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P36167

- SRL3_YEAST

UniProt

P36167 - SRL3_YEAST

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Protein

Protein SRL3

Gene

SRL3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Weakly suppresses a RAD53 null mutation when overexpressed.

GO - Molecular functioni

  1. core promoter binding Source: SGD

GO - Biological processi

  1. nucleobase-containing compound metabolic process Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32054-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SRL3
Alternative name(s):
RAD53 lethality suppressor protein 3
Gene namesi
Name:SRL3
Ordered Locus Names:YKR091W
ORF Names:YKR411
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKR091w.
SGDiS000001799. SRL3.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Protein SRL3PRO_0000203228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei212 – 2121Phosphoserine2 Publications

Post-translational modificationi

Phosphorylated by CDC28, probably in association with G1 cyclin CLN2.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36167.

Expressioni

Gene expression databases

GenevestigatoriP36167.

Interactioni

Subunit structurei

Interacts with CLN2.1 Publication

Protein-protein interaction databases

BioGridi34222. 45 interactions.
DIPiDIP-4750N.
IntActiP36167. 7 interactions.
MINTiMINT-533048.
STRINGi4932.YKR091W.

Structurei

3D structure databases

ProteinModelPortaliP36167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG47730.
InParanoidiP36167.
OMAiSTISNGH.
OrthoDBiEOG7TN03D.

Sequencei

Sequence statusi: Complete.

P36167-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLKTPNWET VNETPKSRVL TINELISPNL DTESNSLLAT PARKYFKTSI
60 70 80 90 100
SEAQDSPTSA PSPDGNEDPT YQYNVQFHFP GPITPTTPRS KNAEMFPSPT
110 120 130 140 150
PPLVSPTAVI EEENDDSVRE FSRTLKSRLN CAMVKLSKEH EQVALIPPPP
160 170 180 190 200
TEKIRKGSYS NKFAAKHRRC HSLDESKKFL SSLEDSSAHA AFLKAISSKH
210 220 230 240
AKSNRVDNVN VSPLRWSSHR RTQSTQENSL QEVVAIDTLL KMSSSD
Length:246
Mass (Da):27,466
Last modified:July 11, 2006 - v2
Checksum:iC305AAC89310E65D
GO

Sequence cautioni

The sequence CAA51945.1 differs from that shown. Reason: Frameshift at position 38. Curated
The sequence CAA82170.1 differs from that shown. Reason: Frameshift at position 38. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73541 Genomic DNA. Translation: CAA51945.1. Frameshift.
Z28316 Genomic DNA. Translation: CAA82170.1. Frameshift.
AY558318 Genomic DNA. Translation: AAS56644.1.
BK006944 Genomic DNA. Translation: DAA09241.1.
PIRiS38169.
RefSeqiNP_013017.2. NM_001179881.1.

Genome annotation databases

EnsemblFungiiYKR091W; YKR091W; YKR091W.
GeneIDi853966.
KEGGisce:YKR091W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73541 Genomic DNA. Translation: CAA51945.1 . Frameshift.
Z28316 Genomic DNA. Translation: CAA82170.1 . Frameshift.
AY558318 Genomic DNA. Translation: AAS56644.1 .
BK006944 Genomic DNA. Translation: DAA09241.1 .
PIRi S38169.
RefSeqi NP_013017.2. NM_001179881.1.

3D structure databases

ProteinModelPortali P36167.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34222. 45 interactions.
DIPi DIP-4750N.
IntActi P36167. 7 interactions.
MINTi MINT-533048.
STRINGi 4932.YKR091W.

Proteomic databases

MaxQBi P36167.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKR091W ; YKR091W ; YKR091W .
GeneIDi 853966.
KEGGi sce:YKR091W.

Organism-specific databases

CYGDi YKR091w.
SGDi S000001799. SRL3.

Phylogenomic databases

eggNOGi NOG47730.
InParanoidi P36167.
OMAi STISNGH.
OrthoDBi EOG7TN03D.

Enzyme and pathway databases

BioCyci YEAST:G3O-32054-MONOMER.

Miscellaneous databases

NextBioi 975401.

Gene expression databases

Genevestigatori P36167.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete sequence of a 15,820 bp segment of Saccharomyces cerevisiae chromosome XI contains the UBI2 and MPL1 genes and three new open reading frames."
    Bou G., Esteban P.F., Baladron V., Gonzalez G.A., Cantalejo J.G., Remacha M.A., Jimenez A., del Rey F., Ballesta J.P.G., Revuelta J.L.
    Yeast 9:1349-1354(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 95-246.
    Strain: ATCC 204508 / S288c.
  5. Cited for: SUBCELLULAR LOCATION.
  6. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF FRAMESHIFT.
  7. Cited for: PHOSPHORYLATION BY CDC28.
  8. Cited for: INTERACTION WITH CLN2, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSRL3_YEAST
AccessioniPrimary (citable) accession number: P36167
Secondary accession number(s): D6VXF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 11, 2006
Last modified: October 29, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3