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P36150 (SUMT_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen-III C-methyltransferase

Short name=Urogen III methylase
EC=2.1.1.107
Alternative name(s):
SUMT
Uroporphyrinogen III methylase
Short name=UROM
Gene names
Name:MET1
Synonyms:MET20
Ordered Locus Names:YKR069W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length593 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Siroheme synthase involved in methionine biosynthesis. Ref.3 Ref.4

Catalytic activity

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.

S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

Sequence similarities

Belongs to the precorrin methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 593593Uroporphyrinogen-III C-methyltransferase
PRO_0000150387

Sequences

Sequence LengthMass (Da)Tools
P36150 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 7C704866B08C0C6D

FASTA59366,125
        10         20         30         40         50         60 
MVRDLVTLPS SLPLITAGFA TDQVHLLIGT GSTDSVSVCK NRIHSILNAG GNPIVVNPSS 

        70         80         90        100        110        120 
PSHTKQLQLE FGKFAKFEIV EREFRLSDLT TLGRVLVCKV VDRVFVDLPI TQSRLCEEIF 

       130        140        150        160        170        180 
WQCQKLRIPI NTFHKPEFST FNMIPTWVDP KGSGLQISVT TNGNGYILAN RIKRDIISHL 

       190        200        210        220        230        240 
PPNISEVVIN MGYLKDRIIN EDHKALLEEK YYQTDMSLPG FGYGLDEDGW ESHKFNKLIR 

       250        260        270        280        290        300 
EFEMTSREQR LKRTRWLSQI MEYYPMNKLS DIKLEDFETS SSPNKKTKQE TVTEGVVPPT 

       310        320        330        340        350        360 
DENIENGTKQ LQLSEVKKEE GPKKLGKISL VGSGPGSVSM LTIGALQEIK SADIILADKL 

       370        380        390        400        410        420 
VPQAILDLIP PKTETFIAKK FPGNAERAQQ ELLAKGLESL DNGLKVVRLK QGDPYIFGRG 

       430        440        450        460        470        480 
GEEFNFFKDH GYIPVVLPGI SSSLACTVLA QIPATQRDIA DQVLICTGTG RKGALPIIPE 

       490        500        510        520        530        540 
FVESRTTVFL MALHRANVLI TGLLKHGWDG DVPAAIVERG SCPDQRVTRT LLKWVPEVVE 

       550        560        570        580        590 
EIGSRPPGVL VVGKAVNALV EKDLINFDES RKFVIDEGFR EFEVDVDSLF KLY 

« Hide

References

« Hide 'large scale' references
[1]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Siroheme biosynthesis in Saccharomyces cerevisiae requires the products of both the MET1 and MET8 genes."
Hansen J., Muldbjerg M., Cherest H., Surdin-Kerjan Y.
FEBS Lett. 401:20-24(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"The role of Saccharomyces cerevisiae Met1p and Met8p in sirohaem and cobalamin biosynthesis."
Raux E., McVeigh T., Peters S.E., Leustek T., Warren M.J.
Biochem. J. 338:701-708(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[6]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z28294 Genomic DNA. Translation: CAA82148.1.
BK006944 Genomic DNA. Translation: DAA09220.1.
PIRS38145.
RefSeqNP_012995.3. NM_001179859.3.

3D structure databases

ProteinModelPortalP36150.
SMRP36150. Positions 301-562.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34200. 9 interactions.
DIPDIP-4843N.
IntActP36150. 2 interactions.
MINTMINT-478835.

Proteomic databases

MaxQBP36150.
PaxDbP36150.
PeptideAtlasP36150.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKR069W; YKR069W; YKR069W.
GeneID853943.
KEGGsce:YKR069W.

Organism-specific databases

CYGDYKR069w.
SGDS000001777. MET1.

Phylogenomic databases

eggNOGCOG0007.
HOGENOMHOG000194244.
KOK00589.
OMAFIARKFP.
OrthoDBEOG7WHHP1.

Enzyme and pathway databases

BioCycMetaCyc:G3O-32035-MONOMER.
YEAST:G3O-32035-MONOMER.

Gene expression databases

GenevestigatorP36150.

Family and domain databases

Gene3D3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR016040. NAD(P)-bd_dom.
IPR012066. SUMT_yeast.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamPF00590. TP_methylase. 1 hit.
[Graphical view]
PIRSFPIRSF036555. SUMT_yeast. 1 hit.
SUPFAMSSF53790. SSF53790. 1 hit.
PROSITEPS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio975336.

Entry information

Entry nameSUMT_YEAST
AccessionPrimary (citable) accession number: P36150
Secondary accession number(s): D6VXD0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 11, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families