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P36164 (TVP38_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Golgi apparatus membrane protein TVP38
Alternative name(s):
TLG2-vesicle protein of 38 kDa
Gene names
Name:TVP38
Ordered Locus Names:YKR088C
ORF Names:YKR408
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Golgi membrane protein involved in vesicular trafficking and spindle migration. Ref.9

Subunit structure

Interacts with YIP5. Ref.9

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein Ref.5 Ref.7 Ref.9.

Miscellaneous

Present with 11300 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the TVP38/TMEM64 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Golgi apparatus membrane protein TVP38
PRO_0000203226

Regions

Topological domain1 – 9595Lumenal Potential
Transmembrane96 – 11621Helical; Potential
Topological domain117 – 13721Cytoplasmic Potential
Transmembrane138 – 15821Helical; Potential
Topological domain159 – 16911Lumenal Potential
Transmembrane170 – 19021Helical; Potential
Topological domain191 – 25161Cytoplasmic Potential
Transmembrane252 – 27221Helical; Potential
Topological domain273 – 28614Lumenal Potential
Transmembrane287 – 30721Helical; Potential
Topological domain308 – 33730Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P36164 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 7EA95DD4E5AF77FE

FASTA33738,311
        10         20         30         40         50         60 
MSQSYEAGNA NMGQGEDDEF DGYFEDFDND IMPNSNNGQR VGTNAGLSFN DEVNVNDDDF 

        70         80         90        100        110        120 
LDIYNMSPRE RLMHNIRKNV QKLQFYFYSL RLWQQIIIVL LGIMLMIMGI LLLVFHNAIL 

       130        140        150        160        170        180 
HKVVVTSNDL REKMSTHFIL MVLIFFVAFP PMIGYSLLST TTGLIYGVSF EGWVTLALGS 

       190        200        210        220        230        240 
VTGSIASFVV FKTILHSRAE KLVHLNRRFE ALASILQENN SYWILALLRL CPFPYSLTNG 

       250        260        270        280        290        300 
AIAGVYGISV RNFSIANIIT TPKLFIYLFI GSRVKSLAES ESTGSRVFDL VSIIITLLIL 

       310        320        330 
SLTAWLLYFK TKKRYLELQN RDRQVSTDQL PELSFEV 

« Hide

References

« Hide 'large scale' references
[1]"The complete sequence of an 18,002 bp segment of Saccharomyces cerevisiae chromosome XI contains the HBS1, MRP-L20 and PRP16 genes, and six new open reading frames."
Garcia-Cantalejo J.M., Baladron V., Esteban P.F., Santos M.A., Bou G., Remacha M.A., Revuelta J.L., Ballesta J.P.G., Jimenez A., del Rey F.
Yeast 10:231-245(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
Inadome H., Noda Y., Adachi H., Yoda K.
Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
[8]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[9]"Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-containing Golgi/endosome compartments of Saccharomyces cerevisiae."
Inadome H., Noda Y., Kamimura Y., Adachi H., Yoda K.
Exp. Cell Res. 313:688-697(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH YIP5.
[10]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z27116 Genomic DNA. Translation: CAA81639.1.
Z28313 Genomic DNA. Translation: CAA82167.1.
AY557916 Genomic DNA. Translation: AAS56242.1.
BK006944 Genomic DNA. Translation: DAA09238.1.
PIRS38166.
RefSeqNP_013014.3. NM_001179878.3.

3D structure databases

ProteinModelPortalP36164.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34219. 34 interactions.
DIPDIP-5167N.
IntActP36164. 6 interactions.
MINTMINT-563946.
STRING4932.YKR088C.

Proteomic databases

PaxDbP36164.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKR088C; YKR088C; YKR088C.
GeneID853963.
KEGGsce:YKR088C.

Organism-specific databases

CYGDYKR088c.
SGDS000001796. TVP38.

Phylogenomic databases

eggNOGCOG0398.
HOGENOMHOG000066098.
OMAFPYSLTN.
OrthoDBEOG744TMD.

Enzyme and pathway databases

BioCycYEAST:G3O-32051-MONOMER.

Gene expression databases

GenevestigatorP36164.

Family and domain databases

InterProIPR015414. SNARE_assoc.
[Graphical view]
PfamPF09335. SNARE_assoc. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio975392.

Entry information

Entry nameTVP38_YEAST
AccessionPrimary (citable) accession number: P36164
Secondary accession number(s): D6VXE8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families