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P36150

- SUMT_YEAST

UniProt

P36150 - SUMT_YEAST

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Protein

Uroporphyrinogen-III C-methyltransferase

Gene

MET1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Siroheme synthase involved in methionine biosynthesis.2 Publications

Catalytic activityi

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

GO - Molecular functioni

  1. precorrin-2 dehydrogenase activity Source: InterPro
  2. uroporphyrin-III C-methyltransferase activity Source: SGD

GO - Biological processi

  1. methionine biosynthetic process Source: SGD
  2. siroheme biosynthetic process Source: SGD
  3. sulfate assimilation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMetaCyc:G3O-32035-MONOMER.
YEAST:G3O-32035-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
Short name:
Urogen III methylase
Alternative name(s):
SUMT
Uroporphyrinogen III methylase
Short name:
UROM
Gene namesi
Name:MET1
Synonyms:MET20
Ordered Locus Names:YKR069W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKR069w.
SGDiS000001777. MET1.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Uroporphyrinogen-III C-methyltransferasePRO_0000150387Add
BLAST

Proteomic databases

MaxQBiP36150.
PaxDbiP36150.
PeptideAtlasiP36150.

Expressioni

Gene expression databases

GenevestigatoriP36150.

Interactioni

Protein-protein interaction databases

BioGridi34200. 10 interactions.
DIPiDIP-4843N.
IntActiP36150. 2 interactions.
MINTiMINT-478835.

Structurei

3D structure databases

ProteinModelPortaliP36150.
SMRiP36150. Positions 301-562.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the precorrin methyltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0007.
HOGENOMiHOG000194244.
InParanoidiP36150.
KOiK00589.
OMAiFIARKFP.
OrthoDBiEOG7WHHP1.

Family and domain databases

Gene3Di3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR016040. NAD(P)-bd_dom.
IPR012066. SUMT_yeast.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamiPF00590. TP_methylase. 1 hit.
[Graphical view]
PIRSFiPIRSF036555. SUMT_yeast. 1 hit.
SUPFAMiSSF53790. SSF53790. 1 hit.
PROSITEiPS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36150-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRDLVTLPS SLPLITAGFA TDQVHLLIGT GSTDSVSVCK NRIHSILNAG
60 70 80 90 100
GNPIVVNPSS PSHTKQLQLE FGKFAKFEIV EREFRLSDLT TLGRVLVCKV
110 120 130 140 150
VDRVFVDLPI TQSRLCEEIF WQCQKLRIPI NTFHKPEFST FNMIPTWVDP
160 170 180 190 200
KGSGLQISVT TNGNGYILAN RIKRDIISHL PPNISEVVIN MGYLKDRIIN
210 220 230 240 250
EDHKALLEEK YYQTDMSLPG FGYGLDEDGW ESHKFNKLIR EFEMTSREQR
260 270 280 290 300
LKRTRWLSQI MEYYPMNKLS DIKLEDFETS SSPNKKTKQE TVTEGVVPPT
310 320 330 340 350
DENIENGTKQ LQLSEVKKEE GPKKLGKISL VGSGPGSVSM LTIGALQEIK
360 370 380 390 400
SADIILADKL VPQAILDLIP PKTETFIAKK FPGNAERAQQ ELLAKGLESL
410 420 430 440 450
DNGLKVVRLK QGDPYIFGRG GEEFNFFKDH GYIPVVLPGI SSSLACTVLA
460 470 480 490 500
QIPATQRDIA DQVLICTGTG RKGALPIIPE FVESRTTVFL MALHRANVLI
510 520 530 540 550
TGLLKHGWDG DVPAAIVERG SCPDQRVTRT LLKWVPEVVE EIGSRPPGVL
560 570 580 590
VVGKAVNALV EKDLINFDES RKFVIDEGFR EFEVDVDSLF KLY
Length:593
Mass (Da):66,125
Last modified:June 1, 1994 - v1
Checksum:i7C704866B08C0C6D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28294 Genomic DNA. Translation: CAA82148.1.
BK006944 Genomic DNA. Translation: DAA09220.1.
PIRiS38145.
RefSeqiNP_012995.3. NM_001179859.3.

Genome annotation databases

EnsemblFungiiYKR069W; YKR069W; YKR069W.
GeneIDi853943.
KEGGisce:YKR069W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28294 Genomic DNA. Translation: CAA82148.1 .
BK006944 Genomic DNA. Translation: DAA09220.1 .
PIRi S38145.
RefSeqi NP_012995.3. NM_001179859.3.

3D structure databases

ProteinModelPortali P36150.
SMRi P36150. Positions 301-562.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34200. 10 interactions.
DIPi DIP-4843N.
IntActi P36150. 2 interactions.
MINTi MINT-478835.

Proteomic databases

MaxQBi P36150.
PaxDbi P36150.
PeptideAtlasi P36150.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKR069W ; YKR069W ; YKR069W .
GeneIDi 853943.
KEGGi sce:YKR069W.

Organism-specific databases

CYGDi YKR069w.
SGDi S000001777. MET1.

Phylogenomic databases

eggNOGi COG0007.
HOGENOMi HOG000194244.
InParanoidi P36150.
KOi K00589.
OMAi FIARKFP.
OrthoDBi EOG7WHHP1.

Enzyme and pathway databases

BioCyci MetaCyc:G3O-32035-MONOMER.
YEAST:G3O-32035-MONOMER.

Miscellaneous databases

NextBioi 975336.

Gene expression databases

Genevestigatori P36150.

Family and domain databases

Gene3Di 3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR016040. NAD(P)-bd_dom.
IPR012066. SUMT_yeast.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view ]
Pfami PF00590. TP_methylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036555. SUMT_yeast. 1 hit.
SUPFAMi SSF53790. SSF53790. 1 hit.
PROSITEi PS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Siroheme biosynthesis in Saccharomyces cerevisiae requires the products of both the MET1 and MET8 genes."
    Hansen J., Muldbjerg M., Cherest H., Surdin-Kerjan Y.
    FEBS Lett. 401:20-24(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "The role of Saccharomyces cerevisiae Met1p and Met8p in sirohaem and cobalamin biosynthesis."
    Raux E., McVeigh T., Peters S.E., Leustek T., Warren M.J.
    Biochem. J. 338:701-708(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSUMT_YEAST
AccessioniPrimary (citable) accession number: P36150
Secondary accession number(s): D6VXD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3