citable) accession number: P36173
Secondary accession number(s): D6VXG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.