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P36167

- SRL3_YEAST

UniProt

P36167 - SRL3_YEAST

Protein

Protein SRL3

Gene

SRL3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Weakly suppresses a RAD53 null mutation when overexpressed.

    GO - Molecular functioni

    1. core promoter binding Source: SGD

    GO - Biological processi

    1. nucleobase-containing compound metabolic process Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32054-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SRL3
    Alternative name(s):
    RAD53 lethality suppressor protein 3
    Gene namesi
    Name:SRL3
    Ordered Locus Names:YKR091W
    ORF Names:YKR411
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKR091w.
    SGDiS000001799. SRL3.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Protein SRL3PRO_0000203228Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei212 – 2121Phosphoserine3 Publications

    Post-translational modificationi

    Phosphorylated by CDC28, probably in association with G1 cyclin CLN2.3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP36167.

    Expressioni

    Gene expression databases

    GenevestigatoriP36167.

    Interactioni

    Subunit structurei

    Interacts with CLN2.1 Publication

    Protein-protein interaction databases

    BioGridi34222. 45 interactions.
    DIPiDIP-4750N.
    IntActiP36167. 7 interactions.
    MINTiMINT-533048.
    STRINGi4932.YKR091W.

    Structurei

    3D structure databases

    ProteinModelPortaliP36167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG47730.
    OMAiSTISNGH.
    OrthoDBiEOG7TN03D.

    Sequencei

    Sequence statusi: Complete.

    P36167-1 [UniParc]FASTAAdd to Basket

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    MFLKTPNWET VNETPKSRVL TINELISPNL DTESNSLLAT PARKYFKTSI    50
    SEAQDSPTSA PSPDGNEDPT YQYNVQFHFP GPITPTTPRS KNAEMFPSPT 100
    PPLVSPTAVI EEENDDSVRE FSRTLKSRLN CAMVKLSKEH EQVALIPPPP 150
    TEKIRKGSYS NKFAAKHRRC HSLDESKKFL SSLEDSSAHA AFLKAISSKH 200
    AKSNRVDNVN VSPLRWSSHR RTQSTQENSL QEVVAIDTLL KMSSSD 246
    Length:246
    Mass (Da):27,466
    Last modified:July 11, 2006 - v2
    Checksum:iC305AAC89310E65D
    GO

    Sequence cautioni

    The sequence CAA51945.1 differs from that shown. Reason: Frameshift at position 38.
    The sequence CAA82170.1 differs from that shown. Reason: Frameshift at position 38.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73541 Genomic DNA. Translation: CAA51945.1. Frameshift.
    Z28316 Genomic DNA. Translation: CAA82170.1. Frameshift.
    AY558318 Genomic DNA. Translation: AAS56644.1.
    BK006944 Genomic DNA. Translation: DAA09241.1.
    PIRiS38169.
    RefSeqiNP_013017.2. NM_001179881.1.

    Genome annotation databases

    EnsemblFungiiYKR091W; YKR091W; YKR091W.
    GeneIDi853966.
    KEGGisce:YKR091W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73541 Genomic DNA. Translation: CAA51945.1 . Frameshift.
    Z28316 Genomic DNA. Translation: CAA82170.1 . Frameshift.
    AY558318 Genomic DNA. Translation: AAS56644.1 .
    BK006944 Genomic DNA. Translation: DAA09241.1 .
    PIRi S38169.
    RefSeqi NP_013017.2. NM_001179881.1.

    3D structure databases

    ProteinModelPortali P36167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34222. 45 interactions.
    DIPi DIP-4750N.
    IntActi P36167. 7 interactions.
    MINTi MINT-533048.
    STRINGi 4932.YKR091W.

    Proteomic databases

    MaxQBi P36167.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKR091W ; YKR091W ; YKR091W .
    GeneIDi 853966.
    KEGGi sce:YKR091W.

    Organism-specific databases

    CYGDi YKR091w.
    SGDi S000001799. SRL3.

    Phylogenomic databases

    eggNOGi NOG47730.
    OMAi STISNGH.
    OrthoDBi EOG7TN03D.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32054-MONOMER.

    Miscellaneous databases

    NextBioi 975401.

    Gene expression databases

    Genevestigatori P36167.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The complete sequence of a 15,820 bp segment of Saccharomyces cerevisiae chromosome XI contains the UBI2 and MPL1 genes and three new open reading frames."
      Bou G., Esteban P.F., Baladron V., Gonzalez G.A., Cantalejo J.G., Remacha M.A., Jimenez A., del Rey F., Ballesta J.P.G., Revuelta J.L.
      Yeast 9:1349-1354(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 95-246.
      Strain: ATCC 204508 / S288c.
    5. Cited for: SUBCELLULAR LOCATION.
    6. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
      Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
      Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF FRAMESHIFT.
    7. Cited for: PHOSPHORYLATION BY CDC28.
    8. Cited for: INTERACTION WITH CLN2, IDENTIFICATION BY MASS SPECTROMETRY.
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSRL3_YEAST
    AccessioniPrimary (citable) accession number: P36167
    Secondary accession number(s): D6VXF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3