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Protein

Glutathione exchanger 2

Gene

GEX2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton/glutathione antiporter that imports glutathione from the vacuole and exports it through the plasma membrane. Involved in resistance to oxidative stress and modulation of the PKA pathway.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32068-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione exchanger 2
Gene namesi
Name:GEX2
Ordered Locus Names:YKR106W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR106W
SGDiS000001814 GEX2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 58CytoplasmicSequence analysisAdd BLAST58
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 120ExtracellularSequence analysisAdd BLAST41
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 152CytoplasmicSequence analysisAdd BLAST11
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 216ExtracellularSequence analysisAdd BLAST43
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 275CytoplasmicSequence analysisAdd BLAST38
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Topological domaini297 – 307ExtracellularSequence analysisAdd BLAST11
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 343CytoplasmicSequence analysisAdd BLAST15
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 383ExtracellularSequence analysisAdd BLAST19
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 407CytoplasmicSequence analysis3
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21
Topological domaini429 – 440ExtracellularSequence analysisAdd BLAST12
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 471CytoplasmicSequence analysis10
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493 – 548ExtracellularSequence analysisAdd BLAST56
Transmembranei549 – 569HelicalSequence analysisAdd BLAST21
Topological domaini570 – 615CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032311 – 615Glutathione exchanger 2Add BLAST615

Proteomic databases

PaxDbiP36173

Expressioni

Inductioni

By iron depletion. Expressed at a very low level.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi34237, 33 interactors
DIPiDIP-4917N
IntActiP36173, 5 interactors
STRINGi4932.YKR106W

Structurei

3D structure databases

ProteinModelPortaliP36173
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002930
InParanoidiP36173
OMAiTYIDRSY
OrthoDBiEOG092C2P9I

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 3 hits

Sequencei

Sequence statusi: Complete.

P36173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSVVGASS NKKSGIRQSC EIIERERHSN DDTYSMTSTF FKLKENEIMS
60 70 80 90 100
AQFDSLKYKI LLISTAFVCG FGISLDYTLR STYTGYATNS YSEHSLLSTV
110 120 130 140 150
QVINAVVSVG SQVVYSRLSD HFGRLRLFLV ATIFYIMGTI IQSQATRLTM
160 170 180 190 200
YAAGSVFYNC GYVGTNLLLT LILSDFSSLK WRMFYQYASY WPYIIIPWIS
210 220 230 240 250
GNIITAANPQ KNWSWNIAMW AFIYPLSTLP IIFLILYMKY KSSKTAEWRS
260 270 280 290 300
LKEQARKERT GGLFENLVFL FWKLDIVGIL LITVSLGCIL VPLTLANETS
310 320 330 340 350
QKWHNSKIIA TLVSGGCLFF IFLYWEAKFA KSPLLPFKLL SDRGIWAPLG
360 370 380 390 400
VTFFNFFTFF ISCDYLYPVL LVSMKESSTS AARIVNLPDF VAATASPFYS
410 420 430 440 450
LLVAKTRKLK LSVIGGCAAW MVCMGLFYKY RGGSGSHEGV IAASVIMGLS
460 470 480 490 500
GLLCSNSVIV ILQAMTTHSR MAVITGIQYT FSKLGAAIGA SVSGAIWTQT
510 520 530 540 550
MPNQLYKNLG NDTLAEIAYA SPYTFISDYP WGSPERDAVV ESYRYVQRII
560 570 580 590 600
MTVGLACTVP FFTFTMFMRN PELIDKATHE EFTEDGLVVL PDEENIFSQI
610
KALFRHNRSN KKSGC
Length:615
Mass (Da):68,954
Last modified:June 1, 1994 - v1
Checksum:iB548FBC6E49326AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28202 Genomic DNA Translation: CAA82047.1
BK006944 Genomic DNA Translation: DAA09257.1
PIRiS40624
RefSeqiNP_013032.1, NM_001179896.1

Genome annotation databases

EnsemblFungiiYKR106W; YKR106W; YKR106W
GeneIDi853981
KEGGisce:YKR106W

Similar proteinsi

Entry informationi

Entry nameiGEX2_YEAST
AccessioniPrimary (citable) accession number: P36173
Secondary accession number(s): D6VXG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health