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Protein

Mitochondrial metalloendopeptidase OMA1

Gene

OMA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease that is part of the quality control system in the inner membrane of mitochondria. Cleaves and thereby promotes the turnover of mistranslated or misfolded membrane proteins. Can cleave the misfolded multi-pass membrane protein OXA1.1 Publication

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi203Zinc; catalyticPROSITE-ProRule annotation1
Active sitei204PROSITE-ProRule annotation1
Metal bindingi207Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi257Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • metalloendopeptidase activity Source: SGD

GO - Biological processi

  • mitochondrial protein catabolic process Source: SGD
  • protein quality control for misfolded or incompletely synthesized proteins Source: SGD
  • TOR signaling Source: SGD

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32050-MONOMER
ReactomeiR-SCE-169911 Regulation of Apoptosis

Protein family/group databases

MEROPSiM48.018

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial metalloendopeptidase OMA1 (EC:3.4.24.-)
Gene namesi
Name:OMA1
Ordered Locus Names:YKR087C
ORF Names:YKR407
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR087C
SGDiS000001795 OMA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 67Mitochondrial intermembraneSequence analysisAdd BLAST67
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 223Mitochondrial matrixSequence analysisAdd BLAST135
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 345Mitochondrial intermembraneSequence analysisAdd BLAST101

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi204E → Q: Loss of protease activity. 1 Publication1
Mutagenesisi207H → Y: Loss of protease activity. 1 Publication1
Mutagenesisi212H → Y: Loss of protease activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032251 – 345Mitochondrial metalloendopeptidase OMA1Add BLAST345

Proteomic databases

MaxQBiP36163
PaxDbiP36163
PRIDEiP36163

Interactioni

Protein-protein interaction databases

BioGridi34218, 36 interactors
DIPiDIP-5087N
IntActiP36163, 4 interactors
STRINGi4932.YKR087C

Structurei

3D structure databases

ProteinModelPortaliP36163
SMRiP36163
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M48 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000007027
HOGENOMiHOG000266075
InParanoidiP36163
OMAiMAEACYD
OrthoDBiEOG092C4VJW

Family and domain databases

InterProiView protein in InterPro
IPR001915 Peptidase_M48
PfamiView protein in Pfam
PF01435 Peptidase_M48, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

P36163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNIIRFKG FGKGTSGGFL KPVSFRVQLT RCYRYDNGPS YRRFNNGEYS
60 70 80 90 100
QKSSFKSILL DKSSRKYLAL LFGGCSLFYY THLDKAPVSD RSRFIWVSRP
110 120 130 140 150
LELTIGNYTY KSIWRQTQQE ILPPQHPLSI KIENIFMKIV EAAYKDPSVD
160 170 180 190 200
NSLLDGIKWE IHVVNDPTAS PNAFVLPGGK VFIFSSILPI CANDDGIATV
210 220 230 240 250
LAHEFAHQLA RHTAENLSKA PIYSLLGLVL YTVTGAHAIN NILLDGFLRM
260 270 280 290 300
PASRQMETEA DYIGLMIMSR ACFQPQESIK VWERMANFEK QMNRGGVVNM
310 320 330 340
EFLSTHPAST RRIENMSKWL PKANEIYEQS DCSSMGNYYK SFFSM
Length:345
Mass (Da):39,328
Last modified:May 16, 2006 - v2
Checksum:i95B0EBCD25F435CF
GO

Sequence cautioni

The sequence CAA81638 differs from that shown. Reason: Frameshift at position 33.Curated
The sequence CAA82166 differs from that shown. Reason: Frameshift at position 33.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27116 Genomic DNA Translation: CAA81638.1 Frameshift.
Z28312 Genomic DNA Translation: CAA82166.1 Frameshift.
BK006944 Genomic DNA Translation: DAA09237.1
PIRiS38165
RefSeqiNP_013013.2, NM_001179877.1

Genome annotation databases

EnsemblFungiiYKR087C; YKR087C; YKR087C
GeneIDi853962
KEGGisce:YKR087C

Similar proteinsi

Entry informationi

Entry nameiOMA1_YEAST
AccessioniPrimary (citable) accession number: P36163
Secondary accession number(s): D6VXE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 16, 2006
Last modified: March 28, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health