SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P36173

- GEX2_YEAST

UniProt

P36173 - GEX2_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glutathione exchanger 2

Gene
GEX2, YKR106W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Proton/glutathione antiporter that imports glutathione from the vacuole and exports it through the plasma membrane. Involved in resistance to oxidative stress and modulation of the PKA pathway.1 Publication

GO - Molecular functioni

  1. solute:proton antiporter activity Source: SGD

GO - Biological processi

  1. glutathione transmembrane transport Source: SGD
  2. hydrogen ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32068-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione exchanger 2
Gene namesi
Name:GEX2
Ordered Locus Names:YKR106W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKR106w.
SGDiS000001814. GEX2.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5858Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei59 – 7921Helical; Reviewed predictionAdd
BLAST
Topological domaini80 – 12041Extracellular Reviewed predictionAdd
BLAST
Transmembranei121 – 14121Helical; Reviewed predictionAdd
BLAST
Topological domaini142 – 15211Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei153 – 17321Helical; Reviewed predictionAdd
BLAST
Topological domaini174 – 21643Extracellular Reviewed predictionAdd
BLAST
Transmembranei217 – 23721Helical; Reviewed predictionAdd
BLAST
Topological domaini238 – 27538Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei276 – 29621Helical; Reviewed predictionAdd
BLAST
Topological domaini297 – 30711Extracellular Reviewed predictionAdd
BLAST
Transmembranei308 – 32821Helical; Reviewed predictionAdd
BLAST
Topological domaini329 – 34315Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei344 – 36421Helical; Reviewed predictionAdd
BLAST
Topological domaini365 – 38319Extracellular Reviewed predictionAdd
BLAST
Transmembranei384 – 40421Helical; Reviewed predictionAdd
BLAST
Topological domaini405 – 4073Cytoplasmic Reviewed prediction
Transmembranei408 – 42821Helical; Reviewed predictionAdd
BLAST
Topological domaini429 – 44012Extracellular Reviewed predictionAdd
BLAST
Transmembranei441 – 46121Helical; Reviewed predictionAdd
BLAST
Topological domaini462 – 47110Cytoplasmic Reviewed prediction
Transmembranei472 – 49221Helical; Reviewed predictionAdd
BLAST
Topological domaini493 – 54856Extracellular Reviewed predictionAdd
BLAST
Transmembranei549 – 56921Helical; Reviewed predictionAdd
BLAST
Topological domaini570 – 61546Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
  3. vacuolar membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 615615Glutathione exchanger 2PRO_0000203231Add
BLAST

Expressioni

Inductioni

By iron depletion. Expressed at a very low level.1 Publication

Gene expression databases

GenevestigatoriP36173.

Interactioni

Protein-protein interaction databases

BioGridi34237. 9 interactions.
DIPiDIP-4917N.
MINTiMINT-497647.
STRINGi4932.YKR106W.

Structurei

3D structure databases

ProteinModelPortaliP36173.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281153.
GeneTreeiENSGT00390000002930.
OMAiRIMVISS.
OrthoDBiEOG7PZS6Z.

Family and domain databases

InterProiIPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequencei

Sequence statusi: Complete.

P36173-1 [UniParc]FASTAAdd to Basket

« Hide

MSSSVVGASS NKKSGIRQSC EIIERERHSN DDTYSMTSTF FKLKENEIMS    50
AQFDSLKYKI LLISTAFVCG FGISLDYTLR STYTGYATNS YSEHSLLSTV 100
QVINAVVSVG SQVVYSRLSD HFGRLRLFLV ATIFYIMGTI IQSQATRLTM 150
YAAGSVFYNC GYVGTNLLLT LILSDFSSLK WRMFYQYASY WPYIIIPWIS 200
GNIITAANPQ KNWSWNIAMW AFIYPLSTLP IIFLILYMKY KSSKTAEWRS 250
LKEQARKERT GGLFENLVFL FWKLDIVGIL LITVSLGCIL VPLTLANETS 300
QKWHNSKIIA TLVSGGCLFF IFLYWEAKFA KSPLLPFKLL SDRGIWAPLG 350
VTFFNFFTFF ISCDYLYPVL LVSMKESSTS AARIVNLPDF VAATASPFYS 400
LLVAKTRKLK LSVIGGCAAW MVCMGLFYKY RGGSGSHEGV IAASVIMGLS 450
GLLCSNSVIV ILQAMTTHSR MAVITGIQYT FSKLGAAIGA SVSGAIWTQT 500
MPNQLYKNLG NDTLAEIAYA SPYTFISDYP WGSPERDAVV ESYRYVQRII 550
MTVGLACTVP FFTFTMFMRN PELIDKATHE EFTEDGLVVL PDEENIFSQI 600
KALFRHNRSN KKSGC 615
Length:615
Mass (Da):68,954
Last modified:June 1, 1994 - v1
Checksum:iB548FBC6E49326AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28202 Genomic DNA. Translation: CAA82047.1.
BK006944 Genomic DNA. Translation: DAA09257.1.
PIRiS40624.
RefSeqiNP_013032.1. NM_001179896.1.

Genome annotation databases

EnsemblFungiiYKR106W; YKR106W; YKR106W.
GeneIDi853981.
KEGGisce:YKR106W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28202 Genomic DNA. Translation: CAA82047.1 .
BK006944 Genomic DNA. Translation: DAA09257.1 .
PIRi S40624.
RefSeqi NP_013032.1. NM_001179896.1.

3D structure databases

ProteinModelPortali P36173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34237. 9 interactions.
DIPi DIP-4917N.
MINTi MINT-497647.
STRINGi 4932.YKR106W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKR106W ; YKR106W ; YKR106W .
GeneIDi 853981.
KEGGi sce:YKR106W.

Organism-specific databases

CYGDi YKR106w.
SGDi S000001814. GEX2.

Phylogenomic databases

eggNOGi NOG281153.
GeneTreei ENSGT00390000002930.
OMAi RIMVISS.
OrthoDBi EOG7PZS6Z.

Enzyme and pathway databases

BioCyci YEAST:G3O-32068-MONOMER.

Miscellaneous databases

NextBioi 975446.

Gene expression databases

Genevestigatori P36173.

Family and domain databases

InterProi IPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  4. "Gex1 is a yeast glutathione exchanger that interferes with pH and redox homeostasis."
    Dhaoui M., Auchere F., Blaiseau P.L., Lesuisse E., Landoulsi A., Camadro J.M., Haguenauer-Tsapis R., Belgareh-Touze N.
    Mol. Biol. Cell 22:2054-2067(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiGEX2_YEAST
AccessioniPrimary (citable) accession number: P36173
Secondary accession number(s): D6VXG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

Similar proteinsi