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P36167 (SRL3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SRL3
Alternative name(s):
RAD53 lethality suppressor protein 3
Gene names
Name:SRL3
Ordered Locus Names:YKR091W
ORF Names:YKR411
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Weakly suppresses a RAD53 null mutation when overexpressed.

Subunit structure

Interacts with CLN2. Ref.8

Subcellular location

Cytoplasm Ref.5.

Post-translational modification

Phosphorylated by CDC28, probably in association with G1 cyclin CLN2. Ref.7

Sequence caution

The sequence CAA51945.1 differs from that shown. Reason: Frameshift at position 38.

The sequence CAA82170.1 differs from that shown. Reason: Frameshift at position 38.

Ontologies

Keywords
   Cellular componentCytoplasm
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnucleobase-containing compound metabolic process

Inferred from genetic interaction PubMed 9744871. Source: SGD

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncore promoter binding

Inferred from direct assay PubMed 23382076. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Protein SRL3
PRO_0000203228

Amino acid modifications

Modified residue2121Phosphoserine Ref.9 Ref.10

Sequences

Sequence LengthMass (Da)Tools
P36167 [UniParc].

Last modified July 11, 2006. Version 2.
Checksum: C305AAC89310E65D

FASTA24627,466
        10         20         30         40         50         60 
MFLKTPNWET VNETPKSRVL TINELISPNL DTESNSLLAT PARKYFKTSI SEAQDSPTSA 

        70         80         90        100        110        120 
PSPDGNEDPT YQYNVQFHFP GPITPTTPRS KNAEMFPSPT PPLVSPTAVI EEENDDSVRE 

       130        140        150        160        170        180 
FSRTLKSRLN CAMVKLSKEH EQVALIPPPP TEKIRKGSYS NKFAAKHRRC HSLDESKKFL 

       190        200        210        220        230        240 
SSLEDSSAHA AFLKAISSKH AKSNRVDNVN VSPLRWSSHR RTQSTQENSL QEVVAIDTLL 


KMSSSD 

« Hide

References

« Hide 'large scale' references
[1]"The complete sequence of a 15,820 bp segment of Saccharomyces cerevisiae chromosome XI contains the UBI2 and MPL1 genes and three new open reading frames."
Bou G., Esteban P.F., Baladron V., Gonzalez G.A., Cantalejo J.G., Remacha M.A., Jimenez A., del Rey F., Ballesta J.P.G., Revuelta J.L.
Yeast 9:1349-1354(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 95-246.
Strain: ATCC 204508 / S288c.
[5]"Subcellular localization of the yeast proteome."
Kumar A., Agarwal S., Heyman J.A., Matson S., Heidtman M., Piccirillo S., Umansky L., Drawid A., Jansen R., Liu Y., Cheung K.-H., Miller P., Gerstein M., Roeder G.S., Snyder M.
Genes Dev. 16:707-719(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"Sequencing and comparison of yeast species to identify genes and regulatory elements."
Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF FRAMESHIFT.
[7]"Targets of the cyclin-dependent kinase Cdk1."
Ubersax J.A., Woodbury E.L., Quang P.N., Paraz M., Blethrow J.D., Shah K., Shokat K.M., Morgan D.O.
Nature 425:859-864(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION BY CDC28.
[8]"Targeted proteomic study of the cyclin-Cdk module."
Archambault V., Chang E.J., Drapkin B.J., Cross F.R., Chait B.T., Rout M.P.
Mol. Cell 14:699-711(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CLN2, IDENTIFICATION BY MASS SPECTROMETRY.
[9]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X73541 Genomic DNA. Translation: CAA51945.1. Frameshift.
Z28316 Genomic DNA. Translation: CAA82170.1. Frameshift.
AY558318 Genomic DNA. Translation: AAS56644.1.
BK006944 Genomic DNA. Translation: DAA09241.1.
PIRS38169.
RefSeqNP_013017.2. NM_001179881.1.

3D structure databases

ProteinModelPortalP36167.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34222. 45 interactions.
DIPDIP-4750N.
IntActP36167. 7 interactions.
MINTMINT-533048.
STRING4932.YKR091W.

Proteomic databases

MaxQBP36167.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKR091W; YKR091W; YKR091W.
GeneID853966.
KEGGsce:YKR091W.

Organism-specific databases

CYGDYKR091w.
SGDS000001799. SRL3.

Phylogenomic databases

eggNOGNOG47730.
OMASTISNGH.
OrthoDBEOG7TN03D.

Enzyme and pathway databases

BioCycYEAST:G3O-32054-MONOMER.

Gene expression databases

GenevestigatorP36167.

Family and domain databases

ProtoNetSearch...

Other

NextBio975401.

Entry information

Entry nameSRL3_YEAST
AccessionPrimary (citable) accession number: P36167
Secondary accession number(s): D6VXF1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 11, 2006
Last modified: June 11, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD