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P36164

- TVP38_YEAST

UniProt

P36164 - TVP38_YEAST

Protein

Golgi apparatus membrane protein TVP38

Gene

TVP38

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Golgi membrane protein involved in vesicular trafficking and spindle migration.1 Publication

    GO - Biological processi

    1. mitotic spindle elongation Source: SGD
    2. vesicle-mediated transport Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32051-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgi apparatus membrane protein TVP38
    Alternative name(s):
    TLG2-vesicle protein of 38 kDa
    Gene namesi
    Name:TVP38
    Ordered Locus Names:YKR088C
    ORF Names:YKR408
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKR088c.
    SGDiS000001796. TVP38.

    Subcellular locationi

    Golgi apparatus membrane 3 Publications; Multi-pass membrane protein 3 Publications

    GO - Cellular componenti

    1. integral component of Golgi membrane Source: SGD

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Golgi apparatus membrane protein TVP38PRO_0000203226Add
    BLAST

    Proteomic databases

    PaxDbiP36164.

    Expressioni

    Gene expression databases

    GenevestigatoriP36164.

    Interactioni

    Subunit structurei

    Interacts with YIP5.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AKR1P390101EBI-26527,EBI-2421
    GCS1P351971EBI-26527,EBI-7475
    KEX1P096201EBI-26527,EBI-9653
    RBD2Q122701EBI-26527,EBI-31471
    TEF1P029941EBI-26527,EBI-6314
    TVP15Q038601EBI-26527,EBI-37537

    Protein-protein interaction databases

    BioGridi34219. 34 interactions.
    DIPiDIP-5167N.
    IntActiP36164. 6 interactions.
    MINTiMINT-563946.
    STRINGi4932.YKR088C.

    Structurei

    3D structure databases

    ProteinModelPortaliP36164.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9595LumenalSequence AnalysisAdd
    BLAST
    Topological domaini117 – 13721CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 16911LumenalSequence AnalysisAdd
    BLAST
    Topological domaini191 – 25161CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 28614LumenalSequence AnalysisAdd
    BLAST
    Topological domaini308 – 33730CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei96 – 11621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei252 – 27221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei287 – 30721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TVP38/TMEM64 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0398.
    HOGENOMiHOG000066098.
    OMAiFPYSLTN.
    OrthoDBiEOG744TMD.

    Family and domain databases

    InterProiIPR015414. SNARE_assoc.
    [Graphical view]
    PfamiPF09335. SNARE_assoc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36164-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQSYEAGNA NMGQGEDDEF DGYFEDFDND IMPNSNNGQR VGTNAGLSFN    50
    DEVNVNDDDF LDIYNMSPRE RLMHNIRKNV QKLQFYFYSL RLWQQIIIVL 100
    LGIMLMIMGI LLLVFHNAIL HKVVVTSNDL REKMSTHFIL MVLIFFVAFP 150
    PMIGYSLLST TTGLIYGVSF EGWVTLALGS VTGSIASFVV FKTILHSRAE 200
    KLVHLNRRFE ALASILQENN SYWILALLRL CPFPYSLTNG AIAGVYGISV 250
    RNFSIANIIT TPKLFIYLFI GSRVKSLAES ESTGSRVFDL VSIIITLLIL 300
    SLTAWLLYFK TKKRYLELQN RDRQVSTDQL PELSFEV 337
    Length:337
    Mass (Da):38,311
    Last modified:June 1, 1994 - v1
    Checksum:i7EA95DD4E5AF77FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z27116 Genomic DNA. Translation: CAA81639.1.
    Z28313 Genomic DNA. Translation: CAA82167.1.
    AY557916 Genomic DNA. Translation: AAS56242.1.
    BK006944 Genomic DNA. Translation: DAA09238.1.
    PIRiS38166.
    RefSeqiNP_013014.3. NM_001179878.3.

    Genome annotation databases

    EnsemblFungiiYKR088C; YKR088C; YKR088C.
    GeneIDi853963.
    KEGGisce:YKR088C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z27116 Genomic DNA. Translation: CAA81639.1 .
    Z28313 Genomic DNA. Translation: CAA82167.1 .
    AY557916 Genomic DNA. Translation: AAS56242.1 .
    BK006944 Genomic DNA. Translation: DAA09238.1 .
    PIRi S38166.
    RefSeqi NP_013014.3. NM_001179878.3.

    3D structure databases

    ProteinModelPortali P36164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34219. 34 interactions.
    DIPi DIP-5167N.
    IntActi P36164. 6 interactions.
    MINTi MINT-563946.
    STRINGi 4932.YKR088C.

    Proteomic databases

    PaxDbi P36164.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKR088C ; YKR088C ; YKR088C .
    GeneIDi 853963.
    KEGGi sce:YKR088C.

    Organism-specific databases

    CYGDi YKR088c.
    SGDi S000001796. TVP38.

    Phylogenomic databases

    eggNOGi COG0398.
    HOGENOMi HOG000066098.
    OMAi FPYSLTN.
    OrthoDBi EOG744TMD.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32051-MONOMER.

    Miscellaneous databases

    NextBioi 975392.

    Gene expression databases

    Genevestigatori P36164.

    Family and domain databases

    InterProi IPR015414. SNARE_assoc.
    [Graphical view ]
    Pfami PF09335. SNARE_assoc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete sequence of an 18,002 bp segment of Saccharomyces cerevisiae chromosome XI contains the HBS1, MRP-L20 and PRP16 genes, and six new open reading frames."
      Garcia-Cantalejo J.M., Baladron V., Esteban P.F., Santos M.A., Bou G., Remacha M.A., Revuelta J.L., Ballesta J.P.G., Jimenez A., del Rey F.
      Yeast 10:231-245(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
      Inadome H., Noda Y., Adachi H., Yoda K.
      Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    9. "Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-containing Golgi/endosome compartments of Saccharomyces cerevisiae."
      Inadome H., Noda Y., Kamimura Y., Adachi H., Yoda K.
      Exp. Cell Res. 313:688-697(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH YIP5.
    10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTVP38_YEAST
    AccessioniPrimary (citable) accession number: P36164
    Secondary accession number(s): D6VXE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 11300 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3