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Protein

Golgi apparatus membrane protein TVP38

Gene

TVP38

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Golgi membrane protein involved in vesicular trafficking and spindle migration.1 Publication

Miscellaneous

Present with 11300 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • mitotic spindle elongation Source: SGD
  • vesicle-mediated transport Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-32051-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi apparatus membrane protein TVP38
Alternative name(s):
TLG2-vesicle protein of 38 kDa
Gene namesi
Name:TVP38
Ordered Locus Names:YKR088C
ORF Names:YKR408
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR088C
SGDiS000001796 TVP38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 95LumenalSequence analysisAdd BLAST95
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 137CytoplasmicSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 169LumenalSequence analysisAdd BLAST11
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 251CytoplasmicSequence analysisAdd BLAST61
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 286LumenalSequence analysisAdd BLAST14
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 337CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032261 – 337Golgi apparatus membrane protein TVP38Add BLAST337

Proteomic databases

PaxDbiP36164
PRIDEiP36164

PTM databases

iPTMnetiP36164

Interactioni

Subunit structurei

Interacts with YIP5.1 Publication

Protein-protein interaction databases

BioGridi34219, 107 interactors
DIPiDIP-5167N
IntActiP36164, 6 interactors
MINTiP36164
STRINGi4932.YKR088C

Structurei

3D structure databases

ProteinModelPortaliP36164
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TVP38/TMEM64 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000066098
InParanoidiP36164
OMAiRDEFTDN
OrthoDBiEOG092C3UE0

Family and domain databases

InterProiView protein in InterPro
IPR032816 SNARE_assoc
IPR015414 TMEM64
PANTHERiPTHR12677 PTHR12677, 1 hit
PfamiView protein in Pfam
PF09335 SNARE_assoc, 1 hit

Sequencei

Sequence statusi: Complete.

P36164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSYEAGNA NMGQGEDDEF DGYFEDFDND IMPNSNNGQR VGTNAGLSFN
60 70 80 90 100
DEVNVNDDDF LDIYNMSPRE RLMHNIRKNV QKLQFYFYSL RLWQQIIIVL
110 120 130 140 150
LGIMLMIMGI LLLVFHNAIL HKVVVTSNDL REKMSTHFIL MVLIFFVAFP
160 170 180 190 200
PMIGYSLLST TTGLIYGVSF EGWVTLALGS VTGSIASFVV FKTILHSRAE
210 220 230 240 250
KLVHLNRRFE ALASILQENN SYWILALLRL CPFPYSLTNG AIAGVYGISV
260 270 280 290 300
RNFSIANIIT TPKLFIYLFI GSRVKSLAES ESTGSRVFDL VSIIITLLIL
310 320 330
SLTAWLLYFK TKKRYLELQN RDRQVSTDQL PELSFEV
Length:337
Mass (Da):38,311
Last modified:June 1, 1994 - v1
Checksum:i7EA95DD4E5AF77FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27116 Genomic DNA Translation: CAA81639.1
Z28313 Genomic DNA Translation: CAA82167.1
AY557916 Genomic DNA Translation: AAS56242.1
BK006944 Genomic DNA Translation: DAA09238.1
PIRiS38166
RefSeqiNP_013014.3, NM_001179878.3

Genome annotation databases

EnsemblFungiiYKR088C; YKR088C; YKR088C
GeneIDi853963
KEGGisce:YKR088C

Similar proteinsi

Entry informationi

Entry nameiTVP38_YEAST
AccessioniPrimary (citable) accession number: P36164
Secondary accession number(s): D6VXE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

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