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P36150

- SUMT_YEAST

UniProt

P36150 - SUMT_YEAST

Protein

Uroporphyrinogen-III C-methyltransferase

Gene

MET1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Siroheme synthase involved in methionine biosynthesis.2 Publications

    Catalytic activityi

    S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
    S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

    GO - Molecular functioni

    1. precorrin-2 dehydrogenase activity Source: InterPro
    2. uroporphyrin-III C-methyltransferase activity Source: SGD

    GO - Biological processi

    1. methionine biosynthetic process Source: SGD
    2. siroheme biosynthetic process Source: SGD
    3. sulfate assimilation Source: SGD

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Methionine biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMetaCyc:G3O-32035-MONOMER.
    YEAST:G3O-32035-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
    Short name:
    Urogen III methylase
    Alternative name(s):
    SUMT
    Uroporphyrinogen III methylase
    Short name:
    UROM
    Gene namesi
    Name:MET1
    Synonyms:MET20
    Ordered Locus Names:YKR069W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKR069w.
    SGDiS000001777. MET1.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 593593Uroporphyrinogen-III C-methyltransferasePRO_0000150387Add
    BLAST

    Proteomic databases

    MaxQBiP36150.
    PaxDbiP36150.
    PeptideAtlasiP36150.

    Expressioni

    Gene expression databases

    GenevestigatoriP36150.

    Interactioni

    Protein-protein interaction databases

    BioGridi34200. 9 interactions.
    DIPiDIP-4843N.
    IntActiP36150. 2 interactions.
    MINTiMINT-478835.

    Structurei

    3D structure databases

    ProteinModelPortaliP36150.
    SMRiP36150. Positions 301-562.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the precorrin methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0007.
    HOGENOMiHOG000194244.
    KOiK00589.
    OMAiFIARKFP.
    OrthoDBiEOG7WHHP1.

    Family and domain databases

    Gene3Di3.30.950.10. 1 hit.
    3.40.1010.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR000878. 4pyrrol_Mease.
    IPR014777. 4pyrrole_Mease_sub1.
    IPR014776. 4pyrrole_Mease_sub2.
    IPR016040. NAD(P)-bd_dom.
    IPR012066. SUMT_yeast.
    IPR003043. Uropor_MeTrfase_CS.
    [Graphical view]
    PfamiPF00590. TP_methylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036555. SUMT_yeast. 1 hit.
    SUPFAMiSSF53790. SSF53790. 1 hit.
    PROSITEiPS00839. SUMT_1. 1 hit.
    PS00840. SUMT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36150-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRDLVTLPS SLPLITAGFA TDQVHLLIGT GSTDSVSVCK NRIHSILNAG    50
    GNPIVVNPSS PSHTKQLQLE FGKFAKFEIV EREFRLSDLT TLGRVLVCKV 100
    VDRVFVDLPI TQSRLCEEIF WQCQKLRIPI NTFHKPEFST FNMIPTWVDP 150
    KGSGLQISVT TNGNGYILAN RIKRDIISHL PPNISEVVIN MGYLKDRIIN 200
    EDHKALLEEK YYQTDMSLPG FGYGLDEDGW ESHKFNKLIR EFEMTSREQR 250
    LKRTRWLSQI MEYYPMNKLS DIKLEDFETS SSPNKKTKQE TVTEGVVPPT 300
    DENIENGTKQ LQLSEVKKEE GPKKLGKISL VGSGPGSVSM LTIGALQEIK 350
    SADIILADKL VPQAILDLIP PKTETFIAKK FPGNAERAQQ ELLAKGLESL 400
    DNGLKVVRLK QGDPYIFGRG GEEFNFFKDH GYIPVVLPGI SSSLACTVLA 450
    QIPATQRDIA DQVLICTGTG RKGALPIIPE FVESRTTVFL MALHRANVLI 500
    TGLLKHGWDG DVPAAIVERG SCPDQRVTRT LLKWVPEVVE EIGSRPPGVL 550
    VVGKAVNALV EKDLINFDES RKFVIDEGFR EFEVDVDSLF KLY 593
    Length:593
    Mass (Da):66,125
    Last modified:June 1, 1994 - v1
    Checksum:i7C704866B08C0C6D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28294 Genomic DNA. Translation: CAA82148.1.
    BK006944 Genomic DNA. Translation: DAA09220.1.
    PIRiS38145.
    RefSeqiNP_012995.3. NM_001179859.3.

    Genome annotation databases

    EnsemblFungiiYKR069W; YKR069W; YKR069W.
    GeneIDi853943.
    KEGGisce:YKR069W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28294 Genomic DNA. Translation: CAA82148.1 .
    BK006944 Genomic DNA. Translation: DAA09220.1 .
    PIRi S38145.
    RefSeqi NP_012995.3. NM_001179859.3.

    3D structure databases

    ProteinModelPortali P36150.
    SMRi P36150. Positions 301-562.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34200. 9 interactions.
    DIPi DIP-4843N.
    IntActi P36150. 2 interactions.
    MINTi MINT-478835.

    Proteomic databases

    MaxQBi P36150.
    PaxDbi P36150.
    PeptideAtlasi P36150.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKR069W ; YKR069W ; YKR069W .
    GeneIDi 853943.
    KEGGi sce:YKR069W.

    Organism-specific databases

    CYGDi YKR069w.
    SGDi S000001777. MET1.

    Phylogenomic databases

    eggNOGi COG0007.
    HOGENOMi HOG000194244.
    KOi K00589.
    OMAi FIARKFP.
    OrthoDBi EOG7WHHP1.

    Enzyme and pathway databases

    BioCyci MetaCyc:G3O-32035-MONOMER.
    YEAST:G3O-32035-MONOMER.

    Miscellaneous databases

    NextBioi 975336.

    Gene expression databases

    Genevestigatori P36150.

    Family and domain databases

    Gene3Di 3.30.950.10. 1 hit.
    3.40.1010.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR000878. 4pyrrol_Mease.
    IPR014777. 4pyrrole_Mease_sub1.
    IPR014776. 4pyrrole_Mease_sub2.
    IPR016040. NAD(P)-bd_dom.
    IPR012066. SUMT_yeast.
    IPR003043. Uropor_MeTrfase_CS.
    [Graphical view ]
    Pfami PF00590. TP_methylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036555. SUMT_yeast. 1 hit.
    SUPFAMi SSF53790. SSF53790. 1 hit.
    PROSITEi PS00839. SUMT_1. 1 hit.
    PS00840. SUMT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Siroheme biosynthesis in Saccharomyces cerevisiae requires the products of both the MET1 and MET8 genes."
      Hansen J., Muldbjerg M., Cherest H., Surdin-Kerjan Y.
      FEBS Lett. 401:20-24(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "The role of Saccharomyces cerevisiae Met1p and Met8p in sirohaem and cobalamin biosynthesis."
      Raux E., McVeigh T., Peters S.E., Leustek T., Warren M.J.
      Biochem. J. 338:701-708(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSUMT_YEAST
    AccessioniPrimary (citable) accession number: P36150
    Secondary accession number(s): D6VXD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3