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Protein

Uroporphyrinogen-III C-methyltransferase

Gene

MET1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Siroheme synthase involved in methionine biosynthesis.2 Publications

Catalytic activityi

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

GO - Molecular functioni

  • uroporphyrin-III C-methyltransferase activity Source: SGD

GO - Biological processi

  • methionine biosynthetic process Source: UniProtKB-KW
  • oxidation-reduction process Source: InterPro
  • siroheme biosynthetic process Source: SGD
  • sulfate assimilation Source: SGD

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis, Porphyrin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMetaCyc:G3O-32035-MONOMER.
YEAST:G3O-32035-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
Short name:
Urogen III methylase
Alternative name(s):
SUMT
Uroporphyrinogen III methylase
Short name:
UROM
Gene namesi
Name:MET1
Synonyms:MET20
Ordered Locus Names:YKR069W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR069W.
SGDiS000001777. MET1.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001503871 – 593Uroporphyrinogen-III C-methyltransferaseAdd BLAST593

Proteomic databases

MaxQBiP36150.
PRIDEiP36150.

PTM databases

iPTMnetiP36150.

Interactioni

Protein-protein interaction databases

BioGridi34200. 38 interactors.
DIPiDIP-4843N.
IntActiP36150. 2 interactors.
MINTiMINT-478835.
STRINGi4932.YKR069W.

Structurei

3D structure databases

ProteinModelPortaliP36150.
SMRiP36150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the precorrin methyltransferase family.Curated

Phylogenomic databases

HOGENOMiHOG000194244.
InParanoidiP36150.
KOiK00589.
OMAiQVSEYWP.
OrthoDBiEOG092C3Q6X.

Family and domain databases

Gene3Di3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProiView protein in InterPro
IPR000878. 4pyrrol_Mease.
IPR035996. 4pyrrol_Methylase_sf.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR012066. Met1_fungi.
IPR003043. Uropor_MeTrfase_CS.
PfamiView protein in Pfam
PF00590. TP_methylase. 1 hit.
PIRSFiPIRSF036555. SUMT_yeast. 1 hit.
SUPFAMiSSF53790. SSF53790. 1 hit.
PROSITEiView protein in PROSITE
PS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P36150-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRDLVTLPS SLPLITAGFA TDQVHLLIGT GSTDSVSVCK NRIHSILNAG
60 70 80 90 100
GNPIVVNPSS PSHTKQLQLE FGKFAKFEIV EREFRLSDLT TLGRVLVCKV
110 120 130 140 150
VDRVFVDLPI TQSRLCEEIF WQCQKLRIPI NTFHKPEFST FNMIPTWVDP
160 170 180 190 200
KGSGLQISVT TNGNGYILAN RIKRDIISHL PPNISEVVIN MGYLKDRIIN
210 220 230 240 250
EDHKALLEEK YYQTDMSLPG FGYGLDEDGW ESHKFNKLIR EFEMTSREQR
260 270 280 290 300
LKRTRWLSQI MEYYPMNKLS DIKLEDFETS SSPNKKTKQE TVTEGVVPPT
310 320 330 340 350
DENIENGTKQ LQLSEVKKEE GPKKLGKISL VGSGPGSVSM LTIGALQEIK
360 370 380 390 400
SADIILADKL VPQAILDLIP PKTETFIAKK FPGNAERAQQ ELLAKGLESL
410 420 430 440 450
DNGLKVVRLK QGDPYIFGRG GEEFNFFKDH GYIPVVLPGI SSSLACTVLA
460 470 480 490 500
QIPATQRDIA DQVLICTGTG RKGALPIIPE FVESRTTVFL MALHRANVLI
510 520 530 540 550
TGLLKHGWDG DVPAAIVERG SCPDQRVTRT LLKWVPEVVE EIGSRPPGVL
560 570 580 590
VVGKAVNALV EKDLINFDES RKFVIDEGFR EFEVDVDSLF KLY
Length:593
Mass (Da):66,125
Last modified:June 1, 1994 - v1
Checksum:i7C704866B08C0C6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28294 Genomic DNA. Translation: CAA82148.1.
BK006944 Genomic DNA. Translation: DAA09220.1.
PIRiS38145.
RefSeqiNP_012995.3. NM_001179859.3.

Genome annotation databases

EnsemblFungiiYKR069W; YKR069W; YKR069W.
GeneIDi853943.
KEGGisce:YKR069W.

Similar proteinsi

Entry informationi

Entry nameiSUMT_YEAST
AccessioniPrimary (citable) accession number: P36150
Secondary accession number(s): D6VXD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 22, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names